An apoptotic signal triggered by cell surface deathreceptors is disseminated to intracellular compartmentsthrough protein-protein interactions mediated by conserveddomains such as the death effector domain (DED). A un...
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An apoptotic signal triggered by cell surface deathreceptors is disseminated to intracellular compartmentsthrough protein-protein interactions mediated by conserveddomains such as the death effector domain (DED). A uniquefamily of single DED-containing proteins, including DEDDand DEDD2, are targeted to the nucleolus. However, the role
Nuclear factor кB-inducing kinase (NIK) is a member of the MAP kinase kinasekinase family that was identified as a component of the TNF-R1 -induced NF-кBactivation pathway (TNF, tumor necrosis factor;NF-кB, nuclear...
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Nuclear factor кB-inducing kinase (NIK) is a member of the MAP kinase kinasekinase family that was identified as a component of the TNF-R1 -induced NF-кBactivation pathway (TNF, tumor necrosis factor;NF-кB, nuclear factor kappaB,). Geneknockout study, however, suggests that NIK is dispensable for TNF-R1- but required forlymphotoxin-βreceptor-induced NF-кB activation. A NIK kinase inactive mutant is a
Unlike in rodents, cholecystokinin (CCK) has not been established as a physiologicalregulator in avian exocrine pancreatic secretion. In the isolated duck pancreatic acini,CCK 1 nM was required for stimulation of amyl...
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Unlike in rodents, cholecystokinin (CCK) has not been established as a physiologicalregulator in avian exocrine pancreatic secretion. In the isolated duck pancreatic acini,CCK 1 nM was required for stimulation of amylase secretion, maximal effect beingachieved at 10 nM;picomolar CCK was without effect. Vasoactive intestinal peptide(VIP) / pituitary adenylate cyclase activating peptide (PACAP) recepto (VPAC)
The transcription factor NF-кB plays important roles in inflammation and cellsurvival. In this study, we identified SINK, an NF-кB -inducible protein. Overxpressionof SINK inhibited NF-кB -dependent transcription i...
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The transcription factor NF-кB plays important roles in inflammation and cellsurvival. In this study, we identified SINK, an NF-кB -inducible protein. Overxpressionof SINK inhibited NF-кB -dependent transcription induced by TNF stimulation or itsdownstream signaling proteins, but did not inhibit NF-кB translocation to the nucleus andbinding to DNA. Co-immunoprecipitation and in vitro kinase assays indicated that SINK
Hepatitis B Virus -related chronic infection is a serious threat to human health, and it'sestimated that there are over 350 million people carrying HBV in the world. The research onthe natural history HBV infectio...
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Hepatitis B Virus -related chronic infection is a serious threat to human health, and it'sestimated that there are over 350 million people carrying HBV in the world. The research onthe natural history HBV infection suggested that the cellular immune response to HBVantigen plays an important role in the elimination or the control of virus infection by *** pre-S antigen protein has particular biological function, it is responsible for the binding
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