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Does sturgeon do use electrosense in predating?

Does sturgeon do use electrosense in predating?

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Hendrik Herzog Institute of zoology University of BonnPoppelsdorfer SchlossBonn 53115Germany

Objective The electro-receptive lateral line system appears in the early evolutionary history of *** of the primitive Chondrostei fish group,sturgeon,is well known to have the electroreceptors(the ampullay Lourenzeni organs) on the *** were thought to be sensitive to weak electric fields in aquatic environment and being used in behaviors of prey detecting,mating,and migrating;however,there was little experimental evidence could find directly to support the *** Here we report our results of behavioral and electrophysiological experiments that are specifically designed to investigate the function and characters of the electrosensory in ***,we record the electronic characters of the bio-electrical field of their living ***,we investigate the behavioral pattern of the Siberian Sturgeon,Acipenser baerii in response to the identified bio-electrical field(produced by embedding the living prey fish in the gel chamber).Third,we record the response properties of the electrosensory neurons in the hind brain from the dorsal octavolateralis nucleus(DON) of the White Sturgeon,Acipenser transmontanus with the simulating sinusoidal electric field according to the identified characters of the bio-electrical field produced by living prey. Results(1) The bio-electrical field of prey fish presented as direct current electric field of dipole type with negative potential on head and positive potential on tail and modulated into alternating electric field by respiration rhythm;(2) During the stimulation,DON units increased their firing rate and phase coupled the stimulation wave and showed the selectivity of dipolar *** These behavioral and electrophysiological results are first solid evidence to point out that the electrosense of Sturgeon does being used in predating(feeding) behavior.

关键词： electrosense sturgeon behavior dipole hindbrain

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Liver X receptor β inhibits the transformation of radial glial cells into astrocytes during cerebral cortex development

Liver X receptor β inhibits the transformation of radial gl...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Jan-Ake Gustafsson Center for Nuclear Receptors and Cell Signaling University of HoustonTX 77054

＜正＞Liver X receptor is a member of the nuclear receptor superfamily of ligand-activated transcription factors, predominantly expressed in the cerebral *** have previously demonstrated that LXRβis essential for migration of later-born neurons during cerebral cortex *** radial glial cells serve as scaffolds for new-born neurons migration during cerebral cortex ***,the radial glial cells were transformationed into astrocytes around postnatal 14 ***,We found that the expression of LXRβmRNA was higher than LXRαin the cerebral cortex of mice,of which the expression of LXRβwas gradually increased from E18.5 to *** specific markers for radial glia cells,we further found that loss of LXRβinduced the decreased level of BLBP in the cerebral cortex from E18.5 to P7 and increased level of GFAP from P2 to P14 compared to the WT littermates at the same age. TGFβ1 and Smad4 are believed to be related to the transformation of radial glial cells into *** expression levels of TGFβ1 and Smad4 were increased significantly in the cerebral cortex of LXRβknockout mice compared to the WT littermates from the E18.5 to ***’s no difference in the expression levels of TGFβ1 and Smad4 between the LXRβknockout mice and WT littermates from the P10 to *** together,our findings suggest that loss of LXRβaccelerates the transformation of radial glial cells into astrocytes through high levels of TGFβ1 and Smad4 in the cerebral cortex.

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Nifedipine reduces iron accumulation and dopamine neuron degeneration in the iron-overloaded substantia nigra of rats

Nifedipine reduces iron accumulation and dopamine neuron deg...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Ze-Gang MA,Jun-Xia XIE~* Department of Physiology,Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines:Physiology,Medical College of Qingdao University,Qingdao,266071

Objective To investigate whether nifedipine,a blocker of L-type calcium channels can prevent iron accumulation and dopamine neuron degeneration in the substantia nigra(SN) of acute and chronic iron-overloaded *** The changes of tyrosine hydroxylase(TH) gene expression in the substantia nigra(SN) were detected by reverse transcription-polymerase chain reaction(RT-PCR),the TH-positive neurons were tested by TH immunohistochemistry,the dopamine content was measured by liquid chromatography-electrochemical detection and the iron contents of SN were determined by iron concentration *** Compared with the control group, the expressions of TH mRNA decreased,and the iron contents increased in the acute iron-overloaded SN of *** with nifedipine may partly restore these *** in the chronic iron-overloaded rats,the dopamine content in the striatum decreased after iron dextran treatment,which could be restored by *** dextran overload increased iron content in the SN and reduced the number of TH-positive *** with nifedipine prevented the increased iron content and restored the numbers of TH-positive neurons to control *** Nifedipine may inhibit iron-overload induced dopamine neuron damage in the iron-overloaded rats by suppressing iron toxicity.

关键词： nifedipine iron substantia nigra Parkinson's disease

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Left-lateralized N170 response to unpronounceable pseudo but not false Chinese characters - the key role of orthography

Left-lateralized N170 response to unpronounceable pseudo but...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Hsuan-Chih CHEN Department of Psychology The Chinese University of Hong KongShatinNTHong KongChina

＜正＞A negative event-related potential（ERP） component,known as N170,can be readily recorded over the posterior left brain region when skilled readers are presented with visual *** left-lateralized word-related N170 has been attributed either to linguistic processes,particularly phonological processing,or to the role of orthographic regularity,emphasizing a perceptual *** debate,however,is difficult to resolve in the context of alphabetic scripts because of the tight relations between orthography and *** contrast,Chinese characters have arbitrary mappings between orthographic and sound forms,making it possible to tease apart these two properties of visual *** therefore addressed this issue by examining ERP responses to Chinese characters and three types of structurally matched but unpronounceable stimuli:pseudo-characters,false-characters,and stroke combinations. A content-irrelevant color matching task was adopted to minimize potentially different top-down modulations across stimulus *** show that,relative to false-characters and stroke combinations,real- and pseudo-characters evoked greater N170 in the left posterior brain ***,despite being unpronounceable,pseudo-characters produced the same amplitude and left-lateralized N170,just as *** results provide strong evidence that orthography rather than phonology serves as the main driver for the enhanced and left-lateralized N170 to visual words.

关键词： N170 Chinese character orthography phonology

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An exploration of emotional face perception in individuals with schizotypal personality features:An ERP study

An exploration of emotional face perception in individuals w...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Raymond C.K.Chan Key Laboratory of Mental Health

Objective Empirical findings showed that individuals with schizotypal personality disorders(SPD) features did not presentthe significant reduction of P300 amplitude elicited by target stimulus compared to healthy *** study aimed to investigate whether emotional face would elicit the P300a and there would be reduction amplitudes for individuals with SPD as compared to healthy controls in the Chinese *** Preliminary ERP data including 33 participants,16 individuals with and 17 individuals without SPD *** procedure consisted of 1200 trials,2 sessions and 600 trails for each session.10 percent of all stimuli were emotional face pictures,10 percent were target stimuli and the other 80 percent were standard *** SOA in the experiment was set at 1000-1500 *** were presented at 500 *** Target stimuli elicited the P300b both in individuals with and without SPD *** individuals with SPD features also exhibited reduced P300b amplitudes for target stimuli as compared to those without SPD ***,there were no significant differences of P300 latency between the two *** face pictures were found to elicite PI and N2 component in both groups. Conclusion The current findings extend our realization about emotional process of schizophrenia spectrum disorders. Individuals with SPD presented similar features to schizophrenia patients that P300 amplitudes were reduced.

关键词： schizotypal personality features visual oddball paradigm emotional face P300

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Molecular mechanism and functional research of GAPDH S-nitrosylation induced by cerebral ischemia-reperfusion

Molecular mechanism and functional research of GAPDH S-nitro...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Chong LI,Jun-Jun FENG,Guang-Yi ZHANG~* Research Center of Biochemistry and Molecular Biology and Jiangsu Key Laboratory of Brain Disease Bioinformation,Xuzhou Medical College,Xuzhou 221002,China

Objective Glycer-aldehyde-3-phosphate dehydrogenase(GAPDH),a glycolytic enzyme,has long been considered a housekeeping *** has been researched as an important role of glycolytic those thirty years. Recently some studies show that administration of some stimuli could induce GAPDH S-nitrosylation and facilitate its combination of Siahl,the latter of which could induce GAPDH nucleus translocation and then cell *** objective of this study is primarily to determine whether GAPDH could be S-nitrosylated,then boost the combination of GAPDH and Siahl induced its nucleus translocation and cell death via GAPDH *** Ischemic model is rat four-vessel occlusion(4-VO) ischemic model.S-nitrosylation was examined mainly by biotin switch *** expression and protein interaction were determined by immunoblotting and immunoprecipitation *** Here we show that S-nitrosylation of GAPDH was induced by cerebral *** cytoplasm,administration of MK801,an antagonist of N-methyl-D-aspartate receptor(NMDAR),or 7NI,inhibitor of nNOS,or DEP,the monoamine oxidase-B(MAO-B) inhibitor,diminished the induced S-nitrosylation of GAPDH and also the combination of GAPDH and *** In nucleus,GAPDH S-nitrosylation facilitates its nuclear *** of the 3 drugs can diminish the nuclear translocation of GAPDH and also diminish the combination of GAPDH and Siahl.

关键词： GAPDH S-nitrosylation Siah1 DEP cerebral ischemia

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Electroacupuncture age-dependently improves traumatic stress induced immuno-suppression via calreticulin-c-Src pathway

Electroacupuncture age-dependently improves traumatic stress...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Ran-Ran YAO,Gen-Cheng WU,Hui ZHAO~* Department of Integrative Medicine and Neurobiology,Institute of Acupuncture Research,Shanghai Medical College, Fudan University,138,Yi Xue Yuan Road,Shanghai 200032,China

Objective Growing evidences suggest that electroacupuncture(EA)can improve traumatic stress-induced immuno-depression,but the mechanism needs further *** the present study,the contribution of EA on the neuroimmune modulation,as well as the involvement of calreticulin(CRT)-c-Src pathway in the traumatic stress was *** Two age groups of rats(3 month and 18 month)were undergone traumatic *** was performed on bilateral acupoints 'zusanli'(ST36)and 'sanyinjiao'(SP6).Immune consequences,cortical CRT and c-Src expression were detected by Western blot,immunofluorescence and CCK8 respectively.A long-term neuron culture was also used herein,time-lapse effect of lipopolysaccharide(LPS)on CRT-c-Src pathway was ***(1) Traumatic stress resulted in a suppression in lymphocyte proliferation and NK cell activity with age dependent manner, EA stimulation could significantly improve this immuno-suppression.(2)The age-dependent immuno-suppression was due to different triggering in CRT-c-Src pathway in cortical neuron.(3)Central modulation of CRT infienced c-Src expression,in the meantime improved traumatic stress induced *** EA could agedependently improved traumatic stress induced immuno-suppression,the effect was proposed to correlated with CRTc -Src pathway in cortical neuron.

关键词： electroacupuncture traumatic stress calreticulin c-Src

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Research on the effect of Neuromedin U 2 receptor activated by the citrus flavonoids

Research on the effect of Neuromedin U 2 receptor activated ...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Xu-Xu ZHENG~(1,*),Dao-Qing WANG~(1,2) 1 Research Center of Medicinal Chemistry & Chemical Biology,Chongqing key Laboratory of Natural Medicine Research,Chongqing Technology and Business University,Chongqing 400067,China 2 Environmental & Biological College,Chongqing Technology and Business University,Chongqing 400067,China

Objective To identify the agonists for Neuromedin U 2 receptor by using NMU2R cell line which was established by cotransfecting HEK293 with the NMU2R plasmid（NMU2R/pCDNA3.1+）and reportergene plasmid （3xMRE/3xCRE/SRE-Luciferase/pGL3）.Methods Plate NMU2R cells in growth medium with 3%FBS in a 96- well format and incubate the cells at 37℃in a CO incubator for 12 *** the citrus flavonoids and Forskolin solutions to each well containing cells and *** the cells at 37°C in a CO incubator for 6-8 hours. Add an equal volume of 0.5xBright-Glo? solution,then test the value of a luciferase *** the activation effect of the various citrus flavonoids to Neuromedin U 2 receptor by the value of a luciferase ***（1） Naringin,Naringenin and Tangeretin can not activate Neuromedin U 2 receptor.（2）Hesperidin and Nobiletin can activate Neuromedin U 2 receptor.（3）The EC50 values of Hesperidin and Nobiletin for the receptor were 319μM and 6μ*** Hesperidin and Nobiletin can be the agonists of Neuromedin U 2 receptor.

关键词： NMU2R agonist hesperidin nobiletin

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Functional atlastin-1 induces neuronal cell loss in cerebral cortex

Functional atlastin-1 induces neuronal cell loss in cerebral...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Ying GAO,Tian JIANG,Hua-Ping TAO,Chun-Sheng QU,Yue-E ZHAO,Jie-Guang CHEN~* Key Laboratory of Visual Science,National Ministry of Health,and School of Optometry and Ophthalmology, Wenzhou Medical College,Wenzhou 325027,China

Hereditary spastic paraplegias(HSPs) are human genetic disorders characterized by lower extremity spasticity and *** the HSPs,SPG3A is particularly notable for its early onset of spastic paraplegia. SPG3A is caused by mutations in atlastin-1,which belongs to the dynamin family of *** previous studies found that atlastin-1 is enriched in brain,little is known about their physiological functions,especially in neuronal ***,we report that expression of atlastin-1 mRNA was restricted in the deep layer of mouse cerebral cortex during early *** expression of atlastin-1 and R217Q,a mutant form defective of GTPase,did not affect neuronal generation,migration and axon growth in the postnatal brains of less than P7. However,when the cortices were examined at a late developmental stage of P14,the expression of atlastin-1 led to fewer and scattered labeled-neurons as compared to that expressing the control *** expressing the R217Q were present normally at P14,which suggests that the GTPase activity of atlastin-1 may be important for its early restricted *** study suggests a possibility that atlastin-1 might act as a neuropathogenic mechanism of hereditary spastic paraplegias if it expresses abnormally during the development.

关键词： SPG3A atlastin-1 migration neuronal cell loss cerebral cortex in utero electroporation

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Assessment of localization to sound in disorder of consciousness:own name versus bell ring

Assessment of localization to sound in disorder of conscious...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Olivia Gosseries Caroline Schnakers International vegetative state and consciousness science institution Hangzhou Normal University

Objective The assessment of orientation to sound is an item in the behavioral evaluation of consciousness in patients with disorders of consciousness(DOC).For the commonly used Coma Recovery Scale-Revised(CRS-R), it is not specified what stimulus to use,so this study uses 2 different stimuli(with one auto-referential) to assess their sensitivity for auditory *** CRS-R scale was used for clinical measurement of consciousness in randomly selected 50 DOC patients diagnosed with vegetative state(VS) or minimally conscious state(MCS). Patients' location response to bell and own name were recorded and the sensitivity of stimuli localization was *** Difference was found between localization responses to own name and bell in 50 DOC patients. In MCS patients(n=27),presentation of the subject's own name elicited more location response than bell ring (P<0.05).In VS patients,there was no significant *** In this study,we compared the sensitivity to elicit localization response between subject's own name and bell ring in DOC *** found that the subject's own name was more sensitive to elicit location response than bell ring(P<0.05) in MCS *** VS patients,no difference was *** result indicates that the subject's own name may be more suitable to elicit a location response than a simple auditory stimulus such as bell ring and should be used as a standard stimulation when assessing auditory functions in DOC.

关键词： auditory localization/location vegetative state minimally conscious state own name bell

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