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检索条件"任意字段=中国神经科学学会第九届全国学术会议暨第五次会员代表大会"

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Derepression of tPA expression by knocking out NRSF enhances mature BDNF and upregulates hippocampal LTP

Derepression of tPA expression by knocking out NRSF enhances...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Xue-Wen CHENG,Lei CAI,Bin LU,Da-Feng XU,Li HUANG,Li XU,Jing ZHENG,Jian FEI,Zhi-Qi XIONG~(1*) 1 Institute of Neuroscience,State Key Laboratory of Neuroscience,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,320 Yueyang Road,Shanghai 200031,China 2School of Life Sciences and Technology,Tongji University,1239 Siping Road,Shanghai 200092,China 3School of Pharmacy,East China University of Science and Technology,130 Meilong Road,Shanghai 200237,China

Neuronal restrictive silencing factor(NRSF)is an epigenetic repressor with important role in regulating neurogenesis and ***,the physiological function of NRSF in postnatal brain remains an interesting ***,we reported that activity-dependent synaptic plasticity was suppressed by *** cre/ loxP system,nrsf was conditionally knockout(cko)in forebrain excitatory *** recording of hippocampus CA1 radiatum area revealed a significantly upregulated long-term potentiation(LTP).We also found that activity stimulation led to significant enhancement of mature BDNF in cko mice,and this enhancement was mediated by the increased level of tissue plasminogen activator(tPA).Moreover,we found tPA was transcriptionally repressed by NRSF through direct binding to RE1 sequence in tPA *** of tPA activity abolished the upregulation of LTP in nrsf-cko *** findings provide an NRSF mediated epigenetic mechanism that moderates LTP in the hippocampus CA3-CA1 pathway.

关键词： NRSF LTP tPA synaptic plasticity

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Neuronal MCP-1 mediates microglia recruitment and neurodegeneration induced by the mild impairment of oxidative metabolism

Neuronal MCP-1 mediates microglia recruitment and neurodegen...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Guang YANG,Ya MENG,Wenxia LI,Zhiqin FAN,Hanqing DING,Youzhen WEI,Jia LUO,Zun-Ji KE~* Key Laboratory of Nutrition and Metabolism,Institute for Nutritional Sciences,Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences,Graduate School of the Chinese Academy of Sciences,Shanghai 200031,China

Chemokines are implicated in neuroinflammation of several chronic neurodegenerative disorders. However,the precise role of chemokines in neurodegeneration is *** deficiency(TD) causes abnormal oxidative metabolism in the brain as well as a well-defined microglia activation and neurodegeneration in the submedial thalamus nucleus(SmTN),which are common features of neurodegenerative *** evaluated the role of chemokines in neurodegeneration and the underlying mechanism in a TD *** the chemokines examined,TD selectively induced neuronal expression of monocyte chemoattractant protein-1(MCP-1) in the SmTN prior to microglia activation and *** conditioned medium collected from TD-induced neurons caused microglia *** a neuron/microglia co-culture system,we showed that MCP-1-induced neurotoxicity required the presence of microglia and exogenous MCP-1 was able to activate microglia and stimulate microglia to produce cytokines.A MCP-1 neutralizing antibody inhibited MCP-1-induced microglia activation and neuronal death in culture and in the ***-1 knock-out mice were resistant to TD-induced neuronal death in *** selectively induced the accumulation of reactive oxygen species in neurons,and antioxidants blocked TDinduced MCP-1 ***,our results indicated an induction of neuronal MCP-1 during mild impairment of oxidative metabolism caused microglia recruitment/activation,which exacerbated neurodegeneration.

关键词： thiamine deficiency chemokines microglia activation neurodegeneration oxidative stress

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Expressions of the imprinted genes from cluster Dill-Dio3 in corticospinal projection neurons

Expressions of the imprinted genes from cluster Dill-Dio3 in...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： CS QU,YJ YANG,HP TAO,J QU,JG CHEN~* School of Ophthalmology and Optometry,Wenzhou Medical Collage,the Key Laboratory of Visual Science,Wenzhou, China

The corticospinal projection neurons(CSPN),originated from the layer V of cerebral cortex,generate neural impulses and control execution of *** of CSPN give rise to upper motor neuron(UMN) *** identify the molecules of the motor neuron related diseases,we labeled the CSPN of postnatal mice by a retrograde tracer Red Beads,and isolated them by laser capture micro-dissection(LCMD).Started with gene expression screening,we found that maternally expressed gene 3(Meg3) and Meg8 were highly enriched in CSPN during the early ***3 and Meg8 are colocalized with Ctip2,a marker of the layer ***3 and Meg8 are from a transcription unit located in the imprinted cluster Dill-Dio3,whereas a paternally expressed gene Rtll is known in the opposite *** had a minimal expression in the cortex as determined by in situ hybridization. The homologous genes Meg3 and Meg8 were also expressed in the deep cortical layer in a human brain of 27 week *** different expression pattern between Meg3 and Rtll suggests that the maternally genetic contributions may be important for the early cortical *** effect is directed to identify the micro RNAs in Dill- Dio3 that inhibit the expression of *** study may help us to better understand the human disorders due to the maternally deletion of this imprinted cluster.

关键词： CSPN LCMD imprinted gene Meg3 Rtll

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The neuroprotective effect of icariin in the cell model of Parkinson's disease

The neuroprotective effect of icariin in the cell model of P...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Lin WU,Ai-Li XU,Wen-Fang CHEN~* Department of Physiology,Medical College of Qingdao University,Qingdao 266071,China

Objective Herba Epimedii（HEP） is one of the most frequently prescribed herbs in traditional Chinese medicine formula for treatment of osteoporosis,cardiovascular diseases,and improvement of neurological functions in ***,a marker flavonoid glycoside in HEP,is believed to be the major active ingredient that account for its biological *** present study was designed to investigate the protective effect of icariin against 1-methyl- 4-phenylpyridinium（MPP）-induced neurotoxicity and the possible *** MES23.5 cells were routinely cultured and treated with icariin in the presence or absence of MPP+.MTT method was used to detect the cell *** mitochondrial membrane potential was determined by flow *** real time RT-PCR was used to detect the gene expression of Bcl-2 and *** activity of ERE promoter was detected by Dual Luciferase Assay. Results Pretreatment with icariin resulted in an enhancement of survival of MES23.5 cells against MPP-induced *** decreased the mitochondrial membrane *** pretreatment could partly reverse the toxic effect of ***,pretreatment with icariin could increase the Bcl-2 gene expression and decrease the Bax gene expression which affected by *** treatment alone could not induce the ERE promoter luciferase *** The present study clearly demonstrated that icariin has neuroprotective effects against MPP- induced neurotoxicity in MES23.5 cells,and its mechanism may be related to its anti-apoptosis eflfects.

关键词： icariin MPP+ apoptosis MES23.5 cell

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Ionotropic glutamate receptors in medial prefrontal cortex and dorsal hippocampus are involved in different components of methamphetamineinduced conditioned place preference in mice

Ionotropic glutamate receptors in medial prefrontal cortex a...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Wen-Yan HAN~1,Fang WANG~1,Shi-Yuan FU~1,Ming SONG~2,Ping DU~1,Xiao-Long JING~1,Chun-Fu WU~(1,*),Jing-Yu YANG~(1,*) 1 Department of Pharmacology,Shenyang Pharmaceutical University,110016,Shenyang,China 2 Liaoning Institute of Crime Detectives,Shenyang 110032,China

Objective The medial prefrontal cortex(mPFC) and dorsal hippocampus(DHC) play significant roles in stimulant-induced neurobehavioral *** order to investigate the role of mPFC and DHC in methamphetamine (MAP) reward and drμg-priming induced relapse,the present study examined the effect of lesions of mPFC or DHC on the acquisition and MAP priming induced reinstatement of conditioned place preference(CPP) in *** After pre-training or establishment day of CPP,the animals received bilateral kainic acid(KA) or N-methyl-daspartate (NMDA) lesions of mPFC or *** The results showed that both KA and NMDA lesions of mPFC significantly blocked the acquisition of MAP-induced CPP,and a KA but not NMDA lesion of the DHC prevented the acquisition of MAP-induced ***,the MAP priming induced CPP-reinstatement was prevented by a KA but not NMDA lesion of mPFC,and was markedly inhibited by only an NMDA lesion of *** These findings indicated that the ionotropic glutamate receptors(iGluRs) in mPFC and DHC were involved in MAP-induced ***,different types of iGluRs in these two regions may be participated in acquisition and MAP-priming induced reinstatement of CPP,respectively.

关键词： methamphetamine conditioned place preference medial prefrontal cortex dorsal hippocampus kainic acid N-methyl-d-aspartate

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Functional connectivity among cortical regions is shaped by associative experiences

Functional connectivity among cortical regions is shaped by ...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Jia LIU National Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal University

＜正＞The emergence of coherent cognition and behavior relies on the coordination of scattered mosaics of functionally-specialized brain ***,little is known about how the neural mechanisms that coordinate this distributed brain activity are *** proposed that brain regions are organized dynamically into functional groups by the temporal structure of their neural activity as co-activation of brain regions leads to the Hebbian strengthening of the functional connectivity between *** test this hypothesis,we trained subjects to learn the association between photos of houses and Chinese characters,and then examined whether the coherence between BOLD signal fluctuation in the parahippocampal place area（PPA） and that in the visual word form area（VWFA） increased after the *** found that the training not only improved the behavioral performance in pairmatching task but more increased the functional connectivity between the PPA and *** increased coherence was not due to the mental imagery of the associated stimulus（***） when a trained stimulus（***） was presented,because the activation level of the trained houses in the VWFA was unchanged between before and after ***,these findings suggest that the functional connectivity between co-activated regions,not their individual activation,may be the material basis of mental ***,when the PPA was activated by untrained house or scene stimuli,the neural activity in the VWFA fluctuated in a coherent fashion,suggesting that the propagation of the temporal structure in neural activation from one node to another is not stimulus *** the other hand,the increased coherence was limited to coactivated regions as the connectivity strength between the VWFA and the lateral occipital complex（LOC） and that between the PPA and the LOC were *** sum,our results provided an example of how large-scale integration is formed through Hebbian learning.

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Comparative study in the spontaneous response of the medial geniculate body and inferior colliculus in rats with thalamic reticular nucleus lesion after contralateral cochlear ablation

Comparative study in the spontaneous response of the medial ...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Dan-Yi LU,Shi-Gang HE,Ju-Fang HE 1 CAS-Hong Kong Joint Research Laboratory for Visuo-Auditory Integration,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China 2 State Key Laboratory of Brain and Cognitive Sciences,Institute of Biophysics,Chinese Academy of Sciences,15 Datun Road,Beijing 100101,China 3 Laboratory of Applied Neuroscience,Department of Rehabilitation Sciences,The Hong Kong Polytechnic University, Hung Horn,Kowloon,Hong Kong,China

Tinnitus is a ringing,swishing,or other type of noise that originated in the ear or *** hypothesize that damage of the cochlear hair cells causes hypersensitivity of the cells after a period of reorganization in the auditory pathway.A malfunctioning of the thalamic reticular nucleus(TRN)would decrease its inhibition to the auditory transmission and eventually causes *** the present study,we would investigate the neuronal property change in the medial geniculate body(MGB)and inferior colliculus(IC)of the rats after cochlear ablation and TRN lesion at different *** acid was injected into the TRN to lesion the *** contralateral cochlea to the recording hemisphere was ablated under an operating *** responses of the MGB and IC were recorded with the implanted extracellular electrodes while the rat was in different physiological *** found that neurons in the auditory thalamus should more changes than those in the *** results would lead us to a further investigation on the potential mechanism focusing on the changes in the MGB.

关键词： Tinnitus cochlea thalamic reticular nucleus(TRN) medial geniculate body(MGB) inferior colliculus(IC)

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Potassium channel of oligodendrocyte precursor cells during perinatal hypoxia-ischemia

Potassium channel of oligodendrocyte precursor cells during ...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Peng-Hui CHEN,Wen-Qin CAI~* Department of Neurobiology,Chongqing Key Laboratory of Neurobiology,Third Military Medical University, Chongqing 400038,China

Objective Oligodendrocyte precursor cells(OPC)are particularly susceptible to perinatal hypoxia-ischemia resulting in decreased myelination and infant cerebral *** precise mechanism remains *** recordings from these cells have revealed that they possess unique potassium channel properties,which are distinct from the traditional class of glial cell and *** study is to explore whether rectified potassium channel of OPC is involved in hypoxia ischemic brain *** Whole cell voltage dependent ion channels were recorded by patch clamp technology in acute brain slices of postnatal 7 days rats after hypoxia-ischemia 2 *** recorded cell,which was injected intracellular Lucifer yellow,was identified with the marker NG2 by fluorescent ***(1)Sodium to potassium conductance ratio was decreased,owing to the increase of inward sodium current amplitude.(2)Outward rectified potassium channel exhibited rectify fall off.(3)There was no significant difference in variable rectified potassium channel and inward rectified potassium channel.(4)Tail current and activation voltage were all raised,which reduced activation and inactivation of potassium *** Outward rectified potassium channel and tail current of potassium channel play more important role in OPC susceptible to hypoxia ischemia.

关键词： oligodendrocyte precursor cell(OPC) patch clamp hypoxia-ischemia potassium channel rectify

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Kinetics of vesicle reuse at the Calyx of Held synapses

Kinetics of vesicle reuse at the Calyx of Held synapses

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Xu-Feng QIU,Qian-Wen ZHU,Jian-Yuan SUN~* Institute of Biophysics,Chinese Academy of Sciences,State Key Laboratory of Brain and Cognitive Science,Beijing 100101,China

Vesicle recycling and reuse is essential in maintaining synaptic *** spite of accumulative studies,it remains elucidated that how many vesicles involve in recycling,how long and how fast a vesicle can be reused after *** made the whole cell recording of the excitatory postsynaptic currents（EPSCs）at a central synapse,the Calyx of Held,under the long duration of stimulation in the presence of folimycin,a vesicular ATPase inhibitor to annihilates the H gradient and block glutamate refilling of synaptic *** was confirmed that vesicles at the Calyceal synpases do recycle and reuse after *** long trains of 20 Hz or 50 Hz stimulation,the evoked EPSCs can be rapidly depressed and finally mostly vanished,implying the depletion of the recycling *** size of the recycling pool was thus estimated as 180,000-350,000 *** did not observe the rapid vesicle reuse within 10 s,which supports the notion that rapid endocytosis does not immediately recycle vesicles within the readily releasable *** comparison between stimulation evoked EPSCs with and without folimycin,we further described the kinetics of synaptic vesicle reuse with double exponential *** from the previous ways to predict and estimate the kinetics of vesicle recycling by endocytotic kinetics,this study proposed a quantitatively description of the kinetics of synaptic vesicle reuse at a central synapse based on direct *** further proposed two pathways of synaptic vesicle recycling with distinguished kinetics.

关键词： vesicle recycling reserve pool,readily releasable pool

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Identification of an adenylyl cyclase inhibitor for treating neuropathic and inflammatory pain

Identification of an adenylyl cyclase inhibitor for treating...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Susan S.KIM Kohei KOGA Giannina DESCALZI Kunjumon I.VADAKKAN Bong-Kiun KAANG Deparment of Physiology University of TorontoToronto M5S1A8Canada Institute of Neuroscience the Fourth Military medical UniversityXi'an 710032China

＜正＞Objective Neuropathic pain,often caused by nerve injury,is commonly observed among patients with different *** its basic mechanisms are poorly understood,effective medications are limited. Previous investigations of basic pain mechanisms and drug discovery efforts have focused mainly on early sensory neurons such as dorsal root ganglion and spinal dorsal horn neurons,and few synaptic-level studies or new drugs are designed to target the injury-related cortical plasticity that accompanies neuropathic *** previous work has demonstrated that calcium-stimulated adenylyl cyclase 1（AC1） is critical for nerve injury-induced synaptic changes in the anterior cingulate *** Rational drug design and chemical screening,a variety of behavioral tests, electrophysiological methods and toxicity studies were performed in the present *** It was identified that a lead candidate AC1 inhibitor,NB001,was relatively selective for AC1 over other adenylate cyclase ***001 has an analgesic effect in animal models of neuropathic pain,without any apparent side effects when administered intraperitoneally or *** AC1 could be a productive therapeutic target for neuropathic pain and describes a new agent for the possible treatment of neuropathic pain.

关键词： adenylyl cyclase anterior cingulate cortex neuropathic pain

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