The mechanisms for apoptotic induced by anti-DR-5 agnoistic mAb(mDRA-6) were studied with Jurkat and U937 *** fragmentation,activation of caspase-9,-3 and PARP were observed in Jurkat and U937 cell lines treated by **...
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The mechanisms for apoptotic induced by anti-DR-5 agnoistic mAb(mDRA-6) were studied with Jurkat and U937 *** fragmentation,activation of caspase-9,-3 and PARP were observed in Jurkat and U937 cell lines treated by ***, in Jurkat cells,caspase-8 was activated after treatment with *** contrast,caspase-10 was activated in U937 *** results indicate that the signal pathways in mDRA-6-induced apoptosis are different in Jurkat and U937 cell lines.
Apolipoprotein CⅢ(ApoCⅢ)has been implicated in hypertriglyceridemia and plasma ApoCⅢis independently predicted as risk factor for coronary heart *** in patients are demonstrated to correlate with elevated plasma A...
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Apolipoprotein CⅢ(ApoCⅢ)has been implicated in hypertriglyceridemia and plasma ApoCⅢis independently predicted as risk factor for coronary heart *** in patients are demonstrated to correlate with elevated plasma ApoCⅢlevels and
AIM:To investigate whether cilostazol suppresses intimal hyperplasia and to elucidate its ***:The effects of cilostazol to the expression of lectin-like oxidized low-density lipoprotein receptor-1(LOX-1)at mRNA and pr...
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AIM:To investigate whether cilostazol suppresses intimal hyperplasia and to elucidate its ***:The effects of cilostazol to the expression of lectin-like oxidized low-density lipoprotein receptor-1(LOX-1)at mRNA and protein levels,superoxide generation and neointimal hyperplasia in the rat carotid artery after balloon injury were *** injury was performed by
Human DNA polymeraseη,a low-fidelity DNA polymerase,plays an important role in genesis of non-targeted mutations in cells in response to the mutagen and carcinogen N-methyl-N'-nitro-N-nitrosoguanidine(MNNG).In th...
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Human DNA polymeraseη,a low-fidelity DNA polymerase,plays an important role in genesis of non-targeted mutations in cells in response to the mutagen and carcinogen N-methyl-N'-nitro-N-nitrosoguanidine(MNNG).In this study,we showed that
Endothelial dysfunction,caused by declining impact of endothelium-derived relaxing factors and/or exaggerated production and activity of endothelium-derived contracting factors in the vascular wall,is the common conse...
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Endothelial dysfunction,caused by declining impact of endothelium-derived relaxing factors and/or exaggerated production and activity of endothelium-derived contracting factors in the vascular wall,is the common consequence of diabetes and *** degree of endothelial dysfunction predicts future cardiovascular *** have examined the cellular mechanisms involved in endothelial dysfunction in diabetes and hypertension using ex vivo and in vivo *** have identified an upregulation of renin-angiotensin system(RAS) components in both hypertension and *** use of RAS blockers(including renin inhibitor,ARB and
作者：
Alex F.ChenVA Vascular Surgery Research
Department of SurgeryVascular Medicine InstituteMcGowan Institute of Regenerative MedicineUniversity of Pittsburgh School of Medicine
Endothelial progenitor cells(EPCs) are a circulating,bone marrow -derived cell population that participate in both vasculogenesis and vascular *** studies have shown that EPCs are reduced by -50%in diabetes that corre...
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Endothelial progenitor cells(EPCs) are a circulating,bone marrow -derived cell population that participate in both vasculogenesis and vascular *** studies have shown that EPCs are reduced by -50%in diabetes that correlates inversely with its mortality *** addition,EPC angiogenic functions are severely impaired in ***,the molecular and cellular mechanisms underlying EPC dysfunction are poorly *** current studies have focused on in vitro and in vivo aspects of oxidative
The present study is to investigate the role of Puma in cardiomyocyte death induced by hypoxia/reoxygenation(H/R).We found that H/R increased the level of Puma mRNA and protein accompanied by the elevation of cardiomy...
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The present study is to investigate the role of Puma in cardiomyocyte death induced by hypoxia/reoxygenation(H/R).We found that H/R increased the level of Puma mRNA and protein accompanied by the elevation of cardiomyocyte *** of endogenous Puma by siRNA attenuated H/R-induced cell *** stimulated caspase-8 *** also found that Puma participated in H/R-induced cardiomyocyte death by stimulating the release of cytochrome C and the activation of *** data reveal that Puma mediates the apoptotic signaling of H/R in cardiomyocytes by a mitochondrial pathway.
AIM:Cyr61 is a secreted matrix protein belonging to the emerging CCN *** knockout of Cyr61 gene in mice results in embryonic lethality due to placental vascular insufficiency and compromised vessel ***61 is able to st...
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AIM:Cyr61 is a secreted matrix protein belonging to the emerging CCN *** knockout of Cyr61 gene in mice results in embryonic lethality due to placental vascular insufficiency and compromised vessel ***61 is able to stimulate neovascularization in both rat cornea and rabbit ischemic hindlimb in vivo,be rapidly induced by vascular endothelial cell growth factor and promote proliferation,migration and tube formation of vascular endothelial cells(ECs) in *** present study was designed to investi-
Hydrogen sulfide（HS） is found to be the third endogenous gaseous transmitter and plays an important role in many systems of organism. In cardiovascular system,HS is produced endogenously by cystathionine gamma-lyase...
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Hydrogen sulfide（HS） is found to be the third endogenous gaseous transmitter and plays an important role in many systems of organism. In cardiovascular system,HS is produced endogenously by cystathionine gamma-lyase（CSE）.The CSE/HS system executes the physiological function of vasorelaxation,inhibition of vascular remodeling and *** results suggest that HS may be a novel cardiovascular functional ***:To study whether hydrogen sulfide has effects on endothelial progenitor cells
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