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Up-regulation of astroglial lipid-sensitive two-pore domain potassium channel TREK-1 in rat CNS after focal ischemia

Up-regulation of astroglial lipid-sensitive two-pore domain ...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Yang LIU~1,Jing-Jiao SONG~2,Ming-Huan WANG~1,Jian-Qing YUAN~1,Wei WANG~1,Zhi-Yuan YU~1,Min-Jie XIE~(1,*) 1 Department of Neurology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430030,China 2 Division of Clinical Immunology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

The lipid-sensitive mechano-gated TREK-1 has been shown to be predominantly expressed in the CNS. However,its regional and cellular expression under ischemic conditions remains to be *** this study,we examined the expression of TREK-1 in the rat central nervous system using an immunohistochemical approach under physiological and focal ischemia *** results show that TREK-1 was broadly expressed in the cortex, CA1 and DG region of hippocampus and subventricular ***,TREK-1 was preferentially expressed on *** focal ischemia,the TREK-1 expression was obviously increased at days 3,7 and 30 following reperfusion compared with control,which correlated with activation and proliferation of *** TREK-1 mediated K conductance establishes a low resting membrane potential for the optimal operation of astrocyte brain homeostatic functions,these data provides important insights into the astrocytic TREK-1 involvement in ischemia pathology.

关键词： TREK-1 channel astrocyte cerebral ischemia hippocampus

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Intermittent hypoxia promotes neurogenesis in dentate gyrus of hippocampus mediated by Notch1

Intermittent hypoxia promotes neurogenesis in dentate gyrus ...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Kuan ZHANG~1,Tong ZHAO~1,Xin HUANG~1,Jia SUN~1,Yun-Ling HE~1,Li-Ying WU~1,Ling-Ling ZHU~(1,*),Ming FAN~(1,*) 1 Department of Brain protection and Plasticity,Institute of Basic Medical Sciences,No.27 Taiping Rd,Beijing 100850, China

Objective Increasing evidence indicates that in vitro neurogenesis is enhanced by hypoxia,and recent studies have shown that Notch1 signaling pathway,a classic pathway regulating neurogenesis,can be activated by *** aim of this study was to investigate whether neurogenesis in dentate gyrus(DG) of hippocampus can be promoted by intermittent hypoxia(IH) and the role of Notchl in the hippocampal neurogenesis enhanced by IH. Methods The proliferation of neural stem cells(NSCs) was identified by Brdu *** differentiation and migration of NSCs were identified by Brdu and NeuN double *** morphology of astrocyte was identified by GFAP immunohistochemistry *** 1-transgenic mice were used to identified the structure of *** deficiency mice were used to identified the role of ***(1) Intermittent hypoxia could promote the neurogenesis in DG of hippocampus,including proliferation of NSCs,migration of neuron,development of spine and astrocyte.(2) The promoted effects of intermittent hypoxia on neurogenesis were inhibited in Notchl deficiency *** Intermittent hypoxia could promote the neurognesis in DG,which was mediated through Notch 1 signaling pathway.

关键词： intermittent hypoxia dentate gyrus neurogenesis Notch1

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Slowed vesicle priming and enhanced synaptic depression at syntaxin1B deficient calyceal synapses

Slowed vesicle priming and enhanced synaptic depression at s...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Jian-Li GUO,Xue-Feng WANG,Hao TIAN,Jian-Yuan SUN~* Institute of Biophysics,Chinese Academy of Sciences,State Key Laboratory of Brain and Cognitive Science,Beijing 100101,China

Syntaxin 1(STX1),including STX1A and STX1B,is a SNARE protein located at presynaptic membrane and considered to be critical for synaptic vesicle priming and ***,the previous studies have shown that homozygous STX1A KO mice exhibited no significant phenotype in both synaptic vesicle release and animal survival. To determine whether/how STX1B functions in vesicle priming and release kinetics,a STX1B hypomorph mouse line (XT1B) was ***-cell patch clamp recordings from these STX1B mutant Calyx of Held synapses showed fewer spontaneous EPSC(mEPSC) and widened action potential-evoked EPSC(eEPSC).Under train stimulations, STX1B mutation caused reduction of the eEPSC amplitude at steady state and the enhancement of synaptic depression. Furthermore,STX1B deficiency largely slowed the recovery of RRP after depletion,suggesting the impairment of vesicle *** summary,this study shows that syntaxin 1B protein,as a critical determinant of vesicle release efficiency,modulates releasable vesicle priming and vesicle exocytosis.

关键词： Syntaxin 1B exocytosis priming synapse short term plasticity

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Satb2 is required for dendritic arborization and soma spacing in mouse cerebral cortex

Satb2 is required for dendritic arborization and soma spacin...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Lei ZHANG~(1,*),Ning-Ning SONG~1,Jia-Yin CHEN~1,Ying HUANG~1,He LI~2,Yu-Qiang DING~(1,*) 1 Department of Anatomy and Neurobiology,Tongji University School of Medicine,Shanghai 200092,China 2 Division of Histology and Embryology,Department of Anatomy,Key Laboratory of Nervous System Diseases, Ministry of Education of China,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

Self-avoidance is a mechanism by which dendrites from the same neuron repel one another in order to establish uniform coverage of the dendritic *** importance of self-avoidance for the development of complex arborization patterns has been highlighted by studies of Drosophila sensory and mouse retinal ***,it is unclear whether branch patterning in the mammalian central nervous system is also governed by this *** reduced Satb2 expression in a population of layerⅡ/Ⅲpyramidal neurons in vivo by RNA interference,and found that the somas of Satb2-deficient neurons clumped together and their dendrites failed to expand laterally but instead formed *** experiments showed that reducing Satb2 caused the adhesion of not only neighboring Satb2-deficient neurons but also neighboring wild-type *** results indicate a cell autonomous and non-cell autonomous role for Satb2 in regulating the adhesive and/or repulsive properties of cerebral pyramidal neurons.

关键词： adhesion dendritic arborization in utero electroporation repulsion self-avoidance

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The influence of anxiety on the framing effect

The influence of anxiety on the framing effect

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Ruolei GU,Yuejia LUO~* State Key Laboratory of Cognitive Neuroscience and Learning,Beijing Normal University,Beijing 100875,China *Corresponding author

Objective Studies on the framing effect indicate that people tend to make risk-avoidant decisions when the choice is framed(***) as a choice between gains,but make risk-seeking decisions when it is framed as a choice between *** far,the role of anxiety and/or depression in decision-making under framing situations is *** examined the impact of anxiety and depression on the framing effect with a classical monetary gambling *** Participants were instructed that they would have to select either a "sure" or "gamble" *** gain frame trials,the sure option was presented as money retained;in loss frame trials,it was presented as money *** participants' decision-making was coded as the proportion of sure option choices for each *** Anxiety,but not depression,had significant effects on framing-related *** levels of anxiety were correlated with stronger framing effects;most interestingly,high-anxious subjects were more risk-seeking in the loss frame compared to low-anxious subjects,which conflicts with previous findings that high-anxious people are consistently more *** The current findings provide evidences that,in contrast with bipolar/ tripolar theoretical models which suggest that all same-valence emotions produce similar cognitive effects,anxiety and depression induce distinct impacts on decision-making.

关键词： decision making framing effect emotion anxiety depression

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Transient cerebral ischemia induces long-term axonopathy:Its importance for the risk of Alzheimer's disease

Transient cerebral ischemia induces long-term axonopathy:Its...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Paul J.LUCASSEN Swammerdam Institute for Life Sciences Center for NeuroscienceUniversity of AmsterdamAmsterdamthe Netherlands

Objective Cerebral ischemia may contribute to the pathogenesis of Alzheimer's disease(AD),however, the neuropathological relationship between these 2 disorders is largely *** investigated axonal changes after transient cerebral ischemia/reperfusion and their relationship to the expression of Aβ42 and hyperphosphorylated Tau, which has been considered as a key neuropathological process of *** Adult Wistar rats were subjected to either sham operation or middle cerebral artery occlusion(MCAO).At the desired time after the onset of reperfusion (6 h,24 h,1 w,2 w,3 w and 4 w),animals were carried out for in vivo tracing and sacrificed for tracer detection, immunochemistry and morphological analysis of axons,and immunoblotting test for hyperphosphorylated Tau was also *** Axonal changes,consisting of swollen axons and varicosities,were found 6 h after ischemia/reperfusion in ischemic regions,such as the sensory and motor cortex and striatum,as well as the perilesional cortex and hippocampus,and were observed for up to 4 *** did not observe Aβplaques or overexpression of Aβ42 in the ischemic brain areas;nevertheless,site-specific hyperphosphorylated Tau could be detected in the ischemic *** Transient cerebral ischemia/reperfusion induces long-term axonal changes(axonopathy), which may be an important mechanism contributing to the development of AD after stroke.

关键词： cerebral ischemia axonopathy stroke Alzheimer's disease

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NAD+ treatment decreases spontaneous recurrent seizures and brain injury of pilocarpine-induced epilepsy model mice

NAD+ treatment decreases spontaneous recurrent seizures and ...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Zhe SUN,Jue-Gang JU,Sheng-Tian LI~* Laboratory of Synaptic Signaling and Behavioral Neurosciences,School of Life Sciences and Biotechnology,Shanghai Jiao Tong University,Shanghai 200240,China

Objective Epilepsy is a major neurological disease characterized by *** 30%of people with epilepsy are not responsive to the treatment even to the best available ***,it is of great theoretical and clinical significance to investigate the mechanisms underlying epilepsy,and to search for effective ***+ is a fundamental molecule in cells,which has been shown to decrease oxidative and excitotoxic cell death as well as ischemic brain *** the current study,we tested the effect of NAD+ on pilocarpine-induced *** NAD+(100 mg/kg) or vehicle was *** 1 h after the onset of pilocarpine-induced status epilepticus(SE) in male C57BL/6J mice(25-30 g,7 weeks of age).Induction of spontaneous recurrent seizures (SRS) was recorded by EEG recording technique in freely moving mice at two weeks *** We found that NAD+ treatment markedly decreases the number of spontaneous epileptiform EEG *** using histological techniques,we also found that NAD+ treatment reduces the brain injury in the pilocarpine-induced epilepsy model *** Our study suggested a therapeutic potential of NAD+ for epilepsy.

关键词： NAD treatment decreases spontaneous recurrent seizures and brain injury of pilocarpine-induced epilepsy model mice

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Kv7/KCNQ channels are functionally expressed in oligodendrocyte progenitor cells

Kv7/KCNQ channels are functionally expressed in oligodendroc...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Wei WANG,Xiao-Fei GAO,Lin XIAO,Zheng-Hua XIANG,Cheng HE~* Institute of Neuroscience and Key Laboratory of Molecular Neurobiology of Ministry of Education,Second Military Medical University,Shanghai 200433,China

Objective K7/KCNQ channels are widely expressed in neurons and they have multiple important functions,including control of excitability,spike afterpotentials,adaptation,and theta *** in KCNQ genes have been demonstrated to associate with human neurological ***,little is known about whether K7/KCNQ channels are expressed in oligodendrocyte lineage cells（OLCs）and what their functions in OLCs. The present study is aim to explore the expression and functions of K7/KCNQ channels in *** In this study,we characterized K7/KCNQ channels expression in rat primary cultured OLCs by RT-PCR,immunostaining and *** function of K7/KCNQ channels in OPCs motility was performed by Boyden chamber migration assay in ***（1）K7.2-5/ KCNQ2-5 channels expressed in OLCs.（2）The inhibition of K7/ KCNQ channels promoted OPCs motility in *** These findings showed that K7/KCNQ channels were functionally expressed in rat primary cultured OLCs and might play an important role in OPCs functioning in physiological or pathological conditions.

关键词： KCNQ potassium channels oligodendrocyte progenitor cells cell motility

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Tbx3 and Ptfla determine the expression of receptors of neurotransmitters and nueropeptides in the dorsal spinal cord

Tbx3 and Ptfla determine the expression of receptors of neur...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Zhen GUO,Jing-Wen NING,Yi-Wen BU,Ying CHEN,Zhi-Qin XIE,Xiao-Lin ZHAO,Guan-Nan XIA, Le-Ping CHENG~* Institute of Neuroscience,Shanghai Institutes for Biological Sciences,Chinese Academy of Science,Shanghai 200031, China

Neurotransmitters and neuropeptides are of most importance in vertebrate central nervous system,which mediate most of the excitatory and inhibitory neural *** evoke postsynaptic electrical responses by binding to members of a repertoire of their receptors,which excite or inhibit *** between the excitation and inhibition within dorsal horn neurons of the spinal cord may lead to chronic *** and others' previous studies have showed that transcription factors Tlx1/3 and Ptf1a control the neurotransmitter phonotype of excitatory and inhibitory neurons respectively in the dorsal spinal *** we analyzed the expression of some neurotransmitters' and neuropeptides' receptors in the dorsal spinal cord of the developing mouse embryos using in situ hybridization and fate mapping *** found most of the receptors were expressed in the dorsal horn,some of which had specific expression ***,we found Tlx1/3 and Ptf1a were required for the expression of some selected receptors,while dispensable for most of other *** studies thus show that specific receptors are subject to local master transcription factors regulation and at the mean time provide several theoretical pain control targets in the dorsal spinal cord.

关键词： receptors Tlx3 Ptfla Lbxl Pax2 dorsal horn spinal cord

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GRK5 mediates F-actin bundling and targets bundles to membrane to control neuronal morphogenesis

GRK5 mediates F-actin bundling and targets bundles to membra...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Yuejun CHEN,Feifei WANG,Hui LONG,Yin CHEN,Ziyan WU,Lan MA~* Pharmacology Research Center and the State Key Laboratory of Medical Neurobiology,Shanghai Medical College and Institutes of Brain Science,Fudan University,Shanghai 200032,China

Neuronal morphogenesis requires extensive membrane remodeling and cytoskeleton *** we show that GRK5,a serine/threonine kinase of G protein-coupled receptors,is critically involved in neurite outgrowth, dendrite branching,and spine morphogenesis,through promoting filopodia ***,GRK5 is not acting as a kinase,but rather provides a key link between the plasma membrane and actin ***5 promotes F-actin bundling at membranes of dynamic neuronal structures through interacting with both F-actin and PI(4,5)***,coupling regulation of actin cytoskeleton dynamics and membrane remodeling is mediated by separate domains of GRK5 and is required for its effects on neuronal ***,GRK5 knockout mice exhibit immature spine morphology and deficient learning and *** findings reveal GRK5 as a critical mediator of dendritic development and suggest that coordinated actin cytoskeleton and membrane remodeling mediated by bifunctional actin-bundling and membrane-targeting molecules such as GRK5 is crucial for proper neuronal morphogenesis and the establishment of functional neuronal circuitry.

关键词： neuronal Morphogenesis G protein-coupled receptor kinases F-actin bundling actin cytoskeleton

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