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The differences between hippocampal LTP and spinal LTP

The differences between hippocampal LTP and spinal LTP

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Xian-Guo LIU~*,Yong LIU,Wen-Jie REN,Jun WANG,He-Qun ZHU Pain Research Center and Department of Physiology,Zhongshan School of Medicine,Sun Yat-Sen University, Guangzhou 510080,China

Long-term potentiation(LTP) in hippocampus is a synaptic model of memory storage,while LTP of C-fiber synapses in spinal dorsal horn underlies chronic pain produced by nerve injury and ***,it is clinically important to explore similarities and differences in the mechanisms of hippocampal LTP and spinal LTP. LTP in both regions is prevented by blockage of NMDA *** protein kinases,such as PKA,PK.C, CaMKII and ERK are critically involved in LTP induction and early-phase maintenance in both hippocampus and in spinal dorsal *** drugs targeting at these molecules may not only inhibit chronic pain but also impair memory. The striking difference is that activation of microglia and subsequent over-expression of pro-inflammatory cytokines, such as tumor necrosis factor-alpha(TNF-α),inhibit LTP in hippocampus but facilitate LTP in spinal dorsal horn. Interestingly,both the inhibition of hippocampal LTP and facilitation of spinal LTP are mediated by activation of nuclear factor kappaB,p38 MAPK and *** we found that peripheral nerve injury,which induces spinal LTP,inhibited hippocampal LTP and impaired working memory by up-regulation of TNF-αin spinal cerebral fluid and in hippocampal *** effect was prevented by pharmacological inhibition of TNF-αor genetic deletion of TNF receptor *** data suggested that over-expression of the pro-inflammatory cytokine in CNS might lead to chronic pain and memory deficit,***,inhibition of TNF-αand its downstream molecules may relieve chronic pain and improve memory function as well.

关键词： LTP hippocampus spinal dorsal horn TNF-a memory chronic pain

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Ethyl pyruvate ameliorates the glial microenvironment and promotes spinal cord repair

Ethyl pyruvate ameliorates the glial microenvironment and pr...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Yi-Min YUAN,Zhi-Da SU,Ying-Yan PU,Jing-Jing CHEN,Feng ZHU,Yang QIU,Cheng HE~* Institute of Neuroscience and MOE Key Laboratory of Molecular Neurobiology,Second Military Medical University, Shanghai 200433,China

Objective After SCI,a series of endogenous processes,including reactive astrogliosis and neuroinflammatory response,are triggered and resulted in the formation of a degenerative microenvironment in the lesion *** many studies,this hostile environment,as well as the intrinsic incapacity of the neuron to regenerate,is regarded as an important contributor to the failure of spontaneous anatomical and functional repair of *** present study is to explore the neuroprotective effect of ethyl pyruvate in the damaged spinal cord using a rat model of SCI. Methods Initially,a scratch-wound model was applied to test reactive astrogliosis in *** vivo,astrogliosis, scar formatting and neuroinflammatory response were further assessed with a spinal cord-hemisectined SCI model. In the damaged spinal cord,survival neurons and regenerative axons was identified by TUNEL staining and BDA anterograde tracing,***,functional recovery was valuated by the Basso,Beattie,and Bresnahan openfield scoring,grid-walk test and foot-print *** In the present study,ethyl pyruvate was found to inhibit reactive astrogliosis in vitro,which was further confirmed in injured spinal *** addition,ethyl pyruvate treatment was also shown to attenuate SCI-induced neuroinflammation by decreasing the Iba-1 or CD11b-positive inflammatory cells at the lesion ***,ethyl pyruvate-treated rats showed a significantly greater number of survival neurons and regenerative axons and their behavioral functions were evidently *** Ethyl pyruvate ameliorates the glial microenvironment and promotes spinal cord repair,suggestive of a potent neuroprotective effect against SCI.

关键词： ethyl pyruvate astrogliosis neuroinflammation glial scar spinal cord injury axon regeneration

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Construction of pEYFP-hApelin-R and pRluc-hNTSRI-pcDNA3.1 eukaryotic expression vectors and their expression in HEK293 cells

Construction of pEYFP-hApelin-R and pRluc-hNTSRI-pcDNA3.1 eu...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Xin CAI~1,Jing CHEN~(2,3) Bo BAI~(2,*) 1 Taishan Medical University,Tai'an 271000,China 2 Jingning Medical University,Jining 272000,China 3 University of Warwick,England 999020,United Kingdom

Objective To construct expression vectors that enhanced yellow fluorescent protein(EYFP)fused with Apelin receptor(Apelin-R)and Renilla reniformis(Rluc)fused with Neurotensin type 1 receptor(NTSR1),to investigate the heterdimerization of human Apelin-R and NTSRl and its role in signal *** The human NTSRl gene was amplified by PCR using the plasmid pcDNA3.1-hNTSRl as *** PCR product was digested,ligased with the plasmid pRluc and then be transformed into the competent cell Top *** construct was identified by DNA *** recombinant plasmid was transiently transfected into human embryonic kidney 293(HEK293)cells,and the expression of pRluc-hNTSRl-pcDNA3.1 was detected by confocal microscopy and Western ***-hApelin-R was also constructed by the same *** Two fragments of 1257 bp and 1143 bp were amplified by PCR,and the DNA sequences were identical with the gene in GenBank(NM002531, NM005161),*** blot showed 91 kDa and 69 kDa *** microscopy showed that NTSRl and Apelin-R were expressed on the plasma *** The pRluc-hNTSRl-pcDNA3.1 and pEYFP-hApelin -R eukaryotic expression vectors were successfully constructed,and the expression vector could be used to investigate the heterdimerization of human Apelin-R and NTSRl and its role in signal transduction,which will provide new target for drug development.

关键词： Apelin receptor EYFP neurotensin type 1 receptor renilla reniformis eukaryotic expression vector HEK293 cells

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Development of a functional electrical stimulation system base on the body area network for stroke and SCI rehabilitation

Development of a functional electrical stimulation system ba...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Hong-En QU,Ting WANG,Ning LAN~* The Institute of Rehabilitation Engineering,The Med-X Research Institute,School of Biomedical Engineering, Shanghai Jiao Tong University,Shanghai 200030,China

Objective This paper describes a functional electrical stimulation(FES) system based on the body area network(BAN) for helping the stroke survivors and SCI patients in the *** FES system not only has very high performance to perform the stimulation and control deciding required in the application of relearning or restoring the motor function,but also has the high flexibility to expand to other related clinical applications such as the medical monitoring platform and rehabilitation *** To achieve the aim,we design three main hardware components of the networked FES system including a master unit(MU),a distributed stimulation-sensor unit(DSSU),and a clinical *** we also develop a Body Area Network and use it to organize the whole FES system following the network *** MU as the controller of this system manages all distributed stimulation-sensor units as the stimulation channels as the network node in *** this structure,the FES system can conveniently provide the multi-channel preprogrammed stimulation current at the same *** We have completed a prototype of system including the hardware and software *** test of the FES system shows that the stimulation current amplitude ranges from 1 mA to 58 mA and that the stimulation pulse width can be from 10μs to 1 000μs with 1 us *** The evaluation test indicates that the system performance meets design *** BAN FES system has been designed and tested for *** MU and DSSU design in the networked FES system is proposed and a prototype has been constructed and tested in laboratory.

关键词： functional electrical stimulation body area network motor rehabilitation

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PirB expression and glial reaction influence synaptic plasticity in the rat brain via intrahippocampal injection of LPS

PirB expression and glial reaction influence synaptic plasti...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Xiao-Hua DENG Department of Anatomy and Neurobiology,Xiangya School of Medicine,Central South University

The aim of our study is to investigate the changes in hippocampal synapses and their relation with learningmemory abilities during chronic brain *** rats were subjected to unilateral intrahippocampal injection LPS,after animals survived for 29 days,we examined the response of glial cells using glial fibrillary acidic protein (GFAP) as astrocyte marker,expression of PirB in the hippocampus of different treatment was also investigated. Astrocytes were labeled with immunohistochemistry,and their number and immunosignal intensity were evaluated with quantitative image *** synaptic loss was examined in the subregions of hippocampus by Golgi *** cell death was examined in the hippocampus using Hoechst ***,synaptophysin (SYP) expression in whole hippocampus was investigated with immunohistochemistry and Western blot in the same brain regions after the intrahippocampal(ih) injection of *** labeling with immunofluorescence was used to investigate whether PirB was expressed not only by neurons but also by glial *** study the relationship of PirB with synapses,PirB and Synaptophysin double staining was *** learning and memory abilities were tested by Morris water *** results indicated an increase in glial reaction during chronic brain inflammation. During this period,intrahippocampal injection of LPS induced markedly PirB protein expression in the activated astrocytes in *** immunoreactivity downregulated in the subregions of *** number of basal dendrite of pyramidal cell decreased markedly with respect to vehicle group by Golgi *** protein is expressed in the neuronal cell membrane and cytoplasm of pyramidal cell layer in CA3 area and were seen to be close to,but rarely overlaps with synaptophysin positive *** protein SYP immunostaining is present in the hippocampus,where appears be puncta and *** is also expressed on the neurons

关键词： learning and memory synapses SYP LPS brain inflammation PirB astrocytes Morris water maze

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Promoter analysis of mouse Scn3a gene and regulation of the promoter activity by GC box and CpG methylation

Promoter analysis of mouse Scn3a gene and regulation of the ...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Guang-Fei DENG,Jia-Ming QIN,Xun-Sha SUN,Zu-Ying KUANG,Tao SU,Qi-Hua ZHAO,Yi-Wu SHI,Xiao-Rong LIU,Mei-Juan YU,Yong-Hong YI,Wei-Ping LIAO,Yue-Sheng LONG Institute of Neuroscience and The Second Affiliated Hospital of Guangzhou Medical University

Voltage-gated sodium channelα-subunit typeⅢ(Nav1.3) is mainly expressed in the central nervous system and is associated with neurological *** expression of mouse Scn3a product(Nav1.3) mainly occurs in embryonic and early postnatal brain but not in adult ***,we report for the first time the identification and characterization of the mouse Scn3a gene promoter region and regulation of the promoter activity by GC box and CpG *** assay showed that the promoter region F1.2(nt -1,049 to +157) had significantly higher activity in PC12 cells,omparing with that in SH-SY5Y cells and HEK293 cells.A stepwise 5' truncation of the promoter region found that the minimal functional promoter located within the region nt -168 to +*** of a GC box(nt -254 to -258) in the mouse Scn3a promoter decreased the promoter *** methylation of the F1.2 without the GC box completely repressed the promoter activity,suggesting that the GC box is a critical element in the CpG-methylated Scn3a *** results suggest that the GC box and CpG methylation might play important roles in regulating mouse Scn3a gene expression.

关键词： voltage-gated sodium channel promoter GC box CpG methylation transcriptional regulation

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BAG5 interacts with the Parkinson-associated protein PINKl to protect against oxidative mitochondrial damage

BAG5 interacts with the Parkinson-associated protein PINKl t...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Xue-Jing WANG~1,Ji-Feng GUO~1,Guang-Hui WANG~2,Bei-Sha TANG~(1,3,*) 1 Department of Neurology,Xiangya Hospital,Central South University,Changsha,China 2 Department of Neurobiology,Laboratory of Molecular Neuropathology,School of Life Sciences,University of Science and Technology of China,Heifei,China 3 National Laboratory of Medical Genetics,Xiangya Hospital,Central South University,Changsha,China

Mutations in PTEN-induced kinase 1(PINK1) gene cause PARK6 familial Parkinsonism,and loss the stability of PINK1 may also contribute to sporadic Parkinson's disease(PD).Degradation of PINK1 occurs predominantly through the ubiquitin-proteasome pathway,however,to date,few of the proteins have been found to regulate the degradation of *** the yeast two-hybrid system and pull-down methods,we identified bcl- 2-associated athanogene 5(BAG5),a BAG family member,directly interacted with *** showed that BAG5 stabilized PINK1 by decreasing the ubiquitination of ***,BAG5 rescued MPP+- and rotenoneinduced mitochondria dysfunction by up-regulating PINK1 in *** PINK1-null mice and MPTP-treated mice, significantly increased in the substantia nigra pars compacta(SNpc) although PINK1 was ***, rasagiline treatment to MPTP-treated mice resulted in further increase of BAG5 *** summary,we present BAG5 as a key protein to stabilize PINK1,thereby proventing mitochondrial dysfunction following oxidative stress.

关键词： Parkinson's disease BAG5 PINKl mitochondrial dysfunction UPS

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Spontaneous and visible light-induced ultraweak photon emission from rat eyes

Spontaneous and visible light-induced ultraweak photon emiss...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Istvn BòKKON Istvn ANTAL Doctoral School of Pharmaceutical and Pharmacological Sciences Semmelweis UniversityBudapestHungary Department of Pharmaceutics Semmelweis UniversityBudapestHungary

Objective The mechanisms of the special visual phenomenon(***,visual negative afterimage, discrete dark noises,etc.) have largely *** has been hypothesized that such special visual phenomenon may be caused by ultraweak photon emissions(aka biophotons),which are kinds of very weak photon emissions from organisms or ***,to date,experimental evidence of spontaneous or visible light-induced ultraweak photon emission in human or animal eyes has not been reported due to technical *** Here we established a new type of the biophoton imaging system equipped with an EM-CCD,which is featured by high quantum efficiency, high sensibility,high signal to noise ratio(SNR) and high spatial and temporal *** this system,we detected and analyzed the ultraweak photon emissions from isolated whole eye,lens,vitreous humor and retina samples from *** We obtained the first experimental evidence for the existence of spontaneous and induced ultraweak photon emission from the whole eye and various parts of eye(lens,vitreous humor or retina).The time course of attenuation of the induced photon emission from the various parts of eye has variants after different durations of exposure(10,20,or 40 s),to different light illuminations(blue,green or red).Conclusion These results suggested that the parts of the eye(***) can emit spontaneous and induced ultraweak photon emissions,which may be the origins of negative afterimage,phosphenes and discrete dark noise.

关键词： ultraweak photon emission negative afterimage discrete dark noise retinal phosphenes

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ERK pathway activation is required for amyloid-β1-40-induced neurotoxicity of THP-1 human monocytes towards SK-N-SH neuroblastoma

ERK pathway activation is required for amyloid-β1-40-induce...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Lin-Lin YIN~1,Wei LI~2,Yan-Qi CHU~1,Lin LI~(1,*) 1 Department of Pharmacology,Xuan-wu Hospital of Capital Medical University,Education Ministry Key Laboratory for Neurodegenerative Disease,45 Chang-chun Street,Beijing 100053,China 2 Department of Neurology,Henan Provincial People's Hospital,7 Wei-wu Road,Zhengzhou 450003,China

Alzheimer's disease（AD） is characterized by amyloid-P peptide deposition,increased activated microglia and progressive loss of neurons in the *** Aβ can elicit inflammation in microglia,the intracellular signaling events mediating these effects are poorly *** we show that cell-free supernatant from Aβ-treated THP-1 monocytes induced cytotoxicity towards neuroblastoma SK-N-SH *** of THP-1 monocytes to Aβ leads to increased tyrosine phosphorylation and extracellular signaling-regulated kinase（ERK） and increased levels of inflammatory cytokines（IL-1β,IL-8 and TNF-α） in the supernatant of THP-1 *** of THP-1 monocytes with either a protein tyrosine kinase（PTK） inhibitor or an ERK inhibitor protects SK-N-SH cells from the cytotoxic effect of conditional supernatant from Aβ-treated THP-1 monocytes.Aβ-treated THP-1 monocytes also leads to upregulation of cyclooxygenase-2 and iNOS expression and increased of nitric oxide *** results suggest that Aβ-induced activation of PTK/MEK/ERK pathway in THP-1 monocytes leads to the release of inflammatory factors that are toxic to SK-N-SH cells and might contribute to the onset of AD.

关键词： amyloid-β1-40 inflammation THP-1 monocytes SK-N-SH neuroblastoma cells PTK/MEK/ERK pathway

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SP8 specifically identifies dorsal lateral ganglionic eminence and dorsal caudal ganglionic eminence derived cortical interneurons

SP8 specifically identifies dorsal lateral ganglionic eminen...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Tong MA,Qiang-Qiang ZHANG,Yu-Qun CAI,Chi-Fei SUN,Yan YOU,Fang LIU,Zhen-Gang YANG~* Institutes of Brain Science and State Key Laboratory of Medical Neurobiology,Fudan University,Shanghai 200032, China

The origin and the diversity of cortical interneurons have been extensively *** studies, using genetic fate mapping,reveal the lateral/caudal ganglionic eminence(LGE/CGE) contribute large population of interneurons to the upper layers of the ***,less is known about this population of cortical interneurons compared with the well characterized MGE derived ones,because of no specific markers available except the recently found CGE lineage marker serotonin 5-hydroxytryptamine 3A(5-HT3A ) *** we show that the zinc finger transcription factor SP8 specifically labels cohorts of mice cortical interneurons originating in the dorsal LGE (dLGE) and dorsal CGE(dCGE).SP8-expressing interneurons initially migrate from rostral dLGE to invade the cortex at embryonic 12.5(E12.5),then from both dLGE and dCGE since *** tangentially migrate through and accumulate in the subventricular/intermediate zone(SVZ/IZ),and only at late embryonic stage and first postnatal week radially migrate into the cortical plate and the marginal ***8-expressing dLGE/dCGE derived interneurons preferentially occupy superficial cortical layers and account for one fifth of all cortical interneurons in adult brain. These results indicate that cortical intemeurons have more heterogeneous origins and subtypes.

关键词： transcription factor SP8 intemeurons lateral ganglionic eminence subventricular zone

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