The objective of this study was to assess the pharmacokinetics of ceftiofur sodium *** healthy,adult cows in two treatment groups were dosed intravenously with ceftiofur sodium liposomes and ceftiofur sodium,serial bl...
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The objective of this study was to assess the pharmacokinetics of ceftiofur sodium *** healthy,adult cows in two treatment groups were dosed intravenously with ceftiofur sodium liposomes and ceftiofur sodium,serial blood samples collected,and plasma concentrations determined by high performance liquid *** plasma concentration profiles of liposomes best fit a two-compartment model and the elimination half-life was 2.11 times that of ceftiofur ***,this liposome preparation provided therapeutically effective plasma concentrations for a longer duration than with the drug alone,making it more effective and convenient for use in treating bovine mastitis that requires long duration maintenance of therapeutic plasma concentrations.
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