Thymosinβ4(Tβ4) is an important molecule functioning in angiogenesis,wound healing,cancer metastasis and cardiac repair and so *** Tβ4 is synthesized chemically for research and this is *** order to obtain sufficie...
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Thymosinβ4(Tβ4) is an important molecule functioning in angiogenesis,wound healing,cancer metastasis and cardiac repair and so *** Tβ4 is synthesized chemically for research and this is *** order to obtain sufficient biologically active Tβ4 economically,we cloned and overexpressed this protein in an Escherichia ***.A high level expression of GST-Tβ4 fusion protein was obtained and purified *** biological activity and function of this recombinant Tβ4 was evaluated by cell proliferation assay using prepared spleen *** data indicated that the recombinant Tβ4 could induce lymphocyte proliferation and *** Tβ4 with bioactive is expressed efficiency and purified,becoming the foundation of the further study of Tβ4.
Sheep pulmonary adenomatosis(SPA) is a naturally occurring pulmonary neoplasm of *** establish the experimental model of SPA in native lambs and to gain insight into the differences in pathogenesis between naturally o...
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Sheep pulmonary adenomatosis(SPA) is a naturally occurring pulmonary neoplasm of *** establish the experimental model of SPA in native lambs and to gain insight into the differences in pathogenesis between naturally occurring and experimentally induced SPA,two naturally occurring cases(Poll Dorset sheep,3-years old)found in Inner Mongolia were investigated and seven native neonatal lambs were inoculated intratracheally with pulmonary tumor *** cases were examined by X-ray of thorax and the dynamic changes of immunocytes were examined in their peripheral blood by flow ***,histological and ultrastructural pathology studies were *** results showed that the natural cases produce watery nasal fluid and the experimentally induced cases were showed the relative classical clinical signs of *** results for the number of lymphocytes in both cases presented a fluctuation under the continuous effect of *** results indicate that we had induced the SPA by experimentally in the native newborn lambs *** the changes of immunocytes of induced sheep,therefore,may play an important role in the pathogenesis of SPA.
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