To investigate whether cAMP-dependent protein kinase（PKA）and/or Ca-calmodulin-dependent protein kinase（CaMKII）is/are involved in Rb and Rg-enhanced synapsinⅠphosphorylation and glutamate release in PC12 cells,dif...
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To investigate whether cAMP-dependent protein kinase（PKA）and/or Ca-calmodulin-dependent protein kinase（CaMKII）is/are involved in Rb and Rg-enhanced synapsinⅠphosphorylation and glutamate release in PC12 cells,differentiated or undifferentiated PC12 cells were incubated with Rb and Rg,following a 30-min pretreatment with or without H89,an inhibitor of PKA or W7,of calmodulin.
Lethal ventricular arrhythmias are a major cause of sudden death during myocardial infarction(MI).β-blockers such as metoprolol and propranolol,have demonstrated to reduce mortality rate in MI patients. A recent stud...
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Lethal ventricular arrhythmias are a major cause of sudden death during myocardial infarction(MI).β-blockers such as metoprolol and propranolol,have demonstrated to reduce mortality rate in MI patients. A recent study demonstrated arrhythmogenic potential of the muscle-specific microRNA(miRNA),miR-1 in *** investigate if the life-saving property ofβ-blockers is related to targeting miR-1,we performed a
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