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Role of different subunit-containing NMDA-receptors in retinal spreading depression

Role of different subunit-containing NMDA-receptors in retin...

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中国神经科学学会第九届全国学术会议暨第五届会员代表大会

作者： Minyan WANG Paul L Chazot Sura Ali Stevens F Duckett Tihomir P Obrenovitch School of Pharmacy and Biomedical Sciences University of Central Lancashire Preston PR1 2HE UK Department of Biological Sciences Department of Biological Sciences Xi ''an Jiaotong-Liverpool University Suzhou 215123 China Department of Biological Sciences University of Durham Durham DH1 3LE UK School of Pharmacy and Biomedical Sciences University of Central Lancashire Preston PR1 2HE UK School of Pharmacy University of Bradford Bradford BD7 1DP UK

Spreading depression (SD) is a temporary disruption of local ionic homeostasis that propagates slowly across the *** depolarisation associated with SD occurs in different types of stroke and may contribute to the initiation of migraine *** receptor (NMDAR) antagonists are known to be the most effective drugs to suppress *** far, NMDAR antagonist are still perceived as unlikely candidate as anti-SD drug for migraine aura treatment because of their unacceptable side effects, but the NMDAR antagonist, memantine is now used chronically in elderly for Alzheimer's and epilepsy patients and some subtype selective receptor antagonists may well be effective with reduced side *** an efficient in vitro chick retinal SD model with imaging for NMDAR pharmacology, we have determined whether NMDAR antagonists, with different type NR2 subunit selectivity, can suppress spreading depolarization associated with SD in the chicken retina *** results suggested NR2A plays a key role in mediating SD, indicating potential therapeutic benefit for NR2A-preferring antagonist to treat SD-related neurological diseases, *** with alleviated side effect.

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Triptolide T10 enhances AAV-mediated gene transfer in mice striatum

Triptolide T10 enhances AAV-mediated gene transfer in mice s...

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中国神经科学学会第九届全国学术会议暨第五届会员代表大会

作者： Xin-Miao REN Ting ZHANG Jing HU Wei DING Xiao-Min WANG Department of Biochemistry and Molecular Biology Capital Medical University Youanmen Beijing 100069 China Department of Physiology and Key Laboratory of the Neurodegenerative Disorders of the Chinese Ministry of Education Capital Medical University Youanmen Beijing 100069 China Department of Biochemistry and Molecular Biology Capital Medical University Youanmen Beijing 100069 China Department of Physiology and Key Laboratory of the Neurodegenerative Disorders of the Chinese Ministry of Education Capital Medical University Youanmen Beijing 100069 China

Adeno-associated virus (AAV)-mediated gene transfer has been demonstrated to be an effective approach for treating Parkinson's disease (PD).Triptolide T10 is a monomeric compound isolated from tripterygium wilfordii Hook.f.(Thunder God vine), a traditional Chinese herb for anti-inflammatory *** the present study, we coadministered T10 with recombinant AAV2 in SH-SY5Y human neuroblastoma cells and in the striatum of C57BL/6 mice, and then evaluated the AAV-mediated gene expression *** results have shown that T10 significantly augmented the expression of AAV-mediated gene in a dose-dependent fashion without detectable *** growing evidence indicated that inflammation contributed to the progression of PD, and the anti-inflammatory effect of T10 was shown in our previous studies, our data of T10 to enhance AAV transduction suggest that T10 might be potentially used as a facilitating reagent for the AAV gene therapy applications in neurodegenerative diseases.

关键词： Triptolide AAV gene therapy Parkinson' s disease

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Research on the effect of Neuromedin U2 receptor activated by the citrus flavonoids

Research on the effect of Neuromedin U2 receptor activated b...

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中国神经科学学会第九届全国学术会议暨第五届会员代表大会

作者： Xu-Xu ZHENG Dao-Qing WANG Research Center of Medicinal Chemistry & Chemical Biology Chongqing key Laboratory of Natural Medicine Research Chongqing Technology and Business University Chongqing 400067 China Research Center of Medicinal Chemistry & Chemical Biology Chongqing key Laboratory of Natural Medicine Research Chongqing Technology and Business University Chongqing 400067 China Environmental & Biological College Chongqing Technology and Business University Chongqing 400067 China

Objective To identify the agonists for Neuromedin U 2 receptor by using NMU2R cell line which was established by cotransfecting HEK293 with the NMU2R plasmid (NMU2R/pCDNA3.1 +) and reportergene plasmid (3×MRE/3×CRE/SRE-Luciferase/pGL3).Methods Plate NMU2R cells in growth medium with 3% FBS in a 96-well format and incubate the cells at 37 ℃ in a CO2 incubator for 12 *** the citrus flavonoids and Forskolin solutions to each well containing cells and *** the cells at 37 ℃ in a CO2 incubator for 6-8 *** an equal volume of 0.5×Bright-GloTM solution, then test the value of a luciferase *** the activation effect of the various citrus flavonoids to Neuromedin U 2 receptor by the value of a luciferase *** (1) Naringin, Naringenin and Tangeretin can not activate Neuromedin U 2 receptor.(2) Hesperidin and Nobiletin can activate Neuromedin U 2 receptor.(3) The EC50 values of Hesperidin and Nobiletin for the receptor were 319 μM and 6 μ*** Hesperidin and Nobiletin can be the agonists of Neuromedin U 2 receptor.

关键词： NMU2R agonist hesperidin nobiletin

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The role of ERK5 signaling pathway in surgical trauma stress induced immunosuppression

The role of ERK5 signaling pathway in surgical trauma stress...

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中国神经科学学会第九届全国学术会议暨第五届会员代表大会

作者： Jing LI Sheng XIAO Hui ZHAO Yan-Qing WANG Jun WANG Gen-Cheng WU Department of Integrative Medicine and Neurobiology Institute of Acupuncture Research WHO Collaborating Center for Traditional Medicine Shanghai Medical School Fudan University Shanghai 200032 China Department of Integrative Medicine and Neurobiology Institute of Acupuncture Research WHO Collaborating Center for Traditional Medicine Shanghai Medical School Fudan University Shanghai 200032 China Institutes of Brain Science State Key Laboratory of Medical Neurobiology Fudan University Shanghai 200032China

Objective: Surgical trauma stress has been reported to induce *** mechanisms involved are still *** mitogen-activated protein kinases (MAPK) transmit extracellular stimuli into intracellular transcriptional and post-translational *** of the intracellular signal transduction pathways ERK1/2 in cortex may contributes to post-traumatic *** the present study we investigated the role of the activation of ERK5, a new member of MAPK family, in a surgical trauma stress induced immunosuppression ***: The phosphorylation of ERK5 in cortex was measured by immunohistochemistry and western blot *** specific ERK5 inhibitor BIX02188 was administrated by intracerebroventricular (icv.) injection to traumatic rat, and the NK cell activity and lymphocyte proliferation was conducted to estimate the immune response in ***: (1) ERK5 was activated in rat cortex 24 h post surgical trauma stress; (2) *** BIX02188 (4 nmol or 20 nmol), an inhibitor of ERK5 phosphorylation, antagonized the surgical trauma induced downregulation of NK cell activity and lymphocyte ***: These findings suggest that ERK5 play an important role in post-traumatic immunodepression.

关键词： surgical trauma stress ERK5 immunosuppression

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Across-ear stimulus-specific adaptation in the rat auditory cortex

Across-ear stimulus-specific adaptation in the rat auditory ...

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中国神经科学学会第九届全国学术会议暨第五届会员代表大会

作者： Xin-Xiu XU Shi-Gang HE Israel Nelken Ju-Fang HE Laboratory of Applied Neuroscience Department of Rehabilitation Sciences The Hong Kong Polytechnic University Hung Hom Kowloon Hong Kong China State Key Laboratory of Brain and Cognitive Sciences Institute of Biophysics Chinese Academy of Sciences 15 Datun Road Beijing 100101 China Department of Neurobiology Institute of Life Sciences The Hebrew University of Jerusalem Jerusalem Israel State Key Laboratory of Brain and Cognitive Sciences Institute of Biophysics Chinese Academy of Sciences 15 Datun Road Beijing 100101 China

The specific adaptation of neuronal responses to a repeated stimulus, which does not fully generalize to other stimuli, is called stimulus-specific adaptation (SSA).The SSA is thought to be with a mechanism for emphasizing rare and potentially interesting sensory *** in the auditory system from the inferior colliculus to the auditory cortex have been reported to show SSA to stimuli with different *** auditory system processes spatial information of the acoustic *** the present study, we investigated whether neurons in auditory cortex showed the phenomenon of SSA over sound stimuli located in different *** recorded single and multiunit neurons in auditory cortex of anaesthetized *** stimuli were noise bursts or tones presented toward different ears with oddball paradigm.(1) The majority of the cortical neurons showed the preference for the stimulus with novel position.(2) The firing rate of neurons was larger to the stimulus with novel frequency and position than that with the only *** reason that neurons in auditory cortex showed across-ear stimulus-specific adaptation was probably that this adaptation to the different spatial information was segregated from the frequency information, so in the oddball paradigm the response to the deviant stimulus was not affected by the adaptation to the standard stimulus.

关键词： auditory cortex stimulus-specific adaptation spatial information

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Habenula "cholinergic" neurons co-release glutamate and acetylcholine and activate postsynaptic neurons via distinct transmission modes

Habenula "cholinergic" neurons co-release glutamate and acet...

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中国神经科学学会第九届全国学术会议暨第五届会员代表大会

作者： Jing REN Chang QIN Fei HU Jie TAN Li QIU Shengli ZHAO Guoping FENG Minmin LUO School of Life Sciences Tsinghua University Beijing 100084 China Graduate Program in Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China National Institute of Biological Sciences Beijing 102206 China McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences MIT Cambridge MA 02139 USA National Institute of Biological Sciences Beijing 102206 China College of Life Sciences Beijing Normal University Beijing 100875 China National Institute of Biological Sciences Beijing 102206 China National Institute of Biological Sciences Beijing 102206 China

Acetylcholine is an important neurotransmitter in the brain andthe habenula-interpeduncular projection is a prominent cholinergic *** study the physiological properties of cholinergic transmission in the interpeduncular nucleus (IPN), we used a transgenic mouse line in which the light-gated cation channel channelrhodopsin-2 is selectively expressed in cholinergic *** axonal terminals were activated by light pulses and postsynaptic responses were recorded from IPN ***, brief photostimulation produces fast excitatory postsynaptic currents that were mediated by AMPA-type glutamate receptors, suggesting glutamate release at the synaptic *** contrast, tetanic photostimulation generates slow inward currents that are largely mediated by nicotinic acetylcholine receptors, suggesting volume transmission of ***, vesicular transporters for glutamate and acetylcholine are co-expressed on the same axonal terminals in the *** results strongly suggest that adult brain "cholinergic" neurons can co-release glutamate and acetylcholine, but these two neurotransmitters activate postsynaptic neurons via different transmission modes.

关键词： co-release acetylcholine volume transmission medial habenula interpeducular nucleus channel-rhodopsin-2

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Triptolide T10 enhances AAV-mediated gene transfer in mice striatum

Triptolide T10 enhances AAV-mediated gene transfer in mice s...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Xin-Miao REN~1,Ting ZHANG~(1,*),Jing HU~1,Wei DING~2,Xiao-Min WANG~(1,2,*) 1 Department of Physiology and Key Laboratory of the Neurodegenerative Disorders of the Chinese Ministry of Education,Capital Medical University,Youanmen,Beijing 100069,China 2 Department of Biochemistry and Molecular Biology,Capital Medical University,Youanmen,Beijing 100069,China

Adeno-associated virus(AAV)-mediated gene transfer has been demonstrated to be an effective approach for treating Parkinson's disease(PD).Triptolide TIO is a monomeric compound isolated from tripterygium wilfordii Hook.f.(Thunder God vine),a traditional Chinese herb for anti-inflammatory *** the present study,we coadministered T10 with recombinant AAV2 in SH-SY5Y human neuroblastoma cells and in the striatum of C57BL/6 mice,and then evaluated the AAV-mediated gene expression *** results have shown that T10 significantly augmented the expression of AAV-mediated gene in a dose-dependent fashion without detectable *** growing evidence indicated that inflammation contributed to the progression of PD,and the anti-inflammatory effect of T10 was shown in our previous studies,our data of T10 to enhance AAV transduction suggest that T10 might be potentially used as a facilitating reagent for the AAV gene therapy applications in neurodegenerative diseases.

关键词： Triptolide AAV gene therapy Parkinson's disease

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Pacsin1 regulates axonal elongation and branching by interacting with tau and promoting microtubule instability

Pacsin1 regulates axonal elongation and branching by interac...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Ying-Ying LIU,Kao-Sheng LU,Jian-Guo CHEN,Jun-Lin TENG Department of Cell Biology,College of Life Sciences,Peking University,Beijing 100871,China

Microtubule dynamics play a crucial role in neuronal ***-associated protein tau promotes microtubule assembly,stabilization and *** forms cross-bridges between microtubules and plays important roles in axonal microtubule ***,the molecular mechanisms of tau-mediated regulation of microtubule dynamics remain largely ***,specifically expressed in the brain,is well reported to be involved in endocytosis,actin organization and membrane tubulation,but its function in neuronal microtubule dynamics has not been ***,we report that pacsin1 directly interacts with tau via its proline rich domain, and negatively regulates microtubule *** pacsin1-blocked DRG neurons,tau is abundant in the central domain of the growth cones,contributing to straight/spread *** of pacsinl suppresses the microtubule bundling ability of tau,so that microtubules become bent and ***,in cultured mouse DRG neurons,either increasing the expression level or blocking pacsin1 leads to shorter axons and higher number of *** effects are compromised when the function of pacsin1 and tau are simultaneously blocked,indicating that pacsin1 regulates neuronal morphogenesis through *** together,our data suggest that the interaction between tau and pacsin1 regulates microtubule dynamics,which in turn influences axonal elongation and branching.

关键词： tau pacsinl microtubule dynamic axonal branching axonal length

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The regulation of carotid body in the process of anti-hypoxia injury on the CHL1-null mice

The regulation of carotid body in the process of anti-hypoxi...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Jia SUN,Xin HUANG,Ling-Ling ZHU~*,Ming FAN Institute of Basic Medical Sciences,Academy of Military Medical Sciences,Beijing 100850,China

Objective Close homolog of L1（also known as neural cell adhesion molecule L1-like protein,CHLl） is a cell adhesion molecule which plays an important role in organism repair of *** recent years there has been evidence of the relation between CHL1 and nervous system *** the role of CHL1 protein in hypoxia injury has not been *** present study is to explore the impact of CHL1 deficiency on the tolerance of mice to acute hypoxia and the Phenotype and Protein Expression of Mouse Carotid *** The hypoxia toleration of CHL1 and CHL1 mice was evaluated by survival time in a normobaric hypoxia *** blot assays were used for measurement of protein expression in carotid *** and Immunofluorescence staining were used for showing morphological structure of carotid ***（1） CHL1 gene deletion increases tolerance to acute hypoxia in the mouse.（2） The total volume,number of TH+ cells and TH protein expression are increased in CHL1 carotid *** CHL1 gene deficiency of mice could change the morphology and function of carotid body,which could explain the enhanced tolerance of CHL1 mice to hypoxia.

关键词： CHLl carotid body hypoxia

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Widespread neuronal targets of the same sensory cue in hippocampal CA1

Widespread neuronal targets of the same sensory cue in hippo...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Yu-Zhang LIU,Wei TANG,Zhi-Ru WANG~* Plasticity of Neural Circuit Lab,Key Laboratory of Brain Functional Genomics,Ministry of Education,East China Normal University,Shanghai 200062,China

Objective Multimodal information processing is fundamental to hippocampal functions,including learning and memory and cognitive processing of information regarding space,time and relationships among cues. But its neural substrates are much less *** Here we investigated this issue by performing in vivo whole-cell recordings from CAl pyramidal cells（PCs）of anaesthetized adult *** We found that a brief flashing of visual stimulus evoked significant synaptic responses in a small fraction of CAl PCs（0%）.Interestingly, when intracellularly treated with CS+/TEA,all neurons exhibited robust synaptic responses to the same stimulus, and most（0%）were *** increase in the proportion of responsive cells was abolished by intracellular application of MK801-a NMDA receptor ***,when voltage-clamped at about +40 mV,0%PCs exhibited outward currents in response to the flashing stimulation,which were also blocked by the intracellular treatment of *** Thus,a simple sensory cue targets widespread CAl PCs at their functional/silent *** may allow the largely unexplored flexibility of the distribution of hippocampal neuronal ensembles to represent and memorize the same information in CAl in different hippocampus-dependent tasks.

关键词： hippocampus learning and memory multimodal information processing silent synapses plasticity

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