Immune thrombocytopenia(ITP), also known as idiopathic thrombocytopenic purpura, is anautoimmune disease characterized by low platelet count and increased bleeding ***, glucocorticoid and splenectomy are the main ther...
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Immune thrombocytopenia(ITP), also known as idiopathic thrombocytopenic purpura, is anautoimmune disease characterized by low platelet count and increased bleeding ***, glucocorticoid and splenectomy are the main therapies for ITP but with obvious side effects including tendency of relapse and risk of internal *** this study, we report the Mongolian medicine Qishunbaolier(QSBLE) can significantly and efficiently increase platelet count with a low recurrent rate and unnoticeable side *** profiled the microRNA(miRNA) expression in the blood sample of ITP patients and identified 44 miRNAs that are differentially expressed in ITP patients before and after QSBLE *** of these 44 miRNAs,25 are expressed in control subjects and are downregulated in ITP patients, whereas the treatment with QSBLE restores their expressions to the level of control *** result suggests that abnormal expression of these 25 miRNAs might be connected to the pathogenesis of ***, 14 of those 44 miNRAs are predicted to target at least once on 31 known IPT associated genes, indicating the possible mechanism of QSBLE on ITP therapy.
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