NF-κB is an inducible transcription factor that plays critical roles in manyphysiological responses such as inflammation, apoptosis and immune systemdevelopment. Receptor Interacting Protein (RIP) is an important mol...
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NF-κB is an inducible transcription factor that plays critical roles in manyphysiological responses such as inflammation, apoptosis and immune systemdevelopment. Receptor Interacting Protein (RIP) is an important molecule requiredfor TNF induced NF-κB activation. ZIN, a newly identified zinc finger protein, isdemonstrated to interact with RIP and inhibit RIP induced NF-κB acivation.
Inhibitors of Apoptosis (IAPs) are crucial regulators ofprogrammed cell death. The mechanism by which IAPs preventapoptosis has previously been attributed to directinhibition of caspases. The function of mammalian IAP...
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Inhibitors of Apoptosis (IAPs) are crucial regulators ofprogrammed cell death. The mechanism by which IAPs preventapoptosis has previously been attributed to directinhibition of caspases. The function of mammalian IAPs isneutralized by cell death inducer Smac/DIABLO. Here we show
The transcription factor NF-κB play importare roles in immun regulation,inflammatory responses and ati-apoptosis. Activation of NF-κB requires theactivity of IKK, a kinase complex that contains two catalytic subunit...
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The transcription factor NF-κB play importare roles in immun regulation,inflammatory responses and ati-apoptosis. Activation of NF-κB requires theactivity of IKK, a kinase complex that contains two catalytic subunits, IKKαandIKKβ, and a non-enzymatic regulatory subunit IKKγ. It has been proposed that
Apoptotic cell death occurs through activation ofprocaspases, the precursors of a group of aspartate-specific cysteine proteases known as caspases. Procaspaseactivation is mediated by death adapter proteins such asthe...
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Apoptotic cell death occurs through activation ofprocaspases, the precursors of a group of aspartate-specific cysteine proteases known as caspases. Procaspaseactivation is mediated by death adapter proteins such asthe mammalian proteins FADD and Apaf-1 and the C. elegansprotein CED-4. These adapters bind to procaspases and
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