Luman/CREB3 has been identified as a novel transcriptional co-regulator of a variety of nuclear *** report herein for the first time that Luman is expressed in male mouse *** and real-time PCR results showed positive ...
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Luman/CREB3 has been identified as a novel transcriptional co-regulator of a variety of nuclear *** report herein for the first time that Luman is expressed in male mouse *** and real-time PCR results showed positive Luman immunostaining in Leydig cells and the expression pattern of Luman in mouse testis exhibited an age-related *** staining of Luman in the MLTC-1 Leydig cell line indicates that Luman is located within the *** significantly up-regulated the levels of expression of Luman in MLTC-1 cells and mouse testes,*** elucidate the function of Luman,experiments were conducted to examine the consequences of lentiviral-mediated RNA interference(RNAi) of Luman on testosterone production and expression of several genes involved in *** silencing caused a increase in HCG-stimulated testosterone *** addition,Luman silencing significantly up-regulated the mRNA levels of P450 scc and P450c17 in primary Ledyig cells and MLTC-1 ***,our data are the first to provide evidence for a possible direct action of Luman in the control of testicular ***,these data indicate that the expression of Luman in mouse testis is stage dependent and androgen inductive,and suggest the important role of Luman in male reproduction.
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