检索结果-内蒙古大学图书馆

您好，读者！请登录

内蒙古大学图书馆

首页
概况
党建
资源
服务
科研支持
- 论文收录引用证明
- 科技查新
知识产权
档案馆
帮助

咨询与建议

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

您的常用邮箱：*

您的手机号码：*

问题描述：

当前已输入0个字，您还可以输入200个字

全部搜索
期刊论文
图书
学位论文
标准
纸本馆藏
外文资源发现
数据库导航
超星发现

高级检索

时间限定

出版年份：

文献类型

图书期刊文献学位论文多媒体

馆藏选择

电子馆藏纸本馆藏

核心期刊

全部期刊 SCI 收录期刊 SSCI 收录期刊 EI 收录期刊 CSCD 收录期刊 CSSCI 收录期刊

语言

中文英文

文献类型

期刊文献图书学位论文标准纸本馆藏

帮助

文字说明：

T=题名（书名、题名），A=作者（责任者），K=主题词，P=出版物名称，PU=出版社名称，O=机构（作者单位、学位授予单位、专利申请人），L=中图分类号，C=学科分类号，U=全部字段，Y=年（出版发行年、学位年度、标准发布年）

检索规则说明：

AND代表“并且”；OR代表“或者”；NOT代表“不包含”；(注意必须大写,运算符两边需空一格)

检索范例：

范例一：(K=图书馆学 OR K=情报学) AND A=范并思 AND Y=1982-2016
范例二：P=计算机应用与软件 AND (U=C++ OR U=Basic) NOT K=Visual AND Y=2011-2016

分类表

所选分类

>> <<

限定检索结果

文献类型

827 篇 会议

馆藏范围

827 篇 电子文献
0 种 纸本馆藏

日期分布

学科分类号

403 篇 理学
- 403 篇 生物学
351 篇 医学
- 245 篇 临床医学
- 79 篇 基础医学(可授医学...
- 33 篇 中西医结合
- 18 篇 药学(可授医学、理...
- 8 篇 中药学(可授医学、...
- 6 篇 中医学
- 3 篇 医学技术（可授医学...
- 2 篇 公共卫生与预防医...
7 篇 工学
- 5 篇 生物医学工程（可授...
- 3 篇 生物工程
- 2 篇 材料科学与工程（可...
2 篇 教育学
- 2 篇 心理学(可授教育学...
1 篇 农学
- 1 篇 畜牧学

主题

37 篇 hippocampus
24 篇 rat
21 篇 nmda receptor
18 篇 parkinson's dise...
15 篇 ischemia
14 篇 depression
14 篇 astrocyte
14 篇 epilepsy
12 篇 alzheimer's dise...
12 篇 synaptic plastic...
12 篇 apoptosis
12 篇 microglia
12 篇 neuron
11 篇 learning and mem...
10 篇 spinal cord
9 篇 migration
9 篇 ltp
9 篇 neuroprotection
9 篇 glutamate
9 篇 帕金森病

机构

15 篇 首都医科大学
9 篇 复旦大学
8 篇 上海交通大学医学...
8 篇 neuroscience res...
6 篇 浙江大学
5 篇 中国医学科学院药...
5 篇 南通大学
4 篇 key laboratory f...
4 篇 南方医科大学
4 篇 department of ne...
4 篇 北京大学
4 篇 山西医科大学
3 篇 institute for bi...
3 篇 key laboratory f...
3 篇 华东师范大学
3 篇 南昌大学
3 篇 infectious disea...
3 篇 laboratory of ap...
2 篇 军事医学科学院基...
2 篇 department of ps...

作者

8 篇 陈生弟
8 篇 陈乃宏
7 篇 albert cheung ho...
6 篇 苑玉和
6 篇 徐志卿
5 篇 徐群渊
5 篇 孙凤艳
5 篇 胡金凤
4 篇 李鹏飞
4 篇 zhejiang provinc...
4 篇 杨予涛
4 篇 王春芳
4 篇 顾晓松
4 篇 丁健青
4 篇 college of pharm...
4 篇 刘彩玉
4 篇 陈忠
4 篇 蔚洪恩
4 篇 高天明
4 篇 key laboratory o...

语言

705 篇 英文
122 篇 中文

检索条件"任意字段=中国神经科学学会第九届全国学术会议暨第五届会员代表大会"

共 827 条记录，以下是741-750 订阅

全选清除本页清除全部题录导出标记到"检索档案"

详细简洁

排序：

The gating role of prefrontal cortex:controling morphine's exciting effect on dopamine neurons in ventral tegmental area

The gating role of prefrontal cortex:controling morphine's e...

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Xing FANG,Chang-Liang LIU,Qian-Qian WU,Guo-Zhang JIN,Xue-Chu ZHEN~* Department of Pharmacology,State Key Laboratory of Drug Research,Institute of Material Medica,Chinese Academy of Sciences,Shanghai,China Department of Pharmacology,College of Pharmacy,Soochow University,China

The dopamine-containing neurons of the midbrain ventral tegmental area(VTA) play a critical role in the reinforcing effects of drugs of *** has long been known that morphine can excite dopamine(DA) neurons in ventral tegmental area(VTA) by increasing both firing rate and burst ***,great deal of evidences indicates that DA cells are not immediately influenced by morphine,the effects are through a rather complicated circuit such as morphine-mediated disinhibition from other *** works have demonstrated that the prefrontal cortex(PFC) terminals project to the dendrites of DA and non-DA neurons in the VTA,and PFC-VTA circuit controls the majority of information flowing into VTA and plays essential role in drug ***,how PFC involves in the regulation of DA neuron activity in response to addictive drug remains largely *** employing in vivo single unit recording techniques,we studied the roles of PFC in the regulation of morphine's effect on VTA DA *** found that morphine(2 mg/kg,i.v.) markedly excited DA cell both in firing rate and in *** excitation could be reversed and prevented by naloxone(0.2 mg/kg,i.v.),suggesting a uopiate receptor dependent *** of PFC by tetradotoxin(TTX) produced no significant influence on basal DA cell activity,but prevented the morphine's effect on DA *** that the PFC might play a gating role in morphine-mediated excitation on DA ***,exciting effect of morphine on DA neurons was not altered by lesion of PFC in rats pretreated with single dose of morphine(20 mg/kg,i.p.,24 h).It appears that the gating effect of PFC disappeared after single morphine ***,we found only 46%(7 in 15) PFC pyramidal neurons recorded was inhibited by morphine challenge in rats that was previously single morphine -exposed,whereas 100%recorded PFC pyramidal neurons were inhibited by morphine in that of nai've *** conclusion,our data provided ev

关键词： PFC The gating role of prefrontal cortex:controling morphine's exciting effect on dopamine neurons in ventral tegmental area

来源：评论

学校读者我要写书评

暂无评论

Nicotine enhanced synaptic transmission to airway preganglionic parasympathetic motoneurons

Nicotine enhanced synaptic transmission to airway preganglio...

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Xu-Jiao ZHOU~1,Yong-Hua CHEN~1,Li-Li HOU~(1,2),Dong-Ying QIU~(1,2),Lei ZHU~2,Ji-Jiang WANG~(1,*) 1 The State Key Laboratory of Medical Neurobiology and Institute of Brain Sciences,Fudan University Shanghai Medical College,138 Yi-Xue-Yuan Road,Shanghai 200032,China 2 Fudan University Zhongshan Hospital,180 Fenglin Road,Shanghai 200032,China

The airway preganglionic parasympathetic motoneurons(APPMs)supply the essential excitatory drive to the postganglionic parasympathetic motoneurons,which predominate in the nervous control of the airway physiologically and play critical roles in the genesis of airway *** APPMs express multiple subunits of nicotinic acetylcholine receptors(nAChR)however the influence of endogenous acetylcholine(ACh)or exogenous nicotine on these neurons is *** this study,the APPMs were retrogradedly labeled from the extrathoracic trachea of newborn rats,the inspiratory-activated APPMs(I-APPMs)innervating the tracheobronchial smooth muscle were functionally identified in rhythmically firing medullary slices,and the effects of nicotine and endogenous ACh were examined using voltage *** results show that nicotine(10μmol/L)and acetyl cholinesterase inhibitor neostigmine(10μmol/L)significantly increased the frequency and amplitude of the tonic excitatory postsynaptic currents(EPSCs),and caused a tonic inward *** nicotine-induced changes of the tonic EPSCs was prevented by dihydro-β-erythroidine(DHβE),an antagonist ofα4β2 type of nAChR,at 3μmol/L that is selective forα4β2 type of *** nicotine-induced tonic inward current was attenuated DHβE(3μmol/L),and was abolished by addition of methyllycaconitine(10 nmol/L),an antagonist of a7 type of *** also caused significant increases in the GABAergic and the glycinergic spontaneous inhibitory postsynaptic currents,in both the frequency and the amplitude,which were also prevented by DHβE(3μmol/L).Nicotine had no effect on the miniature excitatory or inhibitory postsynaptic currents in the pre-existence of *** results demonstrated that nicotine caused a direct postsynaptic excitatory effect that was mediated by bothα7 andα4β2 type of nAChR,and enhanced the excitatory and the inhibitory inputs via activation ofα4β2 type of nAchR in the I-APPMs.

关键词： airway motoneuron parasympathetic preganglionic nicotine receptor

来源：评论

学校读者我要写书评

暂无评论

Quantitative evaluation of dose-effect of subcutaneous injection of bee venom on persistent nociception,pain hypersensitivity and inflammatory responses in rats

Quantitative evaluation of dose-effect of subcutaneous injec...

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Jia-Rui ZHANG~1,Yun-Fei LV~1,Yan WANG~1,Jun CHEN~(1,2,*) 1 Institute for Biomedical Sciences of Pain and Institute for Functional Brain Disorders,Tangdu Hospital,The Fourth Military Medical University,Xi'an 710038,China 2 Institute for Biomedical Sciences of Pain,Capital Medical University,Beijing 100069,China

Objective The bee venom test has long been used to evaluate the antinociceptive,antihyperalgesic and anti-inflammatory effects of endogenous and exogenous substances,however,the dose-effect of subcutaneous(s.c.) injection of bee venom on each pain-related behavior has not been ***,in the current report we used six doses(0.001,0.005,0.01,0.05,0.1,and 0.2 mg in 50 uL)of bee venom solution to see whether there are differences in *** Quantitative methods were used for evaluation of each pain-related *** the number of paw flinches of each 5-min time block from 0-60 min was used to evaluate the intensity of persistent spontaneous nociception,while paw withdrawal thermal latency(PWTL,s)and paw withdrawal mechanical threshold (PWMT,g)were used to evaluate thermal and mechanical hyperalgesia,*** of paw volume, cross-dimensional paw thickness,skin temperature and volume of plasma extravasation were used to evaluate local inflammatory *** Generally,there were significant differences in peak responses between persistent spontaneous nociception,PWTL,PWMT,and local inflammation following *** of bee ***, there was a dose-dependent effect of bee venom on the number and time period of paw flinches,and the dose-effect curve showed a typical 'S' that reached plateau at 0.1 ***,the peak%maximal possible effect(MPE)of bee venom on the reduction in PWTL and PWMT at 2 h after injection was caused by different doses of bee venom, namely 0.05 mg for PWTL and 0.01 mg for *** results suggest that the dose required for%MPE is different from each other in terms of persistent spontaneous nociception,thermal hyperalgesia and mechanical hyperalgesia. Furthermore,the dose for%MPE of four quantitative measurements was also different between paw volume(or thickness),plasma extravasation and skin *** dose of 0.1 mg was required for%MPE of both paw volume and paw thickness,while

关键词： bee venom test dose-effect persistent spontaneous nociception thermal hyperalgesia mechanical hyperalgesia local inflammation

来源：评论

学校读者我要写书评

暂无评论

Thirty minute transcutaneous electric acupoint stimulation modulates resting state brain activities:a perfusion and BOLD fMRI study

Thirty minute transcutaneous electric acupoint stimulation m...

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Yin JIANG,Ying HAO,Yue ZHANG,Jing LIU,Xiao-Ying WANG,Jisheng HAN,Jing FANG, Jue ZHANG,Cai-Lian CUI 1 Neuroscience Research Institute,Peking University Department of Neurobiology,School of Basic Medical Sciences, Peking University Key Laboratory of Neuroscience,The Ministry of Education and Ministry of Public Health,Beijing, China 2 Academy for Advanced Interdisciplinary Studies,Peking University,Beijing,China 3 Department of Engineering,Peking University,Beijing,China 4 Department of Radiology,Peking University First Hospital,Beijing,China

Objective Increasing neuroimaging studies have focused on the sustained after effects of acupuncture, especially for the changes of brain activities in ***,short-period stimuli have mostly been chosen in these *** present study attempted to investigate how resting state brain activities in healthy subjects were modulated by relatively long-period(30 min) acupuncture,a widely used modality for clinical *** Transcutaneous electric acupoint stimulation(TEAS) or intermittent minimal TEAS(MTEAS) were given for 30 min to 10 subjects with at least 3 months *** MRI(fMRI) data were collected including the pre-stimulation resting state and post-stimulation resting state,using arterial spin labeling(ASL) techniques,representing both cerebral blood flow(CBF) signals and blood oxygen-dependent level(BOLD) signals ***(1) While mean global CBF was not altered by TEAS or MTEAS,pain-processing,decision making and impulsive related brain regions(primary and secondary somatosensory cortex,posterior insula and lateral prefrontal cortex) showed more deactivation after 30 min TEAS as compared to MTEAS.(2) Analysis of BOLD signals revealed that TEAS,but not MTEAS,produced an increased functional connection between posterior cingulate cortex and anterior cingulate cortex, a brain region involved in anti-nociceptive,attention and *** Our results implied that modulation of these regional brain activities and brain network may relate to acupuncture analgesia as well as other acupuncture-associated therapeutic ***,the resting state regional CBF quantified by ASL perfusion fMRI may serve as a potential biomarker in future acupuncture studies.

关键词： acupuncture transcutaneous electric acupoint stimulation(TEAS) sustained after effect resting state cerebral blood flow(CBF) functional connectivity

来源：评论

学校读者我要写书评

暂无评论

Myosin X regulates Cdc42 activity downstream of PI3K in neuronal polarization

Myosin X regulates Cdc42 activity downstream of PI3K in neur...

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Hua-Li YU,Nan-Nan WANG,Yan YANG,Jian-Hua ZHANG,Xing-Da JU,Ming-Ming LAI,Xiao-Juan ZHU~* Laboratory of Neural Plasticity,Institute of Genetics and Cytology,Northeast Normal University,Changchun,130024, China

Objective Typical mature neurons usually have highly polarized *** polarization of axon and dendrites underlies the unidirectional flow of information transfer,which is essential for the establishment of functional circuits in the central nervous *** polarization depends on cytoskeleton reorganization. Myosin X(Myo X),a vertebrate-specific unconventional myosin,is not only capable of binding actin and microtubule, but also interacting with cytoskeleton regulators,such as PIP3 and Mena/*** this study,we engaged in studying the potential role of Myo X in neuronal *** The primarily culture system of dissociated rodent hippocampal neurons together with electroporation is applied to loss-of-function *** then analyzed stable and dynamic microtubules in Myo X-suppressed neurons by staining for acetylated and tyrosinatedα-*** dissect the molecular mechanism underlying Myo X-mediated axon specification,we constructed series of truncated mutations and tested their effect on neuronal *** experiments were performed by cotransfecting P110,Rap1Bv12 or Cdc42L28 with Myo X ***-Cdc42 and Myo X siRNA or scramble siRNA were cotransfected into NIH 3T3 cells and pull-down assay was performed to test *** Suppressing the expression of Myo X inhibited axon formation and the majority of Myo X-suppressed neurons arrested in stage 2. However,microtubule stabilization in one neurite was still higher than others suggesting that Myo X functioned in axon outgrowth and *** addition,in respect that cytochalasin D rescued the polarity defect caused by Myo X knockdown,we presume that Myo X participate in neuronal polarization via actin signaling *** X acted downstream of PI3K through PH domain in a motor-independent ***42L28 rescued the loss of polarity caused by Myo X siRNA and pull-down assay revealed that Myo X siRNA suppressed Cdc42 *** Myo X regulates Cdc42 act

关键词： neuronal polarity Myo X Cdc42

来源：评论

学校读者我要写书评

暂无评论

Different roles of Notch signaling in the development of dorsal root ganglion and trigeminal ganglion

Different roles of Notch signaling in the development of dor...

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Ze-Lan HU~1,Ming SHI~2,Ying HUANG~1,Min-Hua ZHENG~3,Zhe PEI~1,Jia-Yin CHEN~1,Hua HAN~3,Yu-Qiang DING~(1,*) 1 Department of Anatomy and Neurobiology,Tongji University School of Medicine,1239 Siping Road,Shanghai 200092,China 2 Department of Neurology,Xijing Hospital,Fourth Military Medical University,Xi'an 710032,China 3 Department of Medical Genetics and Developmental Biology,Fourth Military Medical University,Xi'an 710032, China

Somatosensory ganglia including dorsal root ganglion(DRG) and trigeminal ganglion(TG) are derived from a common pool of neural crest stem cells(NCCs),and are good systems to study the mechanisms of neurogenesis and *** signaling is known to play important roles in DRG and TG development,but the full scope of Notch functions in mammalian DRG and TG development remains poorly *** the present study,we used Wnt1-Cre to conditionally inactivate the transcription factor Rbpj,a critical integrator of activation signals from all Notch receptors,in NCCs and their derived *** of Rbpj caused the up-regulation of NeuroD1 and precocious neurogenesis in DRG early development but led to an eventual deficit of sensory neurons at later stages, due to reduced cell proliferation and abnormal cell *** addition,gliogenesis was delayed initially,but a nearcomplete loss of glia was observed finally in Rbpj-deficient ***,the phenotypes in TG show big differences compared with those in DRG in Rbpj CKO *** deletion of Rbpj also resulted in a reduction of sensory neurons at E16.5 in the TG,the precocious neurogenesis was not observed in TG early development. Furthermore,the initial gliogenesis at E10.0 in TG is also defective in the absence of Rbpj,but the normal distribution of glial cells was observed at E16.5 in the TG which contrasts with the complete loss of glial cells in the *** reason why the glial cells recover to the normal distribution density at later stages remained to be *** together,our data further elucidate the essential role of Rbpj in neurogenesis and gliogenesis during DRG and TG *** differences in phenotypes between DRG and TG indicate the function of Rbpj is diversified and context-dependent.

关键词： Notch signaling dorsal root ganglion trigeminal ganglion neurogenesis

来源：评论

学校读者我要写书评

暂无评论

Amyloid-β peptide induces mitochondrial oxidative stress damage in SH-SY5Y neuroblastoma veils

Amyloid-β peptide induces mitochondrial oxidative stress da...

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Han-Chang HANG~(1,2),Chang-Jun LIN~1,Zhao-Feng JIANG~(1,2,*) 1 College of Arts and Sciences,Beijing Union University,Beijing 100191,China 2 Beijing Key Laboratory of Bioactive Substances and Functional Foods,Beijing Union University,Beijing 100191, China

Objective Alzheimer's disease（AD） is one of the most common forms of neurodegenerative disease. Amyloid-P（AB） is considered as a centre molecule and plays a key role in AD pathological *** accumulating aggregation of Aβin neuritic plaques incurs neuronal oxidative damage,neurofibrillary tangles,and loss of hippocampal neurite,synapse and *** elevated oxidative stress is thought to be associated with the age-related *** elevated oxidative stress is also thought to be a key event on the Aβ-induced ***,the pathways of Aβ-induced oxidative damages are under *** processing of energy metabolism is a key way to generate reactive oxygen species（ROS）,which are the free radicals damaging biomolecules. Cell energy is mainly generated in mitochondria,which plays an important role in cell energy metabolism. In this study,we investigated Aβ-induced oxidative damages on neurons and sub-cellular structures,especially on mitochondria,based on our work and on the recent research progress worldwide on the relations between oxidative stress and Alzheimer's *** Cortical neurons or SH-SY5Y cells were cultured at 37℃for 7 *** the culture medium was removed,the cultured cortical neurons were incubated with fresh culture medium containing 5,10 umol/L Aβ,at 37℃in a humidified *** changes of cells were detected using a microscope at differential interference contrast（DIC） model,and the chromatin condensation of cultured cells was detected by the staining assay of nucleus with Hoechst 33342 dye（a molecular probe）.The hyperphosphorylation of Tau and GSK- 3beta activity were detected by Western blot *** viability was assessed by MTT,Hoechst 33342 assay and lactate dehydrogenase（LDH） assay,and the ROS levels were detected by ROS assay based on the ROS-mediated conversion of nonfluorescent 2',7'-DCFH-DA into fluorescent *** free intracellular Ca2+ in cells was measured using the fl

关键词： Alzheimer's disease amyloid-β mitochondrial damage oxidative stress tau protein

来源：评论

学校读者我要写书评

暂无评论

Modulation of neuron Navl.2 channel by sigma-1 receptor agonist

Modulation of neuron Navl.2 channel by sigma-1 receptor agon...

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Xiao-Fei GAO,Chang-Long HU,Yan-Ai MEI~* Institutes of Brain Science,School of Life Sciences and State Key Laboratory of Medical Neurobiology,Fudan University,Shanghai 200433,China

Objective It has been shown that sigma-1 receptor modulated many biological function and play an important role in neuron signal *** Sigma-1 receptor widely expressed in central nervous system and periphery,the modulation of neuron Na channel isoforms by sigma-1 receptor has not been examined in detail. The present study is to explore the mechanism of neuron Nav1.2 channel modulation by sigma-1 *** Here,we investigated the effects of（+）-SKF 10047,a sigma-1 receptor specific agonist,on rat Navl.2 channel heterogenously expressed in human embryonic kidney cell line 293T *** currents of Navl.2 channel was recorded by whole-cell patch ***（1）100μM（+）-SKF 10047 significantly inhibits the Navl.2 current by 40%.（+）-SKF 10047-induced inhibitory effect on rNaV1.2 current was fast and reversible.（2）In addition to inhibiting the rNav1.2 current amplitude,（+）-SKF 10047 significantly accelerated the inactivation of rNav1.2 channels and shifted the steady-state inactivation curve toward to hyperpolarizing potential.（3）BD 1047,a sigma-1 receptor antagonist reduced the inhibitory effect on rNavl.2 current induced by（+）-SKF 10047.（4）Blocking PKA or PKC pathway by the conventional blockers H-89 or（Go6976）did not modified the effect of（+）-SKF 10047 on rNaV1.2 current.（5）Inhibiting Gas and Gai with NF 449 and NF 023,or by cholera toxin（CTX）and pertussis toxin（PTX）, also did not significantly changed the inhibitory effect of（+）-SKF 10047 on rNaV1.2 *** These results suggested that G-protein coupling receptor or PKA and PKC pathway was not associated with the effect of （+）-SKF 10047 on rNavl.2 *** the effect of（+）-SKF 10047 on rNavl.2 current operate through sigma-1 receptor or channel protein interactions will require further investigations.

关键词： rNav1.2 channel σ-1 receptor agonist (+)-SKF 10047 PKA PKC

来源：评论

学校读者我要写书评

暂无评论

Identification of a third promoter in human voltage-gated sodium channel SCNIA gene and repression of the promoter activity by a transcriptional repressor calsenilin/KChIP3/DREAM

Identification of a third promoter in human voltage-gated so...

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Yue-Sheng LONG~*,Guang-Fei DENG,Jia-Ming QIN,Qi-Hua ZHAO,Yong-Hong YI,Wei-Ping LIAO Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China,Institute of Neuroscience and the Second Affiliated Hospital of Guangzhou Medical University,Guangzhou 510260,China

Objective Voltage-gated sodium channel a subunit type I（Na1.1） is mainly expressed in the central nervous *** expression of SCN1A（encoding Na1.1） is associated with *** SCN1A promoters have been identified in human *** present study is to identify a third promoter of SCN1A and then to explore the functions of potential transcriptional elements in this *** The minimal functional promoter and potential transcriptional elements were identified by 5' truncating or 3' extending *** promoter activity was measured using the Dual-Luciferase Reporter Assay System（Promega）.Transcription factor and DNA flagment binding assay in vitro was performed using Electrophoretic mobility shift assay（EMSA）.Results（1） The third promoter fragment（P1c,nt -1023 to +52） showed a high activity in NGF-induced PC12 cells,but very low in SHSY5Y cells and HEK-293 cells.（2） The minimal functional promoter located within the region between nt -73 and nt +52.（3） The region nt +53 to nt +90 decreased the luciferase activity by～75%that of the minimal functional promoter. （4） EMSA assay using a transcriptional repressor DREAM and the DNA fragment ranging from nt +53 to nt +90 showed that the DNA fragment was retarded after overexpression of DREAM in HEK293 cells.（5） Further truncating analysis demonstrated that the region between nt +53 and nt +62 was the DREAM binding site and was responsible for repressing the promoter *** The Ca binding factor DREAM represses the third SCN1A promoter by binding the downstream repression element（DRE）,which implicates a potential role of Ca in the regulation of SCN1A expression in normal and diseased human tissues.

关键词： voltage-gated sodium channel promoter transcriptional regulation SCNIA epilepsy

来源：评论

学校读者我要写书评

暂无评论

Extensive brain structural network abnormality in first-episode treatment-naive patients with schizophrenia:Morphological and covariation study

Extensive brain structural network abnormality in first-epis...

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Siew E Chua Charlton Cheung Grinne M.McAlonan Pak C Sham David A Collier Marco Picchioni Stefania Benetti Andrea Mechelli Nicolas Crossley Joseph P.Kambeitz Paul Allen Philip McGuire Department of Psychiatry The University of Hong KongPokfulamS.A.R.China MRC SGDP Centre Institute of PsychiatryKing's College LondonLondon SE5 8AFUK Division of Psychological Medicine and Psychiatry Section of NeuroimagingInstitute of PsychiatryKing's College LondonLondon SE5 8AFUK St Andrew's Academic Centre Institute of PsychiatryKing's College LondonNN1 5BG Department of Psychosis Study Institute of PsychiatryKing's College LondonLondon SE5 8AFUK

Objective With a particular focus on putative cortico-striatal-thalamic-cortical(CSTC) networks current study aimed to explore robust gray matter volume(GMV) changes in non-medicated first-episode schizophrenia(FES) *** High-resolution T1-weighted images were obtained using 3.0 Tesla magnetic resonance imaging from 86 first-episode drug-naive schizophrenia patients and 86 healthy controls(CON).Severity of symptoms in patients was evaluated by using Positive and Negative Syndrome Scale(PANSS).Fourteen spherical region of interest (ROI) GMV in the CSTC loop were acquired after optimized voxel-based morphometry(VBM) *** of Spherical ROIs and corresponding correlation coefficients were compared between FES and CON *** associations of GMV with PANSS subscale score and symptom dimension scores were also *** GMV reduction was detected in bilateral hippocampus in FES group by VBM *** located in left inferior frontal gyrus(Brodmann's area 47) and right thalamus(medial dosal nucleus) present GMV *** of ROIs revealed more extensive GMV loss and disassociation between *** Our study support that schizophrenia involves distributed rather than focal pathology and disordered *** analysis could make compensation to VBM and ROI method to uncover more subtle aberrations in regional correlation.

关键词： Extensive brain structural network abnormality in first-episode treatment-naive patients with schizophrenia:Morphological and covariation study

来源：评论

学校读者我要写书评

暂无评论

没有更多数据了...

全选清除本页清除全部题录导出标记到“检索档案”

共83页 << < 71 72 73 74 75 76 77 78 79 80 > >>

检索报告对象比较合并检索0

隐藏清空

合并搜索

回到顶部

执行限定条件

内容：

评分：

请选择保存的检索档案：

请选择收藏分类：

订阅名称：

通借通还

温馨提示：

图书名称：

借书校区：

取书校区：

手机号码：

邮箱地址：

一卡通帐号：

电话和邮箱必须正确填写，我们会与您联系确认。

联系人：

所在院系：

联系邮箱：

联系电话：

内蒙古自治区呼和浩特市赛罕区大学西街235号邮编: 010021

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：