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The crucial period for focal low frequency stimulation inhibiting the development of amygdala-kindling in rats

The crucial period for focal low frequency stimulation inhib...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Yi WANG,Zheng-Hao XU,Yang LIU,Kai ZHONG,Ceng-Lin XU,Wei-Wei HOU,Shi-Hong ZHANG,Zhong CHEN~* Institute of Neuroscience,Department of Pharmacology,College of Pharmaceutical Sciences,School of Medicine, Zhejiang University,Hangzhou 310058,China

Objective To investigate whether there is a crucial period for focal low frequency stimulation(LFS) inhibiting the development of amygdala-kindling in *** The effect of focal LFS(1 Hz,15 min) applied in different periods of the kindling development process were *** was initiated immediately after daily kindling *** LFS given in the first week of kindling or during the whole kindling process had similar antiepileptic effect on the development of kindling,indicated by the slowed development of seizure stage and the shortened afterdischarge duration,while LFS applied after the first week of kindling had no effect,even aggravated afterdischarge *** the rats in the control group or received LFS after the first week were fully kindled within 20 ***,only 44%rats received LFS in the first week and 32.5%rats received LFS during the whole kindling process were fully kindled within 20 *** The first week of kindling process is a crucial period for focal LFS inhibiting the development of *** early period in epileptogenesis may be an ideal time for LFS treatment.

关键词： LFS epilepsy amygdala kindling crucial period

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Activation in human superior temporal cortex is modulated by shortterm auditory word learning

Activation in human superior temporal cortex is modulated by...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Rui DAI~(1,2),Zi-Rui HUANG~(1,3,4),Xu-Chu WENG~(1,*) 1 Research Center of Human Brain and Mental Disease,Hangzhou Normal University,Hangzhou 310015,China 2 Institute of Life Science,South China Normal University,Guangzhou 510631,China 3 Institute of Psychology,Chinese Academy of Sciences,Beijing 100101,China 4 Graduate School of Chinese Academy of Sciences,Beijing 100049,China

Objective Previous studies showed that the superior temporal gyrus and sulcus(STG/STS) plays an important role in auditory speech *** this study,we investigated whether the activation of the STG/STS could be modulated by short term auditory word *** We recorded blood oxygenation responses,using functional magnetic resonance imaging,to frequency-modulated tones,Cantonese words,mandarin Chinese words, and trilled and reversely played Chinese *** were then required to learn a set of Cantonese words during *** for the learned Cantonese words and unlearned control words were *** Activation was most robust in the STG/STS for mandarin Chinese when comparing to other *** the short training session,the participants could understand most of the presented Cantonese *** stronger BOLD signal change was observed for learned Cantonese words than for unlearned control condition in the STG/STS. Conclusion Our results suggest that the STG/STS may be crucial for short term auditory word learning.

关键词： superior temporal gyrus fMRI short-term learning auditory processing

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Coupling asymmetry of electrical synapses is set by Ca2+ signals and mediates network-neurons' asynchrony in hypothalamic suprachiasmatic nucleus

Coupling asymmetry of electrical synapses is set by Ca2+ sig...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Ming-Hui WANG,Shan CUI,Na CHEN~*,Jin-Hui WANG~* Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China

Objective The electrical coupling among inhibitory neurons through gap junctions（i.e.,electrical synapses） presumably synchronizes their rhythmic oscillation and then coordinates principal neurons to encode brain *** revealing to the functional regulation of electrical synapses helps understand the programming of neuronal codes in brain plasticity and *** We investigated the dynamics and regulation of electrical synapses by pair-recording GABAergic cells in hypothalamic suprachiasmatic nucleus（SCN）.Results（1） The efficiency of electrical couplings between SCN neurons through gap junctions is *** asymmetric coupling through electrical synapses is present under various conditions and expresses plasticity.（2） The variances of intracellular Ca signals between these neurons influence their coupling asymmetry.（3） An attenuation of the coupling asymmetry in network neurons leads to their activity *** The asymmetry of electrical coupling among GABAergic cells may confer some of them to be dominant and make network neurons to be asynchronous in outputting electrical signals,such that temporal codes are more widely integrated into the brain programs.

关键词： gap junction neuron action potential suprachiasmatic nucleus

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The transcription factor Sp8 characterizes the configuration of the subventricular zone,rostral migratory stream and olfactory bulb in the adult rhesus monkeys

The transcription factor Sp8 characterizes the configuration...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Rui CHEN,Zhen-Gang YANG~* Institutes of Brain Science and State Key Laboratory of Medical Neurobiology,Fudan University,Shanghai 200032, China

Neurogenesis in the primate subventricular zone(SVZ) of the lateral ventricle(LV) persisted throughout adulthood and the existence of rostral migratory stream(RMS) pathway in the adult primates has been intensely ***,the cellular organization and neurogenesis process in vertebrates,especially in monkeys remains *** the present study,we described the general configuration of the SVZ and RMS in adult monkeys via the expression of zinc finger transcription factor *** we detected the expression of Sp8 in the amphibians,reptiles, birds,rodents and *** of the neuroblasts in SVZ,RMS,olfactory tract and olfactory bulb are Sp8 ***,this transcription factor is highly expressed in the interneurons(CR,CB,TH and PV) of adult monkey olfactory *** with immunohistochemical detection of a marker for DNA replication(BrdU) and several cell type-specific markers,newly generated intemeurons are detected in the monkey olfactory *** together,our data suggest that Sp8 could be used as a marker to characterize neurogenesis of adult SVZ and RMS in rhesus monkeys.

关键词： Sp8 rhesus monkey neurogenesis neuroblasts subventricularzone rostral migratory stream olfactory bulb

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Depletion of cathepsin B and cystatin C affects Aβ levels in transgenic mice over-expressing wild type hAPP

Depletion of cathepsin B and cystatin C affects Aβ levels i...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Seo-Hyun CHO Gladstone Institute of Neurological Disease University of California

Objective Alzheimer's disease(AD) is the most common neurodegenerative *** amyloid B(AP) accumulation in the brain is one of the major factors which may result in AD.Aβaccumulation level in the brain was dependent on the balance between Aβproduction and *** showed previously that cathepsin B-cystatin C axis played key roles in Aβmetabolism of transgenic mice overexpressing hAPP with Swedish and Indiana ***,it is not clear if the cathepsin B-cystatin C axis could affect Apaccumulation in mice overexpressing wild type hAPP,which accounts for more AD cases compared with mutant *** the present study, we want to investigate the effects of cathepsin B and cystatin C deletion on Aβin mice with wild type *** Animals were obtained by crossing hAPPwt mice(line I63) with cathepsin B-/- or cystatin C-/-.ELISA and western blot analyses were used to measure Aβlevels and hAPP fragments,*** also used immunohistochemistry to detect pathology induced by ***(1) Cathepsin B or cystatin C ablation did not affect hAPP processing.(2) Cathepsin B or cystatin C ablation affected Abeta levels in mice with wild type *** Cathepsin B-cystatin C axis played key roles in Aβmetabolism of transgenic mice overexpressing mutant and wild type hAPP.

关键词： Alzheimer's disease Happ ELISA Western blot mouse

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Time to egg-laying:A new model of time-based memory in Drosophila

Time to egg-laying:A new model of time-based memory in Droso...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Yijin WANG,Haiyun GONG,Zhefeng GONG,Li LIU~* State Key Lab.of Brain and Cognitive Science,Institute of Biophysics,Chinese Academy of Sciences,15 Da Tun Road, Chao Yang District,Beijing 100101,China

Light-dark cycles play a critical role of animal circadian rhythms that organize their behavior and physiology to adapt to daily *** formation of conditioning memory also regulates animal response to external *** date,very few studies on memory have considered time-based memory that was regulated by light-dark *** we describe a new model of time-based memory in *** this learning paradigm,light-dark cycle of egg-laying was associated with different food *** female flies reproduce more eggs during the time paired with yeast food,whereas they reproduce less eggs during the time paired with agar *** 9 cycles training, flies could maintain egg-laying memory at least 3 ***,we found that using agar food as punishment is more effective than using yeast as reward in egg-laying memory *** model would supply a new paradigm for the study of molecular and neural mechanism underlying the relationship between conditioning memory and circadian rhythms.

关键词： time-based memory circadian rhythms Drosophila

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RNAi targeting Stat3 expression inhibits growth of glioma in vitro and in vivo

RNAi targeting Stat3 expression inhibits growth of glioma in...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Fu-Xue CHEN~*,Ya-Ming XU,Yong-Hua JI School of Life Sciences,Shanghai University,Shanghai 200444,China

Malignant gliomas are highly invasive tumors with high *** advances in the understanding of gliomas,the treatment of glioma still remains as a major challenge in ***3,as a member of signal transducer and activator of transcription family,plays a critical role in a variety of cancer cells and has been classified as an *** employed RNAi to investigate the biological function of Stat3 in *** data showed that Stat3 is constitutively expressed in human glioma cell line ***-regulation of Stat3 expression could inhibit proliferation,induce apoptosis and decrease invasion activity of human glioma cell line U251,meanwhile,it could suppress the expression of Bcl-xL,survivin and MMP-2 but not 67LR in *** data also showed that down-regulation of Stat3 could inhibit tumor growth and induce apoptosis of tumor cell in a xenograft mouse model. Furthermore,Stat3 RNAi could suppress the expression of Bcl-2 in *** results indicate that Stat3 plays an important role in the survival of glioma,and that targeting Stat3 may offer a potential therapeutic approach for glioma.

关键词： glioma Stat3 RNAi proliferation apoptosis invasion

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14-3-3 proteins interact with the neurofilament light subunit and regulate neurofilament dynamics

14-3-3 proteins interact with the neurofilament light subuni...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Lin-Qing MIAO,Jun-Lin TENG~*,Jian-Guo CHEN~* Department of Cell Biology,College of Life Sciences,Peking University,Beijing 100871,China

Neurofilament light subunit(NFL) is the core component of neurofilaments,which are the main intermediate filaments(IF) in *** dominant inherited diseases are related to mutations in IF *** studies report that NFL mutations are related to the charcot-marie-tooth(CMT) diseases,but the mechanism is ***,we show that seven 14-3-3 isoforms all interact with NFL,which is dependent on the phosphorylation of NFL head domain that is regulated by *** mutation analyses reveal many Serine phosphorylation sites in the head domain that are important for 14-3-3 *** of these sites lead to aggregate ***,14- 3-3 overexpression increases NFL exchange rate and leads to neurofilament *** mutations P8Q,P8L, P22S,found in CMT diseases,inhibit 14-3-3 binding and result in the formation of NFL aggregations,which can be rescued by 14-3-3 ***,14-3-3 proteins regulate NFL assembly and dynamic exchange through interaction with NFL,and can act as potential molecule targets for therapy of human CMT diseases.

关键词： NFL 14-3-3 neurofilament phosphorylation CMT

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Bioinformatics approaches to computationally identify the human proteins with polyphosphate-binding potential

Bioinformatics approaches to computationally identify the hu...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Albert Cheung-Hoi YU Neuroscience Research Institute Peking University

Objective Polyphosphate(polyP) was widely studied in microorganism as potential high-energy phosphate source and stringent response-related regulatory *** was discovered in mammalian brain by Arthur Kornberg in *** have found a decrease of endogenous by transfection of polyP degrading enzyme (exopolyphosphatase,PPX) would cause the transfected cells to respond differently to *** study is to characterize computationally the possible polyP-related proteins to interpret the underlying mechanisms in cellular response to *** In this study,the precomputed structural neighbourhoods provided by DALI database were applied for identifying the structural *** then attempted to use bioinformatics approaches including sequence motif-based search,molecular docking calculation and gene ontology enrichment to identify polyP-related *** analyses were also used to trace the evolutionary history of polyP-related *** The major enzymes in synthesizing and metabolizing polyP - polyphosphate kinase(PPK) and polyphosphatases were not being identified in higher *** identified 280 human genes whose products may be structurally analogous to the PPK family proteins by DALI *** further computationally predicted the polyP binding potential of these gene *** of them were shown to have the binding capacity and possess derivative sequences from polyP-related *** Our strategy could be used for the prediction experiment and help the future characterization of polyP-related *** further study would provide important insight for understanding polyP metabolism and its regulatory functions in higher organisms.

关键词： polyphosphate polyphosphate kinase high-energy phosphate

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Gene expression profile of peripheral ganglion in diabetic and highfat high-sugar diet resistant rats

Gene expression profile of peripheral ganglion in diabetic a...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Xiao-Li TANG,Li-Bin DENG,Fan-Jun KONG,Jia-Ri LIN,Shang-Dong LIANG~* Laboratory of Physiology,Medical college of Nanchang University,Nanchang 100038,China

Objective To screen and identify differentially expressed genes in peripheral ganglion in type 2 diabetic and high-fat high-sugar(HFHS) diet resistant *** We compared the differential gene expression in 2 groups using Illumina? Sentrix? BeadChip ***(1) 158 out of 12 604 genes were differentially expressed.(2) GO analysis showed 4 and 2 biological processes were significant in high expressed genes of diabetic and resistant rats,respectively.(3) KEGG analysis showed 6 and 1 pathways were significant in high expressed genes of diabetic and resistant rats,*** Muscle system process and response to biotic stimulus was involved in the process of diabetes and HFHS diet resistance.

关键词： type 2 diabetes mellitus peripheral ganglion gene expression Sprague Dawley rats

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