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Anterior cingulate cortex substitutes for the impaired retrieval role of prelimbic cortex in trace eyeblink conditioning

Anterior cingulate cortex substitutes for the impaired retri...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Guang-Yan WU~(1,2,3),Zheng-Li FAN~2,Xuan LI~2,Bing WU~2,Rui FAN~4,Jian-Feng SUI~(1,2,*) 1 Department of Physiology,College of Basic Medical Sciences,Third Military Medical University,Chongqing 400038, China 2 Experimental Center of Basic Medicine,College of Basic Medical Sciences,Third Military Medical University, Chongqing 400038,China 3 The Second Team of Cadet Brigade,Third Military Medical University,Chongqing 400038,China 4 Department of Rehabilitation,the Second Affiliated Hospital,Chongqing Medical University,Chongqing 400010, China

Objective It has been suggested that the anterior cingulate cortex(ACC) and prelimbic cortex(PL) of medial prefrontal cortex(mPFC) have critical roles in the acquisition and retrieval(expression) processes of trace eyeblink conditioning(TEC),*** was also reported that re-training after PL lesions following initial learning could recover the impaired behavioral *** on these results,we hypothesized that ACC substituted for the impaired retrieval role of PL in *** present study is to investigate(1) the hypothesis of TEC retrieval substitution and(2) the natural roles of ACC and PL in *** Lidocaine hydrochloride(LH) or saline was microinfused into ACC,or PL,or both ACC and PL after daily pre-infusion session training following 8 days initial acquisition ***(1) Infusion of lidocaine into area 24 does not significantly affect TEC expression.(2) Area 24 infusions affect TEC acquisition as evidenced by a difference in pre-infusion and post-infusion performance between sham and lesion groups that develops over several infusion days.(3) Area 32 infusions have immediate effect on TEC expression.(4) The expression deficits with area 32 infusions fades over 5 infusion sessions,and(5) subsequent dual infusions into both regions produces immediate deficits that do not *** The results support our hypothesis of substitution and also indicate that reversible inactivation of ACC prevented the acquisition of TEC but did not affect its retrieval,whereas reversible inactivation of PL caused significant deficits in retrieval of TEC,but did not affect its acquisition.

关键词： guinea pig lidocaine hydrochloride medial prefrontal cortex retrieval substitution reversible inactivation trace conditioning

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Effects of electromagnetic radiation on learning and memory abilities of rats and its mechanisms

Effects of electromagnetic radiation on learning and memory ...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Chang-Hua SHI,Guo-Bing LU,Yu-Hong LI~*,Qian XU,Zhuo ZHANG Department of Pathology,Chengde Medical College,Chengde 067000,China

Objective Main parameters which effect the electromagnetic radiation health include frequency and *** effects of electromagnetic wave sources of different frequency are *** health effects of microwave exposure by thermalizing have been generally accepted,while health effects of long term low intensity exposure remain controversial,*** 900 MHz GSM *** survey indicates that the electromagnetic radiation can cause the excessive contact of the central nervous system and plant nerve dysfunction. Animal experiments show that the electromagnetic radiation can cause learning and memory and cognitive disabilities. The present study is to evaluate the effects of electromagnetic radiation of 2000μW/cm exposure on expression of immunoreactive protein and mRNA of NR1 and NR2B subunits in rats hippocampal,and reveal the mechanisms of injury of electromagnetic irradiation to weaken the learning and memory abilities of *** Rats were randomly divided into normal control group,sham-radiated group,and 1 h/d,2 h/d,and 3 h/d radiation *** rats in the radiation groups were fixed after microwave exposure of 2000μW/cm,then their learning and memory abilities were tested by Morris water maze experiment,the change of NR1 and NR2B proteins in hippocampal neurons of each group of rats were measured with immunohistochmistry and western blot techniques,and the expressions of NR1 and NR2B mRNA in hippocampus were determined by *** Compared with the normal control group,there had no obvious differences in the sham-radiated group（P>0.05）,while the platform-finding time of rats of radiated group in Morris water maze test were significantly longer（P<0.05）.In the radiation group,the hippocampal neurons of rats showing evident reduction in the ratio of NR1 and NR2B positive cells,irregular,and arrayed in ***,the expessions of NR1 and NR2B protein and mRNA in hippocampal neurons were significant decreased（P<0.

关键词： Effects of electromagnetic radiation on learning and memory abilities of rats and its mechanisms

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The effect of transcutaneous electrical acupoint stimulation for children with autism and its possible relation with plasma level of AVP and OXT:A prospective single-blinded controlled study

The effect of transcutaneous electrical acupoint stimulation...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Rong ZHANG~1,Mei-Xiang JIA~2,Xin-Jie XU~1,Xiao-Jing SHOU~1,Ji-Sheng HAN~(1,*) 1Neuroscience Research Institute,Peking University,38 Xueyuan Road,Beijing 100191,China 2Peking University Institute of Mental Health,51 Huayuan North Road,Beijing 100191,China

Objective To study the efficacy of transcutaneous electrical acupoint stimulation(TEAS) on rehabilitation training for children with autism and primary *** One hundred and twenty four autistic children receiving rehabilitation training were divided into a control group(n=39) and a TEAS treatment group(n=37).The control group received rehabilitation training,the treatment group received TEAS for 60 sessions after rehabilitation *** Autism Rating Scale(CARS),Autism Behavior Checklist(ABC),Aberrant Behavior Checklist (AbBC),Adaptive Deviation Quotient(ADQ),Sleep status questionnaire and Food choice questionnaire were used for outcome ***(1) The total scores of CARS(P<0.05) and ABC(P<0.05) decreased significantly after TEAS intervention,specifically in Emotion(P<0.05),Anxiety(P<0.01) and Intelligence(P<0.05) factors in CARS, Sense(P<0.01) and Social communication(P<0.01) factors in ABC.(2) The kinds of rejected food reduced after TEAS treatment(P<0.05),especially in vegetables(P<0.05),fruits(P<0.01) and snacks(P<0.05).(3) TEAS was more effective on children with passive(P<0.05) but not active-but odd social interaction style.(4) The plasma argininevasopressin (AVP) increased after TEAS treatment(P<0.01).(5) The plasma oxytocin(OT) decreased in both groups after 3 months' intervention,and less decrease were found in TEAS group(P<0.05).(6) The change of plasma AVP was positive correlation with Interpersonal communication(P<0.05),Auditory(P<0.05) and Sense(P<0.01) factors in CARS. Conclusion TEAS combined with habilitation training has a better therapeutic effect than that of simple rehabilitation training for autistic children with passive social interaction style,and which was related with plasma AVP and OT.

关键词： autism TEAS AVP OT

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Effects of estrous cycle on the HPA-axis response to stresses

Effects of estrous cycle on the HPA-axis response to stresse...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Jing LU,Ling-Juan RUAN,Jia LI,Ai-Min BAO~* Deparment of Neurobiology,Key Laboratory of Medical Neurobiology of Ministry of Health of China Zhejiang Province Key Laboratory of Neurobiology,Zhengjiang University School of Medicine.Hangzhou 310058,China

Objective There is a close interaction between the hypothalamo-pituitary-adrenal(HPA)-axis and the hypothalamo-pituitary-gonadal(HPG)-axis,which was presumed to be the basis for the higher prevalence of mood disorders in women as compared to *** addition,the HPA-axis activity is affected by sex *** present study aimed to investigate if the fluctuations in peripheral sex hormones levels among different estrous cycle stages in rats may affect the HPA-axis responses to acute(foot shock,FS) or chronic stressors(chronic unpredicted stress,CUS). In addition,changes in the mRNA levels of a number of related hormone receptors,aromatase and neuropeptides were determined in the *** Via vaginal smear,female Sprague-Dawley(SD) rats[(240±10) g]were randomly divided into 8 groups:control(= no interference) proestrus group(CP,n = 7),control diestrus(CD,n = 6), proestrus rats following foot shock(FSP,n = 4),diestrus rats following foot shock(FSD,n = 5),CUS proestrus rats (CUSP,n = 1)(because of the disorder of estrous cycle,we just catch 1 sample,but we will add samples in the future), CUS diestrus rats(CUSD,n = 10),CUS proestrus rats following foot shock(CUFSP,n = 8),and CUS diestrus rats following foot shock(CUFSD,n = 7).Trunk plasma,hippocampus and hypothalamus were collected after decapitation of the *** levels of estradiol,testosterone and corticosterone were measured by radioimmunology assay or by enzyme-linked immunosorbent *** mRNAs expression of hypothalamic estrogen receptors,androgen receptor, aromatase,mineralocorticoid receptor,glucocorticoid receptor,corticotrophin releasing hormone,vasopressin and oxytocin were determined by real-time quantitative ***(1) The estrous cycle of CUS rats showed as an obvious disorder an extended diestrus stage;(2) The weight of hippocampus of CUS rats was significantly decreased compared with controls;(3) Testosterone levels were found to decrease significantly both in the acute stress(F

关键词： sex hormones HPA-axis stress

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Protective effect of Hv in transgenic drosophila models of SC A3/M JD

Protective effect of Hv in transgenic drosophila models of S...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Hong JIANG~(1,2,*),Ji-Ping YI~1,Bei-Sha TANG~(1,2) 1 Department of Neurology,Xiangya Hospital,Central South University,Changsha 410008,China 2 Neurodegenerative Disorders Research Center,Central South University,Changsha 410008,China

Objective Spinocerebellar ataxia type 3/Machado-Joseph disease(SCA3/MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of polyglutamine tract near the C-terminus of the MIDI gene product,ataxin-3.A growing body of evidence demonstrates that aberrant activity of histone deacetylases or histone acetyltransferase might be an underlying mechanism of transcriptional dysregulation in polyQ diseases including SCA3/MJD,which suggests that the balance of histone acetylation is a good target for therapeutic intervention of polyQ *** studies have shown a therapeutic role for HDAC inhibitors(HDACIs) as candidate drugs for the treatment of polyQ ***,the effects of HDACIs(Hv,confidential now) on models of SCA3/MJD have never been *** present study is to illustrate the therapeutic potential of Hv in SCA3/MJD transgenic Drosophila *** GAL4AJAS system SCA3/MJD transgenic Drosophila models were constructed by using the promoter gmr-GAL4 and elav-GAL4 which drive target selective gene expression in developing eyes and neurons,*** observing was used to understand the effect of Hv on the eye morphology,lifespan and climbing ability of SCA3/MJD transgenic Drosophila *** The loss of pigmentation and collapse of the eyes of SCA3/MJD transgenic Drosophila models were mitigated by feeding *** climbing ability was obviously improved especially by dosage of 1 mM or 1.5 *** of 0.5 mM could extend their lifespan. Conclusions SCA3/MJD transgenic Drosophila models were successfully constructed,which selectively express human MJDtr-Q78 protein with different levels in developing eyes or neurons *** was further confirmed that the expression level of MJDtr-Q78 protein are concerned to the severity of SCA3/MJD *** was also found that proper dosage of Hv has therapeutic potential in these models.

关键词： polyQ diseases SCA3/MJD ataxin-3 transgenic Drosophila models histone deacetylase inhibitors

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HuD regulates the cpg15 expression via the 3'-UTR and AU-rich element

HuD regulates the cpg15 expression via the 3'-UTR and AU-ric...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Zhong-Hui WANG,Shu-Jing LI,Yao Qi,Jing-Jing ZHAO,Xiao-Yan LIU,Ping XU,Xian-Hua CHEN~* State Key Laboratory of Medical Neurobiology,Shanghai Medical College,Fudan University,Shanghai 200032, China

Objective The candidate plasticity related gene 15(cpg15)is a neural-specific expressed gene which is induced by neurotrophins as well as the injury of neurons,and plays important roles in neural development and ***,the mechanism by which the cpg15 expression is regulated remains largely *** present study is to investigate whether the 3'-untranslated region(UTR)play roles in regulating the expression of the candidate plasticity related gene 15(cpg15)gene and whether HuD,a neural-specific RNA binding protein,is involved in the *** The rat cpg15 coding sequence followed with or without its 3'-UTR or the ARE were inserted downstream the GFP coding sequence in the pEGFP-C2 vectors,and the recombinant vectors were used to express the GFP-cpg15 fusion gene in SH-SY5Y *** expression levels of GFP-cpg15 mRNA in the transfected cells were detected by real-time RT-PCR,and the GFP-CPG15 fusion proteins were detected by Western blotting using anti-GFP *** binding of HuD protein to the cpgl5 mRNA in neural cells was analyzed by RNA- binding protein immunoprecipitation(RIP).Results(1)The presence of the 3'-UTR significantly decreases,while loss of the putative ARE in the 3'-UTR increases the cpg15 expression.(2)Over-expression of HuD increased the cpg15 expression,which depends on the presence of the 3'-UTR and the ARE.(3)HuD forms a complex with cpg15 mRNA in the cells of rat hippocampus.(4)Deletion of HuD domains RRM1 plus RRM2 or Hinge region plus RRM3 attenuates the function of HuD in enhancing the cpgl5 *** HuD regulates the cpg15 expression via the 3'-UTR-mediated mechanism,which requires the presence of the ARE.

关键词： cpg15 HuD regulate expression ARE 3'-UTR

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mGluR6 deletion downregulates the TRPMl channel in retinal ON bipolar cells and renders the cells hyperpolarized

mGluR6 deletion downregulates the TRPMl channel in retinal O...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Marie FINA Anuradha DHINGRA Chieko KOIKE Takahisa FURUKAWA Noga VARDI Department of Neuroscience University of PennsylvaniaPhiladelphiaUSA Pharmaceuti.Sci. Ritsumeikan Univ.ShigaJST PRESTOJapan Dev.Biol Osaka Biosci.Inst.OsakaJST CRESTJapan

In darkness,glutamate released from photoreceptors activates the mGluR6 receptor on retinal ON bipolar cells,and this activates the G-protein Go,leading to a closure of TRPM1 channel and cells' *** has been generally assumed that deleting mGluR6 would render the cascade inactive and ON bipolar cells constitutively ***,in mGluR6-null mice,we found that the rod bipolar cells were constitutively hyperpolarized. The slope conductance of theⅠ-Ⅴcurves and the current noise were smaller than in wild ***,while in wild type it was possible to activate TRPM1 by local application of the TRPV1 agonist capsaicin(in 6/15 cells),in null rod bipolar cells such attempts failed(32 cells).These results suggest that the TRPM1 channel in mGluR6 null rod bipolar cells is *** explore the reason for this lack of activity,we tested whether deleting mGluR6 affects the expression of the cascade *** for G-protein subunit candidates Gαo,Gβ3 and Gγ13 showed no significant change in their expression or *** expression of the channel itself,we found that TRPM1 was expressed in mGluR6-null ON bipolar cells' somas,but absent from their dendritic *** absent from the dendritic tips of the null rod bipolar cells were the Gαo modulators Gβ5 and *** also looked at the expression of cascade elements in Gao-null rod bipolar cells because they too maintain a hyperpolarizing resting potential. In this retina,mGluR6 expression appears normal,but Gβ3,Gγ13,and TRPM1 are *** TRPM1 is constitutively active,its downregulation cannot explain total lack of *** is therefore possible that TRPM1 in mGluR6- or Gαo1-null rod bipolar cells fails to reach the plasma membrane,or,if it does,it may lack a factor that is required for its opening.

关键词： retinal ON bipolar cell TRPMl mGluR6

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RU486(mifepristone) ameliorates cognitive dysfunction and reverses the down-regulation of astrocytic n-myc downstream-regulated gene 2(NDRG2) in streptozotocin-induced type 1 diabetic rats

RU486(mifepristone) ameliorates cognitive dysfunction and re...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Zhong-Fu ZUO~(1,2),Wen WANG~1,Le NIU~1,Zhen-Zhen KOU~1,Chao ZHU~1,Wei WANG~1,Xiao-Hui ZHAO~1, Dao-Shu LUO~1,Ting ZHANG~1,Fu-Xing ZHANG~1,Sheng-Xi WU~(1,*),Yun-Qing LI~(1,*) 1 Department of Anatomy,Histology and Embryology and K.K.Leung Brain Research Centre,The Fourth Military Medical University,Xi'an 710032,China 2 Department of Anatomy,Liaoning Medical College,Jinzhou 121000,China

Objective Diabetic cognitive dysfunction(DCD),usually accompanied with chronically elevated glucocorticoids and hippocampal astrocytic alterations,is one of the most serious complications in patients with type 1 ***,the role for chronically elevated glucocorticoids and hippocampal astrocytic activations in DCD remains to be elucidated,and it is not clear whether astrocytic N-myc downstream-regulated gene 2(NDRG2,involved in cell differentiation and development) is participated in *** present study is to explore the potential role of elevated glucocorticoids,astrocytes and NDRG2 for *** Three months after streptozotocin(STZ)-induced type 1 diabetes onset,rats received 9-day administration of glucocorticoids receptor(GR) antagonist,RU486, at doses of 10,25 or 40 mg/*** cognitive function was detected by Morris water maze,serum corticosterone was investigated by radio immuno assay,and the alterations of glial fibrillary acidic protein(GFAP,a key indicator of astrocytic reactivity) and NDRG2 in hippocampus were revealed by immunohistochemistry staining,real-time PCR and Western *** Three months after diabetes onset:(1) Diabetic rats develop remarkable cognitive impairments and elevated serum corticosterone level;(2) Diabetic rats show significant down-regulation of GFAP and NDRG2 in hippocampus;(3) Nine-day administration with RU486 at dose of 25 mg/kg ameliorates DCD and reverses the expression of hippocampal GFAP and NDRG2 *** Glucocorticoids-GR system is crucial for DCD,astrocytic reactivity and NDRG2 are involved in these processes.

关键词： diabetic cognitive dysfunction GFAP glucocorticoids receptor N-myc downstream-regulated gene 2 RU486

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Expression and effect of FPl in the PVL model in vitro

Expression and effect of FPl in the PVL model in vitro

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Qing LIN,Wei WANG Fujian Medical University,Fuzhou 350004,China

Objectives(1) To obtain pure and primary cultured oligodendtocyte/type-2 astrocyte(O2A) progenitors from cortices of neonatal rats.(2) To determine the expression and function of FPl on the primary cultured O2A progenitors.(3) To establish the feasible hypoxic-ischemic PVL model in vitro.(4) To ascertain the expression and effect on the PVL model in ***(1) The O2A progenitors were isolated and primarily cultured from the cortices of neonatal SD rats by twice shaking and using the conditioned *** morphologies of O2A were observed under inverted phase-contrast *** the immunofluorescence staining was used to identify and determine the purity of the cells.(2) Double-label immunofluorescence assay was used to investigate the expression of FPl on the O2 A progenitors and iron efflux test was used to explore the function of FP1.(3) O2A progenitors were treated with Oxygen-glucose deprivation(OGD) for 3,6,12,24 h to mimic hypoxic-ischemic PVL in vitro and their morphologies were observed under inverted phase-contrast *** survival rate of O2A progenitors was investigated by CCK-8 method and testing the lactate dehydrogenase(LDH) leakage.(4) The level of FP1 in the PVL model in vitro was tested by real time PCR and Western ***(1) O2A progenitors were round or oval with strong *** had monopolar,dipolar or tripolar processes,which were fine and straight with no branches. O2A progenitors were A2B5 positive cells and their purity is up to 95%.(2) Double-label immunofluorescence assay showed that O2A progenitors can express FP1,which was located in the cell membrane,body and processes.(3) Iron efflux test showed that the immunofluorescence intensity increased with time-dependence in the routine cultured and 0X42 antibody treated O2A progenitors(P>0.05).While the immunofluorescence intensity of FP1 antibody treated cells did not increase with time.(4) After OGD 3 h,6 h,12 h and 24 h,the morphologies of O2A progenitors had

关键词： FP1 PVL oxygen-glucose deprivation O2A progenitors

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The study of P2X3 receptor role in neonatal rat DRG neurons in pain development

The study of P2X3 receptor role in neonatal rat DRG neurons ...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Lu DU,Wen-Juan HE,Jian CUI,Yan-Dong ZHAO,Huai-Zhen RUAN~* Department of Neurobiology,College of Basic Medical Sciences,Chongqing Key Laboratory of Neurobiology,Third Military Medical University,Chongqing 400038,China

Objective P2X3 receptor plays important role in the onset and persistence of pain,recent study have shown that P2X3 receptor also plays roles during individual *** we want to figure out whether pain in neonatal rat affects the expression level of P2X3 receptor in primary sensory neurons during development,and explore the potential mechanisms *** Rats of postnatal 3,7,14,21,28 d and adult rats all received CCI (chronic constriction injury) operation in the left sciatic nerve,the right nerve received sham *** threshold (TWL and PWT) was assayed by thermal radiation and von Frey filament before and 1,3,7,14,21,28 days after *** of P2X3 receptor in DRG of every group was measured by immunohistochemical staining(IHC), and the expression level was *** statistical calculations were performed usingthe SPSS statistical package(SPSS,Chicago,USA).Results(1) After operation,thermal hyperalgesia and mechanical allodynia appeared on the neonatal and adult rats,and the change pattern of pain threshold in neonatal and adult rats is similar. The TWL and PWT decreased obviously from 1 d,descended to the lowest at 14 d post-operation,then returned to the normal level after 28 d post-operation.(2) The expression of P2X3 receptor in adult rat DRG increased obviously from 1 day post-operation and lasted for 21 days,and returned to the normal level after 28 days;while the expression of P2X3 receptor in neonatal rats DRG dropped obviously in all *** P2X3 receptor plays an important role in the incidence and development of pain and nervous *** the result suggests that pain stimulus might affect the development of neonatal nervous system.

关键词： DRG pain P2X3 receptor development

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