Objective: To determine whether ABCB11 gene polymorphisms affect the time-course of action of rocuronium in Chinese ***: This study included 105 unrelated Chinese patients undergoing general anesthesia with propofol, ...
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Objective: To determine whether ABCB11 gene polymorphisms affect the time-course of action of rocuronium in Chinese ***: This study included 105 unrelated Chinese patients undergoing general anesthesia with propofol, fentanyl and *** monitoring was performed with calibrated *** were allowed to recover spontaneously from the neuromuscular *** time interval between the first maximum depression of the train of four (TOF) and spontaneous recovery TOF ratio of 0.25/0.7/0.8/0.9 was *** Sequenom MassArray(R) SNP detection technology was used to detect the genotypes of the ABCB1 rs12720464, *** and non-genetic clinical data were also ***: In the present study, the mean time to spontaneous recovery of TOF ratio 0.8/0.9 in ABCB1 rs12720464 GG genotype was longer compared to that observed in ABCB1 rs12720464 AG genotype (56.77 ±14.23 min vs.49.50 ±10.49 min, and 62.58 ±18.16 min vs.53.20 ±12.56 min, respectively, P<0.05).Further, the time to spontaneous recovery of TOF 0.7/0.8/0.9 in ABCB1 rs1055302 GG genotype was longer than that in ABCB1 rs1055302 AG genotype (52.00 ±12.10 min vs.44.83 ±7.38 min,55.96 ±13.92 min vs.46.83 ±7.67 min, 61.66 ±17.70 min vs.49.50 ±8.44 min, respectively,P<0.05).Conclusion: In Chinese patients administered a single-dose rocuronium, the genetic variants ABCB1 rs12720464, and rs1055302 contribute to the individual variability of time-course of *** trial registration number: ChoCTR-PRP-15007205.
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