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Contribution of adrenergic and estrogen signaling to visceral hypersensitivity induced by neonatal colonic inflammation in female rats

Contribution of adrenergic and estrogen signaling to viscera...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Jin-De TAO~1,Shao-Feng WANG~1,Ning-Ang LIU~2,Guang-Yin XU~(2,*) 1 Department of Gastroenterology,the Second Affiliated Hospital 2Institute of Neuroscience,Key Laboratory of Pain Research & Therapy,Soochow University,Suzhou 215123,China

Objective Chronic abdominal pain and cramping in patients with irritable bowel syndrome(IBS) remain a big challenge for *** is 2-3 times more prevalent in women than in ***,the precise mechanism remains ***,we investigated whether adrenoceptor and estrogen signaling is involved in visceral hypersensitivity in a rat model of neonatal colonic inflammation(NCI).Methods Visceral hypersensitivity was induced by colonic injection of 0.5%acetic acid(AA) in 10-day-old female rats and ovariectomized(OVX) experiments were conducted at 7 weeks of *** response to colorectal distension(CRD) was measured by visual observation of abdominal withdrawal reflex(AWR).Results NCI significantly increased the visceromoter response to CRD at 10,20,40,60 and 80 *** administration of nonselective P-adrenergic receptor antagonist(propranolol) prevented stress-induced visceral hypersensitivity in a dose-dependent *** significantly decreased AWR scores when compared with those of sham OVX rats with neonatal AA *** produced no obvious effect on rats receiving normal saline injection when they were 10 days *** NCI-induced visceral hypersensitivity in female rats is mediated by P-adrenergic receptor and *** present and future studies might provide insight into mechanisms underlymg chronic visceral pain in female patients with functional gastrointestinal disorders such as IBS.

关键词： neonatal colonic inflammation visceral hyperalgesia adrenergic receptors estrogen

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Rapid effect of estrogen on glutamate related synaptic transmission and plasticity in the anterior cingulate cortex

Rapid effect of estrogen on glutamate related synaptic trans...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Xiao XIAO,Yan ZHANG,Zhi-Qi ZHAO,Yu-Qiu ZHANG~* Institute of Neurobiology,Institutes of Brain Science and State Key Laboratory of Medical Neurobiology,Fudan University,Shanghai 200032,China

Classically,estrogen has multiple actions in the brain via genomic mechanisms which generally take several *** present study was designed to examine that whether estrogen regulates glutamatergic transmission and plasticity within minutes and what is the possible mechanisms underlying the estrogen-induced rapid effects in the anterior cingulate cortex(ACC).Immunohistochemistry results revealed that estrogen receptors(ERs) were highly expressed in glutamatergic neurons of the ***-cell recording from ACC slices results showed that estrogen enhanced the glutamatergic excitatory postsynaptic currents(EPSCs) in a dose-dependent ***,the affect of estrogen on AMPA and NMDA transmission exhibited an opposite manifestation:NMDA-mediated EPSCs(NMDAEPSCs) were significantly enhanced;whereas AMPA-EPSCs were remarkably *** fast onset effect of enhanced NMDA-EPSCs,within 6 minutes bath application of estrogen,lasted for more than 30 minutes(NMDA- LTP).This NMDA-LTP was blocked by ER antagonist(ICI 182780) and was mimicked by E-BSA,a specific agonist of membrane ***,the induction of estrogen-induced NMDA-LTP was also prevented by NR2B inhibitor and PKA *** together,these findings implicate that estrogen has rapid effects on glutamate transmission in ACC ***,estrogen-induced chemical NMDA-LTP is at least partially mediated by membrane ***2BPKA pathway may play a critical role in estrogen-induced NMDA-LTP.

关键词： estrogen rapid effect NMDA receptor LTP anterior cingulate cortex

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Development of the direction-selective neural circuit in mouse retina during early postnatal days

Development of the direction-selective neural circuit in mou...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Thomas Euler Max Planck Institute for Medical Research Jahnstrasse 29D-69120 HeidelbergGermany

＜正＞Objective Direction-selective retinal ganglion cell（dsRGC） has characteristic responses to light stimuli: When light stimulus moving in its preferred direction,dsRGC will response with a large number of action potentials;when the light stimulus moving in its null direction,dsRGC could not response with action potentials,but only excitatory postsynaptic potential（EPSP） can be *** different responses caused by the asymmetric inhibitory connections exist between dsRGC and starburst amacrine cells（SACs）:dsRGC has inhibitory connections with the SACs located in its null side significantly stronger than with the SACs located in its preferred *** study focused on when the asymmetric inhibitory connections between dsRGC and SACs *** We first puffed glutamate（10 mM） around adult mouse retinal dsRGC soma in different orientations and recorded dsRGC’s responses. We found puff glutamate could be used to detect the asymmetric inhibitory connections between dsRGC and SACs: When glutamate was puffed at the preferred side the response intensity was significantly higher than when glutamate was puffed at the null *** and Conclusion We puffed glutamate around adult and P8-11 mouse retinal dsRGCs,used this method we ultimately found in mouse retina the asymmetric inhibitory connections between dsRGC and SACs started to be formed on the 10th day after mouse was born.

关键词： mouse retina direction-selective neural circuit function development

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The role of Gab in the development of neuromuscular junction

The role of Gab in the development of neuromuscular junction

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Jing ZHANG~1,Yue-Hai KE~2,Xiao-Ming LI~(1,*) 1 Department of Neurobiology,Key Laboratory of Medical Neurobiology of Ministry of Health,Zhejiang Province Key Laboratory of Neurobiology,Zhejiang University School of Medicine,Hangzhou 310058,China 2 Department of pathology,Zhejiang University School of Medicine,Hangzhou 310058,China

Objective Grb2-associated binder(Gab)docking proteins have crucialroles in neural development. However,the roles of Gab proteins in the development of synapses remain ***,we investigate the role of Gab in the development of synapses using the neuromuscular junction as a model of *** We generated muscle-specific Gab1 mutant but Gab2 null mice by using a loxP/Cre strategy since Gab1 null mutation cause embryonic *** Gabl(floxed/floxed)Gab2 null mice were crossed with mice expressing the Cre gene under the control of the human skeletal alpha-actin(HSA)*** interaction between Gab 1/2 and postsynaptic proteins were identified by co-immunoprecipition assay and Western Blot *** the morphology analysis of the conditional knockout mutation mice was investigated by Immuno-histochemistry and Immuno-fluorescence. Results The conditional knockout(CKO)mice were viable and *** AChR clusters colocalized with markers of presynaptic and postsynaptic ***,in comparison with age-matched littermates,the CKO micehave shown the decrease in the AChR cluster area and diameter at postnatal day *** Gab proteins may contribute to the early development of post-synapses of neuromuscular junction.

关键词： Gab neuromuscular junction AChR synaptic development

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HAPl protein involved in the transport of KV2.1 in PC12 cells

HAPl protein involved in the transport of KV2.1 in PC12 cell...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Jun HE,Dan WANG,Jing-Ying PAN,Cai ZHANG,He LI~* Division of Histology and Embryology,Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430030,China

Objective Huntingtin-associated protein-1(HAP1) is the first protein identified to interact with the Nterminus of huntingtin(htt).However,the function of HAP1 remains *** present study is to explore the effect of HAP1 on the membrane transport of KV2.1 in PC12 *** SiRNAs(small interfering RNAs) technique was used to silence the expression of HAP1 in PC12 *** current was recorded by whole-cell patch clamp technique and RT-PCR was used to observe the effect of HAP1 silencing on the mRNA expression of Kv2.1 in PC12 *** technique was used to observe the effects of HAP1 protein on Kv2.1 potassium channel cytoplasmic expression and membrane transport in PC12 ***(1) The silence of HAP1 inhibited the voltage-sensitive potassium current and induced slightly up-regulation of the Kv2.1 mRNA expression in PC12 cells.(2) The silence of HAP1 increased the cytoplasmic expression of Kv2.1 but inhibited the membrane transport of KV2.1. Conclusion HAP1 can regulate the membrane transport of KV2.1 expressed in PC12 cells.

关键词： HAPl voltage-sensitive K+ current patch clamp Kv2.1 PC 12 cells small interfering RNAs

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MiR-124 regulates early neurogenesis in the optic vesicle and forebrain,targeting NeuroDl

MiR-124 regulates early neurogenesis in the optic vesicle an...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Jane Y.WU The State Key Laboratory of Brain and Cognitive Science Institute of BiophysicsChinese Academy of Sciences15Datun RoadChaoyang District Department of Neurology Lurie Comprehensive Cancer CenterCenter for Genetic MedicineNorthwestern University Feinberg School of Medicine303 E.SuperiorChicagoIL 60611USA

MicroRNAs(miRNAs) are involved in the fine control of cell proliferation and differentiation during the development of the nervous ***-124,a neural specific miRNA,is expressed from the beginning of eye development in Xenopus and has been shown to repress cell proliferation in the optic ***,its role at earlier developmental stages is *** we show that miR-124 exerts a differential role in cell proliferation at the optic vesicle stage,the stage which precedes the optic cup *** show that miR-124 is both necessary and sufficient to promote cell proliferation and repress neurogenesis at the optic vesicle stage,playing an anti-neural role. Loss of miR-124 upregulates expression of neural markers NCAM,N-tubulin while gain of miR-124 downregulates these ***,miR-124 interacts with a conserved miR-124 binding site in the 3'UTR of NeuroD1 and negatively regulates expression of the proneural marker NeuroD1,a bHLH transcription factor for neuronal *** miR-124-induced effect on cell proliferation can be antagonized by *** results reveal a novel regulatory role of miR-124 in neural development and uncover a previously unknown interaction between NeuroD1 and miR-124.

关键词： MiR-124 NeuroD1 optic vesicle cell proliferation neurogenesis Xenopus laevis

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Distribution and expression of VGSCs in brain in rat with Parkinson's disease

Distribution and expression of VGSCs in brain in rat with Pa...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Ling-Yan WU,Hong-Yan ZHU,Xiao PEI,Yong-Hua JI~* Lab of Neuropharmacology and Neurotoxicology,School of Life Sciences,Shanghai University,Shanghai 200444, China

Voltage-gated sodium channels(VGSCs) play a critical role for electrical signaling in the nervous system by generating action potentials in *** distribution and expression of VGSCs in Parkinson's disease(PD) have not yet been studied,and it is not known whether there are changes in the expression of VGSCs in *** distinct sodium channel a subunits have been reported to be expressed in mammalian central neurons:Navl.l,Navl.2,Navl.3 and *** expression of Navl.6 is at a high density in the *** distribution and expression of Navl.6 in the 6-hydroxydopamine lesion rat of PD model were *** revealed that Navl.6 is exclusively distributed in distinct regions of brain including cerebral cortex,hippocampus,striatum,thalamus,hypothalamus, substantia nigra,cerebellum,etc.,in normal ***,our results show that Navl.6 clustered at a high density in the cell membrane and slender *** the ipsilateral side of PD model,focal and robust upregulation of Navl.6 in the corpus callosum was *** addition,the abundance of Navl.6 in the ipsilateral striatum and substantia nigra was slightly increased,compared to that of the contralateral ***,in some brain regions,plaque-like immunoreactivities for Navl.6 were *** alterations of the expression and distribution of Navl.6 may provide a novel mechanism involved in the pathogenesis of PD,thus addressing a new therapeutic target and strategy for PD.

关键词： voltage-gated sodium channels Nav1.6 Parkinson's disease

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Input to macaque V1 cells revealed with a novel grating stimulus

Input to macaque V1 cells revealed with a novel grating stim...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Yao CHEN~* School of Biomedical Engineering,Shanghai Jiao Tong University,Shanghai 200240,China

Objective Studies of primate vision often use either luminance or chromatic modulation in an attempt to isolate postreceptoral *** is substantial evidence that luminance or chromatic modulation,either red-green(long(L)and middle(M)wavelength-cone opponent)or blue-yellow(short(S)wavelength-cone), was processed in separable psychophysical channels,and the physiological substrates of these channels lie in the magnocellular(MC),parvocellular(PC)and koniocellular(KC)pathways *** the role of these systems in spatial vision is still *** We have recorded responses of cells in VI of the awake macaque monkey to a novel grating stimulus drifting across their receptive fields which we call compound *** consists of equiluminant red and green bars separated by dark *** luminance component of this compound grating is twice the temporal(and spatial)frequency of the chromatic *** The ratios of the second harmonic (luminance)to the first harmonic(chromatic)response is bimodally distributed,with ratios less than one for PC cells and greater than one for MC *** contrast,the distribution of ratios for cortical cells is *** comparing responses to conventional luminance,chromatic gratings and compound gratings,the input to many cortical cells could be identified as predominantly MC(62%of cells),a small group as predominantly PC(21%of cells),with some cells receiving combined input(17%of cells).Conclusion These results confirm previous reports demonstrating a surprising amplification of the MC pathway at the cortical level(60%of cortical cells)and a significant group of luminance/chromatic cells.

关键词： color vision chromatic visual pathway primary visual cortex primate

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Neural coding properties based on spike timing and pattern correlation of retinal ganglion cells

Neural coding properties based on spike timing and pattern c...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Han-Yan GONG,Ying-Ying ZHANG,Pei-Ji LIANG,Pu-Ming ZHANG~* School of Biomedical Engineering,Shanghai Jiao Tong University,Shanghai 200240,China

Objective It has been already known that stimulus information is represented with various rules in neuron spike trains called neural *** aim for understanding neural coding is to explore the distinct relationship between stimulus and the individual or ensemble neural *** between spike trains or neurons sometimes indicates certain neural coding rules in the visual *** relationship between spike timing correlation and pattern correlation is discussed,and their ability to represent stimulus features is compared to examine their coding strategies not only in individual neurons but also in *** Two kinds of stimuli,natural movies and checkerboard,are used to arouse firing activities in chicken retinal ganglion *** spike timing correlation and pattern correlation are calculated by cross-correlation function and Lempel-Ziv distance *** According to the correlation values,it is demonstrated that spike trains with similar spike patterns are not necessarily concerted in firing ***,spike pattern correlation values between individual neurons' responses reflect the difference of natural movies and checkerboard;neurons cooperate with each other with higher pattern correlation values which represent spatiotemporal correlations during response to natural *** timing does not reflect stimulus features as obvious as spike patterns,caused by their particular coding properties or physiological foundation. Conclusion Separating the pattern correlation out of traditional timing correlation concept uncover additional insight in neural coding.

关键词： neural coding spike pattern correlation spike timing correlation cross-correlation Lempel-Ziv distance

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Genotype methods to prevent severe cutaneous hypersensitivity induced by Carbamazepine in treating trigeminal neuralgia

Genotype methods to prevent severe cutaneous hypersensitivit...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Ying WU~1,Xiang-Qing WANG~2,Zhu-Jun GAN~1,Yan WU~1,Shu-Hong LIU~1,Sen-Yang LANG~2,Ming FAN~1 1 Laboratory of Cognitive Science,Beijing Institute of Basic Medical Sciences,Beijing 100850,China 2 Department of Neurology,China PLA General Hospital,Beijing 100853,China

Objective Literatures have shown that strong associations between HLA-B*1502 and Stevens Johnson syndrome(SJS)and toxic epidermal necrolysis(TEN)induced by carbamazepine in Hong Kong and Guangzhou *** are some conflicts between primers in the *** aim of this project is to find correct methods to determine HLA-B**** We enrolled 138 cases including the SJS/TEN patients,milder non-SJS/TEN cutaneous adverse drug reactions(mainly maculopapular)patients,tolerant controls and normal ***-SSP was performed using sets of HLA-specific primers and control primers to genotype HLA-B*1502 and high-resolution genotyping was used to sequence HAL-B**** After testing primers of published papers,we found that 6 cases should be HLA-B*1502 *** among them,high-resolution genotyping proved that only one was HLA-B*1502 *** analyzed HLA-B*1502 sequence and designed new primers for genotyping HLA-B*1502 and confirmed that testing results were exact same with sequence *** New primers used to genotype HLA-B*1502 have been *** strategies can help to guide personalized medicine and predict severe cutaneous adverse reaction in the clinic.

关键词： genotype carbamazepine hypersensitivity

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