Most of what we know about a drug prior to human clinical studies is derived from animal *** animals and humans have substantial differences in their physiology and in their drug metabolism pathways,we do not know ver...
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Most of what we know about a drug prior to human clinical studies is derived from animal *** animals and humans have substantial differences in their physiology and in their drug metabolism pathways,we do not know very much about the pharmacokinetic and pharmacodynamic behavior of a drug in humans until after it is administered to many ***,drug-induced liver injury has become a
A large number of embryos are produced both in domestic animals but the majority of embryos fail to develop to the blastocyst stage and/or implant during early embryo ***,the developmental failures are not well *** Ju...
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A large number of embryos are produced both in domestic animals but the majority of embryos fail to develop to the blastocyst stage and/or implant during early embryo ***,the developmental failures are not well *** Junctions(TJ)perform a critical role in the barrier function of the trophectoderm(TE)during blastocyst formation.A growing body of literature has demonstrated that the
National Institute of Animal Science(NIAS)has developed numbers of transgenic pig lines harboring recombinant genes through various gene transfer protocols such as microinjection of DNA into fertilized one cell pig zy...
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National Institute of Animal Science(NIAS)has developed numbers of transgenic pig lines harboring recombinant genes through various gene transfer protocols such as microinjection of DNA into fertilized one cell pig zygotes,single cell nuclear transfer and so *** goal is to make high-value livestock species through application of advanced biotechnology.
Ovarian steroid hormones and their nuclear receptors PR and ER coupled with locally produced signaling molecules have been well demonstrated essential for embryo implantation,however,the hierarchical landscape of the ...
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Ovarian steroid hormones and their nuclear receptors PR and ER coupled with locally produced signaling molecules have been well demonstrated essential for embryo implantation,however,the hierarchical landscape of the molecular pathways that govern this process remains largely *** crosstalk and interaction between the RTK and steroid hormone receptor has been well studied in the caner related
Artificial gametes that are produced in culture from pluripotent stem cells would have a huge impact on not only infertility treatment but also understanding of molecular mechanism underlying germ cell *** stem cells,...
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Artificial gametes that are produced in culture from pluripotent stem cells would have a huge impact on not only infertility treatment but also understanding of molecular mechanism underlying germ cell *** stem cells,such as embryonic stem cells(ESCs)and induced pluripotent stem cells(iPSCs),are able to
The long-term effects of chronic hypothyroidism on ovarian follicular development in adulthood is not well *** a rat model of chronic diet induced hypothyroidism initiated in the fetal period,we investigated the effec...
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The long-term effects of chronic hypothyroidism on ovarian follicular development in adulthood is not well *** a rat model of chronic diet induced hypothyroidism initiated in the fetal period,we investigated the effects of prolonged reduced plasma thyroid hormone concentrations on the ovarian follicular reserve and ovulation *** outcome of this analysis was related to antioxidant gene
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