检索结果-内蒙古大学图书馆

您好，读者！请登录

内蒙古大学图书馆

首页
概况
党建
资源
服务
科研支持
- 论文收录引用证明
- 科技查新
知识产权
档案馆
帮助

咨询与建议

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

您的常用邮箱：*

您的手机号码：*

问题描述：

当前已输入0个字，您还可以输入200个字

全部搜索
期刊论文
图书
学位论文
标准
纸本馆藏
外文资源发现
数据库导航
超星发现

高级检索

时间限定

出版年份：

文献类型

图书期刊文献学位论文多媒体

馆藏选择

电子馆藏纸本馆藏

核心期刊

全部期刊 SCI 收录期刊 SSCI 收录期刊 EI 收录期刊 CSCD 收录期刊 CSSCI 收录期刊

语言

中文英文

文献类型

期刊文献图书学位论文标准纸本馆藏

帮助

文字说明：

T=题名（书名、题名），A=作者（责任者），K=主题词，P=出版物名称，PU=出版社名称，O=机构（作者单位、学位授予单位、专利申请人），L=中图分类号，C=学科分类号，U=全部字段，Y=年（出版发行年、学位年度、标准发布年）

检索规则说明：

AND代表“并且”；OR代表“或者”；NOT代表“不包含”；(注意必须大写,运算符两边需空一格)

检索范例：

范例一：(K=图书馆学 OR K=情报学) AND A=范并思 AND Y=1982-2016
范例二：P=计算机应用与软件 AND (U=C++ OR U=Basic) NOT K=Visual AND Y=2011-2016

分类表

所选分类

>> <<

限定检索结果

文献类型

827 篇 会议

馆藏范围

827 篇 电子文献
0 种 纸本馆藏

日期分布

学科分类号

403 篇 理学
- 403 篇 生物学
351 篇 医学
- 245 篇 临床医学
- 79 篇 基础医学(可授医学...
- 33 篇 中西医结合
- 18 篇 药学(可授医学、理...
- 8 篇 中药学(可授医学、...
- 6 篇 中医学
- 3 篇 医学技术（可授医学...
- 2 篇 公共卫生与预防医...
7 篇 工学
- 5 篇 生物医学工程（可授...
- 3 篇 生物工程
- 2 篇 材料科学与工程（可...
2 篇 教育学
- 2 篇 心理学(可授教育学...
1 篇 农学
- 1 篇 畜牧学

主题

37 篇 hippocampus
24 篇 rat
21 篇 nmda receptor
18 篇 parkinson's dise...
15 篇 ischemia
14 篇 depression
14 篇 astrocyte
14 篇 epilepsy
12 篇 alzheimer's dise...
12 篇 synaptic plastic...
12 篇 apoptosis
12 篇 microglia
12 篇 neuron
11 篇 learning and mem...
10 篇 spinal cord
9 篇 migration
9 篇 ltp
9 篇 neuroprotection
9 篇 glutamate
9 篇 帕金森病

机构

15 篇 首都医科大学
9 篇 复旦大学
8 篇 上海交通大学医学...
8 篇 neuroscience res...
6 篇 浙江大学
5 篇 中国医学科学院药...
5 篇 南通大学
4 篇 key laboratory f...
4 篇 南方医科大学
4 篇 department of ne...
4 篇 北京大学
4 篇 山西医科大学
3 篇 institute for bi...
3 篇 key laboratory f...
3 篇 华东师范大学
3 篇 南昌大学
3 篇 infectious disea...
3 篇 laboratory of ap...
2 篇 军事医学科学院基...
2 篇 department of ps...

作者

8 篇 陈生弟
8 篇 陈乃宏
7 篇 albert cheung ho...
6 篇 苑玉和
6 篇 徐志卿
5 篇 徐群渊
5 篇 孙凤艳
5 篇 胡金凤
4 篇 李鹏飞
4 篇 zhejiang provinc...
4 篇 杨予涛
4 篇 王春芳
4 篇 顾晓松
4 篇 丁健青
4 篇 college of pharm...
4 篇 刘彩玉
4 篇 陈忠
4 篇 蔚洪恩
4 篇 高天明
4 篇 key laboratory o...

语言

705 篇 英文
122 篇 中文

检索条件"任意字段=中国神经科学学会第九届全国学术会议暨第五届会员代表大会"

共 827 条记录，以下是231-240 订阅

全选清除本页清除全部题录导出标记到"检索档案"

详细简洁

排序：

Biomarkers and drug targets of Alzheimer's disease

Biomarkers and drug targets of Alzheimer's disease

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Jian-Zhi WANG Pathophysiology Department,Key Laboratory of the Chinese Education Ministry for Neurological Disorders,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

Alzheimer's disease(AD) is the most common cause of dementia affecting 47%in the population at age over *** there are licensed treatments that can alleviate the symptoms of AD,the efficacious diseasemodifying treatments are still *** pathophysiological process of AD is believed to begin many years before the diagnosis of dementia and this long preclinical phase would provide opportunity for the *** for improving diagnosis are moving forward,but a better consensus is needed to elucidate the link between the pathological cascade of AD and the clinical *** on the prevailing scientific evidence to date,a panel of biological and neuroimaging biomarkers that support clinical diagnosis have been developed recently,but further work is needed to understand these better and to establish whether interventions can substantially lower these *** this seminar,we will provide an overview of recent evidence regarding the biomarkers or drug targets of *** these molecules are solely intended for research purposes and do not have any clinical implications at this time,we believe that these biomarkers can provide a common rubric to advance the preclinical studies of AD,and ultimately,aid the field in moving toward earlier intervention of AD when some disease-modifying therapies may be most efficacious.

关键词： Alzheimer Biomarkers and drug targets of Alzheimer's disease

来源：评论

学校读者我要写书评

暂无评论

Adjudin attenuates lipopolysaccharide-induced neuroinflammation

Adjudin attenuates lipopolysaccharide-induced neuroinflammat...

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Jia-Xiang SHAO,Qian Reuben XIE,Ye-Wei LIU,Wei-Liang XIA~* Neuroscience and Neuroengineering Center,School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University,Shanghai 200030,China

Neuroinflammation caused by microglial activation plays a key role in brain *** are activated in response to diverse stimuli and release multiple inflammatory *** seek for new drugs to modulate neuroinflammation,we recently found that Adjudin,a potential non-hormonal male contraceptive,exhibits additional function to reduce production of proinflammatory mediators in lipopolysaccharide(LPS)-stimulated microglial *** our present study,one-hour Adjudin pretreatment reduced IL-6 and IL-ip mRNA levels in BV2 microglial ***-6 secretion was also reduced with Adjudin *** determine whether Adjudin might have similar effects in vivo,mice were given Adjudin(100 mg/kg,i.p.) 3 h before and post LPS injection(2.5 mg/kg,i.p.). The results showed that Adjudin decreased the induction of IL-6 and IL-1P mRNA by LPS in the ***,our data suggest that Adjudin might mitigate neuroinflammation.

关键词： Adjudin neuroinflammation IL-6 IL-1β BV2 microglial cells lipopolysaccharide

来源：评论

学校读者我要写书评

暂无评论

TRPC5 is necessary for neurotrophin-3 to induce intracellular calcium elevation and to inhibit dendritic growth in hippocampal neurons

TRPC5 is necessary for neurotrophin-3 to induce intracellula...

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Zhuohao HE,Yizheng WANG Laboratory of Neural Signal Transduction,Institute of Neuroscience,Shanghai Institutes for Biological Sciences,State Key Laboratory of Neuroscience,The Graduate School,Chinese Academy of Sciences,Shanghai 200031,China

Neurotrophin-3(NT-3),a member of neurotrophin family,exerts numerous functions in central nerves system regarding for its ability to induce intracellular calcium elevation,however,the identity of calcium channel and mechanism involved in its actions remains largely ***,we found that the temporal expression and cellular localization pattern of Transient receptor potential canonical(TRPC) 5 protein paralleled that of NT-3 receptor TrkC in hippocampal *** by NT-3 led to production of nonselective cation conductance and PLCγ-dependent intracellular calcium elevation,which was reduced after blockade of TRPC5 but not TRPC6 channels in hippocampal ***,the specific calcium influx through TRPC5 induced by NT-3 inhibited hippocampus neuronal dendritic growth through Camodulin-dependent Kinase(CaMK)Ⅱactivation,whereas the calcium influx through TRPC6 induced by NT-4 promoted hippocampus neuronal dendritic growth through CaMKIV *** TRPC channels emerge as novel and specific mediators of neurotrophin-regulated dendritic development through specific CaMKs.

关键词： TRPC channels dendritic development CaMK

来源：评论

学校读者我要写书评

暂无评论

Cortical representaion of haptic working memory

Cortical representaion of haptic working memory

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Steven S.Hsiao Mark Bodner Fred Lenz Krieger Mind/Brain Institute Johns Hopkins UniversityBaltimoreMD Department of Neuroscience Johns Hopkins UniversityBaltimoreMD Department of Neurosurgery Johns Hopkins UniversityBaltimoreMD

The neuronal activity in SI cortex was collected when monkeys performed a haptic unimodal working memory *** found that in trials with correct task performance a substantial number of cells showed significant differential neural activity only when the monkeys had to make a choice between two different haptic *** of incorrect trials showed that such a difference in neural activity was significantly ***,the choice differential neural activity was barely observed in monkeys who performed a control task that was identical to the haptic unimodal working memory task but did not require the animal to either actively memorize the sample,or make a choice between the two objects at the end of the *** data also suggested the top-down influence on decisionmaking neural activity in SI cortex when the animal performed a haptic crossmodal working memory *** all the above results together,we believe that the differential activity may be a neural correlate of decision making, and thus conclude that some SI cells function particularly in the process of decision making when the animal has to make a haptic *** findings indicate for the first time that primary sensory cortex may play an important role in decision-making.

关键词： monkey working memory haptic decision-making

来源：评论

学校读者我要写书评

暂无评论

Effects of NMDA and AMPA receptors in the hippocampal CA1 region during learning-dependent LTP in conscious rats

Effects of NMDA and AMPA receptors in the hippocampal CA1 re...

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Shi WANG~1,Jun WANG~1,Dan WANG~1,Cheng-Xi WEI~2,Qing-Hua JIN~(1,*) 1 Department of Physiology and Pathophysiology,Yanbian University Medical College,Yanji 133002 China 2 Institute of Neurosurgery,Affiliated Hospital of Inner Mongolia Nationality University,Tongliao 028007 China

Hippocampus is one of the important sites for mammalian learning and memory,and Long-term potentiation (LTP)is a potential neurophysiological mechanism responsible for learning and *** several in vitro studies indicate that glutamate(Glu)and it's ionotropic receptors involved in the hippocampal LTP,however,little is known about the underlying neurophysiological mechanisms of hippocampal learning-dependent LTP in conscious and freely moving *** this work,glutamate receptor antagonists MK-801and CNQX were locally microinjected into the hippocampal CA1 region,then the extracellular concentration of Glu and amplitude of the field excitatory postsynaptic potential(fEPSP)-LTP in CA1 region were measured during the period of establishment and experimental extinction of the conditioned reflex in conscious rats.

关键词： hippocampal CA1 region learning-dependent LTP ionotropic glutamate receptors conscious rats

来源：评论

学校读者我要写书评

暂无评论

Across-ear stimulus-specific adaptation in the rat auditory cortex

Across-ear stimulus-specific adaptation in the rat auditory ...

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Israel Nelken Department of Neurobiology Institute of Life SciencesThe Hebrew University of JerusalemJerusalemIsrael

The specific adaptation of neuronal responses to a repeated stimulus,which does not fully generalize to other stimuli,is called stimulus-specific adaptation(SSA).The SSA is thought to be with a mechanism for emphasizing rare and potentially interesting sensory *** in the auditory system from the inferior colliculus to the auditory cortex have been reported to show SSA to stimuli with different *** auditory system processes spatial information of the acoustic *** the present study,we investigated whether neurons in auditory cortex showed the phenomenon of SSA over sound stimuli located in different *** recorded single and multiunit neurons in auditory cortex of anaesthetized *** stimuli were noise bursts or tones presented toward different ears with oddball paradigm.(1)The majority of the cortical neurons showed the preference for the stimulus with novel position.(2)The firing rate of neurons was larger to the stimulus with novel frequency and position than that with the only *** reason that neurons in auditory cortex showed across-ear stimulus-specific adaptation was probably that this adaptation to the different spatial information was segregated from the frequency information,so in the oddball paradigm the response to the deviant stimulus was not affected by the adaptation to the standard stimulus.

关键词： auditory cortex stimulus-specific adaptation spatial information

来源：评论

学校读者我要写书评

暂无评论

Precise spatiotemporal patterns of neuronal network activation during persistent reverberatory activity

Precise spatiotemporal patterns of neuronal network activati...

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Pak-Ming LAU Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Science University of Science and Technology of China

＜正＞In Hebb’s theory of the cell assembly,short-term memory traces can be stored in closed loop neuronal circuits in form of persistent reverberatory *** previous studies,we have observed persistent network reverberation in cultured hippocampal neurons（Lau and Bi,PNAS,2005）.Here,we investigated the spatiotemporal dynamics of such collective activity of neurons grown on multi-electrode arrays（MEAs）.In this preparation,a reverberation episode consisted of many distinct population bursts defined as reverberation event,each involved the spiking activity of many neurons within a time span of tens of ***,we developed a robust method to define the similarity between two events and use it to find conserved patterns among all *** found that there existed conserved spatiotemporal patterns with high temporal precision in cultured neuronal ***, multiple patterns could co-exist in the same network during spontaneous reverberation and could occur intermittently within the same reverberation *** smaller networks,reverberation could only be evoked by stimulating an input channel,and sometimes only one conserved pattern was *** results suggested that precise spatiotemporal dynamics in neural circuits might allow for more efficient information coding in the brain.

关键词： neural network cell assembly multielectrode array reverberation

来源：评论

学校读者我要写书评

暂无评论

Displaced ganglion cell in the mouse retina

Displaced ganglion cell in the mouse retina

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Rong-Yu LIAO,Ruo-Tong REN,Shi-Gang HE~* State Key Laboratory of Brain and Cognitive Sciences,Institute of Biophysics,Chinese Academy of Sciences,15 Datun Road,Beijing 100101,China

Objective This study represents the most complete morphological classification of mouse retinal displaced ganglion cells(DGCs)in the inner nuclear layer available to date and provides a foundation for further understanding of the correlation of physiology and morphology and ganglion cell function with genetically manipulated ***(1)Flurogold was injected in two adjacent sites or one left site at the SC and the soma of DGCs in the mouse retina was stained by retrograding with Flurogold.(2)The morphology of DGCs was revealed by microinjection with Lucifer yellow.(3)The diameter of soma and dendritic field and distance from soma to the optic nerve were ***(1)The diameter of soma(or dendritic field)and distance from soma to the optic nerve were irrelevant.(2)The DGCs were classified into five groups based on their soma size,dendritic field size,and pattern and level of ***(1)It was proved that all morphological types of GCs in the GCL also existed in the ENL.(2)For monostratified DGCs,there is similar distribution of four morphological types in contralateral projection group and significant preference of B and C types in ipsilateral projection group.

关键词： retina displaced ganglion cell(DGCs) microinjection retrograding

来源：评论

学校读者我要写书评

暂无评论

Identification of orientation-selective ganglion cells in the mouse retina

Identification of orientation-selective ganglion cells in th...

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Xu HAN,Le SUN,Shi-Gang HE~* State Key Laboratory of Brain and Cognitive Sciences,Institute of Biophysics,Chinese Academy of Sciences,15 Datun Road,Beijing 100101,China

Objective In the rabbit retina,orientation-selective ganglion cells（OSGCs）were discovered in *** orientation selectivity results from an incomplete antagonistic surround along the preferred orientation. Pharmacological studies confirmed that the inhibition,originated from amacrine cells,shaped the orientation selectivity of retinal ganglion *** in the mouse retina,there is no information about the OSGCs,that is why we try to identify them and characterized their physiological,morphological and pharmacological ***（1） On-cell and whole-cell patch clamp recording were performed to indentify OSGCs and to examine synaptic inputs.（2） Pharmacological experiments were carried out to check which kinds of neurotransmitters are essential for orientation ***（1）In the mouse retina,ganglion cells classed into B3 and Dl subtypes have orientation selectivity.（2）These cells preferred either vertical or horizontal orientation.（3）The orientation selectivity can be reduced apparently by picrotoxin,which is an antagonist of GABA and GABA *** B3 and D1 ganglion cells,who respond to onset and termination of flashing spot,have orientation *** of them are sensitive to GABA blocker.

关键词： mouse retina orientation selective ganglion cell

来源：评论

学校读者我要写书评

暂无评论

Stage-dependent regulation of oligodendrocyte differentiation and myelin gene expression by Nkx2.2 transcription factor

Stage-dependent regulation of oligodendrocyte differentiatio...

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Xiaofeng ZHAO~(1,2),Qiang ZHU~2,Hong LI~2,Mengsheng QIU~(1,2,*) 1 Institute of Developmental and Regenerative Biology,College of Life Sciences,Hangzhou Normal University, Hangzhou,China 2 Department of Anatomical Sciences and Neurobiology,University of Louisville,Louisville,KY 40292

Nkx2.2 homeodomain transcriptional factor is initially expressed in differentiating oligodendrocyte precursor cells(OPCs) and plays a critical role in regulating the differentiation *** studies showed that Nkx2.2 expression in oligodendrocytes is rapidly down-regulated as OPCs undergo terminal differentiation, but regained in mature myelinating oligodendrocytes in mature *** biphasic pattern of Nkx2.2 expression in oligodendrocyte lineage suggests that Nkx2.2 may have distinct functions during oligodendrocyte lineage progression. To define the role of Nkx2.2 in oligodendrocyte differentiation and maturation,we have used tetracycline-inducible expression system to specifically induce Nkx2.2 expression in oligodendrocyte cells at different developmental stages. Our results demonstrated that Nkx2.2 promoted OPC differentiation at embryonic stages,but repressed myelin protein production at neonatal stages,indicating that regulation of oligodendrocyte differentiation and myelin gene expression by Nkx2.2 is stage-dependent.

关键词： spinal cord Tet-on transgenics oligodendrocyte myelin

来源：评论

学校读者我要写书评

暂无评论

没有更多数据了...

全选清除本页清除全部题录导出标记到“检索档案”

共83页 << < 20 21 22 23 24 25 26 27 28 29 > >>

检索报告对象比较合并检索0

隐藏清空

合并搜索

回到顶部

执行限定条件

内容：

评分：

请选择保存的检索档案：

请选择收藏分类：

订阅名称：

通借通还

温馨提示：

图书名称：

借书校区：

取书校区：

手机号码：

邮箱地址：

一卡通帐号：

电话和邮箱必须正确填写，我们会与您联系确认。

联系人：

所在院系：

联系邮箱：

联系电话：

内蒙古自治区呼和浩特市赛罕区大学西街235号邮编: 010021

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：