Gentamicin is a member of Aminoglycosides which has represented highly effective antimicrobial agents especially in Gram-negative infections despite their toxic effects in the *** diagnosis is vital to preserve renal ...
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Gentamicin is a member of Aminoglycosides which has represented highly effective antimicrobial agents especially in Gram-negative infections despite their toxic effects in the *** diagnosis is vital to preserve renal function and to slow down renal *** to the poor sensitivity and specificity of serum creatinine (SCr) and blood urea nitrogen (BUN),new biomarkers for earlier and more accurate detection are *** aim of our study was to determine whether kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) may be useful biomarkers in the assessment of Gentamycin-induced Nephrotoxicity in *** this study,the two biomarkers of renal toxicity was assessed via quantitative real-time PCR and immunohistochemistry in rats treated with Gentamicin for up to 7 *** administration of Gentamicin to male SD rats for 1,3,or 7 days resulted in a dose- and time-dependent increase in the expression of KIM-1 and *** in gene and protein expressions were fo und to correlate with the progressive histopathological alterations and preceded effects on traditional clinical parameters indicative of impaired kidney *** of the biomarkers are supported to be used as sensitive indicators of acute kidney injury caused by Gentamicn.
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