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Synchrotron radiation based-FTIR microspectroscopy study of the striatum in 6-hydroxydopamine rat model of Parkinson's disease

Synchrotron radiation based-FTIR microspectroscopy study of ...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Hong-Yan ZHU~*,Xiao PEI,Ling-Yan WU Lab.of Neuropharmacology and Neurotoxicology,School of Life Sciences,Shanghai University,Shanghai 200444, China

In the present study,synchrotron radiation-based Fourier transform infrared(FTIR) was used to analyze the biochemical composition of the striatal neurons in normal and Parkinson's disease(PD) rat brain *** rat model of PD was established by 6-hydroxydopamine destroying the nigrostriatal *** detailed spectral analyses showed significant changes of cellular compositions such as lipids,proteins and nucleic acids in PD neurons with respect to *** a result,the intensities of spectral absorption assigned to lipid in the striatal neurons of PD were higher than that of ***,the unsaturation level of phospholipids decreased for PD neurons with respect to normal,indicating the high level of lipid *** analysis of protein secondary structure showed a significantly higher ratio of P-sheet in PD neurons compared to that of ***,the content of nucleic acids in PD neurons decreased in comparison to *** finding suggest that the biochemical changes in the striatal neurons might be involved in the pathogenesis of PD.

关键词： fourier transform infrared Parkinson's disease

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Epileptic electric source localization based on fMRI network information

Epileptic electric source localization based on fMRI network...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： De-Zhong YAO~*,Xu LEI,Cheng LUO Key Laboratory for Neurolnformation of Ministry of Education,Univeristy of Electronic Science and Technology of China,Chengdu 610054,China

Objective The epileptic source localization is an important issue for diagnostics and control of epileptic *** better method has be the major goal in this field for a long *** this work,based on the simultaneously recorded EEG and fMRI,we are aimed at developing novel source localization method based on EEG-fMRI information *** By utilizing Bayesian model,a new epileptic EEG source localization method,network-based source imaging(NESOI),is desinged which adopts the fMRI network information obtained by independent component analysis as the spatial *** Compared with other typical source localization methods on simulation data,NESOI demnostrates itself with the smallest localization error,then an illustration application to a real epileptic data shows that NESOI may result in a more physiologically reasonable source localization result than the fMRI SPM *** The EEG-fMRI fusion based novel method NESOI is a potentially useful tool for clinic practice in epileptic disorder.

关键词： source localization simultaneously recorded EEG and fMRI brain network bayesian model

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Activation of somatostatin sst5 receptor modulates GABA release from cultured rat retinal amacrine cells

Activation of somatostatin sst5 receptor modulates GABA rele...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Wen CHEN,Jiang-Bin KE,Chuang-Qiang ZHANG,Xiong-Li YANG~*,Zhong-Feng WANG~* Institutes of Brain Science,Institute of Neurobiology and State Key Laboratory of Medical Neurobiology,Fudan University,Shanghai 200032,China

Previous study demonstrated that somatostatin（SRIF）sst receptors are expressed in rat retinal amacrine cells（ACs）.Here,we investigated the modulation of SRIF on GABA release in cultured *** significantly reduced the frequency of spontaneous inhibitory postsynaptic currents（sIPSCs）,which was reversed by BIM 23056, a selective sst ***-application of nimodipine andω-conotoxin GVIA suppressed the frequency of sIPSCs, and SRIF failed to further inhibit *** increased,while a PKA inhibitor Rp-cAMP reduced the frequency of *** the presence of Rp-cAMP SRIF had no effect on the sIPSCs.8-Br-cGMP significantly decreased the frequency of sIPSCs,and SRIF shows further inhibition ***,PKG inhibitor KT5823 had no remarkable effect on the frequency of sIPSCs,whereas SRIF inhibits it in the presence of *** results suggest that SRIF inhibits Cainflux via the presynaptic Cachannels by activating the sst receptors,which results in a decrease of GABA release from the ACs through inhibiting the intracellular cAMP-PKA and activating the cGMP-PKG signaling pathways.

关键词： Activation of somatostatin sst5 receptor modulates GABA release from cultured rat retinal amacrine cells

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VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch

VGLUT2-dependent glutamate release from nociceptors is requi...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Omar Abdel SAMAD Claudia LOPES Bradford B LOWELL Dana-Farber Cancer Institute and Department of Neurobiology Harvard Medical School1 Jimmy Fund WayBostonMassachusetts 02115USA

＜正＞Itch can be suppressed by painful stimuli,but the underlying neural basis is *** generated conditional null mice in which VGLUT2-dependent synaptic glutamate release from mainly Navl.8-expressing nociceptors was *** mice showed deficits in pain behaviors including mechanical pain,heat pain, capsaicin-evoked pain,inflammatory pain and neuropathic *** pain deficits were accompanied by greatly enhanced itching,as suggested by i)sensitization of both histamine-dependent and histamine-independent itch pathways,and ii)development of spontaneous scratching and skin ***,intradermal capsaicin injection promotes itch responses,as opposed to pain responses in control *** conditional Vglut2 mutant mice thereby emulate human chronic itch syndromes in which painful stimuli paradoxically promote *** studies suggest that synaptic glutamate release from a group of peripheral nociceptors is required to sense pain and suppress *** of VGLUT2 in these nociceptors creates a mouse model of chronic neurogenic itch.

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Alteration of integrinβ1 expression in spinal dorsal cord of CCI rat

Alteration of integrinβ1 expression in spinal dorsal cord o...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Hong-Jun WANG~(1,2,*),Jun-Ping CAO~(1,2),Jing MENG~(1,2),Jing-Ru WU~(1,2) 1 Jiangsu Province Key Laboratory of Anesthesiology and 2 Center for Pain Research and Treatment,Xuzhou Medical College,Xuzhou 221002,China

Objective Neuropathic pain is associated with reorganization of spinal synaptic circuits,implying that adhesion proteins must be *** present study was to examine the alteration of adhesion protein integrinβ1 expression in relationship of neuropathic *** The left common sciatic nerve of SD rats was ligated to produce a chronic constrictive injury(CCI)*** allodynia was *** co-expression of integrinβ1 with neuron/glia cell was identified by double-labeling immunofluorescence,and the alteration of integrinβ1 expression was detected by RT-PCR,immunohistochemistry and immunoblot *** In L5,integrinβ1 is co-expression with neuron and glia cell within lamina *** mRNA and protein level of integrinβ1 undergoes a time-dependent increase across spinal dorsal cord after *** These results suggest that integrinβ1 plays a crucial role in a painful peripheral neuropathy,making it a very promising target for the development of a novel class of analgesics.

关键词： neuropathic pain integrinpl spinal dorsal cord

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Using Tol2-Gal4 mediated enhancer trap to realize targeted gene expression in zebrafish

Using Tol2-Gal4 mediated enhancer trap to realize targeted g...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： He-Fei ZHANG,Nan XU,Si-Jie CHEN,Gang PENG~* Institutes of Brain Science and State Key Laboratory of Medical Neurobiology,Fudan University,Shanghai 200032, China

Targeted gene expression is a powerful approach in studies of the nervous *** have used Tol2 mediated enhancer trap to find tissue specific enhancers in zebrafish genome and to produce transgenic driver lines expressing Gal4 protein in specific parts of ***4 protein can recognize upstream activator sequence(UAS)and activate the expression of UAS-driven reporter *** 35 driver lines that express Gal4 in specific parts of CNS have been screened *** have also mapped the loci of Tol2-Gal4 insertions in some of our driver *** of the insertion loci are located near developmentally important genes such as *** driver lines will be powerful tools for neuronal development research and behavior studies.

关键词： enhancer trap targeted gene expression Tol2-Gal4 UAS

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Triptolide T10 enhances AAV-mediated gene transfer in mice striatum

Triptolide T10 enhances AAV-mediated gene transfer in mice s...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Xin-Miao REN~1,Ting ZHANG~(1,*),Jing HU~1,Wei DING~2,Xiao-Min WANG~(1,2,*) 1 Department of Physiology and Key Laboratory of the Neurodegenerative Disorders of the Chinese Ministry of Education,Capital Medical University,Youanmen,Beijing 100069,China 2 Department of Biochemistry and Molecular Biology,Capital Medical University,Youanmen,Beijing 100069,China

Adeno-associated virus(AAV)-mediated gene transfer has been demonstrated to be an effective approach for treating Parkinson's disease(PD).Triptolide TIO is a monomeric compound isolated from tripterygium wilfordii Hook.f.(Thunder God vine),a traditional Chinese herb for anti-inflammatory *** the present study,we coadministered T10 with recombinant AAV2 in SH-SY5Y human neuroblastoma cells and in the striatum of C57BL/6 mice,and then evaluated the AAV-mediated gene expression *** results have shown that T10 significantly augmented the expression of AAV-mediated gene in a dose-dependent fashion without detectable *** growing evidence indicated that inflammation contributed to the progression of PD,and the anti-inflammatory effect of T10 was shown in our previous studies,our data of T10 to enhance AAV transduction suggest that T10 might be potentially used as a facilitating reagent for the AAV gene therapy applications in neurodegenerative diseases.

关键词： Triptolide AAV gene therapy Parkinson's disease

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The possible mechanism of Ca2+ induced Ca2+ release in astrocytes

The possible mechanism of Ca2+ induced Ca2+ release in astro...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Jun-Hua YANG,Ke-Qing ZHU,Shu-Min DUAN~* Department of Neuroscience,School of Medicine Zhejiang University,Hangzhou 310058,China

Objective Astrocytes are the primary neuronal structural and trophic supportive *** like neurons which can generate action potential,however astrocytes exhibit diversity intracellur calcium activity and this is thought to play an important part in physiology and pathological *** calcium elevation has various forms,one important is Cainduced Ca release（CICR）which is thought to be mediated by 1,4,5-triphosphate receptor（IP3R）and ryanodine receptor（RyR）but the mechanism is not very *** our research,we want to explore the potential mechanism of CICR by a new *** We used laser scan confocol microscopy to monitor the intraculler calcium variation and used a special method triggering Cainflux in mouse *** inhibitors of different channels were use to investigate the possible role of participating in *** Astrocytes calcium elevation was significantly inhibited by some specificity *** Our primary datas showed that NCX may play an important role in astrocytes *** contrary to some papers which reported RyR relating to CICR,our study didn't find this result.

关键词： astrocytes 1,4,5-triphosphate receptor ryanodine receptor Na+/Ca2+ exchangers

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The role of macroautophagy and chaperon-mediated autophagy in huntingtin metabolism

The role of macroautophagy and chaperon-mediated autophagy i...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Zheng-Hong QIN,Fang LIN,Jun-Chao WU,Lin QIN Deartment of Pharmacology,Soochow University School of Medicin,Suzhou 215123,China

A neuropathological hallmark in human HD and mouse models is the intracellular accumulation and aggregation of N-terminal Htt fragments,suggesting that aberrant Htt proteolysis and/or dysfunction in clearance of truncated Htt may underlie the neuropathology of *** a cell model of HD overexpressing Htt fragment 1-552 amino acid residues(Htt-552).We found that both macroautophagy and chaperon-mediated autophagy(CMA) were involved in degradation of *** the levels of macroautopahgy and CMA effected the accumulation of *** can interact with Htt-552 and redistributed from nucleus to the cytosol and knockdown of beclinl increased the accumulation of mutant Htt552,suggesting macroautophagy regulator beclinl plays a role in promoting degradation of *** of cell lysates containing expressed Htt-552 with isolated lysosomes demonstrated that Htt-552 bound to lysosomes and was transported into the lysosomal lumen for *** of polyQ tract in Htt-552 impaired its uptake and degradation by *** of putative KFERQ motif in wilt-type Htt-552 interfered with interactions between Htt-552 and *** data suggest that CMA also plays a role in Htt *** studies indicate that both macroautophagy and CMA are involved in degradation of Htt and thus may represent an important therapeutic target.

关键词： The role of macroautophagy and chaperon-mediated autophagy in huntingtin metabolism

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Brain functional connectivity analysis during retention period in a visual working memory task

Brain functional connectivity analysis during retention peri...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Ling LI Key Laboratory for Neurolnformation of Ministry of Education,School of Life Science and Technology,University of Electronic Science and Technology of China,Chengdu,610054,China

Objective Visual working memory(VWM) helps us store visual information to prepare for subsequent *** numerous studies have utilized behavioral accuracy and neural activity to estimate VWM capacity, little is known about the load-related changes in functional *** In this study,we recorded electroencephalography(EEG) from 14 normal young adults while they performed a bilateral visual field memory *** connectivity during the retention interval between 128 scalp regions was measured by EEG phase synchronization in the theta,alpha and beta frequency *** resulting matrices were converted to graphs,and the mean degree,clustering coefficient and path length was computed as a function of memory *** Our findings showed that the mean degree of a graph was dependent on the memory load in the theta,alpha and beta frequency ***,in the alpha band,a higher clustering coefficient and shorter path length was found with increasing memory ***,a significantly negative linear correlation between behavioral reaction time and path length was established in the alpha *** The results show that the neural activity and functional phase synchrony in the theta,alpha and beta frequency bands are memory load-dependent and behaviorally relevant during human VWM maintenance.

关键词： functional connectivity visual working memory ERP EEG

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