Filoviruses are enveloped, negative-sense, single stranded, RNA viruses with a genome of approximately *** family consists of Ebola virus (EBOV) and Marburg virus (MARV) which can cause severe hemorrhagic fever in hum...
Filoviruses are enveloped, negative-sense, single stranded, RNA viruses with a genome of approximately *** family consists of Ebola virus (EBOV) and Marburg virus (MARV) which can cause severe hemorrhagic fever in humans and non-human primates with mortality rates up to 90%.Viral outbreaks are rare and endemic in central regions of the Africa *** and MARV infections are predicted to occur in distinct ecological *** infections usually occur in humid rain forests of central and western Africa andMARV infections occur in the drier regions of central and eastern *** mode of transmission of filoviruses is not known, although fruit bats have been recently implicated as the natural reservoirs of Ebola *** promising vaccination methods have been developed in non-human primate models, but currently there is no vaccine or treatment available for filovirus infection in human.
作者：
Pei-Yong ShiWadsworth Center
New York State Department of Health120 New Scotland AvenueAlbanyNew York 12208USA
The genus Flavivirus comprises approximately 70 viruses, many of which are emerging and reemerging human pathogens, including four serotypes of dengue (DENV), yellow fever (YFV), West Nile (WNV), Japanese encephalitis...
The genus Flavivirus comprises approximately 70 viruses, many of which are emerging and reemerging human pathogens, including four serotypes of dengue (DENV), yellow fever (YFV), West Nile (WNV), Japanese encephalitis, and the tick-borne encephalitis complex *** flavivirus genome is asingle-stranded RNA of positive *** 5' end of the genome contains a type 1 cap (m7GpppAm).In this study, I report, for the first time, that flavivirus nonstructural protein 5 (NS5) from DENV, YFV, and WNV methylates both guanine N-7 and ribose 2'-OH during viral type 1 cap *** of GpppA-RNA sequentially generates GpppA → m7GpppA → m7GpppAm, indicating that N-7 precedes 2'-O *** 2'-O methylation can be uncoupled from the N-7 methylation since m7GpppA-RNA can be readily methylated to m7GpppAm-RNA.
H5N1 avian influenza virus is expanding its geographical distribution and human infections are being repeatedly detected in affected *** antiviral drugs has been considered as a component of preparedness for a potenti...
H5N1 avian influenza virus is expanding its geographical distribution and human infections are being repeatedly detected in affected *** antiviral drugs has been considered as a component of preparedness for a potential H5N 1 influenza ***, resistance to amantadine, an ion channel blocker, has been identified in the majority of isolates from some affected *** the stockpiling of the neuraminidase inhibitor oseltamivir has been started in many countries, viral resistance has been detected in some patients with H5N1 disease being treated with *** to anti-influenza virus drugs is a matter of great concern and relevance for pandemic preparedness.
NIFEVIROC, a small molecular compound, is a proprietary drug candidate which is developed by TARGETDRUG and holds great promise in inhibiting HIV-1 replication in infected *** studies suggested that NIFEVIROC is a spe...
NIFEVIROC, a small molecular compound, is a proprietary drug candidate which is developed by TARGETDRUG and holds great promise in inhibiting HIV-1 replication in infected *** studies suggested that NIFEVIROC is a specific CCR5 antagonist determined by multiple receptor functional *** addition, NIFEVIROC demonstrated potent inhibition activity against HIV-1 entry into the target cells by effectively blocking the human CCR5 receptors on the cell ***, NIFEVIROC showed strong antiviral activity against wide variety of HIV strains, including those multi-drug resistant mutants.
作者：
Wuze RenWendong LiXiuxia QuMeng YuHongkui DengShuyi ZhangLinfa WangZhengli ShiState Key Laboratory of Virology
Wuhan Institute of VirologyChinese Academy of Sciences (CAS)WuhanHubei 430071China State Key Laboratory of VirologyWuhan Institute of VirologyChinese Academy of Sciences (CAS)WuhanHubei 430071China CSIRO Livestock Industries
Australian Animal Health LaboratoryGeelongVictoria 3220Australia Department of Cell Biology and GeneticsCollege of Life SciencesPeking UniversityBeijingChina CSIRO Livestock IndustriesAustralian Animal Health LaboratoryGeelongVictoria 3220Australia Institute of ZoologyCASBeijing 100080China
Bats were recently identified as natural reservoirs ot SARS-like coronavirus (SL-CoV) or SARS coronavirus-like *** viruses, together with SARS coronaviruses (SARS-CoV) isolated from human and palm civet, form a distin...
Bats were recently identified as natural reservoirs ot SARS-like coronavirus (SL-CoV) or SARS coronavirus-like *** viruses, together with SARS coronaviruses (SARS-CoV) isolated from human and palm civet, form a distinctive cluster within the group 2 coronaviruses of the genus Coronavirus, tentatively named group 2b (G2b-CoV).The bat G2b-CoV isolates have an identical genome organization and share an overall genome sequence identity of 88 to 92% among themselves, and between them and the human/civet isolates.
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