Background & Aim:As the leading cause of liver dysfunction all over the world,non-alcoholic fatty liver disease(NAFLD) is a clinical metabolic syndrome with fatty accumulation in hepatocytes,nevertheless,without a...
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Background & Aim:As the leading cause of liver dysfunction all over the world,non-alcoholic fatty liver disease(NAFLD) is a clinical metabolic syndrome with fatty accumulation in hepatocytes,nevertheless,without alcohol *** recent years,morbidity of NAFLD has grown in Eastern and Western countries,and the diet composition has become an important health *** and NASH are involved in the spectrum of NAFLD,NASH is easier develop into liver fibrosis,cirrhosis,and even hepatocellular *** clinical,hver biopsy as the gold standard to assess levels of steatosis,inflammation and fibrosis in NAFLD is invasive,costly and associated with possible *** kinds of noninvasive biomarkers for evaluating NAFLD have been investigated but none performed well ***,it is still interest to discover noninvasive method to help detecting *** published data showed that quality of fatty acids(FA) accumulated in liver is associated with the degree of liver damage in *** about serum FA variation in NAFLD is *** study aims to investigate the correlation between serum FA composition and the hepatic steatosis,inflammation,hepatocellular ballooning scores and even liver FA composition in the influence of high-fat diet(HFD) in ***:ICR mice(10mice/group) were fed with HFD or control diet(CD) for 4,6 or *** were collected for pathology and NAFLD activity score(NAS) *** and liver FA composition was analyzed by gas chromatography(GC).The correlation analysis was determined with Pearson correlation ***:Induced by HFD,mice got fatty liver disease of different level without obvious fibrosis,and the liver damage level increased as the HFD feeding time went *** could be diagnosed at the 4th week of HFD feeding and NASH could be diagnosed at the 6th and 8th *** fibrosis has not occurred from the beginning to the end of the *** composition analysis in mice serum and
Quinoxaline 1,4-di-iV-oxides(QdNOs) are widely known as potent antibacterial agents,whereas the antibacterial mechanisms are incompletely *** the transcriptomic and proteomic profiles of Escherichia coli exposed QdNOs...
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Quinoxaline 1,4-di-iV-oxides(QdNOs) are widely known as potent antibacterial agents,whereas the antibacterial mechanisms are incompletely *** the transcriptomic and proteomic profiles of Escherichia coli exposed QdNOs were integratively investigated,demonstrating that QdNOs mainly induced SOS response and oxidative ***,genes and proteins involved in bacterial metabolism,cellular structure maintenance,resistance and virulence were also changed,conferring the bacterial survival *** assays showed that reactive oxygen species were induced in the QdNO-treated bacteria,and free radical scavengers attenuated the antibacterial action of QdNOs and DNA damage,suggesting an oxidative-DNA-damage action of *** QdNO radical intermediates,probably carbon-centered and aryl-type radicals as identified by electron paramagnetic resonance were the major radicals induced by QdNOs,and the xanthine oxidase was one of the QdNO-activating *** study gives new insights into the action of QdNOs in a systematic way as well as the current knowledge of bacterial physiology under antibiotic stresses,which can be of great value in developing new antibiotic-potentiating strategies.
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