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The influence of ages on mortality of patients with hemispheric cerebral infarction underwent standard large craniectomy decompression

The influence of ages on mortality of patients with hemisphe...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Wen-Peng LIU~1,Dong ZHENG~2,Yan LIU~3,Wei-Wu FANG~3,Chao-Li ZHANG~2,Tie-Jun SHI~1,Yun-Feng JIA~1 1 Department of Neurosurgery,The 306th Hospital of the PLA,Beijing 100101,China 2 Department of Radiology,The 306th Hospital of the PLA,Beijing 100101,China 3 Department of Anesthesiology,The 306th Hospital of the PLA,Beijing 100101,China

Objective To identify the influence of ages of patients with hemispheric cerebral infarction on the mortality of large craniectomy *** Thirteen cases underwent large craniectomy decompression in the latest 5 years were retrospectively *** were used to analyze the difference of mortality between the groups of cases with various *** Mortality decreased when standard large craniectomy decompression was *** the treatment effectiveness of the cases with lower ages was better than that of the cases with higher ages,the difference was not statistically *** Standard large craniectomy decompression was an effective method for the treatment of hemispheric cerebral *** factor of age didn't have significant influence on mortality.

关键词： standard large craniectomy decompression hemispheric cerebral infarction age mortality

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Stability of fMRI activation:evidence from fusiform face area

Stability of fMRI activation:evidence from fusiform face are...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Bing CHEN~(1,2),Wei LEI~3,Jie XI~4,Xu-Chu WENG~(2,*) 1 Xiamen University,Xiamen 361005,China 2 Hangzhou Normal University,Hangzhou 310015,China 3 Southwest University,Chongqing 400715,China 4 Institute of Psychology,Chinese Academy of Sciences,Beijing 10010,China

Objective Fusiform face area(FFA) is highly specialized for faces and independent of task modulation. This study was to test the stability of FFA response to face information across 4 fMRI scans spanning one year in the same group of *** Block design was adopted and the stimuli included English words,Chinese characters,and *** Linear Model(GLM) was performed to define the ROI(region of interested),i.e.,the FFA,in each *** stability of space coordinates of activation voxels within the ROI was analyzed by within-subject *** The coordinates of the voxels in the FFA ROI were highly reproducible across the 4 scans whether the ROI was defined by face *** or face *** The position of the FFA measured by fMRI is remarkably *** is feasible to use the FFA as a reference region in fMRI studies on the visual system.

关键词： Fusiform face area General Linear Model within-subject

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Establishment of visuoauditory associative memory in auditory cortex

Establishment of visuoauditory associative memory in auditor...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Xi CHEN,Yi-Ping GUO,Zheng-Li LIAO,Xin-Jian LI,Hai-Tao WANG,Ju-Fang HE~* Laboratory of Applied Neuroscience,Department of Rehabilitation Sciences,The Hong Kong Polytechnic University, Hung Horn,Kowloon,Hong Kong

One important aspect of memory is association of different modality components/*** memory is reflected in neuronal activities in different cortices after intensive *** paper presents most direct evidences of the establishment of associative memory traces in the rat auditory *** produced a conditioned association between cortical electrical activation and a visual stimulus,visualizing the physiological memory traces, i.e.,auditory neuronal responses to the visual stimulus after *** confirm the visuoauditory memory behaviorally,we first associate the sound with the visual *** sound stimulus was then associated with the reward,and the establishment and recall of the associative memory was proven when the rat successfully secured the reward after the sound stimulus was replaced by the visual stimulus for the first *** early and lasting appearance of memory traces indicates that the neocortex is involved in memory storage earlier than the hippocampus-neocortex transfer model suggested.

关键词： Establishment of visuoauditory associative memory in auditory cortex

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miRNAs are important regulators of astrocyte development

miRNAs are important regulators of astrocyte development

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Qing-Ting CHI,Kang ZHENG,Meng-Sheng QIU~* The Institute of Developmental and Regenerative Biology,Hangzhou Normal University,Hangzhou 310036,China

Objective Many CNS pathologies are associated with changes in the structure and function of astrocytes. When the lesioned brain and spinal cord tissues undergo the repairing process,astrocytes reactivate and form glial scars that have a detrimental effect on neural *** the molecular regulation of astrocyte development could help to prevent astrogliosis in CNS ***,at present,little is known about the molecular mechanisms underlying astrocyte *** this study,we attempted to explore the functional role of miRNAs in astrocyte differentiation during *** We generated the GFAP Dicer mice line to block the miRNA function in differentiating astrocytes,and analyze the differential expression of glial specific molecular markers in the spinal cord between mutant and control ***（1） Disruption of miRNAs delays astrocyte maturation;（2） Absence of miRNAs in astrocyte can interfere with oligodendrocyte myelination;（3） miRNAs contribute to the formation and maintenance of astrocyte structure and *** miRNAs are important regulators of astrocyte development.

关键词： astrocyte miRNA spinal cord differentiation

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Latency of depolarization-induced quantal dopamine release from the somata of dopamine neurons in rat substantial nigra brain slices

Latency of depolarization-induced quantal dopamine release f...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Claire Xi ZHANG Institute of Molecular Medicine Peking University

Dopamine(DA)is an important neurotransmitter secreted from dopamine *** the CNS,together with its receptors in striatum,prefrontal cortex,amygdale and many other areas,dopamine acts as a key modulator responsible for essential physiological behaviors including mood,awarding,and movement,and for major mental disorders including neurodegenerative Parkinson’s disease,Alzheimer’s disease,Huntington’s disease,depression mode,and drug *** is well established that dopamine is released from dopaminergic ***, whether and timing of dopamine release from the somata of dopamine neurons in substantial nigra pars compacta (SNc)remains *** we show,for first time,the Cadependent somatic dopamine release from single vesicles in SNc brain *** average,7.8×10 dopamine molecules is released per quantum,which are 2.9%of the contents released from single large dense core vesicle(LDCV)in chromaffin ***,comparing to its terminal release in striatum,the latency of the evoked somatic dopamine release is substantially slower in the somata in SNc vs. terminals in striatum.

关键词： quantal dopamine release substantial nigra brain slices

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Update on susceptibility genes in childhood absence epilepsy

Update on susceptibility genes in childhood absence epilepsy

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Yu-Wu JIANG Peking University First Hospital

＜正＞Genetic factor has long been considered to be related to idiopathic epilepsies and the susceptibility gene for idiopathic generalized epilepsy（IGE） has grown to more than 20 genes *** vast majority of them are genes encoding channels or the proteins regulating the action of excitatory or inhibitory neurotransmission in the central nervous system（CNS）.But,these genes mutations can only explain the minor part for idiopathic epilepsy,and the genes responsible for the most common forms of idiopathic epilepsy still remain mostly *** advances recently have resulted in new high-throughput approaches that promise to accelerate the identification of new susceptibility genes and copy number variations（CNVs） for *** this talk,the recent advance of the susceptibility genes study in childhood absence epilepsy（CAE） will be reviewed,especially the two new genes probably associated to Chinese CAE patients we found by combining the whole genome SNP chip association study and direct sequence of the *** studies have revealed recurrent CNVs related to *** study showed the 15q 11.2 might be the most common CNV in Chinese CAE patients,it will be introduced.

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The "honest" brain region - Decoding true answers from brain activity

The "honest" brain region - Decoding true answers from brain...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Zi-Rui HUANG~(1,2,3),Zhi YANG~(1,*),Rui DAI~(3,4),Xu-Chu WENG~3 1 Institute of Psychology,Chinese Academy of Sciences,Beijing,100101,China 2 Graduate School of Chinese Academy of Sciences,Beijing,100049,China 3 Research Center of Human Brain and Mental Disease,Hangzhou Normal University,310015,China 4 Institute of Life Science,South China Normal University,Guangzhou,510631,China

Men lie for various reasons,hiding their true thoughts which cognitive neuroscientists are eager to read out using neuroimaging techniques yet have to date not reached a clear-cut *** most studies have compared the brain response patterns between honest and deceptive answers,here we directly examined whether the faithful answers for polar questions can be decoded from BOLD *** found a unique region in the left middle frontal gyrus that successfully discriminated between positive and negative faithful responses independent of intentional suppression and stimuli *** propose the activity of this "honest" region may serve as an indicator of one's faithful answers.

关键词： deception detection searchlight fMRI faithful answers

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Derepression of tPA expression by knocking out NRSF enhances mature BDNF and upregulates hippocampal LTP

Derepression of tPA expression by knocking out NRSF enhances...

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中国神经科学学会第九届全国学术会议暨第五届会员代表大会

作者： Xue-Wen CHENG Lei CAI Bin LU Da-Feng XU Li HUANG Li XU Jing ZHENG Jian FEI Zhi-Qi XIONG Institute of Neuroscience State Key Laboratory of Neuroscience Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 320 Yueyang Road Shanghai 200031 China School of Life Sciences and Technology Tongji University 1239 Siping Road Shanghai 200092 China School of Pharmacy East China University of Science and Technology 130 Meilong Road Shanghai 200237 China

Neuronal restrictive silencing factor (NRSF) is an epigenetic repressor with important role in regulating neurogenesis and ***, the physiological function of NRSF in postnatal brain remains an interesting ***, we reported that activity-dependent synaptic plasticity was suppressed by *** cre/ loxP system, nrsfwas conditionally knockout (cko) in forebrain excitatory *** recording of hippocampus CA1 radiatum area revealed a significantly upregulated long-term potentiation (LTP).We also found that activity stimulation led to significant enhancement of mature BDNF in cko mice, and this enhancement was mediated by the increased level of tissue plasminogen activator (tPA).Moreover, we found tPA was transcriptionally repressed by NRSF through direct binding to RE1 sequence in tPA *** of tPA activity abolished the upregulation of LTP in nrsf-cko *** findings provide an NRSF mediated epigenetic mechanism that moderates LTP in the hippocampus CA3-CA1 pathway.

关键词： NRSF LTP tPA synaptic plasticity

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Activation of KCNQ potassium channels by small chemical moleculars

Activation of KCNQ potassium channels by small chemical mole...

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中国神经科学学会第九届全国学术会议暨第五届会员代表大会

作者： Zhaobing GAO Min LI Department of Neuroscience High Throughput Biology Center and Johns Hopkins Ion Channel Center School of Medicine Johns Hopkins University Baltimore Maryland 21205 State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 555 Zu Chong Zhi Road Zhangjiang Hi-Tech Park Shanghai 201203 China State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 555 Zu Chong Zhi Road Zhangjiang Hi-Tech Park Shanghai 201203 China

KCNQ potassium channels play a critical role in controlling membrane *** a typical voltagegated ion channels (Kv), KCNQ channels undergo closed to open transitions by sensing transmembrane potential changes and mediate inhibitory potassium *** of KCNQ channel activity as results of genetic mutation is causal to a variety of human diseases including epilepsy, arrhythmia and ***, discovery of small compounds to activate voltage-gated ion channels is an important strategy for clinical intervention in human diseases caused by membrane hyperexcitability, including anxiety, epilepsy, arrhythmia and neuropathic *** the binding of these molecules induces a conformational change leading to the opening of these channels, there is also a considerable conceptual interest in understanding the molecular basis of these "gain of a function" *** molecule activators of cation channels are rare; however, several novel compounds have been identified for KCNQ potassium ***, we reported two new molecules which potentiate either cardical or neuronal KCNQ channels and identified molecular determinants for their activity, which provide exciting insights into activation of voltage-gated channels by small molecuars.

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Balanced dopamine is critical for pattern completion during associative memory recall

Balanced dopamine is critical for pattern completion during ...

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中国神经科学学会第九届全国学术会议暨第五届会员代表大会

作者： Fei LI L.Phillip WANG Xiaoming SHEN Joe Z.Tsien Brain and Behavior Discovery Institute Medical College of Georgia Augusta Georgia United States of America Brain and Behavior Discovery Institute Medical College of Georgia Augusta Georgia United States of America Department of Developmental and Behavioral Pediatrics of Shanghai Children''s Medical Center & Shanghai Key Laboratory of Children''s Environmental Health XinHua Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of Developmental and Behavioral Pediatrics of Shanghai Children''s Medical Center & Shanghai Key Laboratory of Children''s Environmental Health XinHua Hospital Shanghai Jiao Tong University School of Medicine Shanghai China

Objective Pattern completion, the ability to retrieve complete memories initiated by partial cues, is a critical feature of the *** study investigates the role of dopamine in memory *** We have analyzed dopamine transporter heterozygous knockout mice (DAT+/2).Results (1) While these mice possess normal learning, consolidation, and memory recall under full cue conditions, they exhibit specific deficits in pattern completion under partial cue condition; (2) This form of memory recall deficit in the dopamine transporter heterozygous knockout mice can be reversed by a low dose of the dopamine antagonist haloperidol, further confirming that the inability to retrieve memory patterns is a result of dopamine *** Our results reveal that a delicate control of the brain's dopamine level is critical for pattern completion during associative memory recall.

关键词： memory retrieval Dopamine pattern completion

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