Voltage-gated sodium channel plays an indispensable role in the initiation and propagation of the action *** of sodium channel properities are associated with several neurological pathogenetic disorders such as epilep...
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Voltage-gated sodium channel plays an indispensable role in the initiation and propagation of the action *** of sodium channel properities are associated with several neurological pathogenetic disorders such as epilepsy, movement disorder, ataxia, inherited pain and so *** drugs such as phenytoin, carbamazepine, lamotrigine and sodium valproate targeting on sodium channels have been widely applied in clinical antiepileptic therapies *** thus study, unique sodium channel site3/4-specific modulators from Asian scorpion Buthus martensi Karsch (BmK) were investigated to have capabilities of either kindling convulsant or anticonvulsant effects on the animal *** was found that sodium channel site3-specific modulators named as BmK I and BmK αⅣ can induce strong epileptic behaviors and epileptiform discharges in the hippocampus[1,2].
Cocaine is thought to increase the extracellular dopamine concentration via inhibiting uptake by binding to dopamine *** contrast, several studies showed that cocaine also increases extracellular dopamine by facilitat...
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Cocaine is thought to increase the extracellular dopamine concentration via inhibiting uptake by binding to dopamine *** contrast, several studies showed that cocaine also increases extracellular dopamine by facilitating ***, the mechanism is *** address this issue, by using electrochemical amperometry for dopamine recordings, we found that dopamine overflow contained two kinetically distinct releasable vesicle pools, the fast releasable vesicle pool (RRP) and the slow releasable vesicle pool (SRP) in mouse striatum in *** contrast, there is only SRP in the striatal *** have studied effects of cocaine on the dopamine signals in wide type ***-CI (cocaine-insensitive dopamine transporter) *** find that cocaine binds DAT is necessary for both classic and novel cocaine effects.
Stimulation of α2A-adrenoceptors in the medial prefrontal cortex (mPFC) improves working memory *** improvement is accompanied by a selective increase in the activity of mPFC neurons during delay ***, the cellular me...
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Stimulation of α2A-adrenoceptors in the medial prefrontal cortex (mPFC) improves working memory *** improvement is accompanied by a selective increase in the activity of mPFC neurons during delay ***, the cellular mechanisms responsible for this enhanced response are largely *** the present study, we recorded action potential in the pyramidal neurons of mPFC slice, using whole-cell current clamp recording *** results show that stimulation of oα2A-adrenoceptors enhances intrinsic excitability of neurons.
Vesicle recycling and reuse is essential in maintaining synaptic *** spite of accumulative studies, it remains elucidated that how many vesicles involve in recycling, how long and how fast a vesicle can be reused afte...
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Vesicle recycling and reuse is essential in maintaining synaptic *** spite of accumulative studies, it remains elucidated that how many vesicles involve in recycling, how long and how fast a vesicle can be reused after *** made the whole cell recording of the excitatory postsynaptic currents (EPSCs) at a central synapse, the Calyx of Held, under the long duration of stimulation in the presence of folimycin, a vesicular ATPase inhibitor to annihilates the H+ gradient and block glutamate refilling of synaptic *** was confirmed that vesicles at the Calyceal synpases do recycle and reuse after *** long trains of 20 Hz or 50 Hz stimulation, the evoked EPSCs can be rapidly depressed and finally mostly vanished, implying the depletion of the recycling pool.
Topographic representation of sound frequency in the primary auditory cortex, or tonotopy, is widely *** real-time imaging with voltage-sensitive dyes, we have demonstrated dynamic activity propagation in an isofreque...
Topographic representation of sound frequency in the primary auditory cortex, or tonotopy, is widely *** real-time imaging with voltage-sensitive dyes, we have demonstrated dynamic activity propagation in an isofrequency *** activity can be induced by focal stimulation of the cortex, suggesting the anisotropic nature of the intrinsic circuit in the auditory cortex and the ability of such circuit in supporting activity propagation within an isofrequency *** with this notion, a significant portion of spontaneous events in the primary auditory cortex showed similar spatiotemporal pattern to tone-evoked *** test whether focal stimulation of the cortex can induce auditory perception, we trained animals in a trace-learning paradigm and tested the effect of cortical *** stimulation induced behavioral response conditioned with a tone after learning, but not after *** findings should have implications on auditory prosthesis by cortical stimulation.
In this study, we investigated the neuroprotective effects of paclitaxel in transient cerebral ischemia and the possible regulatory mechanism underlying the *** data show that paclitaxel can down-regulate the increase...
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In this study, we investigated the neuroprotective effects of paclitaxel in transient cerebral ischemia and the possible regulatory mechanism underlying the *** data show that paclitaxel can down-regulate the increased MLK3, JNK3, c-Jun and Bcl-2 phosphorylation induced by ischemia *** violet staining and immunohistochemistry results demonstrated that paclitaxel had a neuroprotective effect against ischemia reperfusion-induced neuronal cell *** results indicate that paclitaxel has a neuroprotective role in ischemic injury through JNK3 signaling pathway and provides a novel possible drug in therapeutics of brain ischemia.
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