Neural stem cells(NSCs)exist widely in the developing and adult mammalian brain,which are self-renewing and can differentiate into neurons,astrocytes or oligodendrocytes in *** proliferation of NSCs in vitro has been ...
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Neural stem cells(NSCs)exist widely in the developing and adult mammalian brain,which are self-renewing and can differentiate into neurons,astrocytes or oligodendrocytes in *** proliferation of NSCs in vitro has been reported to be regulated by various ***,growing studies by the use of oxygen microelectrodes show that the mammalian embryo developed in uterus with a hypoxic environment and neural stem or progenitor cell in the brain are also with hypoxic *** mean oxygen concentration is about 1-5%in brain *** date,in vitro studies using NSCs have primarily been done under atmospheric conditions of 20%oxygen as the standard culture *** indicates that traditional oxygen concentration in cell culture system may be a hyperoxia environment but not a condition of"physiological hypoxia"to most of cells in ***,we performed a series of experiments to testify whether the exogenous hypoxia could impact the growth of NSCs and their function?How hypoxia regulates the property of NSCs?Our studies demonstrate that mild hypoxia not only promote the self-renew ability of NSCs in vitro,but also increase their differentiation ability into ***,via expansion of NSCs in vitro or modification of it’s’property in situ,mild hypoxia could become a potential approach for allograft cell *** hope these findings will aid in the transplantation of NSCs to treat neural degenerative diseases such as Parkinson’s disease and brain trauma.
频率分析是听觉系统的最基本的功能之一。先前的研究发现,在外周和较低位的中枢听觉结构内神经元的频率调谐曲线(FTC)的带宽均比较宽,而在进入较高位的中枢后,FTC变的越来越锐化(sharpness),频率分析也越来越精确(Suga,1995;Phillips et al.,1988),这提示听中枢有锐化神经元FT的能力和机制。后来的研究者沿用双声刺激方法在猫的听皮质(AC)(Sutter et al.,1991;1999)以及蝙蝠的丘脑(Suga et al.,1997)记录到位于兴奋性FTC单边或/和双边的抑制性FTC。并通过在蝙蝠听皮质采用离子电泳的方法,
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