Cholinergic neurons in the basal forebrain provide centrifugal inputs to the main olfactory bulb(MOB)andmodulate the neural circuits in the ***,how the cholinergic fibers interact with different neuronal types in the ...
详细信息
Cholinergic neurons in the basal forebrain provide centrifugal inputs to the main olfactory bulb(MOB)andmodulate the neural circuits in the ***,how the cholinergic fibers interact with different neuronal types in the MOB is still *** this study,we used optogenetic methods to examine the effect of cholinergic activation in the ***2 was selectively expressed in cholinergic neurons in the horizontal limb of the diagonal band of Broca(HDB).By light stimulation of cholinergic fibers in the MOB,we found that granule cells can be directly *** depolarization was blocked by n ACHR antagonists and not affected by CNQX and *** results indicate that cholinergic axons form excitatory synaptic connections with granule cells in the MOB.
Diabetic nephropathy(DN)is the leading cause of end-stage renal disease accounting for more than 50%of the *** is characterized by histological changes such as glomerular sclerosis and interstitial fibrosis,and functi...
详细信息
Diabetic nephropathy(DN)is the leading cause of end-stage renal disease accounting for more than 50%of the *** is characterized by histological changes such as glomerular sclerosis and interstitial fibrosis,and functional changes such as proteinuria and renal *** develops slowly over>10years in 30–40%of patients with *** therapy for DN as well as risk assessment of DN at early stages of diabetes is lacking.
Neurons change their synaptic connectivity by experience,which is fundamental to brain maturation and functions such as learning and *** elucidate the molecular mechanisms,one common approach is to study the changes o...
详细信息
Neurons change their synaptic connectivity by experience,which is fundamental to brain maturation and functions such as learning and *** elucidate the molecular mechanisms,one common approach is to study the changes of synapses in primary neurons upon manipulation of synaptic *** synapses are located on specialized dendritic compartments called dendritic spines,which possess heterogeneous morphologies and are highly *** stability and morphology are influenced by synaptic activity and specific growth factors such as the neurotrophin BDNF,and involve signaling cascades regulated through multiple series of protein *** I will describe the importance of the protein kinase Cdk5 in dendritic spine morphogenesis and synaptic function via phosphorylation of the BDNF receptor Trk B and the signaling protein S6 kinase.
ERp57 participates in the regulation of calcium *** ERp57 modulates calcium flux across the plasma membrane and the endoplasmic reticulum membrane,its functions on mitochondria are largely ***,we found that ERp57 can ...
详细信息
ERp57 participates in the regulation of calcium *** ERp57 modulates calcium flux across the plasma membrane and the endoplasmic reticulum membrane,its functions on mitochondria are largely ***,we found that ERp57 can regulate the expression of the mitochondrial calcium uniporter(MCU)and modulate mitochondrial calcium *** ERp57-silenced He La cells,MCU was downregulated,and the mitochondrial calcium uptake was inhibited,consistent with the effect of MCU *** MCU was re-expressed in the ERp57 knockdown cells,mitochondrial calcium uptake was ***,ERp57 is a potent regulator of mitochondrial calcium homeostasis.
暂无评论