Chemoresistance is a major barrier against effective treatment outcomes in *** cancer cells can survive through chemotherapy and give rise to a revisited *** mechanisms of MDR involve multiple cellular events, such as...
Chemoresistance is a major barrier against effective treatment outcomes in *** cancer cells can survive through chemotherapy and give rise to a revisited *** mechanisms of MDR involve multiple cellular events, such as overexpression of ATP-binding cassette transporters (typically, p-glycoproteins, P-gp) and malfunction of ***-penetrating peptide-based strategies were developed for overcoming the barriers against effective cancer drug delivery, through the mechanisms including increased tumor penetration, enhanced intmcellular and intranuclear delivery, prolonged intracellular drug retention, thus yielding promising treatment benefits in the animal models.
暂无评论