Recently,CMYA5 was suggested as a susceptibility gene for schizophrenia based on two independent studies utilizing different ethnic *** designed a case-control study to examine whether 21 SNPs contained within CMYA5 w...
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Recently,CMYA5 was suggested as a susceptibility gene for schizophrenia based on two independent studies utilizing different ethnic *** designed a case-control study to examine whether 21 SNPs contained within CMYA5 were associated with the disorder in a western Han Chinese sample comprised of 488 schizophrenia patients and 516 healthy control *** allele distribution of SNPs rs7714250,rs 16877135 and rs 13158477 showed significant association with schizophrenia（P=0.008,P=0.04,and P=0.009,respectively）;the genotype distribution of SNPs rs7714250 and rs 13158477 also showed significant association with the disorder（P=0.00004, and P=0.038,respectively）.Analysis of haplotypes comprised of two haploblocks （rs16877133-rs16877135-rs13158477 and rs28362541-rs3828611-rs12514461） showed significant association with schizophrenia(global P=4.91×10,and a significant difference was found for the common haplotype CTGTCGG（P=0.0033）.Replication of the association of CMYA5 with schizophrenia across various studies suggest that it is very likely a potential common schizophrenia-related gene *** studies correlating CMYA5 with DTNBP1 and PKA warrant further investigation of the molecular basis of this gene in relationship to the signal transduction pathway（s） underlying the pathogenesis of schizophrenia.
The human fungal pathogen Candida albicans has at least two types of phenotypic switch systems for growth transitions:white to opaque cell transitions and yeast to hyphal *** cells have historically not been known to ...
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The human fungal pathogen Candida albicans has at least two types of phenotypic switch systems for growth transitions:white to opaque cell transitions and yeast to hyphal *** cells have historically not been known to undergo filamentation under standard filament-inducing *** we find that Bcrl and its downstream regulators Cup9,Nrgl and Czfl and the cAMP-signaling pathway control opaque cell filamentation in *** have shown that deletion of BCR1,CUP9,NRG1 and CZF1 results in opaque cell filamentation under standard culture *** of BCR1 and CZF1 in white cells has no obvious effect on hyphal growth,suggesting that Bcrl and Czfl are opaque specific regulators of filamentation under the conditions ***,inactivation of the cAMP-signaling pathway or disruption of its downstream transcriptional regulators,FL08 and EFG1,strikingly attenuates filamentation in opaque cells of the bcrl/bcrl *** of HGC1,a downstream gene of the cAMP-signaling pathway encoding G1 cyclin-related protein,completely blocks opaque cell filamentation induced by inactivation of ***,filament formation in opaque cell of the bcrl/bcrl,nrgl/nrgl and czfl/czfl mutants is independent of pH *** of filamentation in opaque cells adds another level of complexity to phenotypic switching in C albicans and may increase phenotypic plasticity during host colonization and *** study establishes a link between the white-opaque switch and the yeast-filamentous growth transition in ***,and also provides new insights into the evolution and regulation of biological complexity in eukaryotic organisms.
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