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Information processing in auditory cortex

Information processing in auditory cortex

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Xiao-Qin WANG~(1,2) 1 Laboratory of Auditory Neurophysiology,Department of Biomedical Engineering,Johns Hopkins University 2 Department of Biomedical Engineering,Tsinghua University

In contrast to visual and somatosensory systems,the auditory system has a longer subcortical pathway between the sensory receptor and the cerebral *** unique organization reflects the needs of the auditory system to process complex acoustic signals using strategies that are different from those used by other sensory *** visual and somatosensory systems,the auditory system must also process signals that are self-produced such as human speech and animal vocalizations.I will discuss in my talk recent discoveries on cortical coding of acoustic information and neural mechanisms involved in vocal feedback control and learning in the primate brain.

关键词： auditory cortex hearing sensory system speech vocalizations marmoset

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The cell culture of forebrain neuron in zebrafish early stage embryos

The cell culture of forebrain neuron in zebrafish early stag...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Bin YANG,Gang PENG~* Institutes of Brain Science and State Key Laboratory of Medical Neuroscience,Fudan University,Shanghai 200032, China

Objective The zebrafish(Danio rerio),is an important model organism in nervous system development and animal behavior studies for its fast development and transparent embryos in early *** to in vivo methods,in vitro cell culture investigation approach has advantages in achieving higher resolution morphological observation and identifying typesof neurites with *** We use zebrafish early stage embryos to investigatefunctions of signal molecules and receptors for nervous *** have developed methods involving bleaching,digestion,dissociation,plating of forebrain neurons and followed by *** The cell culture of forebrain neuron in zebrafish early stage embryos provides a new way of studying nervous development.

关键词： Danio rerio forebrain neuron cell culture

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Cortical neural dynamics of auditory attention and its application in neural prosthesis

Cortical neural dynamics of auditory attention and its appli...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Bo HONG Department of Biomedical Engineering,School of Medicine,Tsinghua University

＜正＞The bottom-up and top-down attentional regulation plays an important role for auditory *** track the dynamics of cortical response in an auditory stimulus discrimination task,both scalp EEG recording on normal subject and intracranial EEG recording on epilepsy patients undergoing subdural electrode monitoring for surgical purpose are employed to map the attentional *** low frequency event-related potential and high gamma oscillations were analyzed to obtain the property of early passive components and late active responses respectively. Moreover,these cortical neural dynamics was detected in an online fashion by machine learning algorithms to establish an auditory brain-computer interface,which is potentially useful for locked-in patients with vision impairment.

关键词： auditory attention EcoG EEG neural prosthesis

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不同频率的电针对环磷酰胺小鼠免疫功能的影响

不同频率的电针对环磷酰胺小鼠免疫功能的影响

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者：胡志苹黄志华黄诚赣南医学院生理教研室

目的研究不同频率穴位电针刺激对免疫功能低下小鼠免疫功能的影响。方法昆明小鼠随机分成5组,分别为:对照组、环磷酰胺（cyclophosphamide,CP）组、CP+2 Hz电针刺激（electroacupuncture stimulation,EAS）组、CP+100 HzEAS组、CP+2/100... 详细信息

目的研究不同频率穴位电针刺激对免疫功能低下小鼠免疫功能的影响。方法昆明小鼠随机分成5组,分别为:对照组、环磷酰胺（cyclophosphamide,CP）组、CP+2 Hz电针刺激（electroacupuncture stimulation,EAS）组、CP+100 HzEAS组、CP+2/100Hz EAS组,通过观察小鼠脾脏指数、NK细胞杀伤活性、脾细胞的增殖能力及外周血IL-6含量的改变,探讨不同频率EAS对环磷酰胺小鼠免疫功能的影响。结果（1）各频率单次电针刺激后0 h均可翻转环磷酰胺所诱导的NK细胞杀伤活性降低,其中以2/100 Hz交替频率的效果更好,24 h及48 h后无明显影响;（2）2 Hz及100Hz频率单次刺激后0 h抑制环磷酰胺所诱导的脾细胞增殖能力升高,2/100 HzEAS组的抑制效果不明显;24 h后,2 Hz及100 Hz EAS组继续显示抑制效应,而2/100 Hz EAS组使脾细胞增殖能力升高;48 h后各频率EAS组对脾细胞增殖无明显影响;（3）100 Hz及2/100 Hz交替频率连续3 d EAS组与CP组相比NK细胞杀伤活性、脾脏指数增高,脾细胞的增殖能力下降,2 Hz频率连续3 d电针组无明显变化;（4）连续3 d电针各组血清IL-6水平升高。结论各频率单次或连续穴位电针刺激对免疫功能低下小鼠的脾脏指数、NK细胞的杀伤活性、脾细胞的增殖能力及血清IL-6水平均有一定的影响;其中以2/100 Hz交替频率的穴位电针刺激效果更稳定,这些效应可能与电针刺激后升高IL-6的含量有关。

关键词：电针频率免疫功能

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TRPC6 was neuroprotective in cerebral ischemia

TRPC6 was neuroprotective in cerebral ischemia

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Junbo HUANG,Xinxin HAN,Hailan YAO,Yizheng WANG Laboratory of Neural Signal Transduction,Institute of Neuroscience,Shanghai Institutes for Biological Sciences,State Key Laboratory of Neuroscience,The Graduate School,Chinese Academy of Sciences,Shanghai 200031,China

Neurons are the most vulnerable cells upon ischemic *** of neuronal survival is thus important for prevention of ischemic brain *** report that the transient receptor potential canonical(TRPC) 6 was neuroprotective in focal cerebral ***6 protein level in the neurons was greatly reduced in *** downregulation was specific for TRPC6 in the members of TRPC subfamily and mediated by calpain proteolysis.A peptide that contains a sequence spanning calpain cleavage site on TRPC6 protein specifically blocked TRPC6 ***,this peptide was neuroprotective against ischemic insults in both cultured neurons and *** level of phosphorylated cAMP-response element binding protein(pCREB) was maintained by the peptide,suggesting that the CREB signaling pathway was involved in the neuroprotective *** results indicated that suppression of calpain-mediated TRPC6 degradation preserved neuronal survival and prevented ischemic brain damage.

关键词： TRPC6 ischemia calpain neuroprotection

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Epigenetic regulation in Parkinson disease etiology

Epigenetic regulation in Parkinson disease etiology

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Cheng-Yuan TANG,Jie-Qiong TAN,Dan-Ling WANG,Zhuo-Hua ZHANG State Key Laboratory of Medical Genetics,Xiangya Medical School,Central South University,Changsha,China

It is well documented that both genetic and environmental factors play important roles in etiology of Parkinson disease(PD).Genetic studies of familial cases identify mutations in more than 10 genes causing *** pathophysiological function of these genes remains largely ***,a number of pesticides and herbicides induce parkinsonism in both human and animal *** of them are shown to regulate PD associated genes. During the past decade,we have interested in roles of genes-environmental factors interaction in PD *** results suggest that PD-related environmental factors contribute to PD etiology likely via epigenetically regulation of PD associated *** this presentation,we will discuss in detail PD associated epigenetic modification.

关键词： Epigenetic regulation in Parkinson disease etiology

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The effect of aggregated α-synuclein on microglial activation

The effect of aggregated α-synuclein on microglial activati...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Sen QIAO,Yi LI,Jian-Hong LUO,Jing-Hua JIN~* Department of Neurobiology,Zhejiang University School of Medicine,Hangzhou 310058,China

Objective A growing body of evidence indicates that neuroinflammation characterized by microglial activation probably contributes to the pathogenesis of Parkinson's disease(PD),and the mechanisms underlying microglial activation in PD are largely *** study is to explore whether aggregated a-synuclein can activate microglia and the mechanism underlying *** The activation of microglia was measured by morphological changes,neurotoxic factor production,and phagocytotic activity in BV2 cells as well as primary cultured rat microglia treated with aggregated *** Aggregated a-synuclein clearly changed microglial morphology and enhanced microglial production of extracellular NO,mRNA levels of IL-lβ,IL-6,COX-2,iNOS and phagocytotic *** Aggregated a-synuclein can induce microglial activation,and the underlying mechanisms are under study.

关键词： Parkinson's disease microglia aggregatedα-synuclein

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Two pairs of neurons in CNS control Drosophila innate light preference

Two pairs of neurons in CNS control Drosophila innate light ...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Zhefeng GONG~*,Jiangqu LIU,Chao GUO,Yanqiong ZHOU,Li LIU~* State Key Lab.of Brain and Cognitive Science,Institute of Biophysics,Chinese Academy of Sciences,15 Datun Road, Chaoyang District,Beijing 100101,China

Phototaxis is a basic response to environmental stimuli in the fruit fly Drosophila *** larvae,which prefer darkness to light,receive visual input from 2 bilateral groups of 12 photoreceptor neurons,known as the Bolwig's Organ(BO),which deliver output directly to pdf-expressing neurons in the central *** both the BO and pdf neurons causes blindness in larvae,suggesting that these neurons underlie the visual information flow that guides larval *** examined the neurons involved in larval phototactic behavior,and found that inhibiting the function of 2 pairs of larval CNS neurons that are putatively post-synaptic to pdf neurons results in a preference for light,as opposed to the preference for darkness observed in wild type *** results extend knowledge of the neural circuit that mediates larval phototactic behavior,and also elucidate the neural circuit that controls larval preference between light and darkness.

关键词： phototaxis behavior Drosophila larva

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Pharmacological study of the light/dark preference test in zebrafish larvae

Pharmacological study of the light/dark preference test in z...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Feng-Jiao CHEN,Gang PENG~* Institutes of Brain Science and State Key Laboratory of Medical Neuroscience,Fudan University,Shanghai 200032, China

Objective The zebrafish(Danio rerio) is emerging as a useful behavioral model of human anxiety. Here we further ascertain zebrafish larvae models of anxiety and validate the pharmacological effects of neuroactive compounds by the light/dark preference *** We provide a detailed description of the pattern of exploratory behaviours encountered in zebrafish larvae when exposed to the light/dark preference *** find that the larvae spend less time in the dark compartment relative to the white compartment of the testing *** expression of these dark-avoidance behaviours was significantly attenuated by anxiolytic(diazepam,lorazepam) drugs. Results The findings ascertain the nature of dark-avoidance behaviours as anxiety-like behaviours and provide the pharmacological validation of the light/dark preference test for zebrafish *** behavioural based assay can accommodate drug screening of neuroactive compounds.

关键词： zebrafish larvae anxiolytic drugs anxiety pharmacology

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Apaf1 deletion rescues injury-induced neuronal death after optic nerve injury

Apaf1 deletion rescues injury-induced neuronal death after o...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Kevin K.Park F.M.Kirby Neurobiology Center Children's Hospitaland Department of NeurologyHarvard Medical School300 Longwood AvenueBostonMA 02115USA

In the adult mammals,axotomy of mature neurons in the central nervous system(CNS) triggers massive cell death and failure to spontaneous axon *** relationship between axotomy-induced neuronal death and axon regeneration has not yet well-understood,although promoting intrinsic capability of axon regeneration of CNS neurons is often accompanied by moderately improved neuronal *** we generated a mouse line with conditional knock-out of apoptotic protease activating factor 1(Apfal).Apafl was deleted in retina ganglion cells (RGCs) by intravitreal injection of AAV-Cre virus,followed by optic nerve *** data show that although Apafl is deleted,RGCs have significantly a high survival rate,but their axon regeneration ability is not ***, axon regeneration is not the consequence of rescuing neuronal death.

关键词： Apaf1 conditional knock-out apoptosis axon regeneration

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