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Apaf1 deletion rescues injury-induced neuronal death after optic nerve injury

Apaf1 deletion rescues injury-induced neuronal death after o...

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中国神经科学学会第九届全国学术会议暨第五届会员代表大会

作者： Xin GAO Kevin K.Park Zhigang HE Bin CAI Rugen Therapeutics R&D (Shanghai) Co. Ltd 555 Dongchuan Road Shanghai 200241 China Key Laboratory of Brain Functional Genomics (Ministry of Education) Institute of Cognitive Neuroscience East China Normal University 3663 North Zhongshan Road Shanghai 200062 China F.M.Kirby Neurobiology Center Children''s Hospital and Department of Neurology Harvard Medical School 300 Longwood Avenue Boston MA 02115 USA Key Laboratory of Brain Functional Genomics (Ministry of Education) Institute of Cognitive Neuroscience East China Normal University 3663 North Zhongshan Road Shanghai 200062 China

In the adult mammals, axotomy of mature neurons in the central nervous system (CNS) triggers massive cell death and failure to spontaneous axon *** relationship between axotomy-induced neuronal death and axon regeneration has not yet well-understood, although promoting intrinsic capability of axon regeneration of CNS neurons is often accompanied by moderately improved neuronal *** we generated a mouse line with conditional knock-out of apoptotic protease activating factor 1 (Apfa1).Apaf1 was deleted in retina ganglion cells (RGCs) by intravitreal injection of AAV-Cre virus, followed by optic nerve *** data show that although Apaf1 is deleted, RGCs have significantly a high survival rate, but their axon regeneration ability is not ***, axon regeneration is not the consequence of rescuing neuronal death.

关键词： Apaf1 conditional knock-out apoptosis axon regeneration

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Triptolide T10 enhances AAV-mediated gene transfer in mice striatum

Triptolide T10 enhances AAV-mediated gene transfer in mice s...

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中国神经科学学会第九届全国学术会议暨第五届会员代表大会

作者： Xin-Miao REN Ting ZHANG Jing HU Wei DING Xiao-Min WANG Department of Biochemistry and Molecular Biology Capital Medical University Youanmen Beijing 100069 China Department of Physiology and Key Laboratory of the Neurodegenerative Disorders of the Chinese Ministry of Education Capital Medical University Youanmen Beijing 100069 China Department of Biochemistry and Molecular Biology Capital Medical University Youanmen Beijing 100069 China Department of Physiology and Key Laboratory of the Neurodegenerative Disorders of the Chinese Ministry of Education Capital Medical University Youanmen Beijing 100069 China

Adeno-associated virus (AAV)-mediated gene transfer has been demonstrated to be an effective approach for treating Parkinson's disease (PD).Triptolide T10 is a monomeric compound isolated from tripterygium wilfordii Hook.f.(Thunder God vine), a traditional Chinese herb for anti-inflammatory *** the present study, we coadministered T10 with recombinant AAV2 in SH-SY5Y human neuroblastoma cells and in the striatum of C57BL/6 mice, and then evaluated the AAV-mediated gene expression *** results have shown that T10 significantly augmented the expression of AAV-mediated gene in a dose-dependent fashion without detectable *** growing evidence indicated that inflammation contributed to the progression of PD, and the anti-inflammatory effect of T10 was shown in our previous studies, our data of T10 to enhance AAV transduction suggest that T10 might be potentially used as a facilitating reagent for the AAV gene therapy applications in neurodegenerative diseases.

关键词： Triptolide AAV gene therapy Parkinson' s disease

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Comparative study in the spontaneous response of the medial geniculate body and inferior colliculus in rats with thalamic reticular nucleus lesion after contralateral cochlear ablation

Comparative study in the spontaneous response of the medial ...

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中国神经科学学会第九届全国学术会议暨第五届会员代表大会

作者： Dan-Yi LU Shi-Gang HE Ju-Fang HE Laboratory of Applied Neuroscience Department of Rehabilitation Sciences The Hong Kong Polytechnic University Hung Hom Kowloon Hong Kong China CAS-Hong Kong Joint Research Laboratory for Visuo-Auditory Integration Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China State Key Laboratory of Brain and Cognitive Sciences Institute of Biophysics Chinese Academy of Sciences 15 Datun Road Beijing 100101 China CAS-Hong Kong Joint Research Laboratory for Visuo-Auditory Integration Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China

Tinnitus is a ringing, swishing, or other type of noise that originated in the ear or *** hypothesize that damage of the cochlear hair cells causes hypersensitivity of the cells after a period of reorganization in the auditory pathway.A malfunctioning of the thalamic reticular nucleus (TRN) would decrease its inhibition to the auditory transmission and eventually causes *** the present study, we would investigate the neuronal property change in the medial geniculate body (MGB) and inferior colliculus (IC) of the rats after cochlear ablation and TRN lesion at different *** acid was injected into the TRN to lesion the *** contralateral cochlea to the recording hemisphere was ablated under an operating *** responses of the MGB and IC were recorded with the implanted extracellular electrodes while the rat was in different physiological *** found that neurons in the auditory thalamus should more changes than those in the *** results would lead us to a further investigation on the potential mechanism focusing on the changes in the MGB.

关键词： Tinnitus cochlea thalamic reticular nucleus (TRN) medial geniculate body (MGB) inferior colliculus (IC)

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Research on the effect of Neuromedin U2 receptor activated by the citrus flavonoids

Research on the effect of Neuromedin U2 receptor activated b...

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中国神经科学学会第九届全国学术会议暨第五届会员代表大会

作者： Xu-Xu ZHENG Dao-Qing WANG Research Center of Medicinal Chemistry & Chemical Biology Chongqing key Laboratory of Natural Medicine Research Chongqing Technology and Business University Chongqing 400067 China Research Center of Medicinal Chemistry & Chemical Biology Chongqing key Laboratory of Natural Medicine Research Chongqing Technology and Business University Chongqing 400067 China Environmental & Biological College Chongqing Technology and Business University Chongqing 400067 China

Objective To identify the agonists for Neuromedin U 2 receptor by using NMU2R cell line which was established by cotransfecting HEK293 with the NMU2R plasmid (NMU2R/pCDNA3.1 +) and reportergene plasmid (3×MRE/3×CRE/SRE-Luciferase/pGL3).Methods Plate NMU2R cells in growth medium with 3% FBS in a 96-well format and incubate the cells at 37 ℃ in a CO2 incubator for 12 *** the citrus flavonoids and Forskolin solutions to each well containing cells and *** the cells at 37 ℃ in a CO2 incubator for 6-8 *** an equal volume of 0.5×Bright-GloTM solution, then test the value of a luciferase *** the activation effect of the various citrus flavonoids to Neuromedin U 2 receptor by the value of a luciferase *** (1) Naringin, Naringenin and Tangeretin can not activate Neuromedin U 2 receptor.(2) Hesperidin and Nobiletin can activate Neuromedin U 2 receptor.(3) The EC50 values of Hesperidin and Nobiletin for the receptor were 319 μM and 6 μ*** Hesperidin and Nobiletin can be the agonists of Neuromedin U 2 receptor.

关键词： NMU2R agonist hesperidin nobiletin

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Triptolide T10 enhances AAV-mediated gene transfer in mice striatum

Triptolide T10 enhances AAV-mediated gene transfer in mice s...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Xin-Miao REN~1,Ting ZHANG~(1,*),Jing HU~1,Wei DING~2,Xiao-Min WANG~(1,2,*) 1 Department of Physiology and Key Laboratory of the Neurodegenerative Disorders of the Chinese Ministry of Education,Capital Medical University,Youanmen,Beijing 100069,China 2 Department of Biochemistry and Molecular Biology,Capital Medical University,Youanmen,Beijing 100069,China

Adeno-associated virus(AAV)-mediated gene transfer has been demonstrated to be an effective approach for treating Parkinson's disease(PD).Triptolide TIO is a monomeric compound isolated from tripterygium wilfordii Hook.f.(Thunder God vine),a traditional Chinese herb for anti-inflammatory *** the present study,we coadministered T10 with recombinant AAV2 in SH-SY5Y human neuroblastoma cells and in the striatum of C57BL/6 mice,and then evaluated the AAV-mediated gene expression *** results have shown that T10 significantly augmented the expression of AAV-mediated gene in a dose-dependent fashion without detectable *** growing evidence indicated that inflammation contributed to the progression of PD,and the anti-inflammatory effect of T10 was shown in our previous studies,our data of T10 to enhance AAV transduction suggest that T10 might be potentially used as a facilitating reagent for the AAV gene therapy applications in neurodegenerative diseases.

关键词： Triptolide AAV gene therapy Parkinson's disease

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The role of macroautophagy and chaperon-mediated autophagy in huntingtin metabolism

The role of macroautophagy and chaperon-mediated autophagy i...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Zheng-Hong QIN,Fang LIN,Jun-Chao WU,Lin QIN Deartment of Pharmacology,Soochow University School of Medicin,Suzhou 215123,China

A neuropathological hallmark in human HD and mouse models is the intracellular accumulation and aggregation of N-terminal Htt fragments,suggesting that aberrant Htt proteolysis and/or dysfunction in clearance of truncated Htt may underlie the neuropathology of *** a cell model of HD overexpressing Htt fragment 1-552 amino acid residues(Htt-552).We found that both macroautophagy and chaperon-mediated autophagy(CMA) were involved in degradation of *** the levels of macroautopahgy and CMA effected the accumulation of *** can interact with Htt-552 and redistributed from nucleus to the cytosol and knockdown of beclinl increased the accumulation of mutant Htt552,suggesting macroautophagy regulator beclinl plays a role in promoting degradation of *** of cell lysates containing expressed Htt-552 with isolated lysosomes demonstrated that Htt-552 bound to lysosomes and was transported into the lysosomal lumen for *** of polyQ tract in Htt-552 impaired its uptake and degradation by *** of putative KFERQ motif in wilt-type Htt-552 interfered with interactions between Htt-552 and *** data suggest that CMA also plays a role in Htt *** studies indicate that both macroautophagy and CMA are involved in degradation of Htt and thus may represent an important therapeutic target.

关键词： The role of macroautophagy and chaperon-mediated autophagy in huntingtin metabolism

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The possible mechanism of Ca2+ induced Ca2+ release in astrocytes

The possible mechanism of Ca2+ induced Ca2+ release in astro...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Jun-Hua YANG,Ke-Qing ZHU,Shu-Min DUAN~* Department of Neuroscience,School of Medicine Zhejiang University,Hangzhou 310058,China

Objective Astrocytes are the primary neuronal structural and trophic supportive *** like neurons which can generate action potential,however astrocytes exhibit diversity intracellur calcium activity and this is thought to play an important part in physiology and pathological *** calcium elevation has various forms,one important is Cainduced Ca release（CICR）which is thought to be mediated by 1,4,5-triphosphate receptor（IP3R）and ryanodine receptor（RyR）but the mechanism is not very *** our research,we want to explore the potential mechanism of CICR by a new *** We used laser scan confocol microscopy to monitor the intraculler calcium variation and used a special method triggering Cainflux in mouse *** inhibitors of different channels were use to investigate the possible role of participating in *** Astrocytes calcium elevation was significantly inhibited by some specificity *** Our primary datas showed that NCX may play an important role in astrocytes *** contrary to some papers which reported RyR relating to CICR,our study didn't find this result.

关键词： astrocytes 1,4,5-triphosphate receptor ryanodine receptor Na+/Ca2+ exchangers

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14-3-3 proteins interact with the neurofilament light subunit and regulate neurofilament dynamics

14-3-3 proteins interact with the neurofilament light subuni...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Lin-Qing MIAO,Jun-Lin TENG~*,Jian-Guo CHEN~* Department of Cell Biology,College of Life Sciences,Peking University,Beijing 100871,China

Neurofilament light subunit(NFL) is the core component of neurofilaments,which are the main intermediate filaments(IF) in *** dominant inherited diseases are related to mutations in IF *** studies report that NFL mutations are related to the charcot-marie-tooth(CMT) diseases,but the mechanism is ***,we show that seven 14-3-3 isoforms all interact with NFL,which is dependent on the phosphorylation of NFL head domain that is regulated by *** mutation analyses reveal many Serine phosphorylation sites in the head domain that are important for 14-3-3 *** of these sites lead to aggregate ***,14- 3-3 overexpression increases NFL exchange rate and leads to neurofilament *** mutations P8Q,P8L, P22S,found in CMT diseases,inhibit 14-3-3 binding and result in the formation of NFL aggregations,which can be rescued by 14-3-3 ***,14-3-3 proteins regulate NFL assembly and dynamic exchange through interaction with NFL,and can act as potential molecule targets for therapy of human CMT diseases.

关键词： NFL 14-3-3 neurofilament phosphorylation CMT

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Activation in human superior temporal cortex is modulated by shortterm auditory word learning

Activation in human superior temporal cortex is modulated by...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Rui DAI~(1,2),Zi-Rui HUANG~(1,3,4),Xu-Chu WENG~(1,*) 1 Research Center of Human Brain and Mental Disease,Hangzhou Normal University,Hangzhou 310015,China 2 Institute of Life Science,South China Normal University,Guangzhou 510631,China 3 Institute of Psychology,Chinese Academy of Sciences,Beijing 100101,China 4 Graduate School of Chinese Academy of Sciences,Beijing 100049,China

Objective Previous studies showed that the superior temporal gyrus and sulcus(STG/STS) plays an important role in auditory speech *** this study,we investigated whether the activation of the STG/STS could be modulated by short term auditory word *** We recorded blood oxygenation responses,using functional magnetic resonance imaging,to frequency-modulated tones,Cantonese words,mandarin Chinese words, and trilled and reversely played Chinese *** were then required to learn a set of Cantonese words during *** for the learned Cantonese words and unlearned control words were *** Activation was most robust in the STG/STS for mandarin Chinese when comparing to other *** the short training session,the participants could understand most of the presented Cantonese *** stronger BOLD signal change was observed for learned Cantonese words than for unlearned control condition in the STG/STS. Conclusion Our results suggest that the STG/STS may be crucial for short term auditory word learning.

关键词： superior temporal gyrus fMRI short-term learning auditory processing

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The crucial period for focal low frequency stimulation inhibiting the development of amygdala-kindling in rats

The crucial period for focal low frequency stimulation inhib...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Yi WANG,Zheng-Hao XU,Yang LIU,Kai ZHONG,Ceng-Lin XU,Wei-Wei HOU,Shi-Hong ZHANG,Zhong CHEN~* Institute of Neuroscience,Department of Pharmacology,College of Pharmaceutical Sciences,School of Medicine, Zhejiang University,Hangzhou 310058,China

Objective To investigate whether there is a crucial period for focal low frequency stimulation(LFS) inhibiting the development of amygdala-kindling in *** The effect of focal LFS(1 Hz,15 min) applied in different periods of the kindling development process were *** was initiated immediately after daily kindling *** LFS given in the first week of kindling or during the whole kindling process had similar antiepileptic effect on the development of kindling,indicated by the slowed development of seizure stage and the shortened afterdischarge duration,while LFS applied after the first week of kindling had no effect,even aggravated afterdischarge *** the rats in the control group or received LFS after the first week were fully kindled within 20 ***,only 44%rats received LFS in the first week and 32.5%rats received LFS during the whole kindling process were fully kindled within 20 *** The first week of kindling process is a crucial period for focal LFS inhibiting the development of *** early period in epileptogenesis may be an ideal time for LFS treatment.

关键词： LFS epilepsy amygdala kindling crucial period

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