Objective To observe the hypoxia training on heart,liver,kidney,hippocampus apoptosis and HIF-1α,Bax,Bcl-2 expression,the mechanism of adaptation to hypoxic training of experimental data and theoretical basis. Method...
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Objective To observe the hypoxia training on heart,liver,kidney,hippocampus apoptosis and HIF-1α,Bax,Bcl-2 expression,the mechanism of adaptation to hypoxic training of experimental data and theoretical basis. Methods 70 SD rats were randomly divided into 7 groups of 10 each,namely:normal control group(A),high-living 8h group(B),high-living 12h group
Objective To explore the effective compatibility and their respective dose of Astragaloside Ⅳ,GinsenosideRb1,GinsenosideRg1 and NotoginsenosideR1 resistance to Oxidative damage by CoCl2 of PC12 cells. MethodsPC12 cel...
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Objective To explore the effective compatibility and their respective dose of Astragaloside Ⅳ,GinsenosideRb1,GinsenosideRg1 and NotoginsenosideR1 resistance to Oxidative damage by CoCl2 of PC12 cells. MethodsPC12 cells injury were induced by *** determined the LDH levels in cell culture medium and freeze-thaw liquid,then used Lactate dehydrogenase(LDH)leakage rate as an indicator to study the above four active
Total Panax notoginseng saponin(TPNS)is extracted from Panax notoginseng. Our previous studies suggested that TPNS could inhibit intimal hyperplasia. This study discussed the impact of TPNS on the proliferation of vas...
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Total Panax notoginseng saponin(TPNS)is extracted from Panax notoginseng. Our previous studies suggested that TPNS could inhibit intimal hyperplasia. This study discussed the impact of TPNS on the proliferation of vascular smooth muscle cell(VSMC)and revealed the associated mechanisms through cell
Objective To investigate the effects of visfatin on human osteoblasts(HOBs)and the involved possible mechanisms. Methods HOBs were treated with visfatin or *** Red S staining was used for assessment of human osteoblas...
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Objective To investigate the effects of visfatin on human osteoblasts(HOBs)and the involved possible mechanisms. Methods HOBs were treated with visfatin or *** Red S staining was used for assessment of human osteoblasts matrix mineralization.
Objective To study the effect of Antiflammin-1(AF-1)on proliferation of lung fibroblast,and the mechanism of uteroglobin binding protein(UGBP)in mediating the anti-proliferation effect of AF-1 on lung fibroblasts. Met...
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Objective To study the effect of Antiflammin-1(AF-1)on proliferation of lung fibroblast,and the mechanism of uteroglobin binding protein(UGBP)in mediating the anti-proliferation effect of AF-1 on lung fibroblasts. Methods NIH3T3 were cultured and divided into 8 groups with different ***-ELISA was used to detect cell proliferation of *** change of cell cycle was measured by flow ***-PCR and flow cytometry
Objective This review discusses the current status and progress in studies on the roles of hydrogen sulfide (H2S) in regulation of neurotoxicity, neuroprotection, and neuromodulator, as well as its therapeutic potenti...
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Objective This review discusses the current status and progress in studies on the roles of hydrogen sulfide (H2S) in regulation of neurotoxicity, neuroprotection, and neuromodulator, as well as its therapeutic potential for neurodegenerative disorders. Study selection Articles regarding the regulation of neuronal function,
The spinal cord is a necessary pathway that transfers the body nociceptive inputs to the brain,and endogenous opiate peptides(EOP)play an important role in pain *** previous work has proven that arginine vasopressin(A...
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The spinal cord is a necessary pathway that transfers the body nociceptive inputs to the brain,and endogenous opiate peptides(EOP)play an important role in pain *** previous work has proven that arginine vasopressin(AVP)antinociception in the caudate nucleus(CdN)relates with the acetylcholine(Ach)system mainly. The communication was designed to
Aims This study aim to investigate the association of serine racemase(SRR)rs391300 G/A polymorphism with the development of type 2 diabetes mellitus(T2DM)and assess the impacts on metformin therapeutic efficacy in Chi...
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Aims This study aim to investigate the association of serine racemase(SRR)rs391300 G/A polymorphism with the development of type 2 diabetes mellitus(T2DM)and assess the impacts on metformin therapeutic efficacy in Chinese patients. Material and methods A case-control study of 402 T2DM patients and 171healthy controls was conducted to identify the genotype for SRR rs391300
The purpose of this work is to probe the effect of AST and PNS combination on energy metabolism disturbance after cerebral ischemia-reperfusion in mice. C57BL/6 mice were randomly divided into sham operated group,mode...
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The purpose of this work is to probe the effect of AST and PNS combination on energy metabolism disturbance after cerebral ischemia-reperfusion in mice. C57BL/6 mice were randomly divided into sham operated group,model group,Astragalosides(AST,110 mg·kg-1.d-1,ig)group,Panax notoginseng saponins(PNS,
Aims To explore whether arecoline exerts beneficial effect on impaired endothelium-dependent relaxation induced by high-fructose diet and the potential mechanisms. Main methods Rats were fed with or without high fruct...
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Aims To explore whether arecoline exerts beneficial effect on impaired endothelium-dependent relaxation induced by high-fructose diet and the potential mechanisms. Main methods Rats were fed with or without high fructose diet for 11 weeks. high-fructose fed rats(HF group)and normal rats(control group)at 12 weeks
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