The purpose of the current study is to evaluate the clinical value of F- fluorodeoxyglucose PET/CT on detecting post-operative recurrence in patients with esophageal cancer. Methods 37 post-operative patients with eso...
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The purpose of the current study is to evaluate the clinical value of <'18>F- fluorodeoxyglucose PET/CT on detecting post-operative recurrence in patients with esophageal cancer. Methods 37 post-operative patients with esophageal cancer underwent PET/CT scans from June 2003 through August 2005 to detect recurrent disease;a final diagnosis was reached by the histopathology or clinical follow-up of at least 6 months. The diagnostic sensitivity, specificity, and accuracy of
PET/CT were assessed at local, regional and distant sites, as well as overall estimate for a composite of all the above sites. The false-positive and false- negative results of PET/CT were analyzed as well. Results 31 out of 37 patients were finally confirmed with recurrence in a total of 46 sites. There were six false-positive findings in PET/CT reports
involving two sites at esophagogastric anastomosis, one near the back wall of gastric pull-up, two at hilar lymph nodes, and one in left lower lung. There were three false-negative PET/CT interpretations including one subcarina lymph node, one paratracheal lymph node and one metastatic lesion in the right lower lung. The overall sensitivity, specificity and
accuracy of PET/CT for detecting recurrence were 93.5％(43/46), 76.9％(20/26) and 87.5％ (63/72), respectively. On a site-based analysis, it was found that only the specificity at local sites was lower (50％) because of a high rate of false-positive
findings (3 cases in 6). In contrast, PET/CT had excellent performance both at regional and distant sites, the sensitivity, specificity and accuracy were 86.7％, 84.6％ and 85.7％ for regional recurrence, versus 95.5％, 85.7％ and 93.1％ for distant metastasis, respectively. Conclusion <'18>F-FDG PET/CT is highly effective in detecting regional and distant recurrence for post-operative patients with esophageal cancer. However the specificity was rather low at local area due to a high rate of positive findings, particularly at anastomosis, endoscopy is esse
Objective: To retrospectively evaluate the clinical and dose-volumetric parameters for association with risk of the acute radiation pneumonitis and late radiation lung injury in patients after three-dimensional confor...
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Objective: To retrospectively evaluate the clinical and dose-volumetric parameters for association with risk of the acute radiation pneumonitis and late radiation lung injury in patients after three-dimensional conformal radiotherapy(3D—CRT) for
Squamous Cell Carcinoma(SCC)of the thoracic middle
and lower esophagus.
Methods: Data from 56 patients(41 men, 16 women;median age, 64 years;range，31-81 years)newly diagnosed with SCC of the esophagus and treated with 3D-CRT between January 2002 and June 2004 in our hospital were retrospectively analyzed. Radiation lung injury was scored by using Radiation Therapy Oncology Group criteria. Clinical parameters were analyzed. Dose-volumetric parameters analyzed were percentage of lung volume that received a dose from 5Gy or more(V5)to 50Gy or more(V50);mean lung dose (MLD);and total dose et al．X2 test was performed to compare clinical parameters between patients who
developed severe radiation lung injury and those who did not. Univariate and multivariate logistic regression analyses were performed to evaluate data for association between dose-volumetric parameters and acute severe radiation lung injury. Spearman X <'2> test was used to assess data for correlations among dose-volumetric parameters. P≤0.05 was considered to indicate statistically significant difference.
Results: Of 56 patients, 7(12.5％)developed acute radiation pneumonitis of grade 2;3(5.4％), grade 3. None had grade 4.14(25.0％)developed late radiation lung injury. 1. Univariate analysis showed that X-ray esophageal lesion length, the prescribed dose, V5- V25, MLD, Esophageal PTVD90, PTVV50 and the total number of field beams were significantly differ
between patients who developed severe acute radiation pneumonitis and those who did not. X-ray length of esophogeal lesions, lung V5-V40, MLD and combined with chemotherpapy were sgnificantly differ between patients who developed severe late radiation lung injury and those who did not. 2. In multivariate
analy
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