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The effect of ceftriaxone on global brain ischemia

The effect of ceftriaxone on global brain ischemia

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Jing XU,Yu-Yan HU,Wen-Bin LI~*,Ai-Ju LIU,Min ZHANG Department of Pathophysiology,Hebei Medical University,361 Zhongshan East Road,Shijiazhuang 050017,China.

Objective The present study was undertaken to observe the effect of ceftriaxone(Cef) on the global brain ischemia and the changes of GLT-1 expression after preventive administration of Cef in rat with global brain ischemia. Methods Thionin staining was used to observe the morphological changes of pyramidal neurons in the hippocampal CAl *** and western blot analysis were used to observe the changes of GLT-1 expression. Results It was found that 8-min global brain ischemia resulted in severe delayed neuronal death(DND) on day 7 after the reperfiision,while preventive administration of Cef once daily for 5 consecutive days significantly prevented the DND in the CAl subfield induced by the global brain ***,the GLT-1 expression was significantly decreased on day 1 after global brain ischemia compared with sham group,while the preventive Cef administration could significantly increased the GLT-1 expression on day 1 after the global brain *** The preventive administration of Cef could up-regulate the expression of GLT-1 and protect neurons against global brain ischemia in hippocampal CAl subfield.

关键词： global brain ischemia ceftriaxone GLT-1 hippocampus rat

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Neural mechanisms underlying crossmodal working memory:an EEG sLORETA study

Neural mechanisms underlying crossmodal working memory:an EE...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Peng GUI,Liping WANG,Yong-Di ZHOU,Yixuan KU Institute of Cognitive Neuroscience,School of Psychology and Cognitive Science,East China Normal University, Shanghai,China

Working memory is essential to learning and performing sensory-motor behaviors that in many situations require the integration of stimuli of one modality with stimuli of *** the present study,we focused on the neural mechanisms underlying crossmodal working *** previous studies revealed that in perfonnance of the tactile crossmodal working memory task,there would be sequentially discrete task-correlated neural activities representing the processes of crossmodal working *** this study,participants performed the visual and auditory crossmodal working memory tasks while the EEG signals were *** positive event-related potential peaks LPC- 1 and LPC-2 were observed during the delay of the *** sLORETA analysis revealed that in the visual-tactile crossmodal task,LPC located in superior parietal cortex,while in the auditory-tactile crossmodal task,LPC located in supermarginal *** present study shows the sources of the late components which involved in crossmodal working *** with our former results of SI affected by crossmodal influence,this study revealed a potential processing flow from primary sensory cortices to association cortices.

关键词： Neural mechanisms underlying crossmodal working memory:an EEG sLORETA study LPC

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Haptic decision-making related neuronal activity in primary somatosensory cortex

Haptic decision-making related neuronal activity in primary ...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Liping WANG,Xianchun LI,Peng GUI,Yong-Di ZHOU Key Laboratory of Brain Functional Genomics(Ministry of Education),Institute of Cognitive Neuroscience,East China Normal University,Shanghai 200062,China

The neuronal activity in SI cortex was collected when monkeys performed a haptic-haptic(HH) delayed matching-to-sample *** found that in trials with correct task performance a substantial number of cells showed significant differential neural activity only when the monkeys had to make a choice between two different haptic *** of incorrect trials showed that such a difference in neural activity was significantly reduced. However,the choice differential neural activity was barely observed in monkeys who performed a control task that was identical to the HH task but did not require the animal to either actively memorize the sample,or make a choice between the two objects at the end of the *** all the above results together,we believe that the differential activity may be a neural correlate of decision making,and thus conclude that some SI cells function particularly in the process of decision making when the animal has to make a haptic *** findings indicate for the first time that primary sensory cortex may play an important role in decision making.

关键词： Haptic decision-making related neuronal activity in primary somatosensory cortex

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Alteration of integrinβ1 expression in spinal dorsal cord of CCI rat

Alteration of integrinβ1 expression in spinal dorsal cord o...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Hong-Jun WANG~(1,2,*),Jun-Ping CAO~(1,2),Jing MENG~(1,2),Jing-Ru WU~(1,2) 1 Jiangsu Province Key Laboratory of Anesthesiology and 2 Center for Pain Research and Treatment,Xuzhou Medical College,Xuzhou 221002,China

Objective Neuropathic pain is associated with reorganization of spinal synaptic circuits,implying that adhesion proteins must be *** present study was to examine the alteration of adhesion protein integrinβ1 expression in relationship of neuropathic *** The left common sciatic nerve of SD rats was ligated to produce a chronic constrictive injury(CCI)*** allodynia was *** co-expression of integrinβ1 with neuron/glia cell was identified by double-labeling immunofluorescence,and the alteration of integrinβ1 expression was detected by RT-PCR,immunohistochemistry and immunoblot *** In L5,integrinβ1 is co-expression with neuron and glia cell within lamina *** mRNA and protein level of integrinβ1 undergoes a time-dependent increase across spinal dorsal cord after *** These results suggest that integrinβ1 plays a crucial role in a painful peripheral neuropathy,making it a very promising target for the development of a novel class of analgesics.

关键词： neuropathic pain integrinpl spinal dorsal cord

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Origin and molecular specification of oligodendrocytes in the spinal cord

Origin and molecular specification of oligodendrocytes in th...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Meng-Sheng QIU College of Life and Environmental Sciences,Hangzhou Normal University,Hangzhou,China

Myelin is critical for the rapid conduction of action potentials in the vertebrate nervous *** oligodendrocyte is the cell type responsible for producing myelin and ensheathing axons in central nervous system (CNS).During early neural development,oligodendrocyte progenitor cells(OPCs) can be produced from a small number of neuroepithelial cells in both dorsal and ventral spinal cords,and both subpopulations of oligodendrocytes can contribute to axonal myelination during development and remyelination after *** of their embryonic origins,the development of OPCs appear to be regulated by the same set of regulatory *** Olig2 is essential for the initial specification of OPC cells,the terminal differentiation of OPCs is controlled by the Sox10 and Nkx2.2 transcription *** recent studies revealed a stage-dependent regulation of oligodendrocyte differentiation by Nkx2.2 homeodomain transcription *** myelination process is highly regulated by a number of extrinsic and intrinsic mechanisms during normal development of the oligodendrocyte *** several key factors have been identified to be critical for axonal myelination in the peripheral nervous system,the molecular control of CNS myelination has remained a *** this talk,I will present evidence that nectin-like cell adhesion molecules(Necl) and receptor molecules may participate in early CNS myelination and possibly in myelin regenerative process as well.

关键词： Origin and molecular specification of oligodendrocytes in the spinal cord

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Stimulation of midbrain dopaminergic structures modifies firing rates of rat lateral habenula pain-activated neurons

Stimulation of midbrain dopaminergic structures modifies fir...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Xue-Feng SHEN,Xiao-Guo RUAN,Hua ZHAO~* Department of Physiology,Norman Bethune College of Medicine,Jilin University,Changchun 130021,China

Ventral tegmental area and substantia nigra pars compacta are midbrain structures known to be involved in mediating *** structures give rise to dopaminergic projections that innervate the lateral habenula(LHb), which is also known to be involved in processing painful stimuli,but it's unclear what physiological effects these inputs have on habenular *** this study we distinguished the LHb pain-activated neurons and assessed their electrophysiological responsiveness to the stimulation of the ventral tegmental area and substantia nigra pars compacta with either single-pulse stimulation(300 uA,0.5 Hz) or tetanic stimulation(80 uA,25 Hz).Single-pulse stimulation that was delivered to either midbrain structure triggered transient inhibition of firing of LHb pain-activated neurons. However,tetanic stimulation of the ventral tegmental area tended to evoke an elevation in neuronal firing *** conclude that LHb pain-activated neurons can receive diverse reward-related signals originating from midbrain dopaminergic structures,and thus participate in the regulation of the brain reward system via both positive and negative feedback mechanisms.

关键词： habenula ventral tegmental area substantia nigra pars compacta reward system pain firing rate

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Direct determination of[Pry1]Apelin13 in human plasma by UPLCTOF-MS

Direct determination of[Pry1]Apelin13 in human plasma by UPL...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Yu-Jing TANG~1,Hui-Min XU~1,Jin-Mei ZHANG~2,Bo BAI~(2,*) 1 Taishan Medical College,Taian 271016 2 Jinin Medical College,Jinin 272000,China

To establish a LC-MS method to determine[Pyr]Apelin13 in human *** protein was sediment by trichloroaceticacid and analysis was performed on a UPLC-TOF-MS that was operated in the multireaction monitoring mode using positive ion electrospray ionization（ESI）as the *** monitored ion was m/z 766.7. Chromatography was carried out on an WATERS ACQUITY UPLC BEH C18（2.1×100 mm,1.7μm）column with mehanol and formate as the mobile phase at the flow rate of 0.3 ml/min,and injection volume is 30 ul,column temperature is 45℃.The calibration curve was linear over the range of 5-200μg/L and the limitation of detection and quantification for Apelin was about 1μg/L and 5μg/L respectively;The extraction recoveries of Apelin 13 spiked at concentrations of 5,25,100μg/L was 96.04%-106.3%with RSD 1.5%-2.23%（n=6）.This method is simple,accurate, reliable and suitable for the determination of[Pyr]Apelin13 in plasma.

关键词： UPLC-TOF-MS [Pyr1]Apelin13 Apelin plasma

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Activation of somatostatin sst5 receptor modulates GABA release from cultured rat retinal amacrine cells

Activation of somatostatin sst5 receptor modulates GABA rele...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Wen CHEN,Jiang-Bin KE,Chuang-Qiang ZHANG,Xiong-Li YANG~*,Zhong-Feng WANG~* Institutes of Brain Science,Institute of Neurobiology and State Key Laboratory of Medical Neurobiology,Fudan University,Shanghai 200032,China

Previous study demonstrated that somatostatin（SRIF）sst receptors are expressed in rat retinal amacrine cells（ACs）.Here,we investigated the modulation of SRIF on GABA release in cultured *** significantly reduced the frequency of spontaneous inhibitory postsynaptic currents（sIPSCs）,which was reversed by BIM 23056, a selective sst ***-application of nimodipine andω-conotoxin GVIA suppressed the frequency of sIPSCs, and SRIF failed to further inhibit *** increased,while a PKA inhibitor Rp-cAMP reduced the frequency of *** the presence of Rp-cAMP SRIF had no effect on the sIPSCs.8-Br-cGMP significantly decreased the frequency of sIPSCs,and SRIF shows further inhibition ***,PKG inhibitor KT5823 had no remarkable effect on the frequency of sIPSCs,whereas SRIF inhibits it in the presence of *** results suggest that SRIF inhibits Cainflux via the presynaptic Cachannels by activating the sst receptors,which results in a decrease of GABA release from the ACs through inhibiting the intracellular cAMP-PKA and activating the cGMP-PKG signaling pathways.

关键词： Activation of somatostatin sst5 receptor modulates GABA release from cultured rat retinal amacrine cells

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糖皮质激素非基因组机制的在负荷游泳力竭应激调节中的生理意义

糖皮质激素非基因组机制的在负荷游泳力竭应激调节中的生理意义

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者：刘磊朱珍王云霞蒋春雷第二军医大学军事航海医学教研室

目的糖皮质激素（GC）除经典基因组作用机制外,还存在非基因组机制。GC非基因组作用的临床意义已比较明确,但这一与生俱来的重要调节机制不可能仅为临床用药而准备,一定有其尚未揭示的重要内在生理意义。本研究以应激时GC快速大量分泌... 详细信息

目的糖皮质激素（GC）除经典基因组作用机制外,还存在非基因组机制。GC非基因组作用的临床意义已比较明确,但这一与生俱来的重要调节机制不可能仅为临床用药而准备,一定有其尚未揭示的重要内在生理意义。本研究以应激时GC快速大量分泌的积极意义为切入点,探索糖皮质激素非基因组机制在应激调节中的生理意义。方法将去肾上腺小鼠随机分成GC（给予应激剂量GC）、RU486、RU486+GC、溶剂对照4组,负荷10%体重强迫游泳至力竭,记录各实验组力竭时间,并在各组强迫负荷游泳5分钟时,采用HE染色、电镜、反相高效液相色谱法观察检测心肌和骨骼肌的组织病理学和超微结构、ATP合成改变;采用血糖分析仪、氧化酶比色、Griess Reagent法检测血浆葡萄糖、乳酸、一氧化氮（NO）水平。结果 GC和RU486+GC组力竭时间显著长于RU486和溶剂对照组,各组GC总作用时间均少于30分钟,RU486不能阻断GC这一作用。溶剂对照组心肌和骨骼肌HE染色示组织充血肿胀,电镜下线粒体肿胀、骨骼肌M线消失。GC组较溶剂对照组血糖升高,血乳酸和NO降低,骨骼肌ATP增多。结论结果表明GC在应激调节中的存在快速非基因组防护机制,其中,以葡萄糖和ATP合成为重要节点的能量代谢和以NO为重要节点的自由基损伤可能为GC非基因组机制主要靶点。这一研究提示GC非基因组机制的生理意义可能在应激调节中有重要意义,因此进一步深入研究十分必要,可以预见其可能为抗应激损伤维护机体内环境稳态的新产品开发提供重要新策略。

关键词：糖皮质激素非基因组机制力竭

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Involvement of spinal microglia in the anti-hyperalgesie effects of gabapentin in rat model of monoarthritis

Involvement of spinal microglia in the anti-hyperalgesie eff...

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中国神经科学学会第九届全国学术会议暨第五届会员代表大会

作者： Jia-Le YANG Bo XU Wei-Shi ZHANG Hua XU Xiao-Ming DENG Yu-Qiu ZHANG Institute of Neurobiology Institutes of Brain Science and State Key Laboratory of Medical Neurobiology Fudan University Shanghai 200032 China Department of Anesthesiology Xinhua Hospital Shanghai Jiaotong University School of Medicine Shanghai 200092 China Department of Anesthesiology Changhai Hospital The Second Military Medical University Shanghai 200433 China

This study investigated the effects of gabapentin on spinal α2/δ-1 subunit of voltage-gated calcium channels (VGCCs), fractalkine, CX3CR1 expression levels and glial activation, as well as thermal hyperalgesia evoked by monoarthritis (MA).MA produced a robust upregulation of VGCCs α2/δ-1 subunit, fractaline, CX3CR1 expression levels, and activation of microglia and astrocytes in the spinal cord, which was associated with the development of thermal *** showed that α2/δδ-1 subunit of VGCCs, a proposed action target of gabapentin, was wildly distributed in primary afferent fibers terminals and dorsal horn ***, a potential trigger to activate microglia, colocalized with α2/δ-1 subunit of VGCCs in superficial spinal cord, whereas its receptor CX3CR1 was mainly expressed in spinal *** (i.p.) gabapentin significantly downregulated spinal α2/δ-1 subunit of VGCCs and fractalkine levels, suppressed microglial activation and blocked the development of thermal hyperalgesia in MA *** data suggest that gabapentin may diminish fractalkine release in the spinal cord via modulating α2/δ-1 subunit of VGCCs, thereby leading to the reduction in spinal glial activation and thermal hyperalgesia.

关键词： fractalkine gabapentin glial activation monoarthritis thermal hyperalgesia α2/δ-1 subunit of voltagegated calcium channels (VGCCs)

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