Objectives The aims of this study were to investigate the effects of Nampt on insulin secretion and gene expressions of PDX-1 and FoxO1 which were important transcription factors associated with insulin secretion. Mat...
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Objectives The aims of this study were to investigate the effects of Nampt on insulin secretion and gene expressions of PDX-1 and FoxO1 which were important transcription factors associated with insulin secretion. Materials and methods Insulin secretion level in RIN-m5f cells was detected by rat insulin ELISA detection *** mRNA expression levels of
Objective To explore the association between rs3758539G-803A and rs10882283T-179G polymorphisms of RBP4 and rosiglitazone response in Chinese type 2 diabetes mellitus(T2DM)patients. Methods A total of 472 T2DM patient...
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Objective To explore the association between rs3758539G-803A and rs10882283T-179G polymorphisms of RBP4 and rosiglitazone response in Chinese type 2 diabetes mellitus(T2DM)patients. Methods A total of 472 T2DM patients and 198 healthy subjects wereenrolled to identify G-803A and T-179G genotypes using a polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)assay.42 T2DM patients with different G-803A or T-179G genotypes were selected to undergo
Backgroud Formaldehyde(FA)induces neurotoxicity by overproduction of intracellular reactive oxygen species(ROS).Increasing studies have shown that hydrogen sulfide(H2S),an endogenous gastransmitter,protects nerve cell...
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Backgroud Formaldehyde(FA)induces neurotoxicity by overproduction of intracellular reactive oxygen species(ROS).Increasing studies have shown that hydrogen sulfide(H2S),an endogenous gastransmitter,protects nerve cell against oxidative stress by its antioxidant *** has been shown that overproduction of nitric oxide(NO)inhibits the activity of
Astragalosides(AST)and Panax notoginseng saponins(PNS)are the effective ingredients in Astragalus and Panax notoginseng,respectively,they both have the effects of anti-ischemic brain *** purpose of this work was to pr...
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Astragalosides(AST)and Panax notoginseng saponins(PNS)are the effective ingredients in Astragalus and Panax notoginseng,respectively,they both have the effects of anti-ischemic brain *** purpose of this work was to probe the effects of AST and PNS combination on neuron apoptosis after ischemia-reperfusion through Jun N-terminal kinase(JNK)signaling pathway and mitochondrial apoptosis pathway.C56BL/6 mice were randomly divided into sham group,model group,AST group,
mGluR2/3 has been found reported that the expressing in rat and monkey's kidney,liver,lung,spleen and ***,whether mGluR2/3 expressing in mouse lung tissue is not *** To investigate the expression of group II metab...
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mGluR2/3 has been found reported that the expressing in rat and monkey's kidney,liver,lung,spleen and ***,whether mGluR2/3 expressing in mouse lung tissue is not *** To investigate the expression of group II metabotropic glutamate receptors in lung tissue,and the influence of LPS on its expression in lungs in vivo. Methods mGluR2/3 expression in mice lung tissue were analyzed by SABC immunohistologic,Immuno-fluorescence methods and fluorescence quantitative real-time *** lung injury was induced by LPS.
ACS6,a novel hydrogen sulfide(H2S)-releasing sildenafil,has been demonstrated to inhibit superoxide formation through donating *** have found that ACS6 antagonizes homocysteine-induced apoptosis and cytotoxicity. The ...
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ACS6,a novel hydrogen sulfide(H2S)-releasing sildenafil,has been demonstrated to inhibit superoxide formation through donating *** have found that ACS6 antagonizes homocysteine-induced apoptosis and cytotoxicity. The aim of the present study is to explore the molecular mechanisms underlying ACS6-exerted protective action against homocysteine neurotoxicity to PC12
Our previous study has proven that tea poluphenol has a role in lung *** present communication was to investage the anti-proliferation effect of tea polyphenol on the PG cells,which was a high metastatic human lung ca...
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Our previous study has proven that tea poluphenol has a role in lung *** present communication was to investage the anti-proliferation effect of tea polyphenol on the PG cells,which was a high metastatic human lung carcinoma cell line,by 3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-diphenytetrazoliumromide(MTT)cell viability assay,and to study
Oxytocin(OXT),a nonapeptide posterior hormone of the pituitary,is mainly synthesized and secreted in the hypothalamic paraventricular nucleus(PVN)and supraoptic nucleus(SON).It has been proven that OXT plays a role in...
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Oxytocin(OXT),a nonapeptide posterior hormone of the pituitary,is mainly synthesized and secreted in the hypothalamic paraventricular nucleus(PVN)and supraoptic nucleus(SON).It has been proven that OXT plays a role in *** present study was to investigate by which level,brain or periphery,OXT effecting on the behavioral activity in the behavior despair
Background Some study found that ATP-binding cassette(ABC)efflux transporters play an important role in antiepileptic drug resistance,especially ABCB1 and *** aims of this study were to evaluate the relationship betwe...
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Background Some study found that ATP-binding cassette(ABC)efflux transporters play an important role in antiepileptic drug resistance,especially ABCB1 and *** aims of this study were to evaluate the relationship between the genetic polymorphisms of ABCC2 and ABCB1 and the therapeutic efficacy of antiepileptic drugs(AEDs)in Chinese epileptic patients.
Objective Calcitonin gene-related peptide(CGRP)is related with development of pulmonary hypertension(PH),but the mechanisms of inhibitory effect of CGRP on vascular remodeling remains ***1/2 is necessary for the degra...
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Objective Calcitonin gene-related peptide(CGRP)is related with development of pulmonary hypertension(PH),but the mechanisms of inhibitory effect of CGRP on vascular remodeling remains ***1/2 is necessary for the degradation or down-regulation of the cell cycle inhibitor p27,and is also crucial in mediating proliferation of pulmonary artery smooth muscle
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