Hepatic stellate cell(HSC) activation is an essential event during liver fibrogenesis. Phosphatase and tension homolog deleted on chromosome 10(PTEN),a tumor suppressor, is a negative regulator of this *** promoter hy...
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Hepatic stellate cell(HSC) activation is an essential event during liver fibrogenesis. Phosphatase and tension homolog deleted on chromosome 10(PTEN),a tumor suppressor, is a negative regulator of this *** promoter hypermethylation is a major epigenetic silencing mechanism in *** present study aimed to investigate whether PTEN promoter methylation was involved in HSCs activation and liver *** observed that hypermethyla-
Background/Aims:To reveal the miR--146a expression and related roles in TGF-β1-induced hepatic stellate cells activation. Methods:miR--146a expression was analyzed in TGF-β1-treated HSC and CC14-induced liver brotic...
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Background/Aims:To reveal the miR--146a expression and related roles in TGF-β1-induced hepatic stellate cells activation. Methods:miR--146a expression was analyzed in TGF-β1-treated HSC and CC14-induced liver brotic tissues by one-step real-time quantitative ***,the effects of
Loss of dopaminergic input to the striatum associated with Parkinson's disease brings about a compensatory increase in glutamate release onto the dopaminergic cell bodies in the substantia nigra pars compacta(SNpc...
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Loss of dopaminergic input to the striatum associated with Parkinson's disease brings about a compensatory increase in glutamate release onto the dopaminergic cell bodies in the substantia nigra pars compacta(SNpc).Glutamate over-activation of NMDA receptors on these cells can cause excitotoxicity and contribute to their further *** receptor-mediated neuronal death is reduced by group I mGluR-mediated up-regulation of endocytosis protein RAB5B
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