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Study of dendritic integration rule

Study of dendritic integration rule

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： David CAI Shanghai Jiao Tong University

It has been discovered in experiments recently that the dendritic integration of excitatory glutamatergic inputs and inhibitory GABAergic inputs obeys a simple arithmetic rule in pyramidal *** somatic response can be well described by a linear sum of the excitatory postsynaptic potential(EPSP),the inhibitory postsynaptic potential(IPSP),and a nonlinear term proportional to their product(k*EPSP*IPSP),where the shunting coefficient k depends on the spatial location of excitatory input and inhibitory *** demonstrate both theoretically and numerically that the above dendritic integration rule can be explained by sub-threshold membrane potential dynamics as characterized in the standard Integrate-and-Fire *** order to account for spatial effects on the shunting coefficient k,we propose a simple modified Integrate-and-Fire model and our numerical results show that this model captures the phenomena as observed in experiments.

关键词： Study of dendritic integration rule

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Analyzing the optokinetic responses for detecting the effects of anxiolytic drugs on zebrafish larvae’s visual system

Analyzing the optokinetic responses for detecting the effect...

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Si-Jie CHEN,Gang PENG~* Institutes of Brain Science,Fudan University,Shanghai 200032,China

＜正＞Optokinetic response（OKR） is a reflexive response which is elicited by a slowly moving image across the *** stimulation is generated by a drum with black-white vertical stripes on its internal wall horizontally rotating around the *** treat 8-9 dpf larvae by either egg water or drugs for an hour before the *** larvae are then transferred to a 3.5 cm-diameter petri dish containing 6%methylcellulose at the center of the *** of the optokinetic responses are captured by CCD camera and processed by Image-J to analyze the effects of anxiolytic drugs on visual system.

关键词： OKR anxiolytic drugs visual system

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Translating neural control research into practice of stroke rehabilitation

Translating neural control research into practice of stroke ...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Ning LAN Institute of Rehabilitation Engineering,Med-X Research Institute,Shanghai Jiao Tong University,Shanghai 200030, China

Motor rehabilitation for stroke patients is a process of relearning of motor programs that are either damaged or destroyed in the *** of motor programs can be facilitated by external assistance provided to the neuromuscular *** training in patients with an induced movement that mimics normal motor activities can be benefit recovery of motor ***,functional electrical stimulation(FES) has been proven to be effective for motor *** are using computational methods to understand neural control of movement in normal human,and are developing a hybrid FES robotic device to perform training of stroke *** patterns of neuromuscular activation during movement will be translated into control strategy for FES *** presentation will review our recent work in stimulation of neural control and in the development of the hybrid FES robotic system.

关键词： Translating neural control research into practice of stroke rehabilitation

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Restoring hippocampal metaplasticity by rapid antidepressant ketamine

Restoring hippocampal metaplasticity by rapid antidepressant...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Pakming LAU CAS Key Laboratory of Brain Function and Disease School of Life ScienceUniversity of Science and Technology of ChinaHefei 230027China

＜正＞Recent studies indicate that ketamine,a noncompetitive NMDA receptor antagonist,can produce rapid antidepressant effects within hours that sustains for weeks in patients resistant to conventional antidepressants that increase central serotonergic（5-HT） *** ask whether and how ketamine modulates synaptic plasticity in the schaffer-CAl pathway of the hippocampus in rodents that is known to be involved in the pathology of major depressive disorder（MDD）.Using in vivo field potential recordings,we found that metaplasticity at schaffer-CAl pathway of the hippocampus is disrupted in forced swimming model of ***,after ketamine injection,metaplasticity in the same group of animals is restored to the level comparable to nai’ve animals,apparently through mTOR-dependent synaptic ***,the rapid antidepressant action of ketamine may be mediated by restoring metaplasticity at schaffer-CAl pathway of the hippocampus in rodents.

关键词： depression ketamine metaplasticity hippocampus

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Biology of olfactory entheashing cells in CNS regeneration

Biology of olfactory entheashing cells in CNS regeneration

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Cheng HE Institute of Neuroscience and Key Laboratory of Molecular Neurobiology of Ministry of Education,Second Military Medical University,Shanghai,China.

Olfactory ensheathing cells(OECs) are restricted to the primary olfactory system and are thought to be a unique class of glial *** development,OECs envelop olfactory axons as they project from the olfactory epithelium to the *** differ from typical glia by virtue of the fact that they are present in both the peripheral nervous system(PNS) and the central nervous system(CNS),and share some features and functions of astrocytes as well as Schwann *** is generally accepted that OECs contribute to the growth and targeting of olfactory axons during normal cell turnover and after *** have also emerged as prime candidates for cell transplant strategies for repairing neural *** the present study,we will discuss some molecular and cellular mechanisms of OECs on CNS regeneration.

关键词： olfactory ensheathing cells neural regeneration glial cells

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Neurexin is required for rhodopsin biosynthesis through promoting retinoid transport

Neurexin is required for rhodopsin biosynthesis through prom...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Yao TIAN,Didi WAN,Ming-Kuan SUN,Wen HU,Jun-Hai HAN~*,Wei XIE~* The Key Laboratory of Developmental Genes and Human Disease,Ministry of Education,Southeast University,2 Sipailou Road,Nanjing 210096,China

Vitamin A(all-frans-retinol) and other retinoids are critical for many physiological processes,such as visual pigment generation,development,cell proliferation and neuronal *** is a cell adhesion molecule involved in synapse formation and relates to autistic spectrum *** we report drosophila Neurexin is required for Rhl biosynthesis through promoting retinoids *** of Neurexin leads to reduction of Rhl level,which is due to impaired chromosphere *** further show mat Neurexin exists in the axon of photoreceptor neurons and is essential for retinoids transport from extra retinal to *** results reveal a novel role of Neurexin in facilitating retinoids transport and imply the potential relationship between retinoids function and autistic spectrum disorder.

关键词： Neurexin Rhodopsin retinoid glia autism

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α2A-adrenoceptors activation enhances excitability of pyramidal neurons in the medial prefrontal cortex of rats

α2A-adrenoceptors activation enhances excitability of pyram...

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Hou-Cheng ZHOU~1,Bao-Ming LI~(1,2,*),Xue-Han ZHANG~(1,*) 1 Institute of Neurobiology & State Key Laboratory of Medical Neurobiology,Institutes of Brain Science,Fudan University,Shanghai 200032,China 2 Center for Neuropsychiatric Diseases,Institute of Life Science,Nanchang University,Nanchang 330031,China

Stimulation ofα-adrenoceptors in the medial prefrontal cortex（mPFC）improves working memory *** improvement is accompanied by a selective increase in the activity of mPFC neurons during delay ***,the cellular mechanisms responsible for this enhanced response are largely *** the present study,we recorded action potential in the pyramidal neurons of mPFC slice,using whole-cell current clamp recording *** results show that stimulation ofα-adrenoceptors enhances intrinsic excitability of neurons.

关键词： α2A-adrenoceptors intrinsic excitability medial prefrontal cortex rat

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Information processing in auditory cortex

Information processing in auditory cortex

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Xiao-Qin WANG~(1,2) 1 Laboratory of Auditory Neurophysiology,Department of Biomedical Engineering,Johns Hopkins University 2 Department of Biomedical Engineering,Tsinghua University

In contrast to visual and somatosensory systems,the auditory system has a longer subcortical pathway between the sensory receptor and the cerebral *** unique organization reflects the needs of the auditory system to process complex acoustic signals using strategies that are different from those used by other sensory *** visual and somatosensory systems,the auditory system must also process signals that are self-produced such as human speech and animal vocalizations.I will discuss in my talk recent discoveries on cortical coding of acoustic information and neural mechanisms involved in vocal feedback control and learning in the primate brain.

关键词： auditory cortex hearing sensory system speech vocalizations marmoset

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The cell culture of forebrain neuron in zebrafish early stage embryos

The cell culture of forebrain neuron in zebrafish early stag...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Bin YANG,Gang PENG~* Institutes of Brain Science and State Key Laboratory of Medical Neuroscience,Fudan University,Shanghai 200032, China

Objective The zebrafish(Danio rerio),is an important model organism in nervous system development and animal behavior studies for its fast development and transparent embryos in early *** to in vivo methods,in vitro cell culture investigation approach has advantages in achieving higher resolution morphological observation and identifying typesof neurites with *** We use zebrafish early stage embryos to investigatefunctions of signal molecules and receptors for nervous *** have developed methods involving bleaching,digestion,dissociation,plating of forebrain neurons and followed by *** The cell culture of forebrain neuron in zebrafish early stage embryos provides a new way of studying nervous development.

关键词： Danio rerio forebrain neuron cell culture

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Cortical neural dynamics of auditory attention and its application in neural prosthesis

Cortical neural dynamics of auditory attention and its appli...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Bo HONG Department of Biomedical Engineering,School of Medicine,Tsinghua University

＜正＞The bottom-up and top-down attentional regulation plays an important role for auditory *** track the dynamics of cortical response in an auditory stimulus discrimination task,both scalp EEG recording on normal subject and intracranial EEG recording on epilepsy patients undergoing subdural electrode monitoring for surgical purpose are employed to map the attentional *** low frequency event-related potential and high gamma oscillations were analyzed to obtain the property of early passive components and late active responses respectively. Moreover,these cortical neural dynamics was detected in an online fashion by machine learning algorithms to establish an auditory brain-computer interface,which is potentially useful for locked-in patients with vision impairment.

关键词： auditory attention EcoG EEG neural prosthesis

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