Objectives Intestinal first pass elimination represents a very important role in the in vivo disposition process of natural *** present study was designed to elucidate the intestinal first pass pathways in vivo and in...
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Objectives Intestinal first pass elimination represents a very important role in the in vivo disposition process of natural *** present study was designed to elucidate the intestinal first pass pathways in vivo and in vitro,of berberine (BBR),an isoquinoline alkaloid of the protoberberine
Objectives The present study was designed to investigate the in vivo and in vitro metabolism of astilbin which was the main component isohted from Rhizoma Smilacis Glabrae(RSG) and showed
Objectives The present study was designed to investigate the in vivo and in vitro metabolism of astilbin which was the main component isohted from Rhizoma Smilacis Glabrae(RSG) and showed
Objectives Atherosclerosis is a complicated and multifactorial systemic disease,is the precursor of coronary heart *** metabolic features are of great interest because they may address pathophysiologic ***,the global ...
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Objectives Atherosclerosis is a complicated and multifactorial systemic disease,is the precursor of coronary heart *** metabolic features are of great interest because they may address pathophysiologic ***,the global serumal metabolite alterations underlying early
Objectives The anticancer activity of tanshinoneⅡA(TSA) had been confirmed by extensive research,however,the underlying mechanisms and whether its sulphonate derivative (STS) has similar anticancer activity remained ...
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Objectives The anticancer activity of tanshinoneⅡA(TSA) had been confirmed by extensive research,however,the underlying mechanisms and whether its sulphonate derivative (STS) has similar anticancer activity remained *** present study was designed to discover the
Objective Gliomas are the most common and lethal tumor type in the *** present study reports for the first time the potential anti-glioma activity of oligomer procyanidins (F2) (F2,degree of polymerization 2-15),a nat...
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Objective Gliomas are the most common and lethal tumor type in the *** present study reports for the first time the potential anti-glioma activity of oligomer procyanidins (F2) (F2,degree of polymerization 2-15),a natural fraction isolated from grape *** MTT assay,cell
Objective To investigate the protective effects and mechanism of the polypeptide of the scorpion venom of Buthus martensii Karsch on trauma of cells in cerebral cortex and hippocampal neurons in primary cultured *** T...
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Objective To investigate the protective effects and mechanism of the polypeptide of the scorpion venom of Buthus martensii Karsch on trauma of cells in cerebral cortex and hippocampal neurons in primary cultured *** The nerve cells of cerebral cortex and hippocampus of primary rats were subject to tissue culture,and the media of neuronal cells of rats cultured primarily for 8 d were induced by Mgfree and
Objective The anti-proliferate activity of Brucea Javanica emulsion on human leukemia cell line HL-60 and its possible mechanism were *** cell viability was determined by MTT assay;AO/EB fluorescence staining was used...
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Objective The anti-proliferate activity of Brucea Javanica emulsion on human leukemia cell line HL-60 and its possible mechanism were *** cell viability was determined by MTT assay;AO/EB fluorescence staining was used for morphological observation;agarose gel
Objectives The present study was designed to investigate the effects of Schisandra fruit extract on the pharmacokinetics of midazolam in rats to assess the potential herbal-drug interactions involvement of CYP3A *** S...
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Objectives The present study was designed to investigate the effects of Schisandra fruit extract on the pharmacokinetics of midazolam in rats to assess the potential herbal-drug interactions involvement of CYP3A *** Schisandra fruit extract (0,50,150 mg/kg) was
Objectives The purpose of the study is to investigate the effect of Huanglian Jiedu Decoction(HLJDD) on glucagons-like peptide(GLP)-1(7-36) amide level in diabetic *** Streptozotocin (STZ)-induced diabetic rats were t...
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Objectives The purpose of the study is to investigate the effect of Huanglian Jiedu Decoction(HLJDD) on glucagons-like peptide(GLP)-1(7-36) amide level in diabetic *** Streptozotocin (STZ)-induced diabetic rats were treated with HLJDD for 5 weeks and diabetic syndrome has been
Objective Age-dependent impairment of delay and trace eyeblink conditioning in mice was evaluated in *** Rats were trained delay eyeblink conditioning,in which the conditioned stimulus(CS) overlaped with a coterminati...
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Objective Age-dependent impairment of delay and trace eyeblink conditioning in mice was evaluated in *** Rats were trained delay eyeblink conditioning,in which the conditioned stimulus(CS) overlaped with a coterminating unconditioned stumulus(US),or trace paradigm,in which a stimulus-free trace interval of 500 ms intervened between the CS and
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