Objective:Mylabris is an arthropod of the family Meloidae,including species such as Mylabris phalerata Pallas and Mylabris Cichorii *** major constituent of Mylabris is Cantharidates,which are an effective antitumor *...
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Objective:Mylabris is an arthropod of the family Meloidae,including species such as Mylabris phalerata Pallas and Mylabris Cichorii *** major constituent of Mylabris is Cantharidates,which are an effective antitumor *** the toxicity to the liver and mechanism are *** can provide a new way of study for the toxicity research of Chinese medicine based on "holistic" analytical toxicological biochemical ***:In our study,the aqueous of Mylabris(AEMC) was extracted by alcohol and water *** metabolic profiles and differential metabolites of the aqueous of Mylabris induced hepatotoxicity in rats after intragastric administration were analyzed by untargeted LC-MS *** with serum biochemical indexes and histopathological results,the characteristics and toxicological mechanism of hepatotoxicity induced by AEMC in rats were ***:The results show that the Serum ALT and AST were increased significantly(P< 0.01) after fifteen days of administration compared with the control group and there were different degrees of injury of liver *** liver metabolic profiles changed significantly after the AEMC intervention,sixteen differential metabolites such as Arachidonic acid,5-Phosphomevalonate,Lactoyl-CoA were found and *** enrichment analysis of metabolites was performed by fourteen metabolic pathway such as Arachidonic acid metabolism,Terpenoid backbone biosynthesis,Propanoate ***:This study will give a foundation for further study on the hepatotoxicity mechanism of Mylabris.
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