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Immunoexpression of synaptophysin(SYN) and GABA in the outer part of rat retina following acute high intraocular pressure

Immunoexpression of synaptophysin(SYN) and GABA in the outer...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Jia LUO,Hui WANG,Dan CHEN~*,Ju-Fang HUANG Department of Anatomy and Neurobiology,Xiangya School of Medicine,Central South University,Changsha 410013, China

Objective To investigate the changes of synaptic plasticity in the outer part of rat retina and whether GABAergic neurons being involved in following acute high intraocular pressure（HIOP）.Methods The intraocular pressure of all left eyes was increased until b wave of flash electroretinogragh（fERG）disappeared and such pressure maintained for 60 *** right eyes served as normal *** SD rats were sacrificed respectively on hour 2, 6,12 or day 1,3,7,14 following *** staining and western blot were used to detect the expression of SYN and GAB *** In the outer part of retina,SYN was mainly located in the outer plexiform layer（OPL）in normal *** HIOP 2 h,6 h,12 h,1 d,3 d and 7 d,SYN positive products were extended to the inner part of the outer nuclear layer（ONL）.The expression of SYN in the outer part of retina was similar to the normal condition 14 d after *** was mainly located in the inner nuclear layer（INL）and the inner part of OPL in normal *** HIOP 2 h,6 h,12 h,1 d,3 d and 7 d,GABA expression in OPL was downregulated, while upregulated in *** the 7day,there was silkiness positive product in ONL,which was not double-staining with *** the 14day after HIOP,the positive product was *** There is synaptic plasticity in rat OPL and ONL following HIOP insult,GABA positive neuron may not participate directly in this process.

关键词： HIOP retina synaptophysin GABA

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Activation of translocator protein(TSPO) reverses neuropathic pain behavior

Activation of translocator protein(TSPO) reverses neuropathi...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Xu-Hong WEI,Li-Jun ZHOU,Cui-Cui LIU,Xiao WEI,Xian-Guo LIU~* Pain Research Center of Sun Yat-sen University,Guangzhou 510080,China

Neuropathic pain is characterized by a heightened painful response to noxious(hyperalgesia) or innocuous(allodynia) stimulation,and pain at rest(spontaneous pain).At present no effective drug is available for the clinical symptom.A recent study has shown that the translocator protein(TSPO,18 kDa),a peripheral receptor for benzodiazepine,modulates pain behaviors of rats induced by *** the present study,we evaluated the role of TSPO in neuropthic pain produced by L5 spinal nerve ligation(L5 SNL) with use of behavioral testing, immunohistochemistry and Western blot *** found that TSPO was up-regulated in spinal dorsal horn following L5 SNL and the change lasted until behavioral signs of neuropathic pain diminished(around 50 d).Double immunofluorescence showed that in naive rats,TSPO was located mainly in astrocytes,to a lesser extent in neurons, but not in microglia,whereas following L5 SNL,TSPO was upregulated in astrocytes and microglia,but not in *** data showed that single intrathecal injection of TSPO agonist Ro5-4864 or FGIN-1-27 reversed established mechanical allodynia induced by L5 SNL *** and Western blot showed that intrathecal injection of Ro5-4864 reversed activation of astrocytes,and depressed p38 MAPK activation,which is exclusively activated in spinal microglial cells following peripheral nerve *** data suggested that activation of TSPO by agonists might reverse neuropathic pain by inhibition of activated glial cells.

关键词： TSPO neuropathic pain astrocyte

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Restoration of visual function by ectopic expression of melanopsin in rd mice

Restoration of visual function by ectopic expression of mela...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Amane Koizumi Nobushige Tanaka Satchidananda Panda Richard H.Masland Harvard Medical School BostonMA 02114USA The Salk Institute for Biological Studies La JollaCA 92037

The principal photoreceptors for image forming vision in the retina are rod and cone *** of photoreceptor cells,as happens in a number of human diseases,such as retinitis pigmentosa and age-related macular degeneration,leads to irreversible ***,the current therapeutic treatment for retinal degeneration is very ***,we asked whether *** possible to restore any vision by ectopic expression of melanopsin,a newly discovered light-sensitive photopigment,in the surviving ganglion *** protein melanopin is normally expressed in 2%-3%of ganglion cell population of the mouse *** test this intriguing possibility,we used a viral vector to express mammalian melanopsin in other retinal ganglion cells of rd/rd mice,which suffer an early degeneration of rod photoreceptors and a subsequent degeneration of *** each retina melanopsin was expressed in up to 6000 retinal ganglion cells,of many morphological ***-cell patch-clamp recording showed intrinsic photoresponses in these cells,even after degeneration of the photoreceptors and additional pharmacological or Cd block of synaptic *** newly melanopsin-expressing ganglion cells provided an enhancement of visual function in the rd/rd mice:the pupillary light reflex returned almost to normal;the mice showed behavioral avoidance of light in an open field test;and they could discriminate a light stimulus from a dark one in a two-choice visual discrimination alley. These results show that an effective signalling pathway for melanopsin is not restricted to the retinal ganglion cells that normally contain melanopsin,or to any particular ganglion cell *** of this or other light-sensitive proteins in the surviving retinal neurons might provide some degree of vision for humans blind due to photoreceptor degeneration.

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ACS84,a novel l-dopa derivative,alleviates LPS-stimulated inflammation in microglia

ACS84,a novel l-dopa derivative,alleviates LPS-stimulated in...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Li-Fang HU,Ya-Ping YANG,Chun-Feng LIU Laboratory of Aging and Nervous Diseases,Neuroscience Institute,Soochow University,Suzhou 215123,China

Objective Hydrogen sulfide is a novel gasotransmitter and has been reported to exhibit anti-inflammatory effects on LPS-stimulated glial cells in our previous *** we continued to investigate the role of ACS84,a novel HS-releasing compound derived from /-dopa,in LPS-induced inflammation in *** The microglia were treated with LPS（100 ng/mL） for 24 h to induce *** levels of nitric oxide in the cell-free culture supernatant were determined by Griess reagent with a commercial kit from *** levels of other pro-inflammatory factors,such as TNF-α,ICAM-1 and IL-6 were measured by ELISA with commercial kits from R&*** phosphorylation of p38,JNK,ERK1/2 and STAT-3 were analyzed by Western *** cell viability was assessed by MTT ***（1） ACS84 suppresses LPS-stimulated iNOS upregulation and NO generation in microglia;（2） ACS84 inhibits LPS-evoked inflammatory cytokines generation in microglia;（3） ACS84 attenuates LPS-stimulated phosphorylation of MAPKs in microglia;（4） ACS84 ameliorates LPS-induced phosphorylation of STAT3 in microglia;（5） ACS84 attenuates the microglia-mediated neurotoxicity on SH-SY5Y *** ACS84 may protect against LPS-induced cell injury via anti-inflammation in MAPK/STAT3-dependent mechanisms and thus it may have therapeutic potential for the treatment of Parkinson's disease.

关键词： ACS84 hydrogen sulfide l-dopa Parkinson's disease

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Effects of CXCL12 on GABA and ACh secretion and its mechanism in cultured hippocampal cells

Effects of CXCL12 on GABA and ACh secretion and its mechanis...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Su-Fang LIU~1,Li-Jun WANG~1,Xue-Fei HAN~1,Ping DUAN~1,Wen-Hai YAN1,Ying XING~(1,2,*) 1 Department of Physiology,Medical School,Zhengzhou University,Zhengzhou 450052,China 2 Xinxiang Medical College,Xinxiang,China

Objective This study is to illustrate the effects of CXCL12 on GABA and ACh secretion and its *** Primary hippocampus neurons were obtained from newborn SD *** hippocampi were carefully dissected and digested in 0.25%trypsin at 37°C for 5 *** were used to determine the location of CXCL12 and its receptor *** ELISA was carried to detect the dose of CXCL12 in primary *** addition,GABA and ACh secretion were detected by ELISA under different culture condition, including AMD3100 and CXCL12 *** CXCL12 and its receptor CXCR4 mainly located in membrane and cytoplasma,which suggested the role of CXCL12 and its receptor in nervous *** addition, CXCL12 secretion increased significantly with culture time ***,CXCL12 could stimulate ACh secretion and inhibit GABA *** when CXCR4 was knocked down by AMD3100,ACh and GABA secretion changed sharply in an opposite *** CXCL12 may alter GABA and ACh secretion by CXCR4 pathway in cultured hippocampal cells,which may suggest CXCL12 as an important neurotrophic factor to stimulate neurotransmitters releasing.

关键词： hippocampal stromal cell derived factor CXCR4 neuron

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Contribution of GABAA receptor-mediated activity to self-generated oscillations in hippocampal CA3-CA1 regions

Contribution of GABAA receptor-mediated activity to self-gen...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Yan YANG,Xiao-Lin XUE,Chao DING,Zhi-Ru WANG~* Plasticity of Neural Circuit Lab,Key Laboratory of Brain Functional Genomics,Ministry of Education,East China Normal University,Shanghai 200062,China

Objective Spontaneous oscillations in the hippocampus are believed to play important roles in hippocampus-dependent cognition and learning and *** studies in hippocampal slices indicate that these oscillations are mediated by the activity of intemeurons in the hippocampus,particularly via GABAA receptors. This issue remains to be further *** In this study,we developed a new system of in vitro wholecell patch-clamp recordings in whole-hippocampus *** In such preparation,robust spontaneous oscillations（from 0.8 Hz to 2 Hz）were observed in both pyramidal cells and intemeurons in the absent of any *** whole-cell recordings further revealed that the oscillations were synchronized in CA1, CA3,and across CA1-CA3 *** the presence of bicuculline-a GABA receptor blocker-in bath solution,the frequency of spontaneous oscillations was remarkably reduced to 0.1-0.2 Hz,which was found in the pyramidal cells and intemeurons of both CA1 and CA3 ***,extracellular blockade of GABA receptors by SCH50911 didn't alter the frequency of the *** treatment of ZD7288,which blocks hyperpolarization-activated （I）channels,also slowed down the hippocampal oscillations to .4 *** Our observations from whole-hippocampus formation revealed the important roles of GABA receptors,probably coordinating with the activity of I channels,in mediating the self-generated oscillations in the hippocampus in the absence of extrahippocampus inputs.

关键词： hippocampus oscillation GABAA receptor Ih channel

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Microglial migration mediated by ATP-induced ATP release from lysosomes

Microglial migration mediated by ATP-induced ATP release fro...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Ying DOU~1,Hang-Jun WU~(2,3),Hui-Quan LI~2,Song QIN~1,Hui-Fang LOU~2,Qing-Ming LUO~3,Shu-Min DUAN~(2,*) 1 Institute of Neuroscience and Key Laboratory of Neuroscience,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China 2 Department of Neurobiology,Key Laboratory of Medical Neurobiology of the Ministry of Health of China,Key Laboratory of Neurobiology of Zhejiang Province,Zhejiang University School of Medicine,Hangzhou 310058,China 3 Huazhong University of Science and Technology,Wuhan 430074,China

Microglia are highly motile cells that act as the main form of active immune defense in the central nervous *** by factors released from damaged cells,microglia are recruited towards the damaged or infected site, where they are involved in degenerative and regenerative responses and phagocytotic clearance of cell *** release from damaged neural tissues has been suggested to mediate the rapid extension of microglial process towards the site of ***,the mechanisms of the long-range migration of microglia remain to be ***,we found that lysosomes in microglia contain abundant ATP and exhibit Ca-dependent exocytosis in response to various *** establishing an efficient in vitro chemotaxis assay,we demonstrated that endogenously-released ATP from microglia triggered by local microinjection of ATPyS is critical for the long-range chemotaxis of microglia,a response that was inhibited in microglia treated with an agent inducing lysosome osmodialysis or in cells deficient in Rab 27a,a small GTPase required for the trafficking and exocytosis of secretory *** results suggest that microglia respond to extracellular ATP by releasing ATP themselves through lysosomal exocytosis,thereby providing a positive-feedback mechanism to generate a long-range extracellular signal for attracting distant microglia to migrate towards and accumulate at the site of injury.

关键词： microglia migration ATP lysosome

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Language specificity in the neural processing of auditory feedback during vocal production

Language specificity in the neural processing of auditory fe...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Zhao-Cong CHEN,Han-Jun LIU~* Department of Rehabilitation Medicine,The First Affiliated Hospital,Sun Yat-sen University,Guangzhou 510080, China

Objective Auditory feedback has been demonstrated to play an important role in the control of voice fundamental frequency(FO),but neural mechanisms underlying this control process are poorly *** present cross-language study was to examine whether there is a language-dependent neural processing of auditory feedback by measuring event-related potentials(ERPs) to pitch perturbations during sustained vocalizations of Cantonese and Mandarin *** Native speakers of Cantonese and Mandarin participated in this *** were asked to sustain a vocalization of a vowel sound /u/ at their comfortable habitual FO level for about 5 s,during which their voice pitch feedback was unexpectedly shifted 5 times(- 50,- 100,- 200,or - 500 cents,200 ms duration) and fed back instantaneously to them over *** ERPs to these pitch-shifted stimuli were measured and analyzed across *** Significantly larger amplitudes of P2 were produced by Cantonese speakers as compared to Mandarin speakers when voice pitch feedback was shifted from 200 to 500 cents,while no significant differences were found in P2 amplitude between them in the case of 50 and 100 cents *** addition,a systematic change of P2 amplitude across pitch perturbation magnitude was found for Cantonese speakers but not for Mandarin *** Neural representations of pitch errors in voice FO control can be modulated by subjects' exposure to different languages,and differential effects of pitch perturbation magnitude on the cortical processing of auditory feedback between Mandarin and Cantonese speakers may be related to the specific tonal features of these two languages.

关键词： auditory feedback pitch perturbation event-related potential tonal language

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The experimental study on the transplantation of Nurrl gene transfected neural stem cells for treatment of Parkinson's disease

The experimental study on the transplantation of Nurrl gene ...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Xue-Feng TAN,Guo-Hua JIN~*,Mei-Ling TIAN,Hao-Ming LI,Hui-Xia ZHU,Lei ZHANG Department of Anatomy and Neurobiology,the Key Laboratory of Nerve Regeneration of Jiangsu Province,School of Medicine,Nantong University,Nantong 226001,China

Objective To study the differentiation of neural stem cells(NSCs)transfected with nuclear receptor related factor 1(Nurr1)gene into dopaminergic neurons and its behavioral exertion after transplanted into the striatum of Parkinson's disease(PD)*** The unilateral PD rats were prepared by the rat brain stereotaxic technology using single-point injection of 6-OHDA into the right medial forebrain *** recombinant pEGFP-N1 -Nurr1 was transfected into NSCs through elctroporation,and the expression of Nurrl gene was detected by RTPCR. The NSCs were labled with DIL and transplanted into the right striatum of PD ***-induced rotation test was performed to observe the behaviour amelioration after *** the expression of tyrosine hydroxylase(TH)was detected by immunofluorescence *** PD rats appear typical rotations, and the rate of success was 62%.Nurrl gene was overexpressed after transfected with recombinant *** transplantation,the behaviour of PD rats did not ameliorate obviously in sham and NSCs *** positive cells could be observed in NSCs group,but few of them exhibited TH positive;In Nurr1 group,the rotations of PD rats began to decrease at the sixth week after transplantation,and there were many DIL/TH double-labeled neurons in transplanted *** Overexpression of Nurrl could induce the differentiation of NSCs into TH positive dopaminergic neurons in the striatum of PD rats,and ameliorate the behavioral function of PD rats.

关键词： nuclear receptor related factor 1 neural stem cells gene transfection Parkinson's disease transplantation rat

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The histological study on genesis and development of diencephalon in the salamander Hynobius leechii

The histological study on genesis and development of diencep...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Yong-Gang ZHANG,He CHAO,Shao-Kang BIAN,Chuan-Cheng LIANG,Li-Wen WANG~* College of Chemistry and Life Science,Shenyang Normal University,Shenyang 110034,China

Objective Hynobius leechii belongs to Amphibia,Urodela,Salamander genus,is the lower group in *** research on its diencephalon and its position in the evolution has not been *** using the conventional paraffin section,HE staining,Niss1 staining and silver staining of nerve fibers,we made partitions of diencephalon and localization of nuclei,discussing the histological features of genesis and development of diencephalon in Hynobius and its position in the evolution to fill the blank of study on genesis and development of diencephalon in tailed *** The diencephalon of Hynobius was differentiated from the back-end of forebrain vesicle,the diencephalon developed slightly later than the *** rudiment of diencephalon was formed from post-embryonic limb bud,the primordium of neural pituitary and pineal gland appeared in the incubation *** development of diencephalon experienced the hind limb bud stage,metamorphosis stage, sub-adult stage and the adult stage,completed the differentiation and localization of nuclei in *** the triangle area appeared in the back end of the middle brain as a boundary on the dorsal surface of diencephalon, the diencephalon extended itself to the rear of retuse rostral area of the mesencephalon;taking the preoptic area at the end plate in the back end of the middle telencephalon as a boundary on the ventral surface of diencephalon, the diencephalon extended itself to the end of the medulla oblongata below the ***'s diencephalon consists of the epithalamus,thalamus and *** epithalamus includes two parts of the pineal gland and habenular nucleus,the habenular nucleus divided into the dorsal habenular nucleus(Hd)and the ventral habenular nucleus(Hv);the thalamus consists of three parts-the dorsal and ventral thalamus and the posterior tubercle,the dorsal thalamus includes the anterior nucleus(A),the central nucleus(C)and the posterior nucleus (P);the v

关键词： Hynobius leechii diencephalon genesis development histology

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