In many tissues the parasympathetic and sympathetic nervous system regulate smooth muscle tone via their transmitters acetylcholine and noradrenaline,*** smooth muscle effects of acetylcholine via muscarinic receptors...
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In many tissues the parasympathetic and sympathetic nervous system regulate smooth muscle tone via their transmitters acetylcholine and noradrenaline,*** smooth muscle effects of acetylcholine via muscarinic receptors always promote contraction,but non-neuronal
国内约有1.2％的人群患有智力发育迟滞症.这类疾病主要是由遗传基因缺陷而引起的.、目前对智力发育迟滞症的治疗手段十分有限,这是对提高人们健康生活的一个挑战.如果能找到这二疾病的发病病因,了解其发病的机理,并进行早期治疗,有望减轻这一病症,减小社会对其护理的压力.近年来发现一个引起智力发育迟滞基因CRBN的突变,该突变在第419位氨基酸引入了一个终止密码子,从而导致其所表达的蛋白质失去了羧基端的24个氨基酸.研究目的:研究突变型与野生型CRBN蛋白质的性质,并探索其调控机制.研究结果:我们的研究发现,失去了羧基端的CRBN突变体在细胞内的表达大大降低,但并不影响它与其它蛋白质形成Cullin RING E3泛素连接酶复合物.这一突变导致其在细胞中的泛素化程度和泛素化速率远远高于野生型蛋白质.我们的实验证实:该蛋白质通过自身泛素化一蛋白酶体途径降解.利用蛋白质泛素化位点鉴定技术,我们获得了CRBN的两个泛素化位点.这两个位点位于CRBN的羧基端.
Autism is a highly heritable neurodevelopmental condition characterized by impaired social interaction and ***,the role of synaptic dysfunction during development of autism remains *** the present study,we address the...
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Autism is a highly heritable neurodevelopmental condition characterized by impaired social interaction and ***,the role of synaptic dysfunction during development of autism remains *** the present study,we address the alterations of biochemical signaling
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