猪繁殖与呼吸综合征(porcine reproductive and respiratory syndrome,PRRS)主要表现为妊娠母猪发生早产、流产、产死胎、弱仔和木乃伊胎,仔猪和育肥猪发生呼吸道疾病,该病传播速度极快,给我国养猪业造成了巨大的经济损失。疫苗免疫是...
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猪繁殖与呼吸综合征(porcine reproductive and respiratory syndrome,PRRS)主要表现为妊娠母猪发生早产、流产、产死胎、弱仔和木乃伊胎,仔猪和育肥猪发生呼吸道疾病,该病传播速度极快,给我国养猪业造成了巨大的经济损失。疫苗免疫是控制该病发生的一个有效办法,但目前现有疫苗
A newly emerged porcine reproductive and respiratory syndrome virus (PRRSV) that has caused severe reproductive losses in sows appeared in some regions of China in *** explore the biology of this new PRRSV and underst...
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A newly emerged porcine reproductive and respiratory syndrome virus (PRRSV) that has caused severe reproductive losses in sows appeared in some regions of China in *** explore the biology of this new PRRSV and understand more fully genetic diversity in PRRSV isolates from China, the complete genome of the two 2013 Chinese isolates, designated HLJA 1 and HLJB1, were *** sequence analysis showed that HLJA1 and HLJB1 shared 88.6%-98.3% nucleotide identity with genotype 2 (North American type, NA-type) isolates, but only 61.1% with the genotype 1 (European type, EU-type) isolate of Lelystad virus, indicating that both these isolates belong to the NA-type PRRSV *** analysis showed that the NA-type PRRSV isolates formed three subgroups (1, 2 and 3); representatives of these subgroups are VR-2332, CH-1a and HUN4, ***1 and HLJB1 belong to subgroup *** of NSP2 revealed that HLJA1 has a 48-amino acid deletion at positions 473-480 and 482-521, unlike other HP-PRRSV isolates, while HLJB1 has only a 1-amino acid deletion at position 481 compared with ***, HLJA1 replicated in PAM cells but not in MARC-145 cells, whereas HLJB1 replicated in both cell *** neutralizing antibody titer of pig hyperimmune sera against HUN4 was significantly higher than that of HLJA1 or ***, genetic variability in GP5 and GP3 proteins and in the novel ORF5a protein was *** addition to elucidating the genetic relationships between PRRSV isolates, our results suggest that Chinese PRRSv will remain a pandemic virus.
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