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Bioinformatics approaches to computationally identify the human proteins with polyphosphate-binding potential

Bioinformatics approaches to computationally identify the hu...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Albert Cheung-Hoi YU Neuroscience Research Institute Peking University

Objective Polyphosphate(polyP) was widely studied in microorganism as potential high-energy phosphate source and stringent response-related regulatory *** was discovered in mammalian brain by Arthur Kornberg in *** have found a decrease of endogenous by transfection of polyP degrading enzyme (exopolyphosphatase,PPX) would cause the transfected cells to respond differently to *** study is to characterize computationally the possible polyP-related proteins to interpret the underlying mechanisms in cellular response to *** In this study,the precomputed structural neighbourhoods provided by DALI database were applied for identifying the structural *** then attempted to use bioinformatics approaches including sequence motif-based search,molecular docking calculation and gene ontology enrichment to identify polyP-related *** analyses were also used to trace the evolutionary history of polyP-related *** The major enzymes in synthesizing and metabolizing polyP - polyphosphate kinase(PPK) and polyphosphatases were not being identified in higher *** identified 280 human genes whose products may be structurally analogous to the PPK family proteins by DALI *** further computationally predicted the polyP binding potential of these gene *** of them were shown to have the binding capacity and possess derivative sequences from polyP-related *** Our strategy could be used for the prediction experiment and help the future characterization of polyP-related *** further study would provide important insight for understanding polyP metabolism and its regulatory functions in higher organisms.

关键词： polyphosphate polyphosphate kinase high-energy phosphate

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Mozart music exposure enhanced spatial memory in rats

Mozart music exposure enhanced spatial memory in rats

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Mao-Sen WANG,Ying-Shou XING,Yang XIA~* Key Laboratory for Neurolnformation of Ministry of Education,University of Electronic Science and Technology of China,Chengdu 610054,China

Objective Music seems to have a beneficial effect on promoting mood state and cognitive performance of ***,whether rats exists analogous effect is still *** study was designed to investigate the effect of Mozart K448 on behavior in the developing *** Sprague-Dawley rats exposed to the Mozart K448 (group M),inversed Mozart K448(group M-inv) or silence(control group) from postnatal days 1 to 91,the potential of spatial learning and memory were assessed at postnatal days 28,56 and 91 by Morris water *** The group M and control group rats learned to find the escape platform more rapidly than the group M-inv rats(P<0.01),while no significant difference were found between the group M and control group rats(P>0.05).Compared to control group and group M-inv rats,the group M rats remained more time in the quadrant that contained platform formerly during the spatial probe trial *** Our primary results suggests that classical Mozart music may improve spatial memory in rats,resembling results found in *** inversed Mozart may inhibit spatial learning and ***,it is worth mentioning that more evidences are indispensable on physiology and molecular biology to elucidate the mechanism of Mozart effect.

关键词： Sprague-Dawley rats Mozart music Morris water maze spatial memory

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Sigma-1 receptor mediates the effect of cyproheptadine on theⅠK in mouse cortical neurons

Sigma-1 receptor mediates the effect of cyproheptadine on th...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Yan-Lin HE,Chun-Lei ZHANG,Xiao-Fei GAO,Jin-Jing YAO,Chang-Long HU,Yan-Ai MEI~* Institutes of Brain Science,School of Life Sciences and State Key Laboratory of Medical Neurobiology,Fudan University,Shanghai 200433,China

Cyproheptadine is a histamine- and serotonin- receptor antagonist,and its effects are observed in the modulation of multiple intracellular signals in previous *** demonstrate here that intracellularly delivered cyproheptadine increased the delayed rectifier outward potassium current（I） by reducing the intracellular levels of phosphorylated PKA in mouse cortical ***-receptor binding assay indicated that cyproheptadine bound to sigma-1 receptor and mediate the cAMP/PKA *** to the sigma-1 receptor mimicked effects of CPH and knock down this receptor abolished the effects of CPH on *** of G eliminated the cyproheptadine-induced effect on I and PKA activity.K2.1α-subunit blocker reduced cyproheptadine-induced effect on I in mouse cortical ***,CPH also enhance the K current when expressed the K2.1α-subunit on HEK293 *** reveal for the first time that CPH enhances I by a sigma-1 receptor-dependent mechanism and selective targeting of the K2.1α-subunit. This result may help to explain some of the uncharacterized effects of CPH on neuron excitability and contribute to the understanding of CPH as more than just a competitive inhibitor of the histamine H and serotonin receptors.

关键词： sigma-1 receptor cyprohetadine IK K_γ2.1α-subunit cAMP/PKA pathway cortical neurons

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Neuroanatomical characteristics of "acupoints" in the rat determined by CTB-Alexa488,594

Neuroanatomical characteristics of "acupoints" in the rat de...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Jing-Jing CUI,Wan-Zhu BAI~* Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences,Beijing 100700,China

Objective Neural tracing technique,as an advanced neuroanatomical approach,has been applied for the morphological study on the acupuncture for 30 *** aim of this study is to investigate the correlation between acupoint and nervous system using a new generation of fluorescent neural tracer,cholera toxin subunit B conjugated with Alexa Fluor 488,594(CTB-Alexa488,594).It will help us to further understand the neuroanatomical characteristic of *** Micro-injection with CTB-Alexa488 or CTB-Alexa 594 was carried out in the acupoints of "Chengshan","Jinggu"and "Dazhong" in the adult male SD *** 3 surviving days,the rat's brain,spinal cord and dorsal root ganglia(DRGs)were dissected following perfusion with 4%paraformaldehyde, cut into sections and observed under fluorescent microscope equipped with a digital *** neurons labeled by CTB-Alexa 488 and CTB-Alexa 594 were recorded and *** Under the fluorescent microscope system,the labeled neurons with CTB-Alexa 488 and CTB-Alexa 594 appeared in green and red respectively,and located ipsilaterally on the injection *** sensory and motor neurons innervating each acupoint distributed on the corresponding DRGs and spinal *** The present fluorescent tracing technique may be quite useful for investigating the neuroanatomical basis associated with different acupoints.

关键词： innervation cholera toxin subunit B conjugated with Alexa Fluor 488/594(CTB-Alexa 488/594) sensory neuron motor neuron

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The production of Ap in APP stably transfected HEK293 cells was reduced by overexpression of Tyro 3

The production of Ap in APP stably transfected HEK293 cells ...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Qi WANG,Yan ZHENG,Xiao-Min WANG~* Department of Physiology,Key Laboratory of the Neurodegenerative Disorders of the Chinese Ministry of Education Capital Medical University,No.10 Xitoutiao Street,Youanmen,Beijing 100069,China

Objective Tyro 3 is one of receptor tyrosine kinases in the TAM(Tyro 3,AXL and Mer) family,which is preferentially expressed in the neocortex and CA1,CA3 of hippocampus,and mainly associated with neurons. However,the relationship between tyro 3 and B-Amyloid(AB) is *** study is to investigate the relationship between Tyro 3 and AB *** We transfected APP plasmid to HEK293 cells and then selected by G418 to get HEK293 cells stably expressing APR CMV-Tyro 3-CFP and CMV-GFP reporter plasmids were used to transfect the cells mentioned above,***,the cells were treated with Gas6,which is the native ligand of Tyro *** supernatant AB was detected by *** We observed that the production of AB was decreased in HEK293 cells transfected with CMV-Tyro 3-CFP compared with that of CMV-GFP transfected ***,the effect was reversed by treatment of Gas6 to the *** In summary,our studies demonstrate that overexpression of Tyro 3 has the potential to reduce the generation of ***,the effect of Tyro 3 on the production of AB is independent of Gas6.

关键词： Tyro 3 receptor Gas6 HEK293 Aβ

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GSS通过提高抗氧化能力对脑缺血再灌注损伤起保护作用

GSS通过提高抗氧化能力对脑缺血再灌注损伤起保护作用

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者：黄志华李良东黎晓曾雪亮曾靖赣南医学院生理学教研室赣南医学院第一附属医院赣南医学院药理学教研室

目的研究染料木素磺酸钠（genistein sulfonate sodium,GSS）对大鼠脑缺血再灌注损伤的保护作用。方法采用大鼠大脑中动脉栓塞制作局灶性脑缺血再灌注损伤模型进行实验研究。在缺血后10分钟,假手术组与模型组经舌下静脉注射生理盐水,治... 详细信息

目的研究染料木素磺酸钠（genistein sulfonate sodium,GSS）对大鼠脑缺血再灌注损伤的保护作用。方法采用大鼠大脑中动脉栓塞制作局灶性脑缺血再灌注损伤模型进行实验研究。在缺血后10分钟,假手术组与模型组经舌下静脉注射生理盐水,治疗组分别从舌下静脉注射等体积不同浓度的GSS（0.5 mg/kg,1 mg/kg或2 mg/kg）。缺血1h,再灌注24 h后,行神经功能评分,取大脑进行TTC染色,测定脑梗死体积;取血清,酶法测血清乳酸脱氢酶（lactate dehydrogenase,LDH）活性;取脑组织,制成10%匀浆,测定缺血区脑组织LDH、总抗氧化能力（total antioxidant capacity,T-AOC）、谷胱苷肽过氧化物酶（glutathione peroxidase,GSH-Px）、过氧化氢酶（catalase,CAT）、超氧化物歧化酶（superoxide dismutase,SOD）活性及丙二醛（malondialdehyde,MDA）的含量。结果（1）与模型组相比,各剂量组神经功能学评分降低,其中1 mg/kg GSS组差异有统计学意义,高剂量GSS治疗后大鼠脑梗死体积降低;（2）模型组大鼠血清LDH活性升高,组织LDH活性降低,与模型组相比,各剂量GSS治疗组大鼠血清LDH活性降低,组织LDH活性升高;（3）模型组大鼠组织T-AOC、GSH-Px、CAT、SOD活性降低,MDA含量升高,与模型组相比,各剂量GSS治疗组大鼠T-AOC、GSH-Px、CAT、SOD活性升高,MDA含量降低。结论（1）GSS可降低脑缺血再灌注损伤大鼠脑梗死体积及脑组织LDH的释放,对大鼠脑缺血再灌注损伤具有保护作用;（2）GSS可升高大鼠抗氧化系统的活性,降低MDA的含量,提示GSS可能通过增强机体的抗氧化能力而对大鼠脑缺血再灌注损伤起保护作用。

关键词：染料木素磺酸钠脑缺血再灌注损伤抗氧化作用

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Characterization of monoaminergic neurons in the pretectum of zebrafish larvae

Characterization of monoaminergic neurons in the pretectum o...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Shu-Yi ZHANG,Xiao-Quan LI,Jiu-Lin DU Laboratory of Sensory Integration and Behavior,Institute of Neuroscience,Chinese Academy of Sciences,Shanghai 200031,China

The pretectum,one of the arborization fields of retinal ganglion cells,locates in the dorsal-medial *** the preventricular pretectum,there are monoaminergic neurons which axons project to the neuropil of the ipsilateral optic *** on toads and salamanders indicate that the pretectum may be involved in prey discrimination and avoidance ***,it still remains largely unknown how pretectal monoaminergic neurons regulate prey-relevant information processing in the retinotectal pathway in the optic *** electrical stimulation of the pretectum decreased field potentials in the optic tectum of toads,we propose that the pretectum may play an inhibitory role in the retinotectal pathway via monoaminergic *** test this hypothesis,we need to find anatomical evidence showing that pretectal neurons send their axon to the optic tectum and functional evidence showing that pretectal neurons can exhibit different response patterns evoked by prey-like and prey-unlike visual cues. Using immunostaining and Kaede-based photo-conversion in vivo imaging,we first found that some monoaminergic neurons in the pretectum send processes to the deep layer of tectal *** vivo whole-cell recording and extracellular recording were then made on those monoaminergic *** found that those pretectal neurons showed different subtypes of responses evoked by flash and dimming *** characterization of the input and output of those neurons will be performed at both anatomical and functional levels.

关键词： zebrafish pretectum optic tectum monoaminergic prey capture

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Carbonic anhydrase I:a new player in ALS pathology

Carbonic anhydrase I:a new player in ALS pathology

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Armin AKAHAVAN Robert BOWSER Department of Cancer Biology California Pacific Medical Center Research InstituteSan FranciscoCA 94103USA Department of Pathology University of Pittsburgh School of Medicine200 Lothrop St.PittsburghPA 15261USA

Objective Carbonic anhydrase I(CA I) protein levels were found to be significantly increased in the spinal cords of both mutant SOD1-linked and sporadic ALS *** I is the cytoplamic isoform of the CA family which comprises of a total of 16 *** is not known how change of CA I might be related to ALS *** aims of this study are:(1) determine whether CA I is expressed in motor neurons in the spinal cord;(2) determine how is this expression is affected by ALS at the cellular level;(3) explore the mechanism by which CA I might play in ALS *** Immunohistochemistry and fluorescent immunostainning techniques were used to determine the pattern and changes of CA I expression in human spinal *** biochemistry and Western Blot analysis were used to examine the potential mechanism of subcellular location of CA ***(1) CA I is expressed in the motor neurons in human spinal cord;(2) a subpopulation of CA I is associated with ER membranes;(3) CA I change in ALS is more enhanced with membrane-associated CA *** CA I might play a role in ALS pathology via ER stress-mediated pathway.

关键词： carbonic anhydrase I motor neurons ALS ER stress

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Endocannabinoid signaling modulates synaptic transmission in the rat inner retina

Endocannabinoid signaling modulates synaptic transmission in...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Xiao-Han WANG~#,Yi WU~#,Yan-Ying MIAO,Xiao-Fang YANG,Zhong-Feng WANG~* Institutes of Brain Science,Institute of Neurobiology and State Key Laboratory of Medical Neurobiology,Fudan University,Shanghai 200032,China

Cannabinoid signaling system plays an important role in regulation of many neuronal functions in the CNS. Endocannabinoids function as a retrograde signaling to regulate the synaptic plasticity via activating presynaptic CB1 receptors in many brain *** date,the effects of this signaling on synaptic transmission in retina are poorly *** the present study,we aimed to explore the modulation of cannabinoid signaling on glycinergic and GABAergic inhibitory inputs,and glutamatergic excitatory inputs to retinal ganglion cells(RGCs)by patch-clamp techniques in rat retinal *** results show that activation of presynaptic CB1 receptors in both GABAergic and glycinergic amacrine cells(ACs)suppressed the frequency of miniature inhibitory postsynaptic currents(mIPSCs)in the RGCs through inhibiting the presynaptic voltage-gated calcium *** the effect of cannabinoid on glutamatergic excitatory inputs from bipolar cells to the RGCs is basically similar,the tonic inhibitory inputs from the ACs to the bipolar cells are *** these inhibitory inputs eliminated completely the suppression effect of cannabinoid on the excitatory inputs to the *** underlying mechanism is that deinhibition-induced depolarization of bipolar cells inactivates the presynaptic T-type calcium channels that is a target of the activated presynaptic CB1 receptors in the bipolar *** data revealed a new mechanism of cannabinoid modulating synaptic transmission in the inner retina.

关键词： cannabinoid CBl receptor inner retina mlPSCs mEPSCs deinhibition

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MicroRNA ablation affects Bergmann glial morphology and disrupts tissue morphogenesis in the developing mouse cerebellum

MicroRNA ablation affects Bergmann glial morphology and disr...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Q.Richard LU Department of Developmental Biology University of Texas Southwestern Medical CenterDallasTX 75390USA

MicroRNAs(miRNAs) play important roles during development of the central nervous system(CNS). Several reports indicate that tissue development and cellular differentiation in the developing forebrains are disrupted in the absence of ***,miRNA functions during cerebellar development have not been systematically *** we conditionally knockout Dicer gene under the activity of human glial fibrillary acidic protein (hGFAP) promoter to examine the effect of miRNAs in the developing *** found that ablation of miRNAs resulted in a smaller cerebellum,mis-positioned Purkinje neurons,decreased proliferation and increased apoptosis in granule neuron precursors,decreased number of basket and stellate intemeurons and aberrant morphology of Bergmann *** addition,Notchl signaling appears to be blocked in miRNA-ablated Bergmann *** further identified miR-9 as differentially expressed in Bergmann glial cells,and its expression was promoted by Notchl *** also demonstrated that cortical radial glia exhibited normal morphology in the absence of miRNAs and yet reduced radial glial marker expression at embryonic stage,and that the postnatal radial glial transition to astrocytes was promoted in miRNA-ablated *** results further stressed the critical involvement of miRNAs in the developing CNS including cerebellum and provided first evidence of differential miRNA function in regulating radial glial phenotype in different regions of the developing CNS.

关键词： hGFAP miR-9 Dicer Cre-flox Bergmann glia

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