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Glutamate stimulation induces a two-phase cofilin rod formation mediated by both NMDA and non-NMDA receptors in cultured hippocampal neurons

Glutamate stimulation induces a two-phase cofilin rod format...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Ben CHEN,Min JIANG,Lulan CHEN,Mi ZHOU,Yun WANG~* Institutes of Brain Science and State Key Laboratory for Medical Neurobiology,Fudan University,Shanghai 200032, China

Objective Cofilin is the major actin-depolymerizing factor in the CNS for regulation of actin dynamics. Neurodegenerative stimuli can induce the formation of cofilin rod,a pathological structure composed of cofilin and actin,which disrupts synapse function and causes neurite *** In this study,we used live cell imaging to monitor the whole process of cofilin rod formation in cultured hippocampal neurons overexpressing EGFP-tagged wild type cofilin,and the results were confirmed by *** We found a two-phase rod formation induced by glutamate *** first phase occurred shortly after stimulation（ h） but soon dissolved,and the second phase happened at a much longer time window（>9 h）.Immunostaining of cofilin in neurons without cofilin overexpression also confirmed the two-phase formation *** of either NMDA receptor antagonist or non-NMDA receptor antagonist before glutamate stimulation suppressed both phases of rod *** regulatory mechanism under this cofilin rod formation is under on-going *** Cofilin rod formation induced by glutamate stimulation has a two-phase pattern and is both NMDA and non-NMDA receptor-dependent.

关键词： cofilin rod glutamate NMDA receptor non-NMDA receptor hippocampus

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The effects of morphine on the presynaptic glutamate release in the pyramidal neurons of the basolateral amygdala and its mechanism

The effects of morphine on the presynaptic glutamate release...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Jin-Hui YANG,Ping ZHENG State Key Laboratory of Medical Neurobiology,Shanghai Medical College and Institutes of Brain Science,Fudan University,Shanghai 200032,China

By sustained activation of opioid receptors,chronic opioids cause analgesic tolerance,physical dependence,and opioid addiction,for which an effective treatment is still ***,as a part of limbic system,plays an important role in opioid *** this study,we using patch clamp recording method combined with pharmacological approaches investigated chronic morphine-induced adaptations in glutamatergic synaptic transmission in neurons of the basolateral amygdala（BLA）.Chronic morphine significantly increased glutamate synaptic transmission in pyramidal neurons in BLA containingμ-opioid *** naive rats,DAMGO,μ-opioid receptor's activator,could inhibit the release of presynaptic glutamate,while DAMGO would lost this inhibitory effect in chronic morphine *** found that in saline rats,DAMGO's effect was blocked by AACOCF,an inhibitor of phospholipase A and 4-AP,which blocks the presynaptic voltage-dependent potassium channels regulated by metabolites of the PLA *** PKA didn't play any roles in naive ***,we confirmed that in chronic morphine group,PLA2-AA-Kv pathway was downregulated and PKA was upregulated,which were involved in the effect of DAMGO on presynaptic glutamate *** job provided the new mechanism of opioid receptors in morphine treatment for further clinical perspective.

关键词： morphine opioid receptors basolateral amygdale glutamate release addiction signal transduction pyramidal neuron

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Amyloid precursor protein clusters at CNS nodes of Ranvier and causes an APPThr668 phosphorylation-dependent increase in Nav1.6 sodium channel currents

Amyloid precursor protein clusters at CNS nodes of Ranvier a...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Toshitaka Futagawa Sashi Kesavapany Melitta Schachner Gavin S.Dawe Department of Clinical Research Singapore General HospitalSingapore Department of Biochemistry Yong Loo Lin School of MedicineNational University of SingaporeSingapore Department of Pharmacology and Department of Anatomy Yong Loo Lin School of MedicineNational University of SingaporeSingapore

＜正＞APP,commonly associated with Alzheimer’s disease,marks axonal *** physiological distribution and function along myelinated axons remain *** report that APP null and APP overexpressing transgenic（APPtg） mice show minor hypo- and hyper-myelination,*** axoglial interactions, APP aggregates at nodes of Ranvier（NORs） in the ***,coexpression of APP or its intracellular domains containing a VTPEER motif with Navl.6 sodium channels in Xenopus oocytes resulted in an increase in peak sodium currents,which was enhanced by APPT668E mutation and blocked by APPT668A mutation and inhibitors of CDK5 and *** cell surface expression of Navl.6 sodium channels in the white matter of spinal cord is decreased in APP,p35 and JNK3 null ***,APP,p35 and JNK3 deficiency significantly reduce spinal conduction ***,APP acts as a novel component at CNS NORs,modulating Navl.6 sodium channels in an APPThr668 phosphorylation-dependent manner.

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Dual-peak response pattern of dimming detectors in frog retina

Dual-peak response pattern of dimming detectors in frog reti...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Lei XIAO,Wei JING~+,Hai-Qing GONG,Pei-Ji LIANG~* School of Biomedical Engineering,Shanghai Jiao Tong University,Shanghai 200240,China Department of Neurology,First Hospital of Shanxi Medical University,Taiyuan 030001,China

Objective Dual-peak response of retinal ganglion cells has been observed in several species,such as chicken,turtle and *** the underlying mechanism of dual-peak response pattern is still not *** present study is to explore(1)whether dual-peak response pattern exists in dimming detectors(one type of frog retinal ganglion cells),(2)the relation between dual-peak response and different stimulus pattern,and(3)the possible mechanism of dual-peak *** Ganglion cells' firing activities were recorded using multi-electrode *** uniform visual stimulus was generated from a computer monitor and projected onto retinal surface via a lens focus *** flash stimulations with different On-Off intervals were *** pharmacological experiments,10 mM bicuculline was ***(1)Most of the dimming detectors recorded in our experiments showed the dual-peak pattern in response to flash stimulation.(2)Cells' response pattern was related with stimulus pattern.(3)The dual-peak response pattern could be modulated by exogenously applied *** The dual-peak response exists in frog retinal ganglion cells and is related to stimulus pattern,this response pattern may be related to GABAergic pathways.

关键词： retinal ganglion cells dual-peak response GABAergic pathways

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Hippocampal neuronal nitric oxide synthase mediates the stressrelated depressive behaviors of glucocorticoids by down-regulating glucocorticoid receptor

Hippocampal neuronal nitric oxide synthase mediates the stre...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Qi-Gang ZHOU~(1,#),Li-Juan ZHU~(1,#),Chen CHEN~1,Hai-Yin WU~(1,2),Chun-Xia LUO~(1,2),Lei CHANG~1,Dong-Ya ZHU~(1,2,*) 1 Department of Pharmacology,School of Pharmacy,2 Laboratory of Cerebrovascular Disease,Nanjing Medical University,Nanjing 210029,China

The molecular mechanisms underlying the behavioral effects of glucocorticoids are poorly *** report here that hippocampal neuronal nitric oxide synthase（nNOS） is a crucial *** mild stress and glucocorticoids exposures caused hippocampal nNOS overexpression via activating mineralocorticoid receptor（MR）. In turn,hippocampal nNOS-derived nitric oxide（NO） significantly down-regulated local glucocorticoid receptor （GR） expression through both soluble guanylate cyclase（sGC）/cGMP and peroxynitrite（ONOO）/extracellular signalregulated kinase（ERK） signal pathways,and thence elevated hypothalamic corticotrophin-releasing factor（CRF）,a peptide that governs the hypothalamic-pituitary-adrenal *** importantly,nNOS deletion or intrahippocampal nNOS inhibition and NO-cGMP signaling blockade（using NO scavenger or sGC inhibitor） prevented the corticosterone-induced behavioral modifications,suggesting that hippocampal nNOS is necessary for the role of glucocorticoids in mediating depressive *** addition,directly delivering ONOO donor into hippocampus caused depressive-like *** findings reveal a role of hippocampal nNOS in regulating the behavioral effects of glucocorticoids.

关键词： hippocampal neuronal nitric oxide synthase glucocorticoid receptor glucocorticoids depression

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PKCε shRNA inhibits PMA induced hippocampal neuron growth cone collapse in SD rat

PKCε shRNA inhibits PMA induced hippocampal neuron growth c...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Xiu-Bo LI,Qi TIAN,Ji-Feng ZHANG,Yuan CHEN~* Neurobiology Research Center,Zhongshan Medical School,Sun Yat-sen University,Guangzhou 510080,China

PKCe has fundamental roles in the actions of neurite outgrowth and pathfinding abilities of growth cone. The activity radius of growth cone can be altered by PKCs,meanwhile,the morphology response of growth cone can behaves as ***,the lack of PKC subtype specific inhibitor or activator makes results have less *** investigate the role of PKCe in the neurite outgrowth preciously,shRNA were used to knockdown PKCe in cultured *** studies showed that compared to the scramble control,the knockdown of PKCe can predominance decrease the action areas of growth cones in rat hippocampus,and induce the collapse of growth cone. As a main substrate of PKC in developing nerve terminals,GAP43 is rapidly transported between the cell body and growth cones and nerve terminals,where it *** using approaches of laser scanning confocol image technology,we demonstrated that phosphorylation of GAP43 by PKCe occurs at the Serine 41 single site in cultured hippocampus *** fluorescence intensities of GAP43(Phospho S41)between nomal and interference has significant *** findings indicate that the mechanism of PKCe mediated growth cone collapse may be via phosphorylation of growth-associated protein GAP43.

关键词： growth cone collapse shRNA interference PKCe GAP43

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Hemichannels or gap junctions contributed to neuronal ischemic tolerance induced by astrocyte-conditioned medium

Hemichannels or gap junctions contributed to neuronal ischem...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Juan-Juan ZHAO,Jun-Zhan JING,Qing-Yang XIAO,Shan GAO,Zhen CHAI~* State Key Laboratory of Biomembrane and Membrane Biotechnology,College of Life Sciences,Peking University, Beijing 100871,China

As a main subtype of glia in the central nervous system,astrocytes have diverse and comprehensive functions,from nutrient providing to synaptic transmission *** play protective roles in ischemia injury by taking up glutamate,releasing neurotrophic factors,and so ***,the function of gap junctions in this process is still *** cortical neurons were treated with 3-h oxygen-glucose deprivation(OGD) to induce cell *** found that astrocyte-conditioned medium(ACM) could reduce neuronal death from -95%to～30%,as indicated by MTT *** centrifugal filter devices,the molecular weight of protective factors released from astrocytes was speculated to be<3 *** protection of ACM was remarkably decreased when 50μmol/L gap junction and hemichannel blocker carbenoxolone(CBX) was applied to the cultured astrocytes before ACM collection. Furthermore,ACM pretreatment raised neuronal level of reductive glutathione(GSH) and decreased reactive oxygen species(ROS) content,while ACM pretreated with CBX could block GSH increase in *** results suggested that astrocytes enhanced neuronal tolerance against OGD injury by releasing protective factors dependent on hemichannels or gap junctions.

关键词： astrocyte-conditioned medium cortical neuron astrocyte oxygen-glucose deprivation GSH

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The effect of morphine on N-cadherin expression in addiction rat VTA

The effect of morphine on N-cadherin expression in addiction...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Jun-Ping CAO~(1,2,*),Hong-Jun WANG~(1,2),Jing MENG~(1,2),Jing-Ru WU~(1,2) 1 Jiangsu Province Key Laboratory of Anesthesiology and 2 Centerfor Pain Research and Treatment,Xuzhou Medical College,Xuzhou 221002,China

Objective The dopaminergic(DA)neurons in the ventral tegmental area(VTA)are widely implicated in the addiction and natural reward circuitry of the *** exposure can trigger synaptic plasticity and morphology changes in VTA DA neurons.N-cadherin is involved in the regulation of cell-cell adhesion and in morphology and plasticity *** present study was to explore whether N-cadherin expression is altered in VTA after morphine *** The co-expression of N-cadherin and DA neurons was identified by double-labelling immunofluorescence,and the alteration of N-cadherin expression was detected by RT-PCR, immunohistochemistry and Western-blot *** The results of immunofluorescence double staining showed that N-cadherin was extensively expressed in the DA neurons in the rat *** administration of morphine(5 days)resulted in a time-dependent up-regulation of N-cadherin expression at the level of mRNA and *** These data indicated that the expression of N-cadherin was up-regulated by chronic morphine and this alteration may contribute to the development of the opiate-induced changes in DA morphology and behaviors.

关键词： morphine N-cadherin DA neurons VTA

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Expression pattern of clusterin in the mouse olfactory bulb

Expression pattern of clusterin in the mouse olfactory bulb

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Rui-Qi WU~(1,3),Zhi-Xiang XU~(1,3),Xiao-Ping RAO~(1,3),Fu-Qiang XU~(1,2,*) 1 Wuhan MRC,State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics,Wuhan Institute of Physics and Mathematics,the Chinese Academy of Science,Wuhan 430071,China 2 Wuhan National Laboratory for Optoelectronics,Wuhan 430074,China 3 Graduate University of Chinese Academy of Science,Beijing 100049,China

Objective Clusterin is an enigmatic multifunctional glycoprotein expressed in most mammalian tissues. Some possible roles of clusterin in central nervous system(CNS)have been *** olfactory system is important in CNS for emotional responses,reproductive functions,neuroendocrine regulation,aggressive behavior, *** olfactory bulb(OB)is the center for the coding and processing of the peripheral information,and the hub for the distribution of the processed information in the olfactory *** In order to better understand the functions of this protein in the CNS,we examined the detailed distribution of clusterin in normal and anosmic mouse OB by immunohistochemical *** We found that the signals located in cell bodies at postnatal day 6 (P6),in nerve fibers at P18,and then in neurofibrils after *** addition,less clusterin protein expression was observed for anosmic mouse,except for the high level in the olfactory nerve layer(ONL).Conclusion The dynamic expression in OB at different ages and the increased expression in ONL for anosmic mice may provide important hints toward the potential functions of this protein.

关键词： clusterin olfactory bulb neuronal immunohistochemistry

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Directional index on neural oscillations as a measure of synaptic plasticity

Directional index on neural oscillations as a measure of syn...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Tao Zhang College of Life Sciences,Nankai University,Tianjin 300071,China

Objective The study investigated whether the directionality of neural information flow(NIF) could be used to characterize the synaptic plasticity on thalamocortical(TC) pathway,and examined which oscillatory frequency band reveals the most in the cognitive deficiency caused by *** EMA(Evolution map approach) and IM algorithms were used to determine the direction of NIF between the thalamus and prefrontal cortex in five frequency bands,which are delta(0.5-4 Hz),theta(4-8 Hz),alpha(8-13 Hz),beta(13-30 Hz) and gamma(30- 40 Hz).Meanwhile,the experiment was performed by inducing long-term potentiation of TC pathway after recording local field *** The data presented that the energies were increased in delta and theta bands,and the synchronization between these two regions was decreased in theta band in Str group compared to that in control *** coupling direction index d and the unidirectional influence TC c were significantly decreased in stressed state at theta rhythm in the rats of CUS ***,the field LTP data presented that chronic stress decreased medial prefrontal cortex(mPFC) synaptic plasticity,which was certainly in line with the LFP ***, the decreased SampEn only in mPFC implied that there was a significant role of mPFC(the recipient region) in the information transmission though TC *** The results suggest that the directionality index of NIF in physiological oscillatory bands could be as a measure of synaptic plasticity.

关键词： local field potential long-term potentiation synaptic plasticity neural information flow

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