Neural stem cells(NSCs)exist widely in the developing and adult mammalian brain,which are self-renewing and can differentiate into neurons,astrocytes or oligodendrocytes in *** proliferation of NSCs in vitro has been ...
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Neural stem cells(NSCs)exist widely in the developing and adult mammalian brain,which are self-renewing and can differentiate into neurons,astrocytes or oligodendrocytes in *** proliferation of NSCs in vitro has been reported to be regulated by various ***,growing studies by the use of oxygen microelectrodes show that the mammalian embryo developed in uterus with a hypoxic environment and neural stem or progenitor cell in the brain are also with hypoxic *** mean oxygen concentration is about 1-5%in brain *** date,in vitro studies using NSCs have primarily been done under atmospheric conditions of 20%oxygen as the standard culture *** indicates that traditional oxygen concentration in cell culture system may be a hyperoxia environment but not a condition of"physiological hypoxia"to most of cells in ***,we performed a series of experiments to testify whether the exogenous hypoxia could impact the growth of NSCs and their function?How hypoxia regulates the property of NSCs?Our studies demonstrate that mild hypoxia not only promote the self-renew ability of NSCs in vitro,but also increase their differentiation ability into ***,via expansion of NSCs in vitro or modification of it’s’property in situ,mild hypoxia could become a potential approach for allograft cell *** hope these findings will aid in the transplantation of NSCs to treat neural degenerative diseases such as Parkinson’s disease and brain trauma.
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