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海马ripple节律相关中间神经元

海马ripple节律相关中间神经元

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者：徐佳敏林龙年华东师范大学脑功能基因组学教育部重点实验室

啮齿类动物海马在不同行为状态下表现出不同频率的场电位节律振荡,其中ripple节律是动物在慢波睡眠和静止不动时期海马CAl区出现的高频(150～250 Hz)场电位振荡,是海马中同步化最高的脑电活动模式,它被认为可以协调海马CA1区锥体细胞的... 详细信息

啮齿类动物海马在不同行为状态下表现出不同频率的场电位节律振荡,其中ripple节律是动物在慢波睡眠和静止不动时期海马CAl区出现的高频(150～250 Hz)场电位振荡,是海马中同步化最高的脑电活动模式,它被认为可以协调海马CA1区锥体细胞的同步化输出。大量研究表明,海马是短时记忆转变为长时记忆的关键脑区,而ripple节律振荡在记忆从海马到皮层的迁移过程中起着较为关键的作用。运用多通道在体记录技术,我们考察了小鼠海马CA1区ripple高频节律振荡,并记录到两类与之相关的高频放电中间神经元:rippleⅠ型和Ⅱ型中间神经元。其中Ⅰ型中间神经元对应每个ripple周期有一个放电,其放电的峰值频率可达310±33.17Hz,而Ⅱ型中间神经元在每个ripple周期中有1-2个放电,峰值放电频率可达410±47.61 Hz。Granger因果关系分析是用来分析一个时间序列对另一个时间序列的预测是否有意义的统计学假设检验,曾被广泛用于经济学研究。近年来,Granger因果关系分析也被应用到神经编码领域,用来检测具有神经联系的神经元之间的因果关系。我们对记录到的ripple相关高频放电中间神经元与场电位ripple节律作Granger因果关系分析,结果表明,ripple相关中间神经元在ripple频段对场电位的ripple节律具有单向的Granger因果关系影响,推测这两类ripple相关高频放电中间神经元对ripple节律的产生可能起着重要的作用,并且参与到记忆巩固的过程中。

关键词： ripple振荡中间神经元 Granger因果分析

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坐骨神经再生过程中miR-221/222调控Schwann细胞的分子机制

坐骨神经再生过程中miR-221/222调控Schwann细胞的分子机制

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者：于彬钱天梅王勇军丁斐顾晓松南通大学江苏省神经再生重点实验室

目的坐骨神经损伤后修复与再生的过程受到很多分子和细胞的调控,而Schwann细胞在神经损伤后的变性和再生中有着非常重要的作用。microRNA(miRNA)是一类22nt的内源性单链RNA分子,可诱导转录后基因沉默,在多种生物学过程中发挥重要调控作... 详细信息

目的坐骨神经损伤后修复与再生的过程受到很多分子和细胞的调控,而Schwann细胞在神经损伤后的变性和再生中有着非常重要的作用。microRNA(miRNA)是一类22nt的内源性单链RNA分子,可诱导转录后基因沉默,在多种生物学过程中发挥重要调控作用。本研究的目的是探讨在神经再生过程中miRNA对Schwann细胞增殖和迁移的影响。方法我们系统性分析了大鼠坐骨神经缺损后不同时间点缺损近端神经miRNA表达谱和mRNA表达谱。分析了miRNA与基因的调控网络。通qRT-PCR验证miRNA表达趋势。构建荧光素酶检测质粒。体外培养大鼠Schwann细胞,转入miR-221/222模拟物和抑制剂、LASS2的siRNA。结果 (1)得到网络中具有调控地位的miR-221和miR-222及被调控的靶基因LASS2。(2)在坐骨神经损伤后神经组织中miR-221和miR-222表达上调,LASS2呈现相反的表达趋势;(3)在培养的Schwann细胞中,转入miR-221/222模拟物和抑制剂分别能显著促进和抑制Schwann细胞的增殖和迁移。荧光素酶检测结果证实miR-221/222特异靶向LASS2基因的3'UTR;体外培养的Schwann细胞转入miR-221/222模拟物可以抑制LASS2的表达。进一步体外转染针对LASS2的siRNA能显著促进Schwann细胞的增殖和迁移,并可拮抗miR-221/222抑制剂对Schwann细胞增殖和迁移的抑制作用。结论在坐骨神经缺损后miR-221/222表达显著上调并参与Schwann细胞功能的调节,而这种作用是通过其靶基因参与的。

关键词：神经再生 Schwann细胞 miR-221/222 LASS2

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特异性COX-2抑制剂塞来昔布通过钾离子通道调节作用导致神经元凋亡

特异性COX-2抑制剂塞来昔布通过钾离子通道调节作用导致神经元凋亡

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者：秘尧杜肖娜张海林河北医科大学药理教研室教育部神经血管重点试验室

塞来昔布是目前唯一仍在临床使用的COX-2选择性抑制剂,广泛用于治疗炎症疼痛性疾病,我们前期研究发现塞来昔布对Kv7钾通道功能有显著调节作用。钾离子通道参与了细胞的凋亡过程。众多研究表明钾离子外流是诱发细胞凋亡的早期标志性的细... 详细信息

塞来昔布是目前唯一仍在临床使用的COX-2选择性抑制剂,广泛用于治疗炎症疼痛性疾病,我们前期研究发现塞来昔布对Kv7钾通道功能有显著调节作用。钾离子通道参与了细胞的凋亡过程。众多研究表明钾离子外流是诱发细胞凋亡的早期标志性的细胞容减小AVD(apoptotic volume decrease)及细胞皱缩的主要原因。目前认为钾离子通道触发细胞凋亡的机制钾通道开放增加导致细胞内K外流,由此产生细胞内失钾,进而导致两种后果,一是引起细胞皱缩激活caspases通路,二是减少对caspases和nuclearases的直接抑制,最终导致细胞凋亡。本实验基于前期的研究基础,用罗丹明染色及tunel染色观察Kv7钾通道功能调节剂塞来昔布对海马神经元调亡的影响。结果发现塞来昔布对海马神经元有明显的促调亡作用,包括可使细胞皱缩、线粒体膜电位去极化及细胞染色体断裂等。这一现象可能主要与其对神经细胞膜钾离子通道的调节有关而与其对COX-2的抑制作用无关,因无COX-2抑制作用而具有Kv7钾通道的塞来昔布结构类似物2,5-二甲基塞来昔布对海马神经元仍有明显的促调亡作用。塞来昔布引起海马神经元调亡的具体机制还需进一步深入研究,包括是否通过激活细胞膜的Kv7/M通道引起神经元胞内钾离子丢失等。作为一类广泛应用于临床的解热镇痛抗炎药,塞来昔通过非COX-2抑制作用引起神经细胞的调亡的可能性无疑应予以高度重视。

关键词：塞来昔布钾离子通道海马神经元调亡

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Rolipram,a selective phosphodiesterase-4 inhibitor,decreases ethanol seeking and consumption in alcohol-preferring Fawn Hooded rats

Rolipram,a selective phosphodiesterase-4 inhibitor,decreases...

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中国神经科学学会第九届全国学术会议暨第五届会员代表大会

作者： Rui-Ting WEN Ming ZHANG Wang-Jun QIN Andrew J.Lawrence Han-Ting ZHANG Jian-Hui LIANG National Institute on Drug Dependence Peking University 38 Xueyuan Road Beijing 100191 China Howard Florey Institute and Centre for Neuroscience Parkville Victoria 3010 Australia Departments of Behavioral Medicine & Psychiatry and Physiology & Pharmacology West Virginia University Health Sciences Center Morgantown West Virginia 26506 USA

Alcohol dependence is a complex psychiatric disorder demanding development of novel *** the cyclic AMP (cAMP) signaling cascade has been implicated in mediating the behavioral response to alcohol, it would be of interest to determine whether phosphodiesterase-4 (PDE4), an enzyme that selectively hydrolyzes intracellular cAMP, is involved in the regulation of alcohol ***, the selective PDE4 inhibitor rolipram was used to measure its anti-drinking properties in alcohol-preferring Fawn-Hooded (FH/Wjd) *** showed that acute administration of rolipram (0.05, 0.1, and 0.2 mg/kg) selectively and dose-dependently reduced 5% ethanol, but not 10% sucrose, operant self-administration; it also decreased voluntary 5% ethanol intake, but not water consumption, for the initial 30 min in rats showing high stable preference for ethanol.

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Activation of somatostatin sst5 receptor modulates GABA release from cultured rat retinal amacrine cells

Activation of somatostatin sst5 receptor modulates GABA rele...

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中国神经科学学会第九届全国学术会议暨第五届会员代表大会

作者： Wen CHEN Jiang-Bin KE Chuang-Qiang ZHANG Xiong-Li YANG Zhong-Feng WANG Institutes of Brain Science Institute of Neurobiology and State Key Laboratory of Medical Neurobiology Fudan University Shanghai 200032 China

Previous study demonstrated that somatostatin (SRIF) sst5 receptors are expressed in rat retinal amacrine cells (ACs).Here, we investigated the modulation of SRIF on GABA release in cultured *** significantly reduced the frequency of spontaneous inhibitory postsynaptic currents (sIPSCs), which was reversed by BIM 23056, a selective sst5 ***-application of nimodipine and ω-conotoxin GVIA suppressed the frequency of sIPSCs, and SRIF failed to further inhibit *** increased, while a PKA inhibitor Rp-cAMP reduced the frequency of *** the presence of Rp-cAMP SRIF had no effect on the sIPSCs.8-Br-cGMP significantly decreased the frequency of sIPSCs, and SRIF shows further inhibition ***, PKG inhibitor KT5823 had no remarkable effect on the frequency of sIPSCs, whereas SRIF inhibits it in the presence of *** results suggest that SRIF inhibits Ca2+ influx via the presynaptic Ca2+ channels by activating the sst5 receptors, which results in a decrease of GABA release from the ACs through inhibiting the intracellular cAMP-PKA and activating the cGMP-PKG signaling pathways.

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The "honest" brain region-Decoding true answers from brain activity

The "honest" brain region-Decoding true answers from brain a...

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中国神经科学学会第九届全国学术会议暨第五届会员代表大会

作者： Zi-Rui HUANG Zhi YANG Rui DAI Xu-Chu WENG Graduate School of Chinese Academy of Sciences Beijing 100049 China Institute of Life Science South China Normal University Guangzhou 510631 China Research Center of Human Brain and Mental Disease Hangzhou Normal University 310015 China Institute of Psychology Chinese Academy of Sciences Beijing 100101 China Research Center of Human Brain and Mental Disease Hangzhou Normal University 310015 China Institute of Psychology Chinese Academy of Sciences Beijing 100101 China Research Center of Human Brain and Mental Disease Hangzhou Normal University 310015 China

Men lie for various reasons, hiding their true thoughts which cognitive neuroscientists are eager to read out using neuroimaging techniques yet have to date not reached a clear-cut *** most studies have compared the brain response patterns between honest and deceptive answers, here we directly examined whether the faithful answers for polar questions can be decoded from BOLD *** found a unique region in the left middle frontal gyrus that successfully discriminated between positive and negative faithful responses independent of intentional suppression and stimuli *** propose the activity of this "honest" region may serve as an indicator of one's faithful answers.

关键词： deception detection searchlight fMRI faithful answers

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The influence of anxiety on the framing effect

The influence of anxiety on the framing effect

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中国神经科学学会第九届全国学术会议暨第五届会员代表大会

作者： Ruolei GU Yuejia LUO State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal University Beijing 100875 China

Objective Studies on the framing effect indicate that people tend to make risk-avoidant decisions when the choice is framed (***) as a choice between gains, but make risk-seeking decisions when it is framed as a choice between *** far, the role of anxiety and/or depression in decision-making under framing situations is *** examined the impact of anxiety and depression on the framing effect with a classical monetary gambling *** Participants were instructed that they would have to select either a "sure" or "gamble" *** gain frame trials, the sure option was presented as money retained; in loss frame trials, it was presented as money *** participants' decision-making was coded as the proportion of sure option choices for each *** Anxiety, but not depression, had significant effects on framing-related *** levels of anxiety were correlated with stronger flaming effects; most interestingly, high-anxious subjects were more risk-seeking in the loss frame compared to low-anxious subjects, which conflicts with previous findings that high-anxious people are consistently more *** The current findings provide evidences that, in contrast with bipolar/ tripolar theoretical models which suggest that all same-valence emotions produce similar cognitive effects, anxiety and depression induce distinct impacts on decision-making.

关键词： decision making flaming effect emotion anxiety depression

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Accumulation of blood-derived microglial progenitors in cerebral cortex after acute ischemic stroke

Accumulation of blood-derived microglial progenitors in cere...

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中国神经科学学会第九届全国学术会议暨第五届会员代表大会

作者： Ting LI Xiao-Qian WU Yong-Ping YU Sheng-Xiang ZHANG School of Life Sciences Lanzhou University Lanzhou 730000 China

Objective Microglia are the main immune cells in *** monitor the microenvironment in healthy brain and respond rapidly to changes under pathological *** are activated and accumulate around lesion sites in various neurodegenerative *** it is widely accepted that microglia are embryonically derived from mesoderm, the source of microglia under pathological conditions in adult animals remains *** we combined a parabiosis animal model with a photothrombosis stroke model and investigated the origin of microglia under ischemic *** C57BL/6 mice and transgenic mice expressing GFP in microglial precursors were used to set up a parabiotic and blood chimeric *** the blood chimerism of the parabiotic animals was established, we induced ischemic stroke by injecting rose bengal intravenously and exposing the cortex to green *** brains from coupled-mice were fixed with 4% paraformaldehyde after photothrombosis and sectioned into 30 μm slices on a vibrating *** slices were examined under an epifluorescence microscope or a confocal *** We have successfully induced photothrombosis in parabiotic *** observed GFP-positive microglia in ischemic area of the brain in wild type C57BL/6 *** Microglia can be recruited into the brain from blood-derived progenitors after ischemic stroke.

关键词： microglia ischemic stroke parabiosis

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Direct determination of [Pry1]Apelin13 in human plasma by UPLC-TOF-MS

Direct determination of [Pry1]Apelin13 in human plasma by UP...

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中国神经科学学会第九届全国学术会议暨第五届会员代表大会

作者： Yu-Jing TANG Hui-Min XU Jin-Mei ZHANG Bo BAI Taishan Medical College Taian 271016 Jinin Medical College Jinin 272000 China

To establish a LC-MS method to determine [Pyr1]Apelin13 in human *** protein was sediment by trichloroaceticacid and analysis was performed on a UPLC-TOF-MS that was operated in the multireaction monitoring mode using positive ion electrospray ionization (ESI) as the *** monitored ion was m/z *** was carried out on an WATERS ACQUITY UPLC BEH C18 (2.1 × 100 mm, 1.7 μm) column with mehanol and formate as the mobile phase at the flow rate of 0.3 ml/min, and injection volume is 30 μl, column temperature is 45 ℃.The calibration curve was linear over the range of 5-200 μg/L and the limitation of detection and quantification for Apelin was about 1 μg/L and 5 μg/L respectively; The extraction recoveries of Apelin 13 spiked at concentrations of 5, 25, 100 μg/L was 96.04%-106.3% with RSD 1.5%-2.23% (n=6).This method is simple, accurate, reliable and suitable for the determination of [Pyr1]Apelinl 3 in plasma.

关键词： UPLC-TOF-MS [Pyr1]Apelin13 Apelin plasma

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NRG-1 regulates the proliferation of neural stem cells in adult hippocampus

NRG-1 regulates the proliferation of neural stem cells in ad...

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中国神经科学学会第九届全国学术会议暨第五届会员代表大会

作者： Xiong CAO Hong-Hai HU Liang-Pin LI Qian WANG Ying-Ying FANG Lin MEI Tian-Ming GAO Xin-Hong ZHU Department of Neurobiology Southern Medical University Guangzhou 510515 China Institute of Molecular Medicine and Genetics and Department of Neurology Georgia''s Health Sciences University Augusta GA 30912 Department of Neurobiology Southern Medical University Guangzhou 510515 China School of Chinese Traditional Medicine Southern Medical University Guangzhou 510515 China

Schizophrenia is a severe and disabling mental disorder, cognitive deficits as one of the core symptoms continue to be poorly understood and current antipsychotics are only modestly effective treatments for the cognitive ***-1 and ErbB4 genes, which encode neuregulin-1 (NRG-1) and ErbB4 respectively, are two susceptible genes for *** studies suggest that neurogenesis dysfunction in adult hippocampus may contribute to pathogenesis of cognitive deficits caused by schizophrenia, and the underlying molecular mechanisms are largely ***, we investigated the potential role of NRG-1 on the proliferation of neural stem cells in adult *** showed that ErbB4, the NRG-1 receptor, was primarily expressed on the GFP-positive cells in the adult dentate gyrus of the nestin-GFP transgenic mice.

关键词： NRG-1 ErbB4 schizophrenia adult neurogenesis

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