In many tissues the parasympathetic and sympathetic nervous system regulate smooth muscle tone via their transmitters acetylcholine and noradrenaline,*** smooth muscle effects of acetylcholine via muscarinic receptors...
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In many tissues the parasympathetic and sympathetic nervous system regulate smooth muscle tone via their transmitters acetylcholine and noradrenaline,*** smooth muscle effects of acetylcholine via muscarinic receptors always promote contraction,but non-neuronal
Autism is a highly heritable neurodevelopmental condition characterized by impaired social interaction and ***,the role of synaptic dysfunction during development of autism remains *** the present study,we address the...
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Autism is a highly heritable neurodevelopmental condition characterized by impaired social interaction and ***,the role of synaptic dysfunction during development of autism remains *** the present study,we address the alterations of biochemical signaling
Objective:To investigate the effect of single-wall carbon nanotubes on the mitochondrial electron transport chain(METC) of tumor ***:Human hepatocarcinoma cell line HepG2 were cultured in DMEM medium(Hyclone) suppleme...
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Objective:To investigate the effect of single-wall carbon nanotubes on the mitochondrial electron transport chain(METC) of tumor ***:Human hepatocarcinoma cell line HepG2 were cultured in DMEM medium(Hyclone) supplemented with 10%fetal calf serum
Aims:Total triterpenoid from Prunella vulgaris L.(TTP),known as a traditional Chinese medicinehad,had a preventive effect against hepatic steatosis in our previous *** objective was to evaluate whether TTP could impro...
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Aims:Total triterpenoid from Prunella vulgaris L.(TTP),known as a traditional Chinese medicinehad,had a preventive effect against hepatic steatosis in our previous *** objective was to evaluate whether TTP could improve liver fibrosis in rats and to investigate the mecha-
Backgroud:House dust mite allergens(HDM) is the most commonly encountered pathogen of humans,predominantly causing bronchoconstriction in asthma patients and inducing an inflammatory response in the lungs dune to the ...
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Backgroud:House dust mite allergens(HDM) is the most commonly encountered pathogen of humans,predominantly causing bronchoconstriction in asthma patients and inducing an inflammatory response in the lungs dune to the release of cytokines,chemokines and other medi-
Hepatic stellate cell(HSC) activation is an essential event during liver fibrogenesis. Phosphatase and tension homolog deleted on chromosome 10(PTEN),a tumor suppressor, is a negative regulator of this *** promoter hy...
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Hepatic stellate cell(HSC) activation is an essential event during liver fibrogenesis. Phosphatase and tension homolog deleted on chromosome 10(PTEN),a tumor suppressor, is a negative regulator of this *** promoter hypermethylation is a major epigenetic silencing mechanism in *** present study aimed to investigate whether PTEN promoter methylation was involved in HSCs activation and liver *** observed that hypermethyla-
Objective:To research the effects of docetaxel(DOC) loaded on activated carbon nanopar- ticles(ACNP-DOC) on the cell membrane of A549 human lung cancer cells using atomic force microscope(AFM).Methods:ACNP was prepare...
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Objective:To research the effects of docetaxel(DOC) loaded on activated carbon nanopar- ticles(ACNP-DOC) on the cell membrane of A549 human lung cancer cells using atomic force microscope(AFM).Methods:ACNP was prepared by grinding-suspenssion-centrifugation process and ACNP diameters were measured with Laser particle size analyzer and transmission e-
Background/Aims:To reveal the miR--146a expression and related roles in TGF-β1-induced hepatic stellate cells activation. Methods:miR--146a expression was analyzed in TGF-β1-treated HSC and CC14-induced liver brotic...
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Background/Aims:To reveal the miR--146a expression and related roles in TGF-β1-induced hepatic stellate cells activation. Methods:miR--146a expression was analyzed in TGF-β1-treated HSC and CC14-induced liver brotic tissues by one-step real-time quantitative ***,the effects of
Loss of dopaminergic input to the striatum associated with Parkinson's disease brings about a compensatory increase in glutamate release onto the dopaminergic cell bodies in the substantia nigra pars compacta(SNpc...
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Loss of dopaminergic input to the striatum associated with Parkinson's disease brings about a compensatory increase in glutamate release onto the dopaminergic cell bodies in the substantia nigra pars compacta(SNpc).Glutamate over-activation of NMDA receptors on these cells can cause excitotoxicity and contribute to their further *** receptor-mediated neuronal death is reduced by group I mGluR-mediated up-regulation of endocytosis protein RAB5B
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