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The effect of transcutaneous electrical acupoint stimulation for children with autism and its possible relation with plasma level of AVP and OXT:A prospective single-blinded controlled study

The effect of transcutaneous electrical acupoint stimulation...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Rong ZHANG~1,Mei-Xiang JIA~2,Xin-Jie XU~1,Xiao-Jing SHOU~1,Ji-Sheng HAN~(1,*) 1Neuroscience Research Institute,Peking University,38 Xueyuan Road,Beijing 100191,China 2Peking University Institute of Mental Health,51 Huayuan North Road,Beijing 100191,China

Objective To study the efficacy of transcutaneous electrical acupoint stimulation(TEAS) on rehabilitation training for children with autism and primary *** One hundred and twenty four autistic children receiving rehabilitation training were divided into a control group(n=39) and a TEAS treatment group(n=37).The control group received rehabilitation training,the treatment group received TEAS for 60 sessions after rehabilitation *** Autism Rating Scale(CARS),Autism Behavior Checklist(ABC),Aberrant Behavior Checklist (AbBC),Adaptive Deviation Quotient(ADQ),Sleep status questionnaire and Food choice questionnaire were used for outcome ***(1) The total scores of CARS(P<0.05) and ABC(P<0.05) decreased significantly after TEAS intervention,specifically in Emotion(P<0.05),Anxiety(P<0.01) and Intelligence(P<0.05) factors in CARS, Sense(P<0.01) and Social communication(P<0.01) factors in ABC.(2) The kinds of rejected food reduced after TEAS treatment(P<0.05),especially in vegetables(P<0.05),fruits(P<0.01) and snacks(P<0.05).(3) TEAS was more effective on children with passive(P<0.05) but not active-but odd social interaction style.(4) The plasma argininevasopressin (AVP) increased after TEAS treatment(P<0.01).(5) The plasma oxytocin(OT) decreased in both groups after 3 months' intervention,and less decrease were found in TEAS group(P<0.05).(6) The change of plasma AVP was positive correlation with Interpersonal communication(P<0.05),Auditory(P<0.05) and Sense(P<0.01) factors in CARS. Conclusion TEAS combined with habilitation training has a better therapeutic effect than that of simple rehabilitation training for autistic children with passive social interaction style,and which was related with plasma AVP and OT.

关键词： autism TEAS AVP OT

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Switching of N-methyl-D-aspartate(NMDA) receptor-favorite intracellular signal pathways from ERK1/2 to p38 MAPK leads to developmental changes in NMDA neurotoxicity

Switching of N-methyl-D-aspartate(NMDA) receptor-favorite in...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Lin XIAO~*,Chun HU,Chun-Zhi FENG,Yi-Zhang CHEN~* Institute of Neuroscience,Key laboratory of molecular neurobiology,Ministry of education,Second Military Medical University,Shanghai 200433,China

Excitotoxicity mediated by overactivation of N-methyl-D-aspartate receptors（NMDARs） has been implicated in a variety of neuropathological conditions in the central nervous system（CNS）.It has been suggested that NMDA neurotoxicity is developmentally regulated,but the definite pattern of the regulation has been controversial and the underlying mechanism remains largely ***,we show that NMDA treatment leads to significant cell death in mature（9,12DIV） hippocampal neurons or hippocampi of young（P12） and adult rats but not in immature （3,6DIV） neurons or embryonic（E18） and neonatal rat *** contrast,NMDA promotes survival of immature neuron against tropic ***,it is found that NMDA preferentially activates p38 mitogen activated protein kianse（MAPK） in mature neuron and adult rat hippocampus,but favors extracellular signal-regulated kinases1/2（ERK1/2） activation in immature neuron and P0 rat ***,it is shown that NMDA neurotoxicity in mature neuron is mediated via p38 MAPK activation,and neuroprotection in immature neuron is mediated via ERK1/2 activation,while all these effects are NR2B-containing NMDARs dependent,as well as Ca *** also revealed that mature and immature neuron showed no difference in the amplitude of NMDAinduced intracellular calcium([Ca]) ***,the basal level of[Ca] is shown to elevate with the maturation of neuron,and this elevation is attributable to the changes in NMDA neurotoxicity but not to the switch of NMDAR signaling *** together,our results suggest that a switch of NMDA receptor-favorite intracellular signal pathways from ERK1/2 to p38 MAPK and the elevated basal level of[Ca] with age might be critical for the developmental changes in NMDA neurotoxicity in hippocampal neuron.

关键词： NMDA receptor neurotoxicity development MAPK calcium

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Gene expression profiling and bioinformatic analysis of rat sciatic nerve injury in Wallerian degeneration

Gene expression profiling and bioinformatic analysis of rat ...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Deng-Bing YAO,Mei-Yuan LI,Fei DING,Xiao-Song GU~* Jiangsu Key Laboratory of Neuroregeneration,Nantong University,Nantong 226001,China

Objective Wallerian degeneration(WD) is still a subject of modern *** occurs in peripheral nervous system(PNS) which is a process that nerve fiber is cut or *** is also known as anterograde degeneration,or orthograde degeneration,or secondary *** WD,the distal axons begins degeneration and macrophages enter the distal axons area to remove the myelin and axonal debris of *** cells,accompanied by Schwann cells clear the debris from the *** is rapid and supported by Schwann cells through growth factors release of a lesion follows degeneration in PNS.A large number of genes are differentially regulated during the stages of WD in the development and pathology of WD in the peripheral nerve injury initiating these responses has remained largely *** In this study,we analyzed gene expression patterns of short-term(0,0.5,1,6,12,24 h) and long-term(0,1,4,7,14,21,28 d) series carrying the WD of the distal nerve stump after rat sciatic nerve injury using gene chip *** of differential genes;analysis of gene expression trends;Gene Ontology(GO),Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway and signal-flow analysis;real-time PCR,Western blot and *** GO classification indicated enrichment in genes related to cell adhesion,extracellular matrix,microglial cell activation,positive regulation of synaptic plasticity,positive regulation of chemokine production,positive regulation of acute inflammatory response, nerve development and positive regulation of neuron differentiation,*** pathway analysis showed high expression of genes relating to T cell receptor signaling pathway,Jak-STAT signaling pathway,apoptosis, cytokine-cytokine receptor interaction,toll-like receptor signaling pathway and p53 signaling *** data were validated with real-time PCR,Western blot,and *** These results will help to much better understand

关键词： Wallerian degeneration sciatic nerve microarrays expression profiling rat

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The effects of 8 weeks treadmill exercise on the Rho GTPases in rat special brain regions

The effects of 8 weeks treadmill exercise on the Rho GTPases...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Yan LI,Li ZHAO~*,Li-Jing GONG Beijing Sport University,Beijing 100084,China

＜正＞Objective Recently numerous of epidemiological data have proven that physical activity or regular exercise beneficially affects brain function and increases neuronal development,but the mechanisms of exercise has not been *** GTPases act as the central regulators of cytoskeleton and function as binary molecular switches. In this family,RhoA,Racl and Cdc42 have been characterized most ***,the role of Rho GTPases in neuronal development has been ***,the aim of this study was to investigate the effects of 8 weeks treadmill exercise on the Rho GTPases in the rat special brain *** 3 months male Wistar rats were randomly assigned to either a sedentary or a treadmill exercise *** rats were familiarized to treadmill exercise for 5 days,then ran 30 min/day at 10m/min on a 5%slope for the first 2 *** running speed and duration of the exercise were gradually increased,up to 60 min/day at 22 m/min on a 10%slope for 6 *** rats were killed 48 h after the last exercise *** levels of synaptophysin in the cortex and hippocampus were separately detected with the ICH and IF method,which has been widely used to assess synapse ***, the protein levels of RhoA,Rac1 and Cdc42 were measured using Western blotting and the mRNA levels were measured using real time *** were analyzed using one-way analysis of variance（ANOVA）.The level of statistical significance was set at P＜***（1） The increase of synapse density appeared in both cortex（P＜0.05） and hippocampus（P＜0.05） in exercised groups compared with sedentary groups.（2） Exercise decreased the protein levels of RhoA in both cortex（P＜0.01） and hippocampus（P＜0.01）,at the same time increased the mRNA levels in both cortex（P＜0.001） and hippocampus（PO.001）.（3） Exercise increased the protein levels of Rac1 in both cortex （P＜0.01） and hippocampus（P＜0.01）.Exercise increased the mRNA level of Racl in cortex（P＜0.01） but decreased the mRNA le

关键词： exercise Rho GTPases neuronal development

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Protective effect of Hv in transgenic drosophila models of SC A3/M JD

Protective effect of Hv in transgenic drosophila models of S...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Hong JIANG~(1,2,*),Ji-Ping YI~1,Bei-Sha TANG~(1,2) 1 Department of Neurology,Xiangya Hospital,Central South University,Changsha 410008,China 2 Neurodegenerative Disorders Research Center,Central South University,Changsha 410008,China

Objective Spinocerebellar ataxia type 3/Machado-Joseph disease(SCA3/MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of polyglutamine tract near the C-terminus of the MIDI gene product,ataxin-3.A growing body of evidence demonstrates that aberrant activity of histone deacetylases or histone acetyltransferase might be an underlying mechanism of transcriptional dysregulation in polyQ diseases including SCA3/MJD,which suggests that the balance of histone acetylation is a good target for therapeutic intervention of polyQ *** studies have shown a therapeutic role for HDAC inhibitors(HDACIs) as candidate drugs for the treatment of polyQ ***,the effects of HDACIs(Hv,confidential now) on models of SCA3/MJD have never been *** present study is to illustrate the therapeutic potential of Hv in SCA3/MJD transgenic Drosophila *** GAL4AJAS system SCA3/MJD transgenic Drosophila models were constructed by using the promoter gmr-GAL4 and elav-GAL4 which drive target selective gene expression in developing eyes and neurons,*** observing was used to understand the effect of Hv on the eye morphology,lifespan and climbing ability of SCA3/MJD transgenic Drosophila *** The loss of pigmentation and collapse of the eyes of SCA3/MJD transgenic Drosophila models were mitigated by feeding *** climbing ability was obviously improved especially by dosage of 1 mM or 1.5 *** of 0.5 mM could extend their lifespan. Conclusions SCA3/MJD transgenic Drosophila models were successfully constructed,which selectively express human MJDtr-Q78 protein with different levels in developing eyes or neurons *** was further confirmed that the expression level of MJDtr-Q78 protein are concerned to the severity of SCA3/MJD *** was also found that proper dosage of Hv has therapeutic potential in these models.

关键词： polyQ diseases SCA3/MJD ataxin-3 transgenic Drosophila models histone deacetylase inhibitors

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mGluR6 deletion downregulates the TRPMl channel in retinal ON bipolar cells and renders the cells hyperpolarized

mGluR6 deletion downregulates the TRPMl channel in retinal O...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Marie FINA Anuradha DHINGRA Chieko KOIKE Takahisa FURUKAWA Noga VARDI Department of Neuroscience University of PennsylvaniaPhiladelphiaUSA Pharmaceuti.Sci. Ritsumeikan Univ.ShigaJST PRESTOJapan Dev.Biol Osaka Biosci.Inst.OsakaJST CRESTJapan

In darkness,glutamate released from photoreceptors activates the mGluR6 receptor on retinal ON bipolar cells,and this activates the G-protein Go,leading to a closure of TRPM1 channel and cells' *** has been generally assumed that deleting mGluR6 would render the cascade inactive and ON bipolar cells constitutively ***,in mGluR6-null mice,we found that the rod bipolar cells were constitutively hyperpolarized. The slope conductance of theⅠ-Ⅴcurves and the current noise were smaller than in wild ***,while in wild type it was possible to activate TRPM1 by local application of the TRPV1 agonist capsaicin(in 6/15 cells),in null rod bipolar cells such attempts failed(32 cells).These results suggest that the TRPM1 channel in mGluR6 null rod bipolar cells is *** explore the reason for this lack of activity,we tested whether deleting mGluR6 affects the expression of the cascade *** for G-protein subunit candidates Gαo,Gβ3 and Gγ13 showed no significant change in their expression or *** expression of the channel itself,we found that TRPM1 was expressed in mGluR6-null ON bipolar cells' somas,but absent from their dendritic *** absent from the dendritic tips of the null rod bipolar cells were the Gαo modulators Gβ5 and *** also looked at the expression of cascade elements in Gao-null rod bipolar cells because they too maintain a hyperpolarizing resting potential. In this retina,mGluR6 expression appears normal,but Gβ3,Gγ13,and TRPM1 are *** TRPM1 is constitutively active,its downregulation cannot explain total lack of *** is therefore possible that TRPM1 in mGluR6- or Gαo1-null rod bipolar cells fails to reach the plasma membrane,or,if it does,it may lack a factor that is required for its opening.

关键词： retinal ON bipolar cell TRPMl mGluR6

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The expression of insulin-like growth factor-I and its receptor during development of rat embryo brain

The expression of insulin-like growth factor-I and its recep...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Xiao-Hua JIANG,Li-Li JU,She-Lian LU,Jun-Peng ZHAO,Quan-Yuan XU Beijing Institute for Neuroscience,Capital Medical University Beijing Center of Neural Regeneration & Repair,Key Laboratory for Neurodegenerative Disease of the Ministry of Education,Beijing 100069,China

Objective To study temporal expressions of insulin-like growth factor-Ⅰ(IGF-Ⅰ) and insulin-like growth factor-1 receptor(IGF-1R) in the developing brain of rat and explore their functions in nervous system development. Method IGF-I and IGFR-1 mRNA expressions in the developing brain of rat(from E10.5-E18.5) were studied by Real-time ***(1) The relative quantities(RQ) of IGF-ⅠmRNA from E10.5 to E18.5 were 1,2.6,13.4,15.5, 9.2,51.5,4.6,3.5 *** were two peaks of IGF-I mRNA expression:the first one was on E14.5 when the RQ of IGF-ⅠmRNA was 15 times more than on E10.5,the second one was on E16.5 when the RQ of IGFR-1 mRNA was51 times more than on E10.5.(2) The relative quantities of IGF-1R mRNA from E10.5 to E18.5 were 1,1, 1.5,2.2,1.5,1.5,1.8,0.24,0.24,1.3 *** expression level remained relatively constant and there was no significant expression peak of IGFR-1 *** IGF-Ⅰmaybe have different important roles in regulating neural stem cell proliferation and differentiation according to different expression levels during rat brain development.

关键词： insulin-like growth factor-I(IGF-I) insulin-like growth factor-1 receptor(IGF-1R) rat brain

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RU486(mifepristone) ameliorates cognitive dysfunction and reverses the down-regulation of astrocytic n-myc downstream-regulated gene 2(NDRG2) in streptozotocin-induced type 1 diabetic rats

RU486(mifepristone) ameliorates cognitive dysfunction and re...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Zhong-Fu ZUO~(1,2),Wen WANG~1,Le NIU~1,Zhen-Zhen KOU~1,Chao ZHU~1,Wei WANG~1,Xiao-Hui ZHAO~1, Dao-Shu LUO~1,Ting ZHANG~1,Fu-Xing ZHANG~1,Sheng-Xi WU~(1,*),Yun-Qing LI~(1,*) 1 Department of Anatomy,Histology and Embryology and K.K.Leung Brain Research Centre,The Fourth Military Medical University,Xi'an 710032,China 2 Department of Anatomy,Liaoning Medical College,Jinzhou 121000,China

Objective Diabetic cognitive dysfunction(DCD),usually accompanied with chronically elevated glucocorticoids and hippocampal astrocytic alterations,is one of the most serious complications in patients with type 1 ***,the role for chronically elevated glucocorticoids and hippocampal astrocytic activations in DCD remains to be elucidated,and it is not clear whether astrocytic N-myc downstream-regulated gene 2(NDRG2,involved in cell differentiation and development) is participated in *** present study is to explore the potential role of elevated glucocorticoids,astrocytes and NDRG2 for *** Three months after streptozotocin(STZ)-induced type 1 diabetes onset,rats received 9-day administration of glucocorticoids receptor(GR) antagonist,RU486, at doses of 10,25 or 40 mg/*** cognitive function was detected by Morris water maze,serum corticosterone was investigated by radio immuno assay,and the alterations of glial fibrillary acidic protein(GFAP,a key indicator of astrocytic reactivity) and NDRG2 in hippocampus were revealed by immunohistochemistry staining,real-time PCR and Western *** Three months after diabetes onset:(1) Diabetic rats develop remarkable cognitive impairments and elevated serum corticosterone level;(2) Diabetic rats show significant down-regulation of GFAP and NDRG2 in hippocampus;(3) Nine-day administration with RU486 at dose of 25 mg/kg ameliorates DCD and reverses the expression of hippocampal GFAP and NDRG2 *** Glucocorticoids-GR system is crucial for DCD,astrocytic reactivity and NDRG2 are involved in these processes.

关键词： diabetic cognitive dysfunction GFAP glucocorticoids receptor N-myc downstream-regulated gene 2 RU486

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The study of P2X3 receptor role in neonatal rat DRG neurons in pain development

The study of P2X3 receptor role in neonatal rat DRG neurons ...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Lu DU,Wen-Juan HE,Jian CUI,Yan-Dong ZHAO,Huai-Zhen RUAN~* Department of Neurobiology,College of Basic Medical Sciences,Chongqing Key Laboratory of Neurobiology,Third Military Medical University,Chongqing 400038,China

Objective P2X3 receptor plays important role in the onset and persistence of pain,recent study have shown that P2X3 receptor also plays roles during individual *** we want to figure out whether pain in neonatal rat affects the expression level of P2X3 receptor in primary sensory neurons during development,and explore the potential mechanisms *** Rats of postnatal 3,7,14,21,28 d and adult rats all received CCI (chronic constriction injury) operation in the left sciatic nerve,the right nerve received sham *** threshold (TWL and PWT) was assayed by thermal radiation and von Frey filament before and 1,3,7,14,21,28 days after *** of P2X3 receptor in DRG of every group was measured by immunohistochemical staining(IHC), and the expression level was *** statistical calculations were performed usingthe SPSS statistical package(SPSS,Chicago,USA).Results(1) After operation,thermal hyperalgesia and mechanical allodynia appeared on the neonatal and adult rats,and the change pattern of pain threshold in neonatal and adult rats is similar. The TWL and PWT decreased obviously from 1 d,descended to the lowest at 14 d post-operation,then returned to the normal level after 28 d post-operation.(2) The expression of P2X3 receptor in adult rat DRG increased obviously from 1 day post-operation and lasted for 21 days,and returned to the normal level after 28 days;while the expression of P2X3 receptor in neonatal rats DRG dropped obviously in all *** P2X3 receptor plays an important role in the incidence and development of pain and nervous *** the result suggests that pain stimulus might affect the development of neonatal nervous system.

关键词： DRG pain P2X3 receptor development

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Neuropeptide S promotes active waking through activation of histaminergic and orexinergic neurons

Neuropeptide S promotes active waking through activation of ...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Peng ZHAO,Yu-Feng SHAO,Min ZHANG,Kun FAN,Xiang-Pan KONG,Yi-Ping HOU~* Department of Neuroscience,Anatomy,Histology and Embryology,Key Laboratory of Preclinical Study for New Drugs of Gansu Province,School of Basic Medical Sciences,Lanzhou University,Lanzhou 730000,China

Objective The effect of neuropeptide S(NPS) on characteristics and mechanisms in the regulation of sleep-waking cycle are unclear,though the initial findings that NPS promotes arousal associated to locomotor activity and a genuine anxiolytic-like action have recently been *** hypothesized that NPS activated posterior hypothalamic arousal systems involved histaminergic(HAergic) neurons in tuberomammilary nucleus(TMN) and orexinergic(OXergic) neurons in perifornical(PeF) and lateral hypothalamic(LH) area,where NPSR mRNA has been reported to be highly expressed,to regulate sleep-wakefulness *** present studies were designed to provide more information regarding the NPS-induced sleep-waking characteristics and potential targets in posterior hypothalamus by analyzing each state across sleep-waking cycle,especially focusing on active waking(aW) and quiet waking(qW) states since the rather unique behavioral profile challenges the common idea that anxiolytics are also sedative or that stimulants are also anxiogenic,during the 24 h period after a range dose of NPS intracerebroventricular (ICV) injection and by observing earlier genes c-fos *** Four stainless-steel screws as electroencephalogram(EEG) electrodes were screwed into the animals skull and three silver wire as electromyogram (EMG) electrodes were inserted into the dorsal cervical neck muscles to monitor the sleep-wake cycle,and the EEG and EMG signals were amplified and digitalized with a resolution of 256 and 128 Hz respectively using a CED 1401 MKⅡ.After sleep-waking recording,c-fos immunereactive(Fos-IR),histidine decarboxylase(HDC)-IR,orexin-A (OX-A)-IR,and dual labeling of Fos-IR+HDC-IR and Fos-IR+OX-A-IR neurons were respectively labeled to identify the active sites in the brain for the NPS effects on *** The sleep-wake profile after an ICV injection of NPS at 10:00 h was examined,when rats with saline injection spend most of their time in *** given at 0.1 and

关键词： neuropeptide S sleep-wake states EEG power spectra immunohistochemistry histamine orexin

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