This study identified differences in plasma metabolites among three groups of dairy cows:type Ⅰ ketotic (K1) ,type Ⅱ ketotic (K2), and healthy control cows (C).Plasma metabolomic profiles were analyzed by 1H-nuclear...
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This study identified differences in plasma metabolites among three groups of dairy cows:type Ⅰ ketotic (K1) ,type Ⅱ ketotic (K2), and healthy control cows (C).Plasma metabolomic profiles were analyzed by 1H-nuclear magnetic resonance technology (1 H NMR).The data were processed by principal component analysis (PCA) and orthogonal partial least-squares discriminant analysis (OPLS-DA).The results revealed that OPLS-DA was more effective at distinguishing amongst the three ***, there were seven different metabolites between K2 and C, 19 different metabolites between K1 and C, and 24 different metabolites between K1 and ***, the combination of 1H-NMR and multivariate statistical analyses can effectively distinguish the differential metabolites among the K1, K2, and C groups, thereby providing important information on the pathogenesis, early diagnosis, and prevention of type Ⅰ and type Ⅱ ketosis in dairy cows.
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