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SCIRRIO exerts its neurotrophic activity through thyrotropin releasing hormone receptor 2

SCIRRIO exerts its neurotrophic activity through thyrotropin...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Yong LIU~1,Xiao-Yan SHI~1,Hai-Ping QUE~1,Yu WANG~(1,3),Yan-Li NI~1,Zhen-Lian MA~1,Xin LI~1,Tao LIU~1,Zhi-Yi ZHANG~4,Shu-Qian JING~(1,2),Shao-Jun LIU~(1,*) 1 Department of Neurobiology,Institute of Basic Medical Sciences,Academy of Military Medical Sciences,27 Taiping Road,Beijing 100850,China 2 Department of Clinical Immunology,Amgen Inc.,Thousand Oaks,CA,USA 3 State Key Laboratory of Polymer Physics and Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,5625 Renmin Road,Changchun 130022,China 4 Chinese National Center of Biomedical Analysis,27 Taiping Road,Beijing 100850,China

Spinal cord injury and regeneration related gene No 10(SCIRR10)was first identified as an EST in our efforts of seeking genes responsive to spinal cord neuron *** levels of SCIRRIO mRNA expression were detected in adult CNS and several other *** injured spinal cord,the level of SCIRRIO expression was temporally elevated.A His-tagged-SCIRR10 affinity column was able to capture thyrotropin releasing hormone receptor 2(TRHR2)from spinal cord lysates,suggesting that SCIRR10 interacted with *** interaction between SCIRR10 and TRHR2 was further confirmed by the co-localization of a GFP-SCIRR10 fusion protein with RFP-TRHR2 fusion protein expressed on COS7 *** PC12 cells,recombinant SCIRR10 and conditional medium containing SCIRR10 induced activation of the phospholipase C and MAPK pathways,the major signal transduction pathways shared by *** SCIRR10 protein and conditional medium containing SCIRR10 also enhanced the sprouting and growth of neurites from cultured embryonic rat cortex *** biological function to promote neurite growth could be interdicted with pertussis *** data demonstrated that SCIRR10 is a novel neurotrophic factor that may play an important role in the regeneration of CNS injury.

关键词： SCIRR10 TRHR2 neural regeneration

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Simultaneous neural ensemble recordings of pain in the cerebral cortex of behaving rats

Simultaneous neural ensemble recordings of pain in the cereb...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Jun CHEN~(1,2) 1 Institute for Biomedical Sciences of Pain,Capital Medical University,Beijing 100069,China 2 Institute for Biomedical Sciences of Pain and Institute for Functional Brain Disorders,Tangdu Hospital,Fourth Military Medical University,Xi'an 710038,China

Objective In the past 10 years,a technique allowing simultaneous,multisite and many neuron recordings in freely moving and behaving animals(e.g.,monkeys,rats and mice) and even in human subjects has been well developed and successfully applied in many regions of the *** state-of-the-art technique of in vivo simultaneous multisite recordings of neural ensemble responses in the brain enables a good combination with various behavioral assays in freely moving and behaving *** this report,I would like to introduce the use of this technique in study of pain in the cerebral cortex of behaving *** Microwire electrode arrays(2x4 or 2x8) were implanted into the target brain area of a rat in the aid of stereotaxic surgical *** at least 7 days of recovery, simultaneous recordings of cerebral cortical neural ensemble responses in a behaving rat were carried out using the Plexon multichannel Acquisition Processor(MAP) system and an overhead video tracker system processed by Plexon CinePlex software that enables continuous real-time behavioral tracking and synchronization of video and neural signals through interaction with the MAP system.A Plexon MAP system receives and processes the pre-amplified and filtered neural ensemble signals by RASPUTIN Software for online displaying,sorting,recording and synchronizing of the neural ensemble *** nociceptive stimuli,including mechanical,thermal and chemical modalities,were applied to the rat's *** Long-term unitary stability was confirmed by various statistical analyses. Nociceptive neuronal units were identified by online or offline sorting from the primary somatosensory(S1) cortex and the motor cortex(MCx).The neuronal units identified in the S1 area were wide-dynamic-range(WDR) and nociceptive-specific(NS) in nature,while those in the MCx were also responsive to noxious *** neural ensemble responses can be significantly changed by peripheral inflammatory pain state that a

关键词： simultaneous neural ensemble recordings pain cerebral cortex behaving animals

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Bip overexpression induces tau hyperphosphorylation in HEK293/tau cell

Bip overexpression induces tau hyperphosphorylation in HEK29...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Zan-Chao LIU,Jian-Zhi WANG~*,Qing TIAN~* Department of Pathology and Pathophysiology,Key Laboratory of Neurological Disease of National Education Ministry and Hubei Province,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

Objective Alzhermer's disease(AD) is the most common neurodegenerative disease with the progressive cognitive impairment as the major clinical *** microtubule associated protein tau is the major component of intracellular neurofibrillary(NFTs),which is positively correlated with the decline of learning and memory in AD *** upstream effectors leading to tau hyperphosphorylation are still not fully *** reticulum(ER) is responsible for the posttranslational processing of newly synthesized proteins and ensuring proper protein folding and *** of damages(such as oxidative stress) can induce ER stress,which has been shown activated in the AD *** level of Bip,an ER stress marker,was also shown in the temporal cortex and the hippocampus of AD patients compared with age-matched *** present study is to explore whether Bip overexpression could induce tau *** Plasmid of Bip with EGFP-N1 vector was constructed and transfected into HEK293/tau *** phosphorylation levels of tau protein and the activities of the key tau phosphorylation related protein kinase glycogen synthase kinase-3β(GSK-3β),and the key protein phosphatase protein phosphatase 2A(PP2A),were ***(1) Bip overexpression in HEK293/tau cell induced increased phosphorylation levels of tau at Ser214,Ser262,Ser396,Ser404,Thr205 and Thr231 epitopes.(2) The increased phosphorylation levels of GSK-3βat Tyr216 and decreased phosphorylation levels at Ser9 were observed(indicating GSK-3βactivation).(3) The phosphorylation of PP2A catalytic subunit at Tyr307 had no significant change.(4) Additionally,we also found increased Bip enhanced the association of tau and GSK3βby *** All these data confirmed that overexpression of Bip could induce hyperphosphotylation of tau in vitro by activating GSK-3βand enhancing the association of tau and GSK3β.

关键词： Bip tau GSK3β

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Lipid rafts mediates ATP-induced endocytosis,signal transduction and retrograde transport of P2X3 receptor

Lipid rafts mediates ATP-induced endocytosis,signal transduc...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Xu-Qiao CHEN~(1,#),Bin WANG~(1,#),Chengbiao WU~2,Jin PAN~1,Bo YUAN~3,Yuan-Yuan SU~1,Xing-Yu JIANG~3,Xu ZHANG~4 Lan BAO~(1,*) 1 Laboratory of Molecular Cell Biology,Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China 2 Department of Neurosciences,School of Medicine,University of California,San Diego,La Jolla,California,USA 3National Center of Nanoscience and Technology,Beijing 100190,China 4 Institute of Neuroscience and State Key Laboratory of Neuroscience,Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences,Shanghai 200031,China

P2X receptors are a family of cation channels expressed in neurons and nonneuronal *** play a variety of roles including synaptic transmission,muscle contraction,neuronal secretion and inflammation response. Among P2X receptors,the P2X subtype is selectively expressed in dorsal root ganglion *** raft is a specialized membrane microdomain and participate many signal transduction *** report showed that P2X receptor is localized in the lipid rafts of DRG *** have found P2X receptor engaged in retrograde transport in the form of signaling *** we investigated the role of lipid rafts in a,B-MeATP-dependent endocytosis and signal transduction,and retrograde transport of P2X *** of lipid raft with MBCD or nystatin abolished ATP-dependent endocytosis of P2X receptor and ATP-induced ERK activation in P2X receptor-expressing HEK293 *** vivo sucrose gradient fractionation with vesicular pellets prepared from sciatic nerve axoplasm showed that abundant P2X receptor was localized in lipid raft *** transported P2X receptors were colocalized with the lipid raft marker caveolinla in sciatic *** terminal treatment with MPCD attenuated retrograde transport of P2X receptor in axon of dorsal root ganglion ***,lipid raft mediates ATP-induced endocytosis,signal transduction and retrograde transport of P2X receptor.

关键词： P2X3 receptor lipid raft endocytosis ERK retrograde transport

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Elevated retinal ephrinB2/EphB2 reverse signaling regulates GluR2 trafficking in a rat experimental glaucomatous model

Elevated retinal ephrinB2/EphB2 reverse signaling regulates ...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Ling-Dan DONG,Yanying MIAO,Xiao-Han WANG,Xiao-Fang YANG,Zhong-Feng WANG~* Institutes of Brain Science,Institute of Neurobiology and State Key Laboratory of Medical Neurobiology,Fudan University,Shanghai 200032,China

Objective Glaucoma,the second leading cause of blindness,is a neurodegenerative disease that is characterized by optic nerve degeneration resulting from apoptotic death of retinal ganglion cells（RGCs）.Although previous work has shown that ephrinB2/EphB2 signaling was upregulated in the optic nerve head of glaucomatous DBA/2J mice,the role of ephrinB/EphB signaling in glaucomatous retina is largely *** the present work, we investigated the possible involvement of ephrinB/EphB signaling in the pathogenesis of RGCs death in a rat chronic ocular hypertension（COH） *** COH model was reproduced by blocking episcleral veins. Immunohistochemistry and Western blot techniques were used to detect the expression of EphBl,EphB2,ephrinBl, ephrinB2,phosphorylated EphB,phosphorylated ephrinB,and GluR2 in the *** staining was employed to detect RGCs *** direct interaction between GluR2 and phosphorylated EphB or phosphorylated ephrinB was detected by co-immunoprecipitation（co-IP） ***（1） In normal retina,EphBl was mainly expressed in GFAP-positive Miiller cells and EphB2 was expressed in the ganglion cell layer（GCL） and the inner nuclear layer （INL）,while their ligands ephrinBl and ephrinB2 were expressed in both Miiller cells and neurons in the GCL.（2） In COH retina,the expression of EphBl was remarkably increased in Miiller cells,and the expression of ephrinB2 was increased in the endfeet of Muller cells and in neurons of the GCL,while ephrinBl and EphB2 almost kept unchanged. （3） Although total GluR2 proteins in the retinal extract hardly changed,the GluR2 proteins in the membrane component were significantly decreased in the COH *** intravitreal injection of EphB2-Fc,but not ephrinB2-Fc, induced a significant increase of TUNEL-positive signals in the normal retina,which was similar to the observation in the COH ***,injection of EphB2-Fc intravitreally could mimic the expression change of GluR2 in the COH rats.（4） Altho

关键词： glaucoma EphB ephrinB retinal ganglion cell apoptosis GluR2 trafficking

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NRSF regulates its target genes via epigenetic mechanisms in PD cell model

NRSF regulates its target genes via epigenetic mechanisms in...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Hai-Yun SUO,Mei YU,Jie LIU,Fang HUANG~* National Key Laboratory of Medical Neurobiology,Shanghai Medical College,Fudan University,Shanghai 200032, China

Neuron-restrictive silencer factor/repressor element-1 silencing transcription factor（NRSF/REST） silences a large network of genes through histone deacetylation,methylation and other epigenetic *** previous study showed that the expression of NRSF target gene BDNF,TH,synapsin I and UCH-L1 were transiently decreased in PD cell *** we investigated the effect of epigenetic modulation on the expression of NRSF target genes in the SH-SY5Y cells intoxicated with MPP CHIP assays showed that the binding of NRSF to the target gene promoters was *** we found the MPP treatment promoted deacetylation of histones H3,demethylation of H3-K4 and dimethylation of H3-K9 over the promoters of these target genes,which are the signatures of epigenetic gene *** sequencing results showed that the methylation pattern over the promoters of BDNF and TH transient altered in this PD cell ***,an HDAC inhibitor,has frequently been used to study the effects of HDAC inhibition on NRSF-mediated *** confirm the epigenetic mechanisms regulating the expression of NRSF target genes in PD cell model,we investigated whether the transcriptional repression of NRSF target gene BDNF,TH,synapsin I and UCH-L1 could be relieved by TSA ***-SY5Y cells were pretreated with TSA （100 nM） for 24 h,and then intoxicated with MPP+ for 8 *** RT-PCR analyses showed that TSA treatment induced obviously activation of the BDNF,TH and synapsinl genes,However,the expression of NRSF and REST4 did not vary significantly under the treatment of *** assays showed that TSA treatment did not affect the levels of NRSF occupancy,but caused coordinated changes of histone modifications around the RE1 sites that consistent with a transition from transcriptional repression to *** results demonstrated that NRSF represseses the expression of target genes via an HDAC-dependent pathway,and the cross-talk between acetylation and methylation of histo

关键词： NRSF HDAC PD target genes

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Influence of altitude environment on the adult neurogenesis in mice

Influence of altitude environment on the adult neurogenesis ...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Bing-Feng LIU~1,Wen-Qiang XU~1,Xue ZHENG~1,Ping-Jing GUO~1,Li FAN~1,Jia-Wei LI~1,Jian-Lin WANG~1, Shan-Ting ZHAO~(1,2,*) 1 Institute of Zoology,School of Life Science,Lanzhou University,Lanzhou 730000,China 2 Institute of Anatomy and Cell Biology,University of Freiburg,Freiburg,79104,Germany

Introduction In recent years,people have found that neural stem cells still exist in human and animals after the development and these neural stem cells can constantly generate new neurons and astrozytes in life *** most adult mammalian CNS,active neurogenesis occurs throughout life in the subventricular zone(SVZ) of the lateral ventricle and in the subgranular zone(SGZ) of the dentate gyrus in the ***,the mechanisms of proliferation,differentiation and survival about adult neurogenesis remain *** has been found that experimental changes of living environment can significantly affect the proliferation,differentiation and survival of neural stem cells in the SGZ of the dentate ***,it has not been reported that how the changes of natural environment affect the adult *** The aim of our study is to investigate the influence of high-altitude living environment in the Qinghai-Tibet Plateau on the proliferation and differentiation of adult neural stem cells in the SGZ of the dentate gyrus in mice,and we expect that the results of our experiment can provide evidences for elucidating the mechanism of adult *** Healthy adult Kunming mice were divided into 2 groups:one altitude of control group is 1 500 m in Lanzhou,the other altitude of experimental group is 4 600 m in Tuotuohe on Qinghai-Tibet *** label the newly generated cells 5-bromine deoxidizing urine nucleoside(BrdU,50 mg/kg) were injected intraperitoneally for 6 times within 3 *** immunocytochemistry against BrdU and double immunocytochemistry against BrdU and Prox-1 were ***,the newly generated BrdU-postive cells and double labeled cells for BrdU and Prox-1 were counted in laser confocal microsopy photographs,*** The BrdU-positive cells of experimental group significantly reduced to 60%compared with the control group(P = 0.001),indicating that the high-altitude(low oxygen) environment inhibit the prolif

关键词： adult neural stem cell hypoxemiahypoxia dentate gyrus Prox-1 BrdU

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Convergence of cerebellar fastigial nuclear inputs and feeding-related signals on neurons of ventromedial hypothalamic nucleus in rats

Convergence of cerebellar fastigial nuclear inputs and feedi...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Bin LI,Guan-Yi WU,Hong-Zhao LI,Jing-Ning ZHU~*,Jian-Jun WANG~* Department of Biological Science and Technology and State Key Laboratory of Pharmaceutical Biotechnology,School of Life Sciences,Mailbox 426,Nanjing University,22 Hankou Road,Nanjing 210093,China

The ventromedial hypothalamic nucleus(VMN) has traditionally been implicated in feeding behavior, energy balance,and body weight *** studies have indicated that neurons in the VMN receive feeding-related signals from the gatric vagal nerves and blood *** ghrelin,a peptide primarily produced in the stomach,stimulates both feeding and growth hormone ***,the cerebellum participates in regulating nonsomatic visceral activities including food intake via the direct cerebellohypothalamic *** present study was designed to investigate,by using extracellular recordings in vivo in rats,whether the cerebellar fastigial nucleus could reach and converge with the feeding-related gastric vagal,glycemia and ghrelin signals onto single VMN neurons. Of the 105 VMN neurons recorded,42(42/105,40%) and 63(63/105,60%) responded to the cerebellar FN and the gastric vagal stimulations,*** the VMN neurons that were responsive to either of the cerebellar FN or gastric vagal stimulation,30 responded to both of the stimuli,suggesting a convergence of cerebellar FN and gastic vagal inputs on the VMN ***,a summation of responses was observed(n = 5) when the cerebellar FN and gastric vagal nerve were simultaneously *** the 12 VMN neurons receiving convergent inputs from the cerebellar FN and gastric vagal nerves,8(66.7%) cells also responded to the systemic administrations of glucose and *** results demonstrated that the somatic information forwarded by the cerebellar FN,together with the feeding signals from the gastric vagal nerves,blood glucose as well as ghrelin,converge onto single VMN neurons, suggesting that a somatic-visceral integration related to the feeding may occur in the VMN and the cerebellum may actively participate in the feeding regulation through the cerebellar FN-VMN projections.

关键词： Convergence of cerebellar fastigial nuclear inputs and feeding-related signals on neurons of ventromedial hypothalamic nucleus in rats

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20S Proteasome is essential for neural stem cells maintenance in SVZ

20S Proteasome is essential for neural stem cells maintenanc...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Zhong-Nian XIA,Wei-Guo ZHANG,Yun-He ZHAO,Qian ZHU~1,Li LU~* Department of Anatomy,Shanxi medical university,Taiyuan 030001,China

Objective To examine 20S proteasome activity and its expression in the subventricular zone(SVZ) of mice at different ages,then investigating the effects of proteasome inhibitor MG132 on the viability and proliferation potential of neural stem cells(NSCs),thus to establish the relationships between 20S proteasome activity and NSCs *** work aimed to unveil the underlying mechanism for NSCs dysfunction in aging brain,so as to develop a new treatment stratedgy for age-related neurodegenerative *** In the present study,immunostaining was used to check the expression of 20S proteasome in embryonic and adult mice *** test whether 20S proteasome deficiency and expression level display in an age-dependent manner in SVZ,proteasome peptidase assay and Western Blot assay were performed on mice at embryonic(embryonic day 14),neonatal(postnatal day 0),adult(postnatal day 90),aged(postnatal day 540) ***,proteasome inhibitor MG132 was injected into lateral ventricles of adult mice to examine its effects on NSCs proliferation by BrdU labeling at day 3 postinjection. Furthermore,in vitro analyses were used to determine the effect of MG132 on NSCs viability from SVZ by BrdU incorporation and Cell Counting Kit-8(CCK-8) ***(1) 20S proteasome was collocalized with NSCs marker nestin in SVZ of embryonic and aged mouse,20S proteasome-positive cells were distributed along the ventricular wall.(2) Age-dependent decline in the activity and expression of 20S proteasome were found in SVZ,the 20S proteasome activity was significantly reduced 3～4 times in aged mice verse embryonic or neonatal mice(P<0.05). Moreover,the decreased numbers of BrdU-positive cells were founded in SVZ of aged *** observations indicated that 20S proteasome is associated with neural stem cells maintenance.(3) After intracerebroventricular injection of MG132,the numbers of BrdU-positive cells were significantly decreased to 21+4 at post-injection day 3 compared to c

关键词： 20S proteasome neural stem cells MG132 maintenance

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Hypotonic stimulation induced the astrocytes release taurine via connexin hemichannels and regulate activation of the neurons in the supraoptic nucleus of rats

Hypotonic stimulation induced the astrocytes release taurine...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Bei GAO~(1,3,**),Li DUAN~(1,**),Yan XU~2,Ling-Feng TU~1,Le YANG~1,Zhi-Ren RAO~(1,*) 1 Institute of Neuroscience,Forth Military Medical University,Xi'an 710032,China 2 Xijing Hospital of the Fourth Medical University,Xi'an 710032,China 3 Neurology Department of 323 Hospital of PLA,Xi'an 710054,China

Objective This study is to observe the mechanism of the astrocytes regulating activation of the neurons induced by hypotonic stimulation in rat supraoptic *** Rats used for this study were divided into four groups:(1)The isotonic control group,physiological saline was injected into the caudal vein;(2)The hypotonic stimulation group,a solution containing 0.83%glucose and 0.3%NaCl was injected into the caudal vein;(3)The fluorocitrate(FCA)plus hypotonic stimulation group,FCA was delivered into the lateral ventricle,two hours late,hypotonic stimulation was preformatted in the same way asdescribed above;(4)The carbennoxolon(CBX) + hypotonic stimulation group,CBX was injected into the lateral ventricle,two hours late,hypotonic stimulation was preformatted in the same way as described *** 90 min after hypotonic stimulation,by using convention method,rats were perfused,the brains were removed immediately,and serial coronal forebrain sections through the hypothalamus were cut on a *** sets of six serial sections through the SON from each rat were collected. By using single labeled and double labeled immunofluorescence staining method,we observed the expression of vasopressin(VP),connexin43(Cx43),glycine receptor(GlyR),glial fibrillary acidic protein(GFAP)and Fos in neurons and astrocytes in *** Hypotonic stimulation activated SON astrocytes,their cell bodies appeared hypertrophic,the process thickened,the MFI of GFAP,Tau and Cx43 significantly increased,this response was blocked by FCA,but not by *** positive SON neurons were increased,FCA and CBX blocked ClyR increase, while Fos and VP positive neurons were decreased compared isotonic stimulation *** Hypoosmotic stimulation activated SON astrocytes,activated astrocytes release taurine via Cx43 hemichannel,and inhibit the release of VP from SON neurons.

关键词： Astrocyte Neurons Hypotonic stimulation Taurine Connexin43 Rat

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