检索结果-内蒙古大学图书馆

您好，读者！请登录

内蒙古大学图书馆

首页
概况
党建
资源
服务
科研支持
- 论文收录引用证明
- 科技查新
知识产权
档案馆
帮助

咨询与建议

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

您的常用邮箱：*

您的手机号码：*

问题描述：

当前已输入0个字，您还可以输入200个字

全部搜索
期刊论文
图书
学位论文
标准
纸本馆藏
外文资源发现
数据库导航
超星发现

高级检索

时间限定

出版年份：

文献类型

图书期刊文献学位论文多媒体

馆藏选择

电子馆藏纸本馆藏

核心期刊

全部期刊 SCI 收录期刊 SSCI 收录期刊 EI 收录期刊 CSCD 收录期刊 CSSCI 收录期刊

语言

中文英文

文献类型

期刊文献图书学位论文标准纸本馆藏

帮助

文字说明：

T=题名（书名、题名），A=作者（责任者），K=主题词，P=出版物名称，PU=出版社名称，O=机构（作者单位、学位授予单位、专利申请人），L=中图分类号，C=学科分类号，U=全部字段，Y=年（出版发行年、学位年度、标准发布年）

检索规则说明：

AND代表“并且”；OR代表“或者”；NOT代表“不包含”；(注意必须大写,运算符两边需空一格)

检索范例：

范例一：(K=图书馆学 OR K=情报学) AND A=范并思 AND Y=1982-2016
范例二：P=计算机应用与软件 AND (U=C++ OR U=Basic) NOT K=Visual AND Y=2011-2016

分类表

所选分类

>> <<

限定检索结果

文献类型

1,394 篇 会议

馆藏范围

1,394 篇 电子文献
0 种 纸本馆藏

日期分布

学科分类号

403 篇 理学
- 403 篇 生物学
351 篇 医学
- 245 篇 临床医学
- 79 篇 基础医学(可授医学...
- 33 篇 中西医结合
- 18 篇 药学(可授医学、理...
- 8 篇 中药学(可授医学、...
- 6 篇 中医学
- 3 篇 医学技术（可授医学...
- 2 篇 公共卫生与预防医...
7 篇 工学
- 5 篇 生物医学工程（可授...
- 3 篇 生物工程
- 2 篇 材料科学与工程（可...
2 篇 教育学
- 2 篇 心理学(可授教育学...
1 篇 农学
- 1 篇 畜牧学

主题

70 篇 hippocampus
66 篇 receptor
51 篇 rat
38 篇 neuron
37 篇 ischemia
36 篇 cortex
36 篇 disease
36 篇 cell
35 篇 memory
34 篇 pain
34 篇 nmda
33 篇 s
31 篇 epilepsy
30 篇 astrocyte
30 篇 cells
28 篇 neural
27 篇 depression
26 篇 apoptosis
26 篇 development
26 篇 spinal

机构

17 篇 neuroscience res...
15 篇 首都医科大学
10 篇 department of ne...
9 篇 复旦大学
9 篇 key laboratory f...
8 篇 上海交通大学医学...
7 篇 key laboratory f...
7 篇 infectious disea...
6 篇 laboratory of tr...
6 篇 浙江大学
6 篇 institutes of br...
5 篇 department of ne...
5 篇 institute of neu...
5 篇 institute for bi...
5 篇 department of an...
5 篇 institutes of br...
5 篇 department of ph...
5 篇 state key labora...
5 篇 中国医学科学院药...
5 篇 department of bi...

作者

14 篇 albert cheung ho...
10 篇 shi-gang he
10 篇 wei wang
8 篇 陈生弟
8 篇 min zhang
8 篇 陈乃宏
7 篇 ying huang
7 篇 yu-qiu zhang
7 篇 yong-di zhou
7 篇 zhong chen
7 篇 tian-ming gao
7 篇 xin-hong zhu
6 篇 wen-bin li
6 篇 jun-xia xie
6 篇 xiao-min wang
6 篇 gen-cheng wu
6 篇 jun chen
6 篇 ning lan
6 篇 hong jiang
6 篇 jin-hui wang

语言

1,268 篇 英文
124 篇 中文
2 篇 法文

检索条件"任意字段=中国神经科学学会第九届全国学术会议暨第五次会员代表大会"

共 1394 条记录，以下是421-430 订阅

全选清除本页清除全部题录导出标记到"检索档案"

详细简洁

排序：

Examination of MMP9 in cortical lesions from patients with malformations of cortical development

Examination of MMP9 in cortical lesions from patients with m...

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Song LI~1,Si-Xun YU~1,Hai-Feng SHU~1,Chun-Qing ZHANG~1,Qing YIN~2,Hui YANG~(1,*) 1 Department of Neurosugery,Xinqiao Hospital,Third Millitary Medical University,Chongqing 400037,China 2 Department of Rehabilitation,Southwest Hospital,Third Millitary Medical University,Chongqing 400038,China

Objective In focal cortical dysplasia typeⅡb(FCDIIb) and tuberous sclerosis complex(TSC), malformative cortical lesions in the cerebral cortex cause epilepsy and other neurological ***, the mechanisms of epilepsy in FCDIIb and TSC remains largely *** evidences indicate that Matrix metalloproteinase 9(MMP9) may be closely involved in *** this study,we investigated whether MMP9 might be involved in malformations of cortical development(MCDs) associated with *** We analyzed the expression and activity of MMP9 in FCDIIb lesions(n = 9) and TSC tubers(n = 13) and in control cortex(CTX, n = 8) by *** methods are used for the specific cellular distribution of MMP9. Results Elevation of protein levels and overactivity of MMP9 were observed in FCDIIb and TSC lesions versus *** studies indicated that MMP9 was strongly characteristically expressed in misshappend cells,namely,hypertrophic neurons,dysmorphic neurons,balloon cells and gaint *** immunofluorescent staining indicated that the reactive astrocytes,not the microglia,highly expressed *** These results suggest that overexpression and overactivity of MMP9 may contribute to the epileptogenesis of FCDIIb and TSC.

关键词： epilepsy Matrix metalloproteinase 9 focal cortical dysplasia tuberous sclerosis complex

来源：评论

学校读者我要写书评

暂无评论

Effects of androgen and leptin on behavioral and cellular responses in female rats

Effects of androgen and leptin on behavioral and cellular re...

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Birgitta Weijdegrd Julia Johansson Emil Egecioglu Hakan Billig Elisabet Stener-Victorin Department of Obstetrics and Gynaecology First Affiliated HospitalHeilongjiang University of Chinese MedicineHarbinChina

The causes of anxiety and depression in women with polycystic ovary syndrome(PCOS) remain elusive. To identify steps linking androgen signaling to the regulation of affective symptoms in vivo,we compared behavioral responses in female rats continuously exposed to DHT from puberty(a model of DHT-induced PCOS) and in rats exposed to DHT for 1 *** both groups,locomotor activity decreased,indicating anxiety-like *** with DHT-induced PCOS have increases in adiposity and circulating leptin levels accompanied by leptin *** week of DHT exposure decreased androgen receptor(AR) expression in the hypothalamus and leptin synthesis and function in adipocytes;it also inhibited signal transducer and activator of transcription 3(STAT3) and attenuated leptin activity by increasing levels of soluble leptin receptor,a leptin-binding protein,in the *** may affect the androgen-induced anxiety-related behavior in female *** results highlight the central role of androgens in behavioral function in female rats and suggest that androgens directly regulate the AR by decreasing its hypothalamic *** also increase leptin synthesis in adipocytes,which drives central leptin signaling,and may regulate anxiety-related *** molecular factors are responsible for anxiety-related behavioral responses. Elucidating mechanisms by which androgens modulate female anxiety-like behavior may uncover useful approaches for treating women with PCOS who have symptoms of anxiety.

关键词： dihydrotestosterone leptin,brain adipose tissue behavior anxiety depression polycystic ovary syndrome

来源：评论

学校读者我要写书评

暂无评论

Glial gap-junction communication is involved in hippocampal damage and cognitive deficits following middle cerebral artery occlusion

Glial gap-junction communication is involved in hippocampal ...

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Minjie XIE,Chenju YI,Xiang LUO,Shabei XU,Zhiyuan YU,Bitao BU,Wei WANG~* Department of Neurology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430030,China

Stroke induced by middle cerebral artery occlusion(MCAO) is a common cause of adult disability leading to motor-sensory disturbances and cognitive *** is generally accepted that cognitive impairment in stroke patients caused by MCAO results from damage to the cerebral cortex rather than the hippocampus,because the middle cerebral artery does not supply blood to the *** we provide the first evidence that patients with exclusively unilateral MCAO show hippocampal damage characterized by an infarct size-independent atrophy and alterations in neuronal and glial metabolites in the ipsilateral hippocampus as assessed by MRI,in parallel with a significant decline in cognitive *** MCAO also induces delayed shrinkage and pyramidal neuronal death in the ipsilateral hippocampus and an impairment of hippocampal-dependent spatial *** glutamate and pyramidal neuronal intracellular calcium levels were significantly elevated and spreading depression waves were observed in the hippocampus which correlated with neuronal *** gap junctional communication (GJC) with carbenoxolone or down-regulation Cx43 significantly increased the survival of the pyramidal neurons in the ipsilateral hippocampus and improved behavioral ***,Cx43 heterozygous mice showed reduced shrinkage and metabolites abnormality in ipsilateral hippocampus after *** results suggest a significant role of astroglial GJC in MCAO-induced remote hippocampal damage and cognitive impairment.

关键词： astrocyte gap junctional communication hippocampus ischemia

来源：评论

学校读者我要写书评

暂无评论

Liver X receptor β inhibits the transformation of radial glial cells into astrocytes during cerebral cortex development

Liver X receptor β inhibits the transformation of radial gl...

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Jan-Ake Gustafsson Center for Nuclear Receptors and Cell Signaling University of HoustonTX 77054

＜正＞Liver X receptor is a member of the nuclear receptor superfamily of ligand-activated transcription factors, predominantly expressed in the cerebral *** have previously demonstrated that LXRβis essential for migration of later-born neurons during cerebral cortex *** radial glial cells serve as scaffolds for new-born neurons migration during cerebral cortex ***,the radial glial cells were transformationed into astrocytes around postnatal 14 ***,We found that the expression of LXRβmRNA was higher than LXRαin the cerebral cortex of mice,of which the expression of LXRβwas gradually increased from E18.5 to *** specific markers for radial glia cells,we further found that loss of LXRβinduced the decreased level of BLBP in the cerebral cortex from E18.5 to P7 and increased level of GFAP from P2 to P14 compared to the WT littermates at the same age. TGFβ1 and Smad4 are believed to be related to the transformation of radial glial cells into *** expression levels of TGFβ1 and Smad4 were increased significantly in the cerebral cortex of LXRβknockout mice compared to the WT littermates from the E18.5 to ***’s no difference in the expression levels of TGFβ1 and Smad4 between the LXRβknockout mice and WT littermates from the P10 to *** together,our findings suggest that loss of LXRβaccelerates the transformation of radial glial cells into astrocytes through high levels of TGFβ1 and Smad4 in the cerebral cortex.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Ubiquitin self-aggregation and interaction with α-synuclein

Ubiquitin self-aggregation and interaction with α-synuclein

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Makoto Hashimoto Department of Chemistry and Metabolism Tokyo Metropolitan Institute for NeuroscienceTokyo 183-8526Japan

＜正＞Objective Parkinson’s disease（PD） and dementia with Lewy bodies（DLB） are characterized by the accumulation of abnormal a-synuclein and ubiquitin in protein aggregates conforming Lewy bodies and Lewy *** proteinaceous intracellular aggregates may contribute to subsequent dopaminergic neurodegeneration. The a-synuclein is a natively unfolded protein that is capable of self-aggregation to form both oligomers and fibrillar polymers with amyloid-like *** is an extremely conserved,8.5 kD,76 residue protein found in all *** has multiple functions but it is primarily involved in a pathway that regulates the bulk of intracellular protein *** demonstrates that ubiquitin plays an important role in alpha-synuclein ***,the feature and mechanism among ubiquitin and synuclein proteins in neurodegeneration are not *** present study is to investigate the characteristic of ubiquitin and interaction with *** The aggregation features and the interaction between ubiquitin and synuclein was identified by immunobloting and morphological *** （1） Ubiquitin protein is aggregated and fibrillated under certain conditions,i.e.,increasing time lag,high temperature, low pH and ferrous iron oxidation in vitro.（2）α-Synuclein WT appears bamboo-like longer fibril,while ubiquitin looks thin twisted thread,and can fuse and hybrid with a-synuclein filaments by immunoelectron microscopy assay. （3） In stable synuclein B103 neuroblastoma cells,ubiquitin colocalized with synuclein in inclusion bodies and could accumulate and ubiquitinate with synuclein in certain *** These results suggest that ubiquitin could self-aggregate and might interact with a-synuclein in neurodegeneration.

关键词： ubiquitin synuclein aggregation neurodegeneration dementia with lewy bodies（DLB）

来源：评论

学校读者我要写书评

暂无评论

MicroRNA-21 stimulates neurite growth by targeting paired-like homeodomain 2 following sciatic nerve injury

MicroRNA-21 stimulates neurite growth by targeting paired-li...

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Song-Lin ZHOU,Deng-Bing YAO,Yong-Jun WANG,Xiao-Song GU,Fei DING~* Jiangsu Key Laboratory of Neuroregeneration,Nantong University,Nantong 226001,China

Objective Nerve regeneration is a complex biological phenomenon incorporating multiple cells,growth factors and an extracellular *** are endogenous,non-coding 21-to 23-nucleotide small RNA molecules that regulate gene expression by binding to the 3' untranslated region of target mRNAs,leading to their translational inhibition or *** present study is to explore whether miRNAs are capable of mobilizing the intrinsic capacity for neurite growth and promoting axon *** We analyzed the changes in miRNA and mRNA expression in the DRG,following sciatic nerve transection,using microarray and bioinformatics *** validate the microarray platform,we assessed the expression by real time Taqman *** validate the target,we performed luciferase reporter ***,we transfected the miRNA-21 mimics and PITX2 siRNA to the cultured DRG ***(1)The bioinformatics analysis indicated that miRNA-21 play important roles in regulating nerve regeneration via the target PITX2 in the network.(2)miRNA-21 is inversely correlated with PITX2 expression in DRG tissues.(3)In the cultured DRG neurons,miRNA-21 promotes neurite growth and inhibits PITX2 expression. Transfection of PITX2 siRNA also promotes neurite *** miRNA-21 is significantly up-regulated following sciatic nerve injury and promotes neurite growth by targeting PITX2.

关键词： nerve regeneration miRNA-21 PITX2 DRG

来源：评论

学校读者我要写书评

暂无评论

Altered responses of sodium channels to cAMP-dependent protein kinase activator in an epilepsy-associated SCNIA mutation

Altered responses of sodium channels to cAMP-dependent prote...

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Shuai LIU,Ping ZHENG State Key Laboratory of Medical Neurobiology,Shanghai Medical College and Institutes of Brain Science,Fudan University,Shanghai 200032,China

Familial inherited epilepsy with febrile seizures plus(GEFS+)caused by the mutation(I1656M)in SCN1A,the gene encoding the brain voltage-gated sodium channel a,subunit,has received a considerable attention because it provides a novel epileptic model to understand the pathogenesis of *** studies examined biophysical characteristics of I1656M using whole-cell patch-clamp analysis of heterologously expressed recombinant human *** the present paper,we examined changes of channel properties in responses to cAMP-dependent protein kinase(PKA)activator forskolin and protein kinase C(PKC)activator PDBu in the mutant channels by using whole-cell patch-clamp *** results showed that the response of the amplitude of sodium currents to forskolin significantly decreased in the mutant channels,but did not to *** addition,the response of the voltage dependence of activation and fast inactivation to forskolin disappeared in mutant channels,but the response of the voltage dependence of slow inactivation did *** overall effect of PKA activation on neuronal excitability were opposite in the mutant *** results indicate that altered responses of the mutant channels to PKA signaling may impair the delicate balances between chemical and electrical harmony and lead to abnormal neuronal excitability.

关键词： epilepsy familial inherited epilepsy with febrile seizures plus Nav1.1 SCN1A mutation whole-cell patchclamp cAMP-dependent protein kinase

来源：评论

学校读者我要写书评

暂无评论

Nifedipine reduces iron accumulation and dopamine neuron degeneration in the iron-overloaded substantia nigra of rats

Nifedipine reduces iron accumulation and dopamine neuron deg...

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Ze-Gang MA,Jun-Xia XIE~* Department of Physiology,Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines:Physiology,Medical College of Qingdao University,Qingdao,266071

Objective To investigate whether nifedipine,a blocker of L-type calcium channels can prevent iron accumulation and dopamine neuron degeneration in the substantia nigra(SN) of acute and chronic iron-overloaded *** The changes of tyrosine hydroxylase(TH) gene expression in the substantia nigra(SN) were detected by reverse transcription-polymerase chain reaction(RT-PCR),the TH-positive neurons were tested by TH immunohistochemistry,the dopamine content was measured by liquid chromatography-electrochemical detection and the iron contents of SN were determined by iron concentration *** Compared with the control group, the expressions of TH mRNA decreased,and the iron contents increased in the acute iron-overloaded SN of *** with nifedipine may partly restore these *** in the chronic iron-overloaded rats,the dopamine content in the striatum decreased after iron dextran treatment,which could be restored by *** dextran overload increased iron content in the SN and reduced the number of TH-positive *** with nifedipine prevented the increased iron content and restored the numbers of TH-positive neurons to control *** Nifedipine may inhibit iron-overload induced dopamine neuron damage in the iron-overloaded rats by suppressing iron toxicity.

关键词： nifedipine iron substantia nigra Parkinson's disease

来源：评论

学校读者我要写书评

暂无评论

The convergent regulation of the specification of D mns by unc-30 and unc-55 in ***

The convergent regulation of the specification of D mns by u...

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Ge SHAN School of Life Science,University of Science and Technology,443 Huangshan Road,Hefei,230027,China

How do genetic programs create features common to a specific cell or tissue type while generating modifications necessary for functional diversification? We have addressed this question using the nematode Caenorhabditis *** dorsal D(DD) and ventral D(VD) motorneurons(mns),referred to collectively as the D mns,compose a cross-inhibitory network that contributes to the animal's sinuous *** D mns share a number of structural and functional features,but are distinguished from one another by their synaptic patterns and the expression of a neuropeptide *** findings suggest that the similarities and differences are generated at the transcriptional ***-30 contains a homeodomain and activates structural and functional genes expressed in both ***-55 is a nuclear receptor expressed in the VD mns that is necessary for generating features that distinguish the two classes of D mns from one *** unc-55 mutants,the VD mns adopt the DD mn synaptic pattern and peptide expression ***,ectopic expression of unc-55 in the DD mns causes them to adopt VD mn *** promoters of the a neuropeptide gene and several other genes expressed in the DD mns contain putative binding sites for both UNC-30 and UNC-55;alteration of these sites suggests that UNC-55 represses the ability of UNC-30 to activate a subset of genes that are expressed in the DD mns but not in the VD *** UNC-55 acts as a switch for the features that distinguish these two functionally related classes of mns.

关键词： GABAergic motor neurons unc-30 unc-55 C.elegans

来源：评论

学校读者我要写书评

暂无评论

Mapping synaptic connectivity by optogenetic activation with an AOD-assisted laser stimulation system

Mapping synaptic connectivity by optogenetic activation with...

引用

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Yi-Ding LI~1,Ya-Feng LIU~2,Pei-Pei SONG~1,Shao-Qun ZENG~2,Xiao-Hui ZHANG1 1 Institute of Neuroscience,State Key Laboratory of Neuroscience,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China 2 Britton Chance Center for Biomedical Photonics,Wuhan National Laboratory for Optoelectronics,Huazhong University of Science and Technology,Wuhan 430074,China

Light activation and inactivation of neurons by optogenetic techniques has emerged as an important tool for studying neural circuit function and *** achieve a rapid and precise manipulation of neuronal or circuitry activity at sub-millisecond time resolution,we have designed an acousto-optic device(AOD)-assisted blue-laser stimulation system for exciting neurons with an optogenetic probe light-activated Channelrhdopsin-2(ChR2)channels. We further evaluated the performance of this system for activating ChR2-expressing neurons in the neocortical slices acutely isolated from the Thy-l-ChR2-YFP transgenic or AAV vector injected *** results demonstrate that the AOD-assisted light activation of ChR2 channels in neurons is capable of efficiently and precisely controlling the rate and temporal sequence of neuronal spikes of different types of neocortical neurons in brain slices,and this system is promising for the studies on the mapping of functional connectivity in a local circuit as well as on the synaptic integration in a single principle cell in brain slices.

关键词： Mapping synaptic connectivity by optogenetic activation with an AOD-assisted laser stimulation system AOD

来源：评论

学校读者我要写书评

暂无评论

没有更多数据了...

全选清除本页清除全部题录导出标记到“检索档案”

共140页 << < 39 40 41 42 43 44 45 46 47 48 > >>

检索报告对象比较合并检索0

隐藏清空

合并搜索

回到顶部

执行限定条件

内容：

评分：

请选择保存的检索档案：

请选择收藏分类：

订阅名称：

通借通还

温馨提示：

图书名称：

借书校区：

取书校区：

手机号码：

邮箱地址：

一卡通帐号：

电话和邮箱必须正确填写，我们会与您联系确认。

联系人：

所在院系：

联系邮箱：

联系电话：

内蒙古自治区呼和浩特市赛罕区大学西街235号邮编: 010021

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：