Efficient drug delivery via polymeric nanocarriers has to cope with multiple challenges,one of which is the dilemma of premature drug release and site-specific controlled drug ***- triggered drug release is a versatil...
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Efficient drug delivery via polymeric nanocarriers has to cope with multiple challenges,one of which is the dilemma of premature drug release and site-specific controlled drug ***- triggered drug release is a versatile strategy to address such dilemma due to the abundance of pH gradients in human body and the presence of a large collection of acid-liable *** we report four examples utilizing pH as a trigger at organ and cellular ***,the acne skin is characteristic of a relatively lower pH microenvironment compared to the healthy *** anti-acne agent,adapalene,was encapsulated in pH-responsive polymer(Eudragit EPO)nanocarriers that exhibited enhanced drug release at acidic conditions;this indicated that the pH abnormality of diseased skin could be a useful trigger for to enhance topical drug ***,we found that hydro zone-linked polymer-drug conjugate micelles demonstrated improved intracellular drug delivery,but the split amino-ended polymer also showed considerable *** results are encouraging for chemotherapy due to the potential of enhanced efficacy,but present the issue of elevated side-effects to healthy ***,a pleiotropic agent,curcumin was selected to generate two types of amphophilic polymer-curcumin conjugates with hydrazone as a pH-liable linker;one is linear and the other is *** was revealed that the conjugate architecture played a significant role in determining the pharmaceutical properties and delivery efficiency of nanocarriers assembled by these *** linear one is superior to its counterpart regarding loading,release,cellular uptake,and cytotoxicity,except the ***,tailored dendrimer surfece engineering was employed to produce uniform nanocarriers with tunable surfece hydrophobicity for controlled drug *** neutral condition,the drug was secured inside the nanocarriers,whereas a rapid drug release was observed under the acidic circumstances.T
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