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The effect of morphine on N-cadherin expression in addiction rat VTA

The effect of morphine on N-cadherin expression in addiction...

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中国神经科学学会第九届全国学术会议暨第五届会员代表大会

作者： Jun-Ping CAO Hong-Jun WANG Jing MENG Jing-Ru WU Jiangsu Province Key Laboratory of Anesthesiology and Center for Pain Research and Treatment Xuzhou Medical College Xuzhou 221002 China

Objective The dopaminergic (DA) neurons in the ventral tegmental area (VTA) are widely implicated in the addiction and natural reward circuitry of the *** exposure can trigger synaptic plasticity and morphology changes in VTA DA neurons.N-cadherin is involved in the regulation of cell-cell adhesion and in morphology and plasticity *** present study was to explore whether N-cadherin expression is altered in VTA after morphine *** The co-expression of N-cadherin and DA neurons was identified by double-labelling immunofluorescence, and the alteration of N-cadherin expression was detected by RT-PCR, immunohistochemistry and Western-blot *** The results of immunofluorescence double staining showed that N-cadherin was extensively expressed in the DA neurons in the rat *** administration of morphine (5 days) resulted in a time-dependent up-regulation of N-cadherin expression at the level of mRNA and *** These data indicated that the expression of N-cadherin was up-regulated by chronic morphine and this alteration may contribute to the development of the opiate-induced changes in DA morphology and behaviors.

关键词： morphine N-cadherin DA neurons VTA

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The transcription factor Sp8 characterizes the configuration of the subventricular zone,rostral migratory stream and olfactory bulb in the adult rhesus monkeys

The transcription factor Sp8 characterizes the configuration...

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中国神经科学学会第九届全国学术会议暨第五届会员代表大会

作者： Rui CHEN Zhen-Gang YANG Institutes of Brain Science and State Key Laboratory of Medical Neurobiology Fudan University Shanghai 200032 China

Neurogenesis in the primate subventricular zone (SVZ) of the lateral ventricle (LV) persisted throughout adulthood and the existence of rostral migratory stream (RMS) pathway in the adult primates has been intensely ***, the cellular organization and neurogenesis process in vertebrates, especially in monkeys remains *** the present study, we described the general configuration of the SVZ and RMS in adult monkeys via the expression of zinc finger transcription factor *** we detected the expression of Sp8 in the amphibians, reptiles, birds, rodents and *** of the neuroblasts in SVZ, RMS, olfactory tract and olfactory bulb are ***, this transcription factor is highly expressed in the interneurons (CR, CB, TH and PV) of adult monkey olfactory *** with imrmunohistochemical detection of a marker for DNA replication (BrdU) and several cell type-specific markers, newly generated interneurons are detected in the monkey olfactory *** together, our data suggest that Sp8 could be used as a marker to characterize neurogenesis of adult SVZ and RMS in rhesus monkeys.

关键词： Sp8 rhesus monkey neurogenesis neuroblasts subventricularzone rostral migratory stream olfactory bulb

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Monitoring dynamic protein-protein interactions during GABAB receptor mediated IGF-1R transactivation by an activity based probe

Monitoring dynamic protein-protein interactions during GABAB...

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中国神经科学学会第九届全国学术会议暨第五届会员代表大会

作者： Fa-Jun NAN Jian-Feng LIU National Center for Drug Screening State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institutes of Biological Sciences Chinese Academy of Sciences Shanghai China Sino-France Laboratory for Drug Screening Key Laboratory of Molecular Biophysics of Ministry of Education College of Life Science and Technology Huazhong University of Science and Technology Wuhan China

Many GPCR agonists can activate receptor-tyrosine-kinases (RTKs) through transactivation, the mechanisms of which are poorly ***, we have investigated IGF-1 receptor (IGF-1R) transactivation by GABAB receptor using a chemical biology approach in rat primary *** show that GABAB receptor activation induces a dynamic assembly and disassembly of a protein complex, including both receptors and their downstream ***, a non-receptor tyrosine kinase, plays a key role in coordinating this dynamic ***, such a dynamic process is critical for transactivation and transactivation-dependent neuronal *** results reveal an important mechanism underlying GPCR transactivation of RTKs.

关键词： GABAB receptor IGF-1R transactivation FAK dynamic protein-protein interactions activity-based probe

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Adjudin attenuates lipopolysaccharide-induced neuroinflammation

Adjudin attenuates lipopolysaccharide-induced neuroinflammat...

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中国神经科学学会第九届全国学术会议暨第五届会员代表大会

作者： Jia-Xiang SHAO Qian Reuben XIE Ye-Wei LIU Wei-Liang XIA Neuroscience and Neuroengineering Center School of Biomedical Engineering and Med-X Research Institute Shanghai Jiao Tong University Shanghai 200030 China

Neuroinflammation caused by microglial activation plays a key role in brain *** are activated in response to diverse stimuli and release multiple inflammatory *** seek for new drugs to modulate neuroinflammation, we recently found that Adjudin, a potential non-hormonal male contraceptive, exhibits additional function to reduce production of proinflammatory mediators in lipopolysaccharide (LPS)-stimulated microglial *** our present study, one-hour Adjudin pretreatment reduced IL-6 and IL-1β mRNA levels in BV2 microglial ***-6 secretion was also reduced with Adjudin *** determine whether Adjudin might have similar effects in vivo, mice were given Adjudin (100 mg/kg, i.p.) 3 h before and post LPS injection (2.5 mg/kg, i.p.).The results showed that Adjudin decreased the induction of IL-6 and IL-1 β mRNA by LPS in the ***, our data suggest that Adjudin might mitigate neuroinfiammation.

关键词： Adjudin neuroinflammation IL-6 IL-1β BV2 microglial cells lipopolysaccharide

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A novel automated quantifiable and graphical format for Irwin test

A novel automated quantifiable and graphical format for Irwi...

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中国神经科学学会第九届全国学术会议暨第五届会员代表大会

作者： Hui ZHAO Yang GUO Zhijing HU Aiyun SHAO Qiang LU Di BIAN Wuxi AppTec (Shanghai) Co. Ltd.Biology Dept. NPⅡ (Neuroscience/Pain/Inflammation/Immunology) Business Unit Shanghai 200131 China

Objective Irwin test is one of the most commonly used assays for pre-clinical neuro-toxicological *** a descriptive assay, there are many disadvantages in its original data analysis and presentation *** some reported formatting improvements in the literature, it is still not quantifiable and is difficult to make side by side comparisons of different test *** process of data analysis is also *** In order to make the parameters in Irwin test more quantifiable, we categorized the descriptive data into four, including general behaviors, autonomic and sensorimotor functions, convulsive behaviors and excitability, and reflex capabilities; and quantified them mathematically as incidence, abnormality and *** Incidence refers to a frequency of occurrence of abnormal *** implies percentage of abnormal *** severity is a quantitative description of abnormal *** the same time, the onset and offset of abnormal behaviors would be *** The data processing for Irwin test is cumbersome, we automated the process which makes data process *** presentation, all data were presented in clustered columns which make the Irwin test results visually understandable, comparable and quantifiable.

关键词： irwin test automation quantifiable neuro-toxic neurobehavioral assessments

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Robo3 suppresses Slit-triggered growth cone repulsion by triggering degradation of Robo1/2

Robo3 suppresses Slit-triggered growth cone repulsion by tri...

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中国神经科学学会第九届全国学术会议暨第五届会员代表大会

作者： Lingyong LI Xuechu ZHEN State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China

Slits and Robos control the midline crossing of commissural axons, which are not sensitive to the midline repellent Slit before crossing but gain the Slit responsiveness to exit the midline and avoid the *** mammals the expression of the Robo family member Robo3 is responsible for the low Slit responsiveness in pre-crossing ***, how Robo3 silences Slit repulsion remains *** using cell surface binding assay and immunoprecipitation, we observed that Robo3 did not bind Slit on its own, but prevented the specific binding of Slit to the cell surface when it was co-expressed with its close homologue Robol or Robo2 (Robol/2), which are known to mediate the Slit *** knockdown the expression of endogenous Robo3 by specific small interference RNA (siRNA), Slit binding to the cell surface of cultured cortical neurons was significantly elevated and Slit-triggered growth cone collapse in newborn neurons appeared.

关键词： axon guidance Slit Robo2 Robo3 degradation lysosome

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PirB expression and glial reaction influence synaptic plasticity in the rat brain via intrahippocampal injection of LPS

PirB expression and glial reaction influence synaptic plasti...

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中国神经科学学会第九届全国学术会议暨第五届会员代表大会

作者： Xiao-Hua DENG Department of Anatomy and Neurobiology Xiangya School of Medicine Central South University

The aim of our study is to investigate the changes in hippocampal synapses and their relation with learning-memory abilities during chronic brain *** rats were subjected to unilateral intrahippocampal injection LPS, after animals survived for 29 days, we examined the response of glial cells using glial fibrillary acidic protein (GFAP) as astrocyte marker, expression of PirB in the hippocampus of different treatment was also *** were labeled with immunohistochemistry, and their number and immunosignal intensity were evaluated with quantitative image *** synaptic loss was examined in the subregions of hippocampus by Golgi *** cell death was examined in the hippocampus using Hoechst ***, synaptophysin (SYP) expression in whole hippocampus was investigated with irnmunohistochemistry and Western blot in the same brain regions after the intrahippocampal (ih) injection of *** labeling with immunofluorescence was used to investigate whether PirB was expressed not only by neurons but also by glial *** study the relationship of PirB with synapses, PirB and Synaptophysin double staining was *** learning and memory abilities were tested by Morris water *** results indicated an increase in glial reaction during chronic brain inflammation.

关键词： learning and memory synapses SYP LPS brain inflammation PirB astrocytes Morris water maze

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Neuroprotective effects of BayK8644 against ischemic neuronal death in vivo and in vitro

Neuroprotective effects of BayK8644 against ischemic neurona...

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中国神经科学学会第九届全国学术会议暨第五届会员代表大会

作者： Feng-Qing HOU Hong-Hai HU Xin-Hong ZHU Tian-Ming GAO Department of Neurobiology Southern Medical University Guangzhou 510515 China

Stroke is the leading cause of disability and the third cause of death in the ***, underlying mechanisms of neuronal death induced by ischemic brain injury remain unclear and treatments for stroke are limited, mainly because of the short therapeutic window for *** Ca2+ very early plays critical role in neuronal death induced by brain ischemia, activation of L-type Ca2+ channel effectively triggers a group of genes required for neuronal survival and the currents mediated by L-type Ca2+ channel indeed decreased in CA1 neurons 24 h after forebrain *** we showed that L-type Ca2+ channel agonist, BayK8644 produced neuroprotective effects in oxygen-glucose deprivation (OGD) and forebrain ischemic animal *** present study, by using these two models, we tested the extended therapeutic window of BayK8644 for treatment of ischemic brain injury and the involved mechanisms were also determined.

关键词： L-type Ca2+channel neuroprotection ischemia ERK

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Neuroprotective effect of formoononetin against NMDA induced apoptosis in cortical neurons

Neuroprotective effect of formoononetin against NMDA induced...

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中国神经科学学会第九届全国学术会议暨第五届会员代表大会

作者： Zhen TIAN Ming-Gao ZHAO Department of Pharmacology School of Pharmacy Fourth Military Medical University Xi ''an 710032 China

Formoononetin is one kind of isoflavones which is contained in many herbs, such as Trifoliurn pratense L., Caulis *** this study, we investigated the protective effect of formoononetin on primary-cultured mouse cortical neurons injured by N-methyl-D-asparate (NMDA).After exposure of cortical neurons to 200 μM NMDA for 40 min, the cell viability decreased significantly, which was determined by MTT ***, pretreatment with 10 μM formoononetin for 12 h attenuated the cell apoptosis *** blot analysis showed that formoononetin not only increased the expression of Bc1-2, but also attenuated the NMDA-induced up-regulation of Bax and suppressed the activation of *** could also improve NMDA-induced morphologic impairment which was detected by Hoechst/PI double fluorescent *** further evaluate neuron apoptosis, flow cytometry was *** results revealed that the number of apoptotic cells decreased remarkably in formoononetin-treating *** the results demonstrated that formoononetin was capable of protecting pramiary-cultured cortical neurons from NMDA-induced *** to this investigation, formoononetin has a good perspective to be a medicine treating NMDA-related neuronal diseases.

关键词： formoononetin NMDA neuroprotective

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Transmembrane protein VSD is required for axon crossing for the formation of central complex

Transmembrane protein VSD is required for axon crossing for ...

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中国神经科学学会第九届全国学术会议暨第五届会员代表大会

作者： Xue-Bo CHENG Hai-Yun GONG Zhe-Feng GONG Li LIU State Key Laboratory of Brain and Cognitive Science Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China

Objective Neuronal connections between the hemispheres are considered important for organisms to organize information to adapt to variable *** central complex split flies, the locomotor activity and the visual learning and memory are *** midline crossing is an event that requires many components to regulate each *** study is aimed to find the genes that affect the formation of central *** Histochemistry with antibody nc82 was used to observe the shape of central *** blot with antivsd specific antibodies were used to study the characteristic of the *** (1) Nonsense mutation in the extracellular domain of VSD contributed to the central complex defect.(2) VSD can be cleaved by an unknown protease and release the intracellular domain from the membrane.(3) Overexpression the extracellular domain of NRG can partially rescue the mutant phenotype caused by knockdown of *** Transmembrane protein VSD (visual system disorganization) is essential for the formation of the central complex and NRG cooperates with VSD to regulate the axon midline crossing.

关键词： Drosophila melanogaster central complex histochemistry transmembrane protein

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